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Associate Professor Amy McCart Reed
Associate Professor

Amy McCart Reed

Email: 
Phone: 
+61 7 334 66030

Overview

Background

Associate Prof Amy McCart Reed holds a PhD in molecular biology from The University of Queensland. She is a Fellow of the Faculty of Science of the Royal College of Pathologists Australasia. Her early postdoctoral work focused on understanding the genetic basis of colorectal cancer using experimental disease models, as part of a Cancer Research UK-funded colorectal cancer program led by Professors Ian Tomlinson and Andrew Silver. After returning to Australia, she was recruited to the Molecular Breast Pathology group at UQ’s Centre for Clinical Research and has undertaken a series of studies investigating the genomic landscape of breast cancer special types. Amy's research program includes studies on Metaplastic breast cancer and Invasive Lobular Carcinoma, two breast cancer special types in need of targetted therapy options. A/Prof McCart Reed is the scientific lead on an MRFF-funded genomics program investigating the potential for the application of Whole Genome Sequencing in the breast cancer care pathway in Australia, 'Q-IMPROvE'. She applies genomics and spatial transcriptomics methodologies to archival clinical samples to understand the differences between tumour types and their potential for treatment. Amy is passionate about clinical research, biobanking and precision oncology. In addition to her breast cancer research portfolio, she is on the steering committee for the Brisbane Breast Bank and the Scientific Advisory Board for Breast Cancer Trials.

Availability

Associate Professor Amy McCart Reed is:
Available for supervision
Media expert

Qualifications

  • Doctor of Philosophy, The University of Queensland

Research interests

  • Breast Cancer

  • Genomics

  • Biobanking

  • Molecular pathology

  • Precision medicine

Works

Search Professor Amy McCart Reed’s works on UQ eSpace

110 works between 1999 and 2025

81 - 100 of 110 works

2015

Journal Article

Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib

Bessette, Darrell C., Tilch, Erik, Seidens, Tatjana, Quinn, Michael C. J., Wiegmans, Adrian P., Shi, Wei, Cocciardi, Sibylle, McCart-Reed, Amy, Saunus, Jodi M., Simpson, Peter T., Grimmond, Sean M., Lakhani, Sunil R., Khanna, Kum Kum, Waddell, Nic, Al-Ejeh, Fares and Chevenvix-Trench, Georgia (2015). Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib. PLoS One, 10 (5) e0125232, e0125232-e0125232. doi: 10.1371/journal.pone.0125232

Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib

2015

Journal Article

Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines

Momeny, Majid, Saunus, Jodi M., Marturana, Flavia, McCart Reed, Amy E., Black, Debra, Sala, Gianluca, Iacobelli, Stefano, Holland, Jane D., Yu, Dihua, Da Silva, Leonard, Simpson, Peter T., Khanna, Kum Kum, Chenevix-Trench, Georgia and Lakhani, Sunil R. (2015). Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines. Oncotarget, 6 (6), 3932-3946. doi: 10.18632/oncotarget.2846

Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines

2015

Journal Article

Invasive lobular carcinoma of the breast: morphology, biomarkers and 'omics

McCart Reed, Amy E., Kutasovic, Jamie R., Lakhani, Sunil R. and Simpson, Peter T. (2015). Invasive lobular carcinoma of the breast: morphology, biomarkers and 'omics. Breast Cancer Research, 17 (12) 12, 1-11. doi: 10.1186/s13058-015-0519-x

Invasive lobular carcinoma of the breast: morphology, biomarkers and 'omics

2015

Conference Publication

The role of epithelial to mesenchymal plasticity in driving the invasive capacity of 'lobular-like' tumour cell differentiation in breast cancer

Reed, McCart A. E., Kutasovic, J. R., Vargas, A. C., Da Silva, L., Jayanthan, J., Al-Murrani, A., Reid, L. E., Evans, E., Porter, A., Lakhani, S. R. and Simpson, P. T. (2015). The role of epithelial to mesenchymal plasticity in driving the invasive capacity of 'lobular-like' tumour cell differentiation in breast cancer. 15th International Biennial Congress of the Metastasis Research Society, Heidelberg, Germany, June 28th–July 1st, 2014. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/s10585-015-9708-3

