
Overview
Background
Associate Prof Amy McCart Reed holds a PhD in molecular biology from The University of Queensland. She is a Fellow of the Faculty of Science of the Royal College of Pathologists Australasia. Her early postdoctoral work focused on understanding the genetic basis of colorectal cancer using experimental disease models, as part of a Cancer Research UK-funded colorectal cancer program led by Professors Ian Tomlinson and Andrew Silver. After returning to Australia, she was recruited to the Molecular Breast Pathology group at UQ’s Centre for Clinical Research and has undertaken a series of studies investigating the genomic landscape of breast cancer special types. Amy's research program includes studies on Metaplastic breast cancer and Invasive Lobular Carcinoma, two breast cancer special types in need of targetted therapy options. A/Prof McCart Reed is the scientific lead on an MRFF-funded genomics program investigating the potential for the application of Whole Genome Sequencing in the breast cancer care pathway in Australia, 'Q-IMPROvE'. She applies genomics and spatial transcriptomics methodologies to archival clinical samples to understand the differences between tumour types and their potential for treatment. Amy is passionate about clinical research, biobanking and precision oncology. In addition to her breast cancer research portfolio, she is on the steering committee for the Brisbane Breast Bank and the Scientific Advisory Board for Breast Cancer Trials.
Availability
- Associate Professor Amy McCart Reed is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Research interests
-
Breast Cancer
-
Genomics
-
Biobanking
-
Molecular pathology
-
Precision medicine
Works
Search Professor Amy McCart Reed’s works on UQ eSpace
2015
Journal Article
Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib
Bessette, Darrell C., Tilch, Erik, Seidens, Tatjana, Quinn, Michael C. J., Wiegmans, Adrian P., Shi, Wei, Cocciardi, Sibylle, McCart-Reed, Amy, Saunus, Jodi M., Simpson, Peter T., Grimmond, Sean M., Lakhani, Sunil R., Khanna, Kum Kum, Waddell, Nic, Al-Ejeh, Fares and Chevenvix-Trench, Georgia (2015). Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib. PLoS One, 10 (5) e0125232, e0125232-e0125232. doi: 10.1371/journal.pone.0125232
2015
Journal Article
Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines
Momeny, Majid, Saunus, Jodi M., Marturana, Flavia, McCart Reed, Amy E., Black, Debra, Sala, Gianluca, Iacobelli, Stefano, Holland, Jane D., Yu, Dihua, Da Silva, Leonard, Simpson, Peter T., Khanna, Kum Kum, Chenevix-Trench, Georgia and Lakhani, Sunil R. (2015). Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines. Oncotarget, 6 (6), 3932-3946. doi: 10.18632/oncotarget.2846
2015
Journal Article
Invasive lobular carcinoma of the breast: morphology, biomarkers and 'omics
McCart Reed, Amy E., Kutasovic, Jamie R., Lakhani, Sunil R. and Simpson, Peter T. (2015). Invasive lobular carcinoma of the breast: morphology, biomarkers and 'omics. Breast Cancer Research, 17 (12) 12, 1-11. doi: 10.1186/s13058-015-0519-x
2015
Conference Publication
The role of epithelial to mesenchymal plasticity in driving the invasive capacity of 'lobular-like' tumour cell differentiation in breast cancer
Reed, McCart A. E., Kutasovic, J. R., Vargas, A. C., Da Silva, L., Jayanthan, J., Al-Murrani, A., Reid, L. E., Evans, E., Porter, A., Lakhani, S. R. and Simpson, P. T. (2015). The role of epithelial to mesenchymal plasticity in driving the invasive capacity of 'lobular-like' tumour cell differentiation in breast cancer. 15th International Biennial Congress of the Metastasis Research Society, Heidelberg, Germany, June 28th–July 1st, 2014. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/s10585-015-9708-3
2015
Conference Publication
Breast cancer metastasis to gynaecological organs: impacting young women diagnosed with a luminal tumour subtype
Kutasovic, Jamie, Reed, Amy McCart, Sim, Sarah, Cummings, Margaret, Lakhani, Sunil and Simpson, Peter (2015). Breast cancer metastasis to gynaecological organs: impacting young women diagnosed with a luminal tumour subtype. 15th International Biennial Congress of the Metastasis Research Society, Heidelberg, Germany, June 28th–July 1st, 2014. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/s10585-015-9708-3
2014
Journal Article
Intratumour heterogeneity in the progression to breast cancer metastasis
Kutasovic, Jamie R., Sim, Sarah Y. M., McCart Reed, Amy E., Cummings, Margaret C. and Simpson, Peter T. (2014). Intratumour heterogeneity in the progression to breast cancer metastasis. Cancer Forum, 38 (2), 138-142.
