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Associate Professor Brett Ferguson
Associate Professor

Brett Ferguson

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+61 7 334 69951

Overview

Background

A/Prof Brett Ferguson’s research interest are in molecular genetics, genomics, genetic transformation and genome editing, such as CRISPR, to unravel the molecular mechanisms driving plant development. His primary focus is on legume crops, using biotechnology and bioinformatic approaches to identify key genes and signals controlling traits of interest. This includes the agriculturally- and environmentally-important symbiosis between legume plants and beneficial rhizobia bacteria that fix critical nitrogen for their host plant. In addition, A/Prof Ferguson works with the fascinating legume tree, Pongamia pinatta, which has tremendous potential as a feedstock for the sustainable production of biodiesel and aviation fuel.

A/Prof Brett Ferguson leads the Integrative Legume Research Group (ILRG) in the School of Agriculture and Food Sciences (SAFS) at the University of Queensland (UQ). He is an Affiliate of the Centre for Crop Science in the Queensland Alliance for Agriculture and Food Innovation (QAAFI), and an Affiliate of the ARC Centre of Excellence for Innovations in Peptide and Protein Science (CIPPS). A/Prof Ferguson is also a Chief Investigator in the large, multi-national Hy-Gain for Smallholders Project primarily funded by the Bill & Melinda Gates Foundation.

The work of A/Prof Ferguson has contributed to the discovery of many new genes and signals, such as novel microRNAs and peptide hormones, that have critical roles in controlling plant development. His research group identified the complete family of CLE peptide encoding genes of several legume species using an array of molecular and bioinformatic approaches. Additional discoveries of genes involved in legume nodule formation, nitrogen signalling and the regulation of root development, are also having an impact in the research field. Many of these factors could be useful in supporting translational studies and breeding programs that look to improve crop performance. His work also established a requirement for brassinosteroid hormones in legume nodulation and demonstrated a central role for gibberellins in nodule development. Moreover, he contributed to some of the initial work reporting a role of strigolatones in shoot branching, and demonstrated that plants can transport quantities of auxin far in excess of their endogenous levels.

A/Prof Ferguson has also contributed to the developed of new tools and techniques, such as petiole feeding, precision feeding in growth pouches, stem girdling, pHairyRed for promoter-reporter fusions, new hairy-root transformation techniques, novel integrative vectors to enhance transformation efficiency, synthetic biology approaches to generate mature double stranded miRNA, etc.

Availability

Associate Professor Brett Ferguson is:
Available for supervision
Media expert

Qualifications

  • Doctor of Philosophy, University of Tasmania

Research interests

  • Legumes, legume nodulation, nitrogen and nitrogen fixation.

  • Functional genomics using plant biotechnology (genetics, genomics, bioinformatics, transcriptomics), genetic transformation and genome editing (CRISPR).

  • Pongamia pinnata as a source of sustainable biofuel.

  • Plant physiology, signalling and development, plant-microbe interactions (symbioses).

  • Discovery and characterisation of novel genes and signals required for plant development, including CLE peptide hormones, classical plant hormones, and microRNAs.

  • Establishment of the molecular mechanisms responsible for acid-soil inhibition of legume crop development, and nitrogen and phosphorous signalling networks.

  • Development of superior cowpea and sorghum crop varieties (Hy-Gain project).

Works

Search Professor Brett Ferguson’s works on UQ eSpace

97 works between 2001 and 2025

81 - 97 of 97 works

2010

Conference Publication

Identifying novel factors required for legume nodule development and autoregulation.

Ferguson, B. J., Lin, Y. -H., Reid, D. E., Hayashi, S., Lin, M. -H., Zhang, H., Capon, R. and Gresshoff, P. M. (2010). Identifying novel factors required for legume nodule development and autoregulation.. OzBio2010 combined conference, Melbourne, Australia, 26 September - 1 October 2010.

Identifying novel factors required for legume nodule development and autoregulation.