The role of epithelial to mesenchymal plasticity in driving the invasive capacity of 'lobular-like' tumour cell differentiation in breast cancer

2015

Conference Publication

Breast cancer metastasis to gynaecological organs: impacting young women diagnosed with a luminal tumour subtype

Kutasovic, Jamie, Reed, Amy McCart, Sim, Sarah, Cummings, Margaret, Lakhani, Sunil and Simpson, Peter (2015). Breast cancer metastasis to gynaecological organs: impacting young women diagnosed with a luminal tumour subtype. 15th International Biennial Congress of the Metastasis Research Society, Heidelberg, Germany, June 28th–July 1st, 2014. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/s10585-015-9708-3

Breast cancer metastasis to gynaecological organs: impacting young women diagnosed with a luminal tumour subtype

2014

Journal Article

Intratumour heterogeneity in the progression to breast cancer metastasis

Kutasovic, Jamie R., Sim, Sarah Y. M., McCart Reed, Amy E., Cummings, Margaret C. and Simpson, Peter T. (2014). Intratumour heterogeneity in the progression to breast cancer metastasis. Cancer Forum, 38 (2), 138-142.

Intratumour heterogeneity in the progression to breast cancer metastasis

2014

Journal Article

Metastatic progression of breast cancer: Insights from 50 years of autopsies

Cummings, Margaret C., Simpson, Peter T., Reid, Lynne E., Jayanthan, Janani, Skerman, Joanna, Song, Sarah, McCart Reed, Amy E., Kutasovic, Jamie R., Morey, Adrienne L., Marquart, Louise, O'Rourke, Peter and Lakhani, Sunil R. (2014). Metastatic progression of breast cancer: Insights from 50 years of autopsies. Journal of Pathology, 232 (1), 23-31. doi: 10.1002/path.4288

Metastatic progression of breast cancer: Insights from 50 years of autopsies

2013

Journal Article

Thrombospondin-4 expression is activated during the stromal response to invasive breast cancer

McCart Reed, Amy E., Song, Sarah, Kutasovic, Jamie R., Reid, Lynne E., Valle, Jordan M., Vargas, Ana Cristina, Smart, Chanel E. and Simpson, Peter T. (2013). Thrombospondin-4 expression is activated during the stromal response to invasive breast cancer. Virchows Archiv, 463 (4), 535-545. doi: 10.1007/s00428-013-1468-3

Thrombospondin-4 expression is activated during the stromal response to invasive breast cancer

2013

Journal Article

Evaluating the repair of DNA derived from formalin-fixed paraffin-embedded tissues prior to genomic profiling by SNP-CGH analysis

Hosein, Abdel Nasser, Song, Sarah, McCart Reed, Amy E., Jayanthan, Janani, Reid, Lynne E., Kutasovic, Jamie R., Cummings, Margaret C., Waddell, Nic, Lakhani, Sunil R., Chenevix-Trench, Georgia and Simpson, Peter T. (2013). Evaluating the repair of DNA derived from formalin-fixed paraffin-embedded tissues prior to genomic profiling by SNP-CGH analysis. Laboratory Investigation, 93 (6), 701-710. doi: 10.1038/labinvest.2013.54

Evaluating the repair of DNA derived from formalin-fixed paraffin-embedded tissues prior to genomic profiling by SNP-CGH analysis

2013

Book Chapter

Breast cancer heterogeneity in primary and metastatic disease

Saunus, Jodi M., McCart-Reed, Amy, Momeny, Majid, Cummings, Margaret and Lakhani, Sunil R. (2013). Breast cancer heterogeneity in primary and metastatic disease. Breast Cancer Metastasis and Drug Resistance: Challenges and Progress. (pp. 65-95) edited by Aamir Ahmad. New York, NY, USA: Springer. doi: 10.1007/978-1-4614-5647-6