2014
Journal Article
Metastatic progression of breast cancer: Insights from 50 years of autopsies
Cummings, Margaret C., Simpson, Peter T., Reid, Lynne E., Jayanthan, Janani, Skerman, Joanna, Song, Sarah, McCart Reed, Amy E., Kutasovic, Jamie R., Morey, Adrienne L., Marquart, Louise, O'Rourke, Peter and Lakhani, Sunil R. (2014). Metastatic progression of breast cancer: Insights from 50 years of autopsies. Journal of Pathology, 232 (1), 23-31. doi: 10.1002/path.4288
2013
Journal Article
Thrombospondin-4 expression is activated during the stromal response to invasive breast cancer
McCart Reed, Amy E., Song, Sarah, Kutasovic, Jamie R., Reid, Lynne E., Valle, Jordan M., Vargas, Ana Cristina, Smart, Chanel E. and Simpson, Peter T. (2013). Thrombospondin-4 expression is activated during the stromal response to invasive breast cancer. Virchows Archiv, 463 (4), 535-545. doi: 10.1007/s00428-013-1468-3
2013
Journal Article
Evaluating the repair of DNA derived from formalin-fixed paraffin-embedded tissues prior to genomic profiling by SNP-CGH analysis
Hosein, Abdel Nasser, Song, Sarah, McCart Reed, Amy E., Jayanthan, Janani, Reid, Lynne E., Kutasovic, Jamie R., Cummings, Margaret C., Waddell, Nic, Lakhani, Sunil R., Chenevix-Trench, Georgia and Simpson, Peter T. (2013). Evaluating the repair of DNA derived from formalin-fixed paraffin-embedded tissues prior to genomic profiling by SNP-CGH analysis. Laboratory Investigation, 93 (6), 701-710. doi: 10.1038/labinvest.2013.54
2013
Book Chapter
Breast cancer heterogeneity in primary and metastatic disease
Saunus, Jodi M., McCart-Reed, Amy, Momeny, Majid, Cummings, Margaret and Lakhani, Sunil R. (2013). Breast cancer heterogeneity in primary and metastatic disease. Breast Cancer Metastasis and Drug Resistance: Challenges and Progress. (pp. 65-95) edited by Aamir Ahmad. New York, NY, USA: Springer. doi: 10.1007/978-1-4614-5647-6
2012
Journal Article
Expression profiling of archival tumors for long-term health studies
Waldron, Levi, Ogino, Shuji, Hoshida, Yujin, Shima, Kaori, Reed, Amy E. McCart, Simpson, Peter T., Baba, Yoshifumi, Nosho, Katsuhiko, Segata, Nicola, Vargas, Ana Cristina, Cummings, Margaret C., Lakhani, Sunil R., Kirkner, Gregory J., Giovannucci, Edward, Quackenbush, John, Golub, Todd R., Fuchs, Charles S., Parmigiani, Giovanni and Huttenhower, Curtis (2012). Expression profiling of archival tumors for long-term health studies. Clinical Cancer Research, 18 (22), 6136-6146. doi: 10.1158/1078-0432.CCR-12-1915
2012
Journal Article
Molecular pathology of pre-invasive breast disease in the screening setting: Application in diagnosis and management
McCart Reed, Amy E., Cummings, Margaret C., Lakhani, Sunil R. and Simpson, Peter T. (2012). Molecular pathology of pre-invasive breast disease in the screening setting: Application in diagnosis and management. Diagnostic Histopathology, 18 (2), 64-69. doi: 10.1016/j.mpdhp.2011.11.006
2012
Journal Article
Gene expression profiling of tumour epithelial and stromal compartments during breast cancer progression
Vargas, Ana Cristina, McCart Reed, Amy E., Waddell, Nic, Lane, Annette, Reid, Lynne E., Smart, Chanel E., Cocciardi, Sibylle, da Silva, Leonard, Song, Sarah, Chenevix-Trench, Georgia, Simpson Peter T. and Lakhani, Sunil R. (2012). Gene expression profiling of tumour epithelial and stromal compartments during breast cancer progression. Breast Cancer Research and Treatment, 135 (1), 153-165. doi: 10.1007/s10549-012-2123-4
2012
Conference Publication
Abrogated cell-cell adhesion in the phenotypic drift from ductal to lobular breast cancer types
Da Silva, Leonard, McCart Reed, Amy E., Kutasovic, Jamie R., Vargas, Ana Cristina, Jayanthan, Janani, Reid, Lynne, Fritz, Brian, Cummings, Margaret C., Porter, Alan, Evans, Elizabeth, Lakhani, Sunil R. and Simpson, Peter T. (2012). Abrogated cell-cell adhesion in the phenotypic drift from ductal to lobular breast cancer types. 24th Lorne Cancer Conference 2012, Lorne, VIC, Australia, 9-11 February 2012.
2011
Conference Publication
The Role of Type XI and Type XVII Collagen in Breast Cancer Progression
Vargas, Ana Cristina, Simpson, Peter, McCart Reed, Amy, Lane, Annette, Smart, Chanel, Da Silva, Leonard and Lakhani, Sunil (2011). The Role of Type XI and Type XVII Collagen in Breast Cancer Progression. 100th Annual Meeting of the United States and Canadian Academy of Pathology, San Antonio, Texas, United States, February 6 - March 4 2011. London, United Kingdom: Nature Publishing Group.