2010

Journal Article

Molecular analysis of legume nodule development and autoregulation

Ferguson, Brett J., Indrasumunar, Arief, Hayashi, Satomi, Lin, Meng-Han, Lin, Yu-Hsiang, Reid, Dugald E. and Gresshoff, Peter M. (2010). Molecular analysis of legume nodule development and autoregulation. Journal of Integrative Plant Biology, 52 (1), 61-76. doi: 10.1111/j.1744-7909.2010.00899.x

Molecular analysis of legume nodule development and autoregulation

2009

Journal Article

Modern genetics and biotechnology of soybean: Nitrogen fixation and nodulation

Gresshoff, Peter M., Ferguson, Brett J., Indrasumunar, Arief and Jiang, Qunyi (2009). Modern genetics and biotechnology of soybean: Nitrogen fixation and nodulation. Chinese Journal of Nature, 31 (6), 320-326.

Modern genetics and biotechnology of soybean: Nitrogen fixation and nodulation

2009

Journal Article

Genetic analysis of ethylene regulation of legume nodulation

Gresshoff, Peter M., Lohar, Dasharath, Chan, Pick-Kuen, Biswas, Bandana, Jiang, Qunyi, Reid, Duguld, Ferguson, Brett and Stacey, Gary (2009). Genetic analysis of ethylene regulation of legume nodulation. Plant Signaling and Behavior, 4 (9), 818-823. doi: 10.4161/psb.4.9.9395

Genetic analysis of ethylene regulation of legume nodulation

2009

Journal Article

Strigolactone acts downstream of auxin to regulate bud outgrowth in pea and arabidopsis

Brewer, Philip B., Dun, Elizabeth A., Ferguson, Brett J., Rameau, Catherine and Beveridge, Christine A. (2009). Strigolactone acts downstream of auxin to regulate bud outgrowth in pea and arabidopsis. Plant Physiology, 150 (1), 482-493. doi: 10.1104/pp.108.134783

Strigolactone acts downstream of auxin to regulate bud outgrowth in pea and arabidopsis

2009

Journal Article

Roles for auxin, cytokinin, and strigolactone in regulating shoot branching

Ferguson, B. J. and Beveridge, C. A. (2009). Roles for auxin, cytokinin, and strigolactone in regulating shoot branching. Plant Physiology, 149 (4), 1929-1944. doi: 10.1104/pp.109.135475

Roles for auxin, cytokinin, and strigolactone in regulating shoot branching

2009

Conference Publication

Functional genomic analysis of systemic cell division regulation in legumes

Gresshoff, P. M., Indrasumunar, A., Miyahara, A., Nontachaiyapoom, S., Biswas, B., Lin, Y-H., Lin, M-H, Reid, D., Callahan, D., Capon, R., Zhang, H., Jiang, Q., Hirani, T., Kobe, B., Men, A., Scott, P., Kereszt, A., Miyagi, M., Li, D., Chan, P-K., Roessner, U., Djordjevic, M. A., Kinkema, M. and Ferguson, B. (2009). Functional genomic analysis of systemic cell division regulation in legumes. International Symposium on Induced Mutations in Plants, Vienna, Austria, 2–15 August 2008. Vienna, Austria: Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture.

Functional genomic analysis of systemic cell division regulation in legumes

2009

Conference Publication

Functional genomics of soybean nodulation control: Plant stem cell biology biotechnology

Djordjevic, M., Ferguson, B,, Gresshoff, P. M., Hayashi, S., Indrasumunar, A., Lin, M. H., Lin, Y. H., Oakes, M. and Reid, D. (2009). Functional genomics of soybean nodulation control: Plant stem cell biology biotechnology. World Soybean Research Conference VIII, Beijing, China, 10-15 August 2009. Beijing, China: The Chinese Academy of Agricultural Sciences, Crop Science Society of China.