Breast cancer heterogeneity in primary and metastatic disease

2012

Journal Article

Expression profiling of archival tumors for long-term health studies

Waldron, Levi, Ogino, Shuji, Hoshida, Yujin, Shima, Kaori, Reed, Amy E. McCart, Simpson, Peter T., Baba, Yoshifumi, Nosho, Katsuhiko, Segata, Nicola, Vargas, Ana Cristina, Cummings, Margaret C., Lakhani, Sunil R., Kirkner, Gregory J., Giovannucci, Edward, Quackenbush, John, Golub, Todd R., Fuchs, Charles S., Parmigiani, Giovanni and Huttenhower, Curtis (2012). Expression profiling of archival tumors for long-term health studies. Clinical Cancer Research, 18 (22), 6136-6146. doi: 10.1158/1078-0432.CCR-12-1915

Expression profiling of archival tumors for long-term health studies

2012

Journal Article

Molecular pathology of pre-invasive breast disease in the screening setting: Application in diagnosis and management

McCart Reed, Amy E., Cummings, Margaret C., Lakhani, Sunil R. and Simpson, Peter T. (2012). Molecular pathology of pre-invasive breast disease in the screening setting: Application in diagnosis and management. Diagnostic Histopathology, 18 (2), 64-69. doi: 10.1016/j.mpdhp.2011.11.006

Molecular pathology of pre-invasive breast disease in the screening setting: Application in diagnosis and management

2012

Journal Article

Gene expression profiling of tumour epithelial and stromal compartments during breast cancer progression

Vargas, Ana Cristina, McCart Reed, Amy E., Waddell, Nic, Lane, Annette, Reid, Lynne E., Smart, Chanel E., Cocciardi, Sibylle, da Silva, Leonard, Song, Sarah, Chenevix-Trench, Georgia, Simpson Peter T. and Lakhani, Sunil R. (2012). Gene expression profiling of tumour epithelial and stromal compartments during breast cancer progression. Breast Cancer Research and Treatment, 135 (1), 153-165. doi: 10.1007/s10549-012-2123-4

Gene expression profiling of tumour epithelial and stromal compartments during breast cancer progression

2012

Conference Publication

Abrogated cell-cell adhesion in the phenotypic drift from ductal to lobular breast cancer types

Da Silva, Leonard, McCart Reed, Amy E., Kutasovic, Jamie R., Vargas, Ana Cristina, Jayanthan, Janani, Reid, Lynne, Fritz, Brian, Cummings, Margaret C., Porter, Alan, Evans, Elizabeth, Lakhani, Sunil R. and Simpson, Peter T. (2012). Abrogated cell-cell adhesion in the phenotypic drift from ductal to lobular breast cancer types. 24th Lorne Cancer Conference 2012, Lorne, VIC, Australia, 9-11 February 2012.

Abrogated cell-cell adhesion in the phenotypic drift from ductal to lobular breast cancer types

2011

Conference Publication

The Role of Type XI and Type XVII Collagen in Breast Cancer Progression

Vargas, Ana Cristina, Simpson, Peter, McCart Reed, Amy, Lane, Annette, Smart, Chanel, Da Silva, Leonard and Lakhani, Sunil (2011). The Role of Type XI and Type XVII Collagen in Breast Cancer Progression. 100th Annual Meeting of the United States and Canadian Academy of Pathology, San Antonio, Texas, United States, February 6 - March 4 2011. London, United Kingdom: Nature Publishing Group.

The Role of Type XI and Type XVII Collagen in Breast Cancer Progression

2011

Conference Publication

The role of Type XI Collagen in Breast Cancer Progression

Vargas, Ana Cristina, Simpson, Peter T., McCart Reed, Amy E., Smart, Chanel, Waddell, Nic, Lane, Annette and Lakhani, Sunil (2011). The role of Type XI Collagen in Breast Cancer Progression. LICR Translational Oncology Conference, Melbourne, Australia, 24-26 October 2011.

