
Overview
Background
Associate Prof Amy McCart Reed holds a PhD in molecular biology from The University of Queensland. She is a Fellow of the Faculty of Science of the Royal College of Pathologists Australasia. Her early postdoctoral work focused on understanding the genetic basis of colorectal cancer using experimental disease models, as part of a Cancer Research UK-funded colorectal cancer program led by Professors Ian Tomlinson and Andrew Silver. After returning to Australia, she was recruited to the Molecular Breast Pathology group at UQ’s Centre for Clinical Research and has undertaken a series of studies investigating the genomic landscape of breast cancer special types. Amy's research program includes studies on Metaplastic breast cancer and Invasive Lobular Carcinoma, two breast cancer special types in need of targetted therapy options. A/Prof McCart Reed is the scientific lead on an MRFF-funded genomics program investigating the potential for the application of Whole Genome Sequencing in the breast cancer care pathway in Australia, 'Q-IMPROvE'. She applies genomics and spatial transcriptomics methodologies to archival clinical samples to understand the differences between tumour types and their potential for treatment. Amy is passionate about clinical research, biobanking and precision oncology. In addition to her breast cancer research portfolio, she is on the steering committee for the Brisbane Breast Bank and the Scientific Advisory Board for Breast Cancer Trials.
Availability
- Associate Professor Amy McCart Reed is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Research interests
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Breast Cancer
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Genomics
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Biobanking
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Molecular pathology
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Precision medicine
Works
Search Professor Amy McCart Reed’s works on UQ eSpace
2018
Book Chapter
Breast Cancer: Pathology and Genetics
McCart Reed, Amy E., Kalaw, Emarene, Reid, Andrew and Lakhani, Sunil R. (2018). Breast Cancer: Pathology and Genetics. Encyclopedia of Cancer, Third Edition: Volumes 1-3. (pp. V1:170-V1:183) Elsevier. doi: 10.1016/B978-0-12-801238-3.65263-7
2018
Book Chapter
Breast cancer - pathology and genetics
McCart Reed, Amy Ellen, Kalaw, Emarene, Reid, Andrew Scott and Lakhani, Sunil R. (2018). Breast cancer - pathology and genetics. Encyclopedia of cancer. (pp. 170-183) edited by Paolo Boffetta and Pierre Hainaut. Cambridge, MA United States: Academic Press. doi: 10.1016/B978-0-12-801238-3.65263-7
2017
Journal Article
Molecular signatures in breast cancer
Lal, Samir, McCart Reed, Amy E., de Luca, Xavier M. and Simpson, Peter T. (2017). Molecular signatures in breast cancer. Methods, 131, 135-146. doi: 10.1016/j.ymeth.2017.06.032
2017
Journal Article
Association analysis identifies 65 new breast cancer risk loci
Michailidou, Kyriaki, Lindström, Sara, Dennis, Joe, Beesley, Jonathan, Hui, Shirley, Kar, Siddhartha, Lemaçon, Audrey, Soucy, Penny, Glubb, Dylan, Rostamianfar, Asha, Bolla, Manjeet K, Wang, Qin, Tyrer, Jonathan, Dicks, Ed, Lee, Andrew, Wang, Zhaoming, Allen, Jamie, Keeman, Renske, Eilber, Ursula, French, Juliet D, Qing Chen, Xiao, Fachal, Laura, McCue, Karen, McCart Reed, Amy E, Ghoussaini, Maya, Carroll, Jason S, Jiang, Xia, Finucane, Hilary, Adams, Marcia ... Easton, Douglas F (2017). Association analysis identifies 65 new breast cancer risk loci. Nature, 551 (7678), 92-94. doi: 10.1038/nature24284
2017
Journal Article
Multidimensional phenotyping of breast cancer cell lines to guide preclinical research