Functional genomics of soybean nodulation control: Plant stem cell biology biotechnology

2009

Journal Article

Soybean as a model legume

Ferguson, B. J. and Gresshoff, P. M. (2009). Soybean as a model legume. Grain Legumes, 53 (7)

Soybean as a model legume

2008

Journal Article

Apical Wilting and Petiole Xylem Vessel Diameter of the rms2 Branching Mutant of Pea are Shoot Controlled and Independent of a Long-Distance Signal Regulating Branching

Dodd, I.C., Ferguson, B.J. and Beveridge, C. A. (2008). Apical Wilting and Petiole Xylem Vessel Diameter of the rms2 Branching Mutant of Pea are Shoot Controlled and Independent of a Long-Distance Signal Regulating Branching. Plant and Cell Physiology, 49 (5), 791-800. doi: 10.1093/pcp/pcn052

Apical Wilting and Petiole Xylem Vessel Diameter of the rms2 Branching Mutant of Pea are Shoot Controlled and Independent of a Long-Distance Signal Regulating Branching

2006

Journal Article

Role of brassinosteroids in autoregulation of nodulation

O’Rourke, T. A., Ferguson, B. J., Reid, J. B. and Foo, E. (2006). Role of brassinosteroids in autoregulation of nodulation. Phytopathology, 96 (6 Suppl.), S88-S88.

Role of brassinosteroids in autoregulation of nodulation

2006

Journal Article

Apical dominance and shoot branching. Divergent opinions or divergent mechanisms?

Dun, E. A., Ferguson, B. J. and Beveridge, C. A. (2006). Apical dominance and shoot branching. Divergent opinions or divergent mechanisms?. Plant Physiology, 142 (3), 812-819. doi: 10.1104/pp.106.086868

Apical dominance and shoot branching. Divergent opinions or divergent mechanisms?

2005

Journal Article

Cochleata: Getting to the root of legume nodules

Ferguson, Brett J. and Reid, James B. (2005). Cochleata: Getting to the root of legume nodules. Plant And Cell Physiology, 46 (9), 1583-1589. doi: 10.1093/pcp/pci171

Cochleata: Getting to the root of legume nodules

2005

Journal Article

Nodulation phenotypes of gibberellin and brassinosteroid mutants of pea

Ferguson, Brett J., Ross, John J. and Reid, James B. (2005). Nodulation phenotypes of gibberellin and brassinosteroid mutants of pea. Plant Physiology, 138 (4), 2396-2405. doi: 10.1104/pp.105.062414

Nodulation phenotypes of gibberellin and brassinosteroid mutants of pea

2005

Journal Article

Cytokinin accumulation and an altered ethylene response mediate the pleiotropic phenotype of the pea nodulation mutant R50 (sym16)

Ferguson, Brett J., Wiebe, Ericka M., Emery, R. J. Neil and Guinel, Frédérique C. (2005). Cytokinin accumulation and an altered ethylene response mediate the pleiotropic phenotype of the pea nodulation mutant R50 (sym16). Canadian Journal of Botany, 83 (8), 989-1000. doi: 10.1139/B05-049

Cytokinin accumulation and an altered ethylene response mediate the pleiotropic phenotype of the pea nodulation mutant R50 (sym16)

2003

Journal Article

Signaling interactions during nodule development

Ferguson, Brett James and Mathesius, Ulrike (2003). Signaling interactions during nodule development. Journal of Plant Growth Regulation, 22 (1), 47-72. doi: 10.1007/s00344-003-0032-9

Signaling interactions during nodule development

2001

Journal Article

Effects of cytokinin on ethylene production and nodulation in pea (Pisum sativum) cv. Sparkle

Lorteau, Marie-Agathe, Ferguson, Brett James and Guinel, Frédérique Catherine (2001). Effects of cytokinin on ethylene production and nodulation in pea (Pisum sativum) cv. Sparkle. Physiologia Plantarum, 112 (3), 421-428. doi: 10.1034/j.1399-3054.2001.1120316.x

Effects of cytokinin on ethylene production and nodulation in pea (Pisum sativum) cv. Sparkle

Funding

Current funding

  • 2024 - 2028
    Genetic initiative to transform symbiotic nitrogen fixation in Australian pulse crops
    PROC-9176963 Genetic initiative to transform symbiotic nitrogen fixation in Australian pulse crops
    Open grant
  • 2023 - 2026
    Rapid generation of superior legume crops using tissue culture-free genome editing
    The Hermon Slade Foundation
    Open grant
  • 2020 - 2026
    Hy-Gain for Smallholders (2020-2025)
    Bill & Melinda Gates Foundation
    Open grant