2011
Conference Publication
The role of Type XI Collagen in Breast Cancer Progression
Vargas, Ana Cristina, Simpson, Peter T., McCart Reed, Amy E., Smart, Chanel, Waddell, Nic, Lane, Annette and Lakhani, Sunil (2011). The role of Type XI Collagen in Breast Cancer Progression. LICR Translational Oncology Conference, Melbourne, Australia, 24-26 October 2011.
2010
Journal Article
The stem cell marker CD133 associates with enhanced colony formation and cell motility in colorectal cancer
Elsaba, Tarek M. A., Martinez-Pomares, Luisa, Robins, Adrian R., Crook, Simon, Seth, Rashmi, Jackson, Darryl, McCart, Amy, Silver, Andrew R., Tomlinson, Ian P. M. and Ilyas, Mohammad (2010). The stem cell marker CD133 associates with enhanced colony formation and cell motility in colorectal cancer. PLoS One, 5 (5) e10714, 1-11. doi: 10.1371/journal.pone.0010714
2009
Journal Article
The Apc1322T Mouse Develops Severe Polyposis Associated With Submaximal Nuclear β-Catenin Expression
Pollard, Patrick, Deheragoda, Maesha, Segditsas, Stefania, Lewis, Annabelle, Rowan, Andrew, Howarth, Kimberley, Willis, Lisa, Nye, Emma, McCart, Amy, Mandir, Nikki, Silver, Andrew, Goodlad, Robert, Stamp, Gordon, Cockman, Matthew, East, Philip, Spencer-Dene, Bradley, Poulsom, Richard, Wright, Nicholas and Tomlinson, Ian (2009). The Apc1322T Mouse Develops Severe Polyposis Associated With Submaximal Nuclear β-Catenin Expression. Gastroenterology, 136 (7), 2204-2213. doi: 10.1053/j.gastro.2009.02.058
2008
Conference Publication
Characterisation of an intestinal neoplasm modifier locus in Apc Min mice
McCart, A., Haines, J., Suraweera, N., Tomlinson, I. and Silver, A. (2008). Characterisation of an intestinal neoplasm modifier locus in Apc Min mice. 20th Meeting of the European Association for Cancer Research, Lyon, France, 5-8 July 2008. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. doi: 10.1016/S1359-6349(08)71321-1
2008
Journal Article
Apc mice: Models, modifiers and mutants
McCart, Amy E., Vickaryous, Nicola K. and Silver, Andrew (2008). Apc mice: Models, modifiers and mutants. Pathology Research and Practice, 204 (7), 479-490. doi: 10.1016/j.prp.2008.03.004
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Amy McCart Reed is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Investigating therapeutic vulnerabilities in breast cancer.
Principal Advisor
Other advisors: Professor Sunil Lakhani, Associate Professor Peter Simpson
-
Doctor Philosophy
Circulating biomarkers in invasive lobular breast carcinoma
Principal Advisor
Other advisors: Professor Sunil Lakhani, Associate Professor Peter Simpson
-
Master Philosophy
E-cadherin, ROS1 and synthetic lethality in ILC
Associate Advisor
Other advisors: Professor Sunil Lakhani
-
Master Philosophy
Application of molecular genetics in Translational Breast Cancer Research
Associate Advisor
Other advisors: Associate Professor Peter Simpson, Professor Sunil Lakhani
-
Master Philosophy
Applications of Molecular Genetics in Translational Breast Cancer Research
Associate Advisor
Other advisors: Associate Professor Peter Simpson, Professor Sunil Lakhani
Completed supervision
-
2024
Doctor Philosophy
Identifying and characterising targetable proteins in breast cancer brain metastasis
Principal Advisor
Other advisors: Professor Sunil Lakhani
-
2021
Doctor Philosophy
Detailed Characterisation of Metaplastic Breast Carcinoma
Principal Advisor
Other advisors: Dr Jodi Saunus, Professor Sunil Lakhani
-
2021
Doctor Philosophy
Multi-omics: Leveraging omics data integration to identify dysregulated biology in breast cancer
Associate Advisor
Other advisors: Dr Katia Nones, Associate Professor Peter Simpson
-
2019
Doctor Philosophy
Identifying novel potential prognostic biomarkers in breast cancer
Associate Advisor
-
2018
Doctor Philosophy
Genomic and transcriptomic biomarkers of prognosis in invasive lobular breast cancer.
Associate Advisor
Other advisors: Professor Sunil Lakhani, Associate Professor Peter Simpson
-
2016
Doctor Philosophy
Intratumour heterogeneity in the development and progression of breast cancer
Associate Advisor
Other advisors: Professor Sunil Lakhani, Associate Professor Peter Simpson
Media
Enquiries
Contact Associate Professor Amy McCart Reed directly for media enquiries about:
- breast cancer
- DNA
- genomics
- lobular breast cancer
- metaplastic breast cancer
- personalised medicine
- precision medicine
- precision oncology
Need help?
For help with finding experts, story ideas and media enquiries, contact our Media team: