
Overview
Background
Associate Prof Amy McCart Reed holds a PhD in molecular biology from The University of Queensland. She is a Fellow of the Faculty of Science of the Royal College of Pathologists Australasia. Her early postdoctoral work focused on understanding the genetic basis of colorectal cancer using experimental disease models, as part of a Cancer Research UK-funded colorectal cancer program led by Professors Ian Tomlinson and Andrew Silver. After returning to Australia, she was recruited to the Molecular Breast Pathology group at UQ’s Centre for Clinical Research and has undertaken a series of studies investigating the genomic landscape of breast cancer special types. Amy's research program includes studies on Metaplastic breast cancer and Invasive Lobular Carcinoma, two breast cancer special types in need of targetted therapy options. A/Prof McCart Reed is the scientific lead on an MRFF-funded genomics program investigating the potential for the application of Whole Genome Sequencing in the breast cancer care pathway in Australia, 'Q-IMPROvE'. She applies genomics and spatial transcriptomics methodologies to archival clinical samples to understand the differences between tumour types and their potential for treatment. Amy is passionate about clinical research, biobanking and precision oncology. In addition to her breast cancer research portfolio, she is on the steering committee for the Brisbane Breast Bank and the Scientific Advisory Board for Breast Cancer Trials.
Availability
- Associate Professor Amy McCart Reed is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Research interests
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Breast Cancer
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Genomics
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Biobanking
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Molecular pathology
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Precision medicine
Works
Search Professor Amy McCart Reed’s works on UQ eSpace
2020
Conference Publication
Characterising clinicopathological and biological parameters predictive of outcome for patients diagnosed with invasive lobular carcinoma
Simpson, P., Reed, A. McCart, Kutasovic, J., Coorey, C., Kuo, L., Nguyen, H., Pei, W., Ong, J., Sokolova, A., Evans, E., Porter, A. and Lakhani, S. (2020). Characterising clinicopathological and biological parameters predictive of outcome for patients diagnosed with invasive lobular carcinoma. ESMO Breast Cancer Virtual Meeting, Online, 23-24 May 2020. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.annonc.2020.03.186
2020
Journal Article
Morphologic and Genomic Heterogeneity in the Evolution and Progression of Breast Cancer
Kutasovic, Jamie R., McCart Reed, Amy E., Sokolova, Anna, Lakhani, Sunil R. and Simpson, Peter T. (2020). Morphologic and Genomic Heterogeneity in the Evolution and Progression of Breast Cancer. Cancers, 12 (4) 848, 848. doi: 10.3390/cancers12040848
2020
Journal Article
Non-coding RNAs underlie genetic predisposition to breast cancer
Moradi Marjaneh, Mahdi, Beesley, Jonathan, O'Mara, Tracy A., Mukhopadhyay, Pamela, Koufariotis, Lambros T., Kazakoff, Stephen, Hussein, Nehal, Fachal, Laura, Bartonicek, Nenad, Hillman, Kristine M., Kaufmann, Susanne, Sivakumaran, Haran, Smart, Chanel E., McCart Reed, Amy E., Ferguson, Kaltin, Saunus, Jodi M., Lakhani, Sunil R., Barnes, Daniel R., Antoniou, Antonis C., Dinger, Marcel E., Waddell, Nicola, Easton, Douglas F., Dunning, Alison M., Chenevix-Trench, Georgia, Edwards, Stacey L. and French, Juliet D. (2020). Non-coding RNAs underlie genetic predisposition to breast cancer. Genome Biology, 21 (1) 7, 7. doi: 10.1186/s13059-019-1876-z
2020
Book Chapter
Metaplastic breast cancer
Reis-Filho, J.S., Gobbi, H., McCart Reed, A.E., Rakha, E.A., Shin, S.J., Sortiriou, C. and Vincent-Salomon, A. (2020). Metaplastic breast cancer. WHO Classification of Tumours: Breast Tumours. (pp. 134-138) edited by WHO Classification of Tumours Editorial Board. Geneva, Switzerland: World Health Organization.
2019
Journal Article
LobSig is a multigene predictor of outcome in invasive lobular carcinoma
McCart Reed, Amy E., Lal, Samir, Kutasovic, Jamie R., Wockner, Leesa, Robertson, Alan, de Luca, Xavier M., Kalita-de Croft, Priyakshi, Dalley, Andrew J., Coorey, Craig P., Kuo, Luyu, Ferguson, Kaltin, Niland, Colleen, Miller, Gregory, Johnson, Julie, Reid, Lynne E., Males, Renique, Saunus, Jodi M., Chenevix-Trench, Georgia, Coin, Lachlan, Lakhani, Sunil R. and Simpson, Peter T. (2019). LobSig is a multigene predictor of outcome in invasive lobular carcinoma. npj Breast Cancer, 5 (1) 18, 18. doi: 10.1038/s41523-019-0113-y
2019
Journal Article
A molecular and morphological deep-dive into metaplastic breast cancers
McCart Reed, Amy E. and Lakhani, Sunil R. (2019). A molecular and morphological deep-dive into metaplastic breast cancers. Cancer Informatics, 18, 1-2. doi: 10.1177/1176935119850155
2019
Journal Article
Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers
Nones, K., Johnson, J., Newell, F., Patch, A. M., Thorne, H., Kazakoff, S. H., de Luca, X. M., Parsons, M. T., Ferguson, K., Reid, L. E., McCart Reed, A. E., Srihari, S., Lakis, V., Davidson, A. L., Mukhopadhyay, P., Holmes, O., Xu, Q., Wood, S., Leonard, C., The Kathleen Cuningham Foundation Consortium for Research into Familial Aspects of Breast Cancer (kConFab), The Australian Breast Cancer Tissue Bank (ABCTB), The Brisbane Breast Bank (BBB), Beesley, J., Harris, J. M., Barnes, D., Degasperi, A., Ragan, M. A., Spurdle, A. B., Khanna, K. K. ... Simpson, P. T. (2019). Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers. Annals of Oncology, 30 (7) mdz132, 1071-1079. doi: 10.1093/annonc/mdz132
2019
Journal Article
Diff-Quik cytology smears from endobronchial ultrasound transbronchial needle aspiration lymph node specimens as a source of DNA for next-generation sequencing instead of cell blocks
Fielding, David, Dalley, Andrew J., Bashirzadeh, Farzad, Singh, Mahendra, Nandakumar, Lakshmy, McCart Reed, Amy E., Black, Debra, Kazakoff, Stephen, Pearson, John V., Nones, Katia, Waddell, Nicola, Lakhani, Sunil R. and Simpson, Peter T. (2019). Diff-Quik cytology smears from endobronchial ultrasound transbronchial needle aspiration lymph node specimens as a source of DNA for next-generation sequencing instead of cell blocks. Respiration, 97 (6), 1-14. doi: 10.1159/000495661
2019
Journal Article
Phenotypic and molecular dissection of Metaplastic Breast Cancer and the prognostic implications
McCart Reed, Amy Ellen, Kalaw, Emarene, Nones, Katia, Bettington, Mark, Lim, Malcolm, Bennett, James, Johnstone, Kate, Kutasovic, Jamie Rose, Saunus, Jodi Marie, Kazakoff, Stephen, Xu, Qinying, Wood, Scott, Holmes, Oliver, Leonard, Conrad, Reid, Lynne Estelle, Black, Debra, Niland, Colleen, Ferguson, Kaltin, Gresshoff, Irma, Raghavendra, Ashwini, Harvey, Kate, Cooper, Caroline, Liu, Cheng, Kalinowski, Lauren, Reid, Andrew Scott, Davidson, Morgan, Pearson, John V, Pathmanathan, Nirmala, Tse, Gary ... Lakhani, Sunil R. (2019). Phenotypic and molecular dissection of Metaplastic Breast Cancer and the prognostic implications. Journal of Pathology, 247 (2), 214-227. doi: 10.1002/path.5184
2019
Book Chapter
Breast cancer heterogeneity in primary and metastatic disease
Kalinowski, Lauren, Saunus, Jodi M., McCart Reed, Amy E. and Lakhani, Sunil R. (2019). Breast cancer heterogeneity in primary and metastatic disease. Breast cancer metastasis and drug resistance: challenges and progress. (pp. 75-104) edited by Aamir Ahmad. Cham, Switzerland: Springer. doi: 10.1007/978-3-030-20301-6_6
2019
Conference Publication
LobSig, a prognostic signature for Invasive Lobular Carcinoma
McCart Reed, Amy E., Lal, Samir, Kutasovic, Jamie R., Wockner, Leesa, Robertson, Alan, de Croft, Priyakshi Kalıta, Dalley, Andrew, Coorey, Craig P., Kuo, Luyu, Ferguson, Kaltin, Niland, Colleen, Miller, Gregory, Johnson, Julie, Reid, Lynne E., Males, Renique, Saunus, Jodi M., Chenevix-Trench, Georgia, Coin, Lachlan, Lakhani, Sunil R. and Simpson, Peter T. (2019). LobSig, a prognostic signature for Invasive Lobular Carcinoma. 7th International PacRim Breast and Prostate Cancer Meeting, Barossa Novotel, South Australia, Australia, 17-20 March 2019.
2019
Journal Article
Breast cancer metastasis to gynaecological organs: a clinico‐pathological and molecular profiling study
Kutasovic, Jamie R., McCart Reed, Amy E., Males, Renique, Sim, Sarah, Saunus, Jodi M., Dalley, Andrew, McEvoy, Christopher R., Dedina, Liana, Miller, Gregory, Peyton, Stephen, Reid, Lynne, Lal, Samir, Niland, Colleen, Ferguson, Kaltin, Fellowes, Andrew P., Al-Ejeh, Fares, Lakhani, Sunil R., Cummings, Margaret C. and Simpson, Peter T. (2019). Breast cancer metastasis to gynaecological organs: a clinico‐pathological and molecular profiling study. The Journal of Pathology: Clinical Research, 5 (1), 25-39. doi: 10.1002/cjp2.118
2019
Conference Publication
Using whole genome sequencing and somatic mutation signatures to unravel insight into familial breast cancer aetiology
Simpson, P., Nones, K., Johnson, J., Newell, F., Patch, A-M, Thorne, H., Kazakoff, S., De Luca, X., Parsons, M., Ferguson, K., Reid, L., Reed, A. McCart, Srihari, S., Lakis, V., Davidson, A., Mukhopadhyay, P., Holmes, O., Xu, Q., Wood, S., Leonard, C., Beasley, J., Degasperi, A., Nik-Zainal, S., Ragan, M., Spurdle, A., Khanna, K. K., Lakhani, S., Pearson, J., Chenevix-Trench, G. and Waddell, N. (2019). Using whole genome sequencing and somatic mutation signatures to unravel insight into familial breast cancer aetiology. San Antonio Breast Cancer Symposium, San Antonio, TX, United States, 4-8 December 2018. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.SABCS18-P5-10-01
2019
Conference Publication
Implementation of precision oncology in breast cancer care in Qld (Q-IMPROvE).
McCart Reed, Amy , Simpson, Peter , Inglis, Po , Green, Ben , Ung, Owen , Snell, Cameron , Woodward, Natasha , Pyke, Chris , Walpole, Euan , Waddell, Nic , Ladwa, Rahul , Santamaria, Gorane , O'Byrne, Ken , McCarthy, Nicole and Lakhani, Sunil (2019). Implementation of precision oncology in breast cancer care in Qld (Q-IMPROvE).. Australian Precision Oncology Symposium, Adelaide, SA Australia, 9-11 November 2019.
2018
Journal Article
Recent advances in breast cancer research impacting clinical diagnostic practice : Breast cancer research - where are we now?
McCart Reed, Amy E, Kalita-de Croft, Priyakshi, Kutasovic, Jamie, Saunus, Jodi M and Lakhani, Sunil R (2018). Recent advances in breast cancer research impacting clinical diagnostic practice : Breast cancer research - where are we now?. The Journal of Pathology, 247 (5), 552-562. doi: 10.1002/path.5199
2018
Other Outputs
Breast cancer: molecular pathology driving precision oncology
McCart Reed, Amy and Lakhani, Sunil (2018). Breast cancer: molecular pathology driving precision oncology. MJA Insight website: Medical Journal of Australia.
2018
Journal Article
Mixed ductal-lobular carcinomas: evidence for progression from ductal to lobular morphology
McCart Reed, Amy E., Kutasovic, Jamie R., Nones, Katia, Saunus, Jodi M., Da Silva, Leonard, Newell, Felicity, Kazakoff, Stephen, Melville, Lewis, Jayanthan, Janani, Vargas, Ana Cristina, Reid, Lynne E., Beesley, Jonathan, Chen, Xiao Qing, Patch, Anne Marie, David Clouston, D., Porter, Alan, Evans, Elizabeth, Pearson, John V., Chenevix-Trench, Georgia, Cummings, Margaret C., Waddell, Nic, Lakhani, Sunil R. and Simpson, Peter T. (2018). Mixed ductal-lobular carcinomas: evidence for progression from ductal to lobular morphology. The Journal of Pathology, 244 (4), 460-468. doi: 10.1002/path.5040
2018
Journal Article
Corrigendum to "Molecular signatures in breast cancer" [Methods 131 (2017) 135-146]
Lal, Samir, McCart Reed, Amy E., de Luca, Xavier M. and Simpson, Peter T. (2018). Corrigendum to "Molecular signatures in breast cancer" [Methods 131 (2017) 135-146]. Methods, 164-165, 120-120. doi: 10.1016/j.ymeth.2018.01.007
2018
Book Chapter
Breast Cancer: Pathology and Genetics
McCart Reed, Amy E., Kalaw, Emarene, Reid, Andrew and Lakhani, Sunil R. (2018). Breast Cancer: Pathology and Genetics. Encyclopedia of Cancer, Third Edition: Volumes 1-3. (pp. V1:170-V1:183) Elsevier. doi: 10.1016/B978-0-12-801238-3.65263-7
2018
Book Chapter
Breast cancer - pathology and genetics
McCart Reed, Amy Ellen, Kalaw, Emarene, Reid, Andrew Scott and Lakhani, Sunil R. (2018). Breast cancer - pathology and genetics. Encyclopedia of cancer. (pp. 170-183) edited by Paolo Boffetta and Pierre Hainaut. Cambridge, MA United States: Academic Press. doi: 10.1016/B978-0-12-801238-3.65263-7
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Amy McCart Reed is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Investigating therapeutic vulnerabilities in breast cancer.
Principal Advisor
Other advisors: Professor Sunil Lakhani, Associate Professor Peter Simpson
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Doctor Philosophy
Circulating biomarkers in invasive lobular breast carcinoma
Principal Advisor
Other advisors: Professor Sunil Lakhani, Associate Professor Peter Simpson
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Master Philosophy
Application of molecular genetics in Translational Breast Cancer Research
Associate Advisor
Other advisors: Associate Professor Peter Simpson, Professor Sunil Lakhani
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Master Philosophy
Applications of Molecular Genetics in Translational Breast Cancer Research
Associate Advisor
Other advisors: Associate Professor Peter Simpson, Professor Sunil Lakhani
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Master Philosophy
E-cadherin, ROS1 and synthetic lethality in ILC
Associate Advisor
Other advisors: Professor Sunil Lakhani
Completed supervision
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2024
Doctor Philosophy
Identifying and characterising targetable proteins in breast cancer brain metastasis
Principal Advisor
Other advisors: Professor Sunil Lakhani
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2021
Doctor Philosophy
Detailed Characterisation of Metaplastic Breast Carcinoma
Principal Advisor
Other advisors: Dr Jodi Saunus, Professor Sunil Lakhani
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2021
Doctor Philosophy
Multi-omics: Leveraging omics data integration to identify dysregulated biology in breast cancer
Associate Advisor
Other advisors: Dr Katia Nones, Associate Professor Peter Simpson
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2019
Doctor Philosophy
Identifying novel potential prognostic biomarkers in breast cancer
Associate Advisor
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2018
Doctor Philosophy
Genomic and transcriptomic biomarkers of prognosis in invasive lobular breast cancer.
Associate Advisor
Other advisors: Professor Sunil Lakhani, Associate Professor Peter Simpson
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2016
Doctor Philosophy
Intratumour heterogeneity in the development and progression of breast cancer
Associate Advisor
Other advisors: Professor Sunil Lakhani, Associate Professor Peter Simpson
Media
Enquiries
Contact Associate Professor Amy McCart Reed directly for media enquiries about:
- breast cancer
- DNA
- genomics
- lobular breast cancer
- metaplastic breast cancer
- personalised medicine
- precision medicine
- precision oncology
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