Past funding

  • 2019 - 2024
    Molecular dissection of systemic regulation of nodulation in legumes
    ARC Discovery Projects
    Open grant
  • 2018 - 2024
    Development of sterile Leucaena to enhance red-meat production in new regions of Australia
    Meat & Livestock Australia
    Open grant
  • 2014 - 2017
    Identification and characterisation of new plant peptide hormones that control legume nodulation and nitrogen fixation.
    The Hermon Slade Foundation
    Open grant
  • 2013 - 2017
    Developing sugarcane-legume companion cropping systems
    Department of Agriculture, Fisheries, and Forestry
    Open grant
  • 2013 - 2015
    Discovering the Activity of Novel CLE Peptide Hormones that Regulate Legume Nodulation
    ARC Discovery Projects
    Open grant
  • 2013 - 2018
    Discovery of the Systemic Regulator of Legume Nodulation
    ARC Discovery Projects
    Open grant
  • 2011
    Characterising the function of novel legume nodulation genes using virus-induced gene silencing
    UQ Early Career Researcher
    Open grant

Supervision

Availability

Associate Professor Brett Ferguson is:
Available for supervision

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Available projects

  • Discovery and Functional Characterisation of New Plant Peptide Hormones

    The world is facing a serious and urgent threat to food security, with several studies concluding that crop production needs to double by the year 2050 to feed the rapidly growing population. Discovering new factors that enhance crop growth and yields is regarded as a pivotal step in meeting this demand. This project will characterise and synthesise exciting new peptide hormones recently identified in soybean that control plant development. Known members of this peptide family have critical roles in regulating shoot, root and seed growth, but the function of most remains unknown. Findings will enhance the molecular mechanisms of plant development, and could benefit agricultural sustainability and food security by aiding in the selection of superior crops and the commercialisation of novel regulatory compounds that increase crop yields.

  • Development of new tools for genetic transformation and genome editing of legume plants.

    Looking to improve genetric transformation and CRISPR genome editing capacity of plants through the development of new vectors, methods and techniques.

  • Overcoming Negative Impacts of Soil Acidity on Legume Nodulation and Nitrogen Fixation

    Legume plants can enter into a symbiotic relationship with nitrogen-fixing rhizobia bacteria. This relationship can considerably improve soil health and crop yields, whilst also reducing the need for expensive and polluting nitrogen fertilisers, thus helping to enhance agricultural sustainability and food security. Legume plants form new root organs, called nodules, to house their rhizobia partners. The process of forming a nodule is called nodulation and it is tightly regulated by the host plant to optimise resources, often based on environmental conditions. Soil acidity is one environmental factor that can negatively influence nodulation. It represents a serious global problem as many of the world’s agricultural soils are acidic. This project aims to identify and characterize critical new molecular factors of legumes that function in acid-regulation of nodulation. Findings will enhance our knowledge of the genes and signals that act in acid-inhibition, and could benefit future efforts to overcome the negative effect of soil acidity on legume nodulation.

  • Enhancing the genetic and genomic understanding of the legume tree, Pongamia pinnata, as a source of sustainable biodiesel and aviation fuel.

    Pongamia pinnata is a fast-growing legume tree native to Australia that produces abundant seeds that are rich in oil (35–55%), including mono-unsaturated oleic acid (C18:1). These properties make Pongamia ideal for the production of renewable biofuel, including biodiesel and sustainable aviation fuels (SAFs). Indeed, Pongamia oil can be readily converted via transesterification to form a biodiesel called FAME (Fatty Acid Methyl Ester) or it can be converted to aviation fuel using hydrogenation in place of transesterification. Being a legume, Pongamia trees can engage into a symbiotic relationship with compatible rhizobia bacteria, resulting in the formation of nitrogen-fixing root nodules. This provides Pongamia with a tremendous competitive advantage as they can access critical nitrogen for growth and development that is unavailable to non-legume plants. As a result, Pongamia can thrive in the absence of excessive nitrogen fertiliser inputs, which are expensive and pollute. This represents a tremendous economic and agriculturally-sustainable advantage for growing Pongamia compared with alternative, non-legume, feedstocks that are used for biofuels.

  • Functional Characterisation of Novel Components Required for the Development and Control of Legume Nodules.

    Nitrogen fertiliser use in agriculture is inefficient, costly and can be environmentally damaging. Legume crops represent an economically and environmentally sound alternative, as their relationship with nitrogen-fixing soil bacteria enables them to thrive in the absence of nitrogen fertiliser. The bacteria (commonly referred to as rhizobia) are housed in specialised root organs, called nodules. Identifying critical components in the development and control of legume nodules is now needed to optimise the process and improve agriculture sustainability. Projects include those that aim to discover and functionally characterise novel factors that 1) are required early in the molecular process of legume nodule development, 2) act to control legume nodule numbers, or 3) are regulated by acid soils to inhibit nodule formation. Findings can considerably enhance the current nodulation model and could help to underpin strategies to reduce the over-reliance on nitrogen fertiliser use in agriculture.

  • Genetic transformation and CRISPR genome editing to establish molecular mechanisms of plant development.

    We have identified numerous genetic targets having roles in controlling plant growth and development in response to abiotic and biotic factors, including interactions with beneficial microbes. These factors now need to be functionally characterised to understand their activity and to establish alleles to target of generate in breeding programs to optimise crop performance. Genetic transformation of genes of interest, promotor:reporter fusions, and CRISPR genome editing represent three biotechnology approaches we can use to help achieve this.

Supervision history

Current supervision

  • Doctor Philosophy

    Molecular analysis of novel CLE peptide hormones that respond to legume pathogens

    Principal Advisor

    Other advisors: Professor Elizabeth Aitken

  • Doctor Philosophy

    Revolutionising CRISPR genome editing to generate superior legume crops

    Principal Advisor

  • Doctor Philosophy

    Molecular analysis of novel CLE peptide hormones that respond to legume pathogens

    Principal Advisor

    Other advisors: Professor Elizabeth Aitken

  • Doctor Philosophy

    Nannochloropsis: a potential chassis strain for synthetic biology in microbial photoautotrophs

    Principal Advisor

    Other advisors: Dr Harendra Parekh

  • Doctor Philosophy

    Regulators of female reproductive development in cowpea

    Principal Advisor

    Other advisors: Professor Anna Koltunow

  • Doctor Philosophy

    Regulators of female reproductive development in cowpea

    Principal Advisor

    Other advisors: Professor Anna Koltunow

  • Doctor Philosophy

    Characterising novel molecular signals involved in Legume nodulation

    Principal Advisor

    Other advisors: Emeritus Professor Peter Gresshoff

  • Doctor Philosophy

    Nannochloropsis: a synthetic biology platform

    Principal Advisor

    Other advisors: Dr Harendra Parekh

  • Doctor Philosophy

    A Biomimetic Modular Platform to Deliver Plant Actives and Microbes to Crop Seed to Improve Seed Germination and Plant Development

    Associate Advisor

    Other advisors: Dr Jitka Kochanek

  • Doctor Philosophy

    The Characterization of Root Meristem Growth Factor (RGF) Peptides in Soybean Root Development and Nodulation

    Associate Advisor

  • Doctor Philosophy

    Helping crops cope as climatic extremes escalate: elucidating plant responses to novel growth enhancing compounds

    Associate Advisor

    Other advisors: Dr Jitka Kochanek

  • Doctor Philosophy

    Expediting genetic gains in faba bean using new breeding strategies

    Associate Advisor

    Other advisors: Dr Karen Massel

  • Doctor Philosophy

    The Characterisation of Root Meristem Growth Factor (RGF)/GOLVEN (GLV)/CLE-Like (CLEL) Peptides in Soybean Root Development and Nodulation

    Associate Advisor

Completed supervision

Media

Enquiries

Contact Associate Professor Brett Ferguson directly for media enquiries about:

  • Biofuel
  • Genetics - plants
  • Legumes
  • Microbe-plant interactions
  • Nodulation - Botany
  • Plant molecular biology
  • Plant-microbe interactions
  • Plants - development, physiology, genetics
  • Pongamia pinnata
  • Soybean
  • Sustainable Aviation Fuel (SAF)
  • Symbiosis

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