Overview
Background
Dr Shim's research revolves around developing computational methods to understand determinants of cell identity by analysing various genomic data. Trained in bioinformatics, pharmacy and biomedical science (majoring in biochemistry and immunology), Dr Shim incorporates inter-disciplinary knowledge to solve research questions in both basic science and translational medicine.
Availability
- Dr Woo Jun Shim is:
- Available for supervision
Qualifications
- Bachelor of Biomedical Science, University of Adelaide
- Bachelor (Honours), The University of Queensland
- Masters (Coursework), The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research impacts
Dr Shim's discovery has helped address an area of unmet need in genetic analysis pipelines as evidenced by significant international uptake. Working with UQ’s main commercialisation company UniQuest, Dr Shim's work formed the basis for successful contracts with industry partners including HAYA Therapeutics (Switzerland), Merck (Germany), Mogrify (UK), and ConcR (UK) to improve the accuracy and efficiency of clinical diagnostic and drug discovery pipelines. Dr Shim was awarded a UQ Early-Mid Career Researcher (EMCR) Industry Engagement Award in 2022 for his successful engagement with HAYA Therapeutics.
Works
Search Professor Woo Jun Shim’s works on UQ eSpace
2024
Conference Publication
Preclinical models of Glycaemic variability recapitulate Clinical Cardiovascular outcomes in Diabetes
Cao, Y., Redd, M., Outhwaite, J., Shim, W., Fang, C., Negi, S., Shen, S., Mizikovsky, D., Chiu, H., Tan, C., Thomas, U., Dragicevic, E., Sng, J., Short, K. and Palpant, N. (2024). Preclinical models of Glycaemic variability recapitulate Clinical Cardiovascular outcomes in Diabetes. 72nd Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Perth, WA Australia, 1-4 August 2024. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2024.06.332
2023
Conference Publication
Disease modeling utilizing human pluripotent stem cell-derived cardiomyocytes and physiological characterization
Cao, Yuanzhao, Redd, Meredith A., Shim, Woo Jun, Fang, Chen, Chiu, Han, Azofeifa, Daniela Rojas, Thomas, Ulrich, Lemme, Marta, Dragicevic, Elena, Stoelzle-Feix, Sonja and Palpant, Nathan J. (2023). Disease modeling utilizing human pluripotent stem cell-derived cardiomyocytes and physiological characterization. Safety Pharmacology Society Annual Meeting, Brussels, Belgium, 18-21 September 2023. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.vascn.2023.107267
2023
Journal Article
Inferring cell diversity in single cell data using consortium-scale epigenetic data as a biological anchor for cell identity
Sun, Yuliangzi, Shim, Woo Jun, Shen, Sophie, Sinniah, Enakshi, Pham, Duy, Su, Zezhuo, Mizikovsky, Dalia, White, Melanie D., Ho, Joshua W. K., Nguyen, Quan, Bodén, Mikael and Palpant, Nathan J (2023). Inferring cell diversity in single cell data using consortium-scale epigenetic data as a biological anchor for cell identity. Nucleic Acids Research, 51 (11), e62-e62. doi: 10.1093/nar/gkad307
2023
Journal Article
Repressive epigenetic mechanisms, such as the H3K27me3 histone modification, were predicted to affect muscle gene expression and its mineral content in Nelore cattle
Afonso, Juliana, Shim, Woo Jun, Boden, Mikael, Salinas Fortes, Marina Rufino, da Silva Diniz, Wellison Jarles, de Lima, Andressa Oliveira, Rocha, Marina Ibelli Pereira, Cardoso, Tainã Figueiredo, Bruscadin, Jennifer Jessica, Gromboni, Caio Fernando, Nogueira, Ana Rita Araujo, Mourão, Gerson Barreto, Zerlotini, Adhemar, Coutinho, Luiz Lehmann and de Almeida Regitano, Luciana Correia (2023). Repressive epigenetic mechanisms, such as the H3K27me3 histone modification, were predicted to affect muscle gene expression and its mineral content in Nelore cattle. Biochemistry and Biophysics Reports, 33 101420, 1-9. doi: 10.1016/j.bbrep.2023.101420
2023
Journal Article
PDGF-AB Reduces Myofibroblast Differentiation Without Increasing Proliferation After Myocardial Infarction
Hume, Robert D., Deshmukh, Tejas, Doan, Tram, Shim, Woo Jun, Kanagalingam, Shaan, Tallapragada, Vikram, Rashid, Fairooj, Marcuello, Maria, Blessing, Daniel, Selvakumar, Dinesh, Raguram, Kalyan, Pathan, Faraz, Graham, Dinny, Ounzain, Samir, Kizana, Eddy, Harvey, Richard P., Palpant, Nathan J. and Chong, James J.H. (2023). PDGF-AB Reduces Myofibroblast Differentiation Without Increasing Proliferation After Myocardial Infarction. JACC: Basic to Translational Science, 8 (6), 658-674. doi: 10.1016/j.jacbts.2022.11.006
2023
Journal Article
A transposable element into the human long noncoding RNA CARMEN is a switch for cardiac precursor cell specification