The role of Type XI Collagen in Breast Cancer Progression

2010

Journal Article

The stem cell marker CD133 associates with enhanced colony formation and cell motility in colorectal cancer

Elsaba, Tarek M. A., Martinez-Pomares, Luisa, Robins, Adrian R., Crook, Simon, Seth, Rashmi, Jackson, Darryl, McCart, Amy, Silver, Andrew R., Tomlinson, Ian P. M. and Ilyas, Mohammad (2010). The stem cell marker CD133 associates with enhanced colony formation and cell motility in colorectal cancer. PLoS One, 5 (5) e10714, 1-11. doi: 10.1371/journal.pone.0010714

The stem cell marker CD133 associates with enhanced colony formation and cell motility in colorectal cancer

2009

Journal Article

The Apc1322T Mouse Develops Severe Polyposis Associated With Submaximal Nuclear β-Catenin Expression

Pollard, Patrick, Deheragoda, Maesha, Segditsas, Stefania, Lewis, Annabelle, Rowan, Andrew, Howarth, Kimberley, Willis, Lisa, Nye, Emma, McCart, Amy, Mandir, Nikki, Silver, Andrew, Goodlad, Robert, Stamp, Gordon, Cockman, Matthew, East, Philip, Spencer-Dene, Bradley, Poulsom, Richard, Wright, Nicholas and Tomlinson, Ian (2009). The Apc1322T Mouse Develops Severe Polyposis Associated With Submaximal Nuclear β-Catenin Expression. Gastroenterology, 136 (7), 2204-2213. doi: 10.1053/j.gastro.2009.02.058

The Apc1322T Mouse Develops Severe Polyposis Associated With Submaximal Nuclear β-Catenin Expression

2008

Conference Publication

Characterisation of an intestinal neoplasm modifier locus in Apc Min mice

McCart, A., Haines, J., Suraweera, N., Tomlinson, I. and Silver, A. (2008). Characterisation of an intestinal neoplasm modifier locus in Apc Min mice. 20th Meeting of the European Association for Cancer Research, Lyon, France, 5-8 July 2008. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. doi: 10.1016/S1359-6349(08)71321-1

Characterisation of an intestinal neoplasm modifier locus in Apc Min mice

2008

Journal Article

Apc mice: Models, modifiers and mutants

McCart, Amy E., Vickaryous, Nicola K. and Silver, Andrew (2008). Apc mice: Models, modifiers and mutants. Pathology Research and Practice, 204 (7), 479-490. doi: 10.1016/j.prp.2008.03.004

Apc mice: Models, modifiers and mutants

Funding

Current funding

  • 2024 - 2028
    Reducing invasive lobular carcinoma mortality by enhanced liquid biopsy monitoring
    NHMRC MRFF Genomics Health Futures Mission
    Open grant
  • 2024 - 2025
    Prognostic biomarkers in Invasive Lobular Carcinoma
    Peter MacCallum Cancer Centre
    Open grant
  • 2024 - 2029
    The EARLY study: Evaluating the Specificity and feasibility of the EARLY Test for Ovarian Cancer Detetion
    NHMRC Partnership Projects
    Open grant
  • 2024 - 2026
    Proof of concept studies for a novel immunotherapy for triple negative Breast cancer and companion diagnostic
    United States Congressionally Directed Medical Research Programs - Breast Cancer Research Program
    Open grant
  • 2023 - 2025
    High-resolution investigation of pre- and post-neoadjuvant treatment breast cancers
    National Breast Cancer Foundation Investigator Initiated Research Scheme
    Open grant
  • 2020 - 2025
    Whole Genome Sequencing in high-risk breast cancer patients.
    MRFF Genomics Health Futures Mission, Project Grant administered by AusIndustry
    Open grant

Past funding

  • 2019 - 2022
    Lobular Breast Cancer - can we identify the patients likely to have a poor prognosis?
    NHMRC Project Grant
    Open grant
  • 2014 - 2015
    The Brisbane Breast Bank
    Royal Brisbane and Women's Hospital Foundation
    Open grant
  • 2013 - 2015
    Prospective study of breast cancer progression by content analysis of circulating exosomes in serially collected blood samples
    Royal Brisbane and Women's Hospital
    Open grant

Supervision

Availability

Associate Professor Amy McCart Reed is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Media

Enquiries

Contact Associate Professor Amy McCart Reed directly for media enquiries about:

  • breast cancer
  • DNA
  • genomics
  • lobular breast cancer
  • metaplastic breast cancer
  • personalised medicine
  • precision medicine
  • precision oncology

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