Saunus, Jodi M., Smart, Chanel E., Kutasovic, Jamie R., Johnston, Rebecca L., Kalita-de Croft, Priyakshi, Miranda, Mariska, Rozali, Esdy N., Vargas, Ana Cristina, Reid, Lynne E., Lorsy, Eva, Cocciardi, Sibylle, Seidens, Tatjana, McCart Reed, Amy E., Dalley, Andrew J., Wockner, Leesa F., Johnson, Julie, Sarkar, Debina, Askarian-Amiri, Marjan E., Simpson, Peter T., Khanna, Kum Kum, Chenevix-Trench, Georgia, Al-Ejeh, Fares and Lakhani, Sunil R. (2017). Multidimensional phenotyping of breast cancer cell lines to guide preclinical research. Breast Cancer Research and Treatment, 167 (1), 1-13. doi: 10.1007/s10549-017-4496-x
2017
Journal Article
Next-generation sequencing of endobronchial ultrasound transbronchial needle aspiration specimens in lung cancer
Fielding, David, Dalley, Andrew J., Bashirzadeh, Farzad, Singh, Mahendra, Nandakumar, Lakshmy, Reed, Amy E. McCart, Black, Debra, Kazakoff, Stephen, Nones, Katia, Pearson, John, Waddell, Nic, Lakhani, Sunil R. and Simpson, Peter T. (2017). Next-generation sequencing of endobronchial ultrasound transbronchial needle aspiration specimens in lung cancer. American Journal of Respiratory and Critical Care Medicine, 196 (3), 388-391. doi: 10.1164/rccm.201609-1935LE
2017
Journal Article
Breast cancer brain metastases: clonal evolution in clinical context
Saunus, Jodi M., McCart Reed, Amy E., Lim, Zhun Leong and Lakhani, Sunil R. (2017). Breast cancer brain metastases: clonal evolution in clinical context. International Journal of Molecular Sciences, 18 (1) 152, 152. doi: 10.3390/ijms18010152
2017
Conference Publication
An integrated molecular analysis of invasive lobular carcinoma
Lal, S., Reed, A. McCart, Nones, K., Wockner, L., Song, S., Lakhani, S. and Simpson, P. (2017). An integrated molecular analysis of invasive lobular carcinoma. 39th Annual San Antonio Breast Cancer Symposium, San Antonio, Texas, 6-10 December 2016. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.SABCS16-P1-05-16
2017
Conference Publication
Immunohistochemical evaluation of FOXA1 expression and its correlation with breast cancer-specific survival: queensland follow up cohort
Dedina, Liana, Kutasovic, Jamie R., McCart Reed, Amy E., Simpson, Peter T. and Lakhani, Sunil R. (2017). Immunohistochemical evaluation of FOXA1 expression and its correlation with breast cancer-specific survival: queensland follow up cohort. Pathology Update 2017, Sydney Australia, 24 - 26 February 2017. London, United Kingdom: Lippincott Williams & Wilkins. doi: 10.1016/j.pathol.2016.12.174
2017
Conference Publication
Diffquik Stained Cytology Smears Provide Improved Malignant Cell Dna Yields From Lymph Nodes At Endobronchial Ultrasound Transbronchial Needle Aspiration (Ebus-Tbna)
Fielding, D., Dalley, A., Bashirzadeh, F., Singh, M., Nandakumar, L., Reed, McCart A., Black, D., Waddell, N., Kazakoff, Stephen, Nones, Katia, Pearson, John, Lakhani, S. and Simpson, P. (2017). Diffquik Stained Cytology Smears Provide Improved Malignant Cell Dna Yields From Lymph Nodes At Endobronchial Ultrasound Transbronchial Needle Aspiration (Ebus-Tbna). ANZSRS/TSANZ Annual Scientific Meeting, Canberra, Australia, 24-28 March 2017. Richmond, VIC, Australia: Wiley-Blackwell.
2017
Conference Publication
Brocade: The National Breast Cancer Foundation Repository of Primary Tumours and Metastases from Breast Cancer Patients
Anderson, Robin L., Swarbrick, Alex, Johnstone, Ricky, Chua, Boon, Gill, Anthony, Saunders, Christobel, Lakhani, Sunil, Lim, Elgene, Loi, Sherene, O'Toole, Sandra A., Khanna, Kum Kum, Devereux, Lisa, Harvey, Kate and Reed, Amy McCart (2017). Brocade: The National Breast Cancer Foundation Repository of Primary Tumours and Metastases from Breast Cancer Patients. COSA's 44th Annual Scientific Meeting: Immunotherapy: Molecules and Moutains, Darling Harbour, Sydney, NSW, 13–15 November 2017. Hoboken, NJ United States: Wiley.
2016
Journal Article
'Omics approaches in breast cancer research and clinical practice
Kalita-De Croft, Priyakshi, Al-Ejeh, Fares, McCart Reed, Amy E., Saunus, Jodi M. and Lakhani, Sunil R. (2016). 'Omics approaches in breast cancer research and clinical practice. Advances in Anatomic Pathology, 23 (6), 356-367. doi: 10.1097/PAP.0000000000000128
2016
Journal Article
Long-range regulators of the lncRNA HOTAIR enhance its prognostic potential in breast cancer
Milevskiy, Michael J. G., Al-Ejeh, Fares, Saunus, Jodi M., Northwood, Korinne S., Bailey, Peter J., Betts, Joshua A., McCart Reed, Amy E., Nephew, Kenneth P., Stone, Andrew, Gee, Julia M. W., Dowhan, Dennis H., Dray, Eloise, Shewan, Annette M., French, Juliet D., Edwards, Stacey L., Clark, Susan J., Lakhani, Sunil R. and Brown, Melissa A. (2016). Long-range regulators of the lncRNA HOTAIR enhance its prognostic potential in breast cancer. Human Molecular Genetics, 25 (15), 3269-3283. doi: 10.1093/hmg/ddw177
2016
Journal Article
High content screening application for cell-type specific behaviour in heterogeneous primary breast epithelial subpopulations
Johnston, Rebecca L., Wockner, Leesa, McCart Reed, Amy E., Wiegmans, Adrian, Chenevix-Trench, Georgia, Khanna, Kum Kum, Lakhani, Sunil R. and Smart, Chanel E. (2016). High content screening application for cell-type specific behaviour in heterogeneous primary breast epithelial subpopulations. Breast Cancer Research, 18 (18) 18, 1-18. doi: 10.1186/s13058-016-0681-9
2016
Conference Publication
Next Generation Sequencing On Endobronchial Ultrasound Transbronchial Needle Aspirate Lymph Node Specimens in Lung Cancer Shows a High Incidence of Mutations and Consistency with Single Gene Testing
Fielding, D., Bashirzadeh, F., Singh, M., Nandakumar, L., Reed, Mccart A., Black, D., Dalley, A., Pearson, J., Nones, K., Waddell, N., Simpson, P. and Lakhani, S. (2016). Next Generation Sequencing On Endobronchial Ultrasound Transbronchial Needle Aspirate Lymph Node Specimens in Lung Cancer Shows a High Incidence of Mutations and Consistency with Single Gene Testing. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting, Perth, WA, Australia, 1-6 April 2016. Wiley. doi: 10.1111/resp.12754_12
2016
Conference Publication
An integrative analysis of invasive lobular breast cancer
Lal, Samir, McCart Reed, Amy E, Nones, Katia, Wockner Leesa, Song, Sarah, Waddell, Nic, Lakhani, Sunil and Simpson, Peter t (2016). An integrative analysis of invasive lobular breast cancer. Lorne Cancer Conference, Lorne VIC, Australia, February 11-13th 2016.
2016
Book Chapter
Genomic analysis
Hunter, Sally M., McCart Reed, Amy E., Campbell, Ian G. and Gorringe, Kylie L. (2016). Genomic analysis. Molecular pathology in cancer research. (pp. 83-106) edited by Sunil R. Lakhani and Stephen Fox. New York, United States: Springer. doi: 10.1007/978-1-4939-6643-1_5
2016
Book Chapter
Forgotten resources - the autopsy
Smith, Deborah, Reed, Amy McCart and Lakhani, Sunil R. (2016). Forgotten resources - the autopsy. Molecular pathology in cancer research. (pp. 335-348) edited by Sunil R. Lakhani and Stephen B. Fox. New York, NY, U.S.A.: Springer . doi: 10.1007/978-1-4939-6643-1_15
2016
Journal Article
An epithelial to mesenchymal transition programme does not usually drive the phenotype of invasive lobular carcinomas
McCart Reed, Amy E., Kutasovic, Jamie R., Vargas, Ana Cristina, Jayanthan, Janani, Al-Murrani, Amel, Reid, Lynne E., Chambers, Rachael, Da Silva, Leonard, Melville, Lewis, Evans, Elizabeth, Porter, Alan, Papadimos, David, Thompson, Erik W., Lakhani, Sunil R. and Simpson, Peter T. (2016). An epithelial to mesenchymal transition programme does not usually drive the phenotype of invasive lobular carcinomas. Journal of Pathology, 238 (4), 489-494. doi: 10.1002/path.4668
2015
Journal Article
Integrated genomic and transcriptomic analysis of human brain metastases identifies recurrently altered pathways of potential clinical significance
Saunus, Jodi M., Quinn, MIchael C. J., Patch, Ann-Marie, Pearson, John V., Bailey, Peter J., Nones, Katia, McCart Reed, Amy E., Miller, David, Peter J. Wilson, Al-Ejeh, Fares, Mariasegaram, Mythily, Lau, Queenie, Withers, Teresa, Jeffree, Rosalind L., Reid, Lynne E., Da Silva, Leonard, Matsika, Admire, Niland, Colleen M., Cummings, Margaret C., Bruxner, Timothy J. C., Christ, Angelika N., Harliwong, Ivon, Idrisoglu, Senel, Manning, Suzanne, Nourse, Craig, Nourbakhsh, Ehsan, Wani, Shivangi, Anderson, Matthew J., Fink, J. Lynn ... Lakhani, Sunil R. (2015). Integrated genomic and transcriptomic analysis of human brain metastases identifies recurrently altered pathways of potential clinical significance. Journal of Pathology, 237 (3), 363-378. doi: 10.1002/path.4583
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Amy McCart Reed is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Investigating therapeutic vulnerabilities in breast cancer.
Principal Advisor
Other advisors: Professor Sunil Lakhani, Associate Professor Peter Simpson
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Doctor Philosophy
Circulating biomarkers in invasive lobular breast carcinoma
Principal Advisor
Other advisors: Professor Sunil Lakhani, Associate Professor Peter Simpson
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Master Philosophy
Applications of Molecular Genetics in Translational Breast Cancer Research
Associate Advisor
Other advisors: Associate Professor Peter Simpson, Professor Sunil Lakhani
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Master Philosophy
Application of molecular genetics in Translational Breast Cancer Research
Associate Advisor
Other advisors: Associate Professor Peter Simpson, Professor Sunil Lakhani
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Master Philosophy
E-cadherin, ROS1 and synthetic lethality in ILC
Associate Advisor
Other advisors: Professor Sunil Lakhani
Completed supervision
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2024
Doctor Philosophy
Identifying and characterising targetable proteins in breast cancer brain metastasis
Principal Advisor
Other advisors: Professor Sunil Lakhani
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2021
Doctor Philosophy
Detailed Characterisation of Metaplastic Breast Carcinoma
Principal Advisor
Other advisors: Dr Jodi Saunus, Professor Sunil Lakhani
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2021
Doctor Philosophy
Multi-omics: Leveraging omics data integration to identify dysregulated biology in breast cancer
Associate Advisor
Other advisors: Dr Katia Nones, Associate Professor Peter Simpson
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2019
Doctor Philosophy
Identifying novel potential prognostic biomarkers in breast cancer
Associate Advisor
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2018
Doctor Philosophy
Genomic and transcriptomic biomarkers of prognosis in invasive lobular breast cancer.
Associate Advisor
Other advisors: Professor Sunil Lakhani, Associate Professor Peter Simpson
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2016
Doctor Philosophy
Intratumour heterogeneity in the development and progression of breast cancer
Associate Advisor
Other advisors: Professor Sunil Lakhani, Associate Professor Peter Simpson
Media
Enquiries
Contact Associate Professor Amy McCart Reed directly for media enquiries about:
- breast cancer
- DNA
- genomics
- lobular breast cancer
- metaplastic breast cancer
- personalised medicine
- precision medicine
- precision oncology
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