Plaisance, Isabelle, Chouvardas, Panagiotis, Sun, Yuliangzi, Nemir, Mohamed, Aghagolzadeh, Parisa, Aminfar, Farhang, Shen, Sophie, Shim, Woo Jun, Rochais, Francesca, Johnson, Rory, Palpant, Nathan and Pedrazzini, Thierry (2023). A transposable element into the human long noncoding RNA CARMEN is a switch for cardiac precursor cell specification. Cardiovascular Research, 119 (6), 1361-1376. doi: 10.1093/cvr/cvac191
2022
Conference Publication
H3K27me3 predicted regulation of gene expression linked to calcium quantification in Nelore muscle
Afonso, J., Shim, W.J., Boden, M., Palpant, N., Fortes, M.R.S., Diniz, W.J.S., Lima, A.O., Rocha, M.I.P., Cardoso, T.F., Bruscadin, J.J., Gromboni, C.F., Nogueira, A.R.A., Mourão, G.B., Zerlotini, A., Coutinho, L.L. and Regitano, L.C.A. (2022). H3K27me3 predicted regulation of gene expression linked to calcium quantification in Nelore muscle. 12th World Congress on Genetics Applied to Livestock Production (WCGALP), Rotterdam, Netherlands, 3-8 July 2022. Wageningen, Netherlands: Wageningen Academic Publishers. doi: 10.3920/978-90-8686-940-4_553
2022
Journal Article
Alternative splicing of a transposable element into the human long noncoding RNA CARMEN is a switch for cardiac precursor cell specification
Plaisance, Isabelle, Chouvardas, Panagiotis, Sun, Yuliangzi, Nemir, Mohamed, Aghagolzadeh, Parisa, Aminfar, Farhang, Shen, Sophie, Shim, Woo Jun, Rochais, Francesca, Johnson, Rory and Pedrazzini, Thierry (2022). Alternative splicing of a transposable element into the human long noncoding RNA CARMEN is a switch for cardiac precursor cell specification. Journal of Molecular and Cellular Cardiology, 173, S182-S182. doi: 10.1016/j.yjmcc.2022.08.344
2021
Journal Article
Integrating single-cell genomics pipelines to discover mechanisms of stem cell differentiation
Shen, Sophie, Sun, Yuliangzi, Matsumoto, Maika, Shim, Woo Jun, Sinniah, Enakshi, Wilson, Sean B., Werner, Tessa, Wu, Zhixuan, Bradford, Stephen T., Hudson, James, Little, Melissa H., Powell, Joseph, Nguyen, Quan and Palpant, Nathan J. (2021). Integrating single-cell genomics pipelines to discover mechanisms of stem cell differentiation. Trends in Molecular Medicine, 27 (12), 1135-1158. doi: 10.1016/j.molmed.2021.09.006
2021
Other Outputs
Identifying genetic regulators of cell fate through computational analysis of epigenetic repression
Shim, Woo Jun (2021). Identifying genetic regulators of cell fate through computational analysis of epigenetic repression. PhD Thesis, School of Chemistry and Molecular Biosciences, The University of Queensland. doi: 10.14264/4d7b321
2021
Journal Article
Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype
Kojic, Marija, Gawda, Tomasz, Gaik, Monika, Begg, Alexander, Salerno-Kochan, Anna, Kurniawan, Nyoman D., Jones, Alun, Drożdżyk, Katarzyna, Kościelniak, Anna, Chramiec-Głąbik, Andrzej, Hediyeh-Zadeh, Soroor, Kasherman, Maria, Shim, Woo Jun, Sinniah, Enakshi, Genovesi, Laura A., Abrahamsen, Rannvá K., Fenger, Christina D., Madsen, Camilla G., Cohen, Julie S., Fatemi, Ali, Stark, Zornitza, Lunke, Sebastian, Lee, Joy, Hansen, Jonas K., Boxill, Martin F., Keren, Boris, Marey, Isabelle, Saenz, Margarita S., Brown, Kathleen ... Wainwright, Brandon J. (2021). Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype. Nature Communications, 12 (1) 2678, 2678. doi: 10.1038/s41467-021-22888-5
2021
Journal Article
J-domain proteins promote client relay from Hsp70 during tail-anchored membrane protein targeting
Cho, Hyunju, Shim, Woo Jun, Liu, Yumeng and Shan, Shu-ou (2021). J-domain proteins promote client relay from Hsp70 during tail-anchored membrane protein targeting. Journal of Biological Chemistry, 296 100546, 1-15. doi: 10.1016/j.jbc.2021.100546
2020
Journal Article
Conserved epigenetic regulatory logic infers genes governing cell identity
Shim, Woo Jun, Sinniah, Enakshi, Xu, Jun, Vitrinel, Burcu, Alexanian, Michael, Andreoletti, Gaia, Shen, Sophie, Sun, Yuliangzi, Balderson, Brad, Boix, Carles, Peng, Guangdun, Jing, Naihe, Wang, Yuliang, Kellis, Manolis, Tam, Patrick P L, Smith, Aaron, Piper, Michael, Christiaen, Lionel, Nguyen, Quan, Bodén, Mikael and Palpant, Nathan J. (2020). Conserved epigenetic regulatory logic infers genes governing cell identity. Cell Systems, 11 (6), 625-639.e13. doi: 10.1016/j.cels.2020.11.001
2009
Conference Publication
Sortilin localisation in the rat retina during early postnatal development
Shim, W. J. and Firth, S. I. (2009). Sortilin localisation in the rat retina during early postnatal development. 29th Annual Meeting Australian Neuroscience Society, Canberra, ACT, Australia, 27-30 January 2009.
Supervision
Availability
- Dr Woo Jun Shim is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Using signatures of cell identity to improve cell type prediction in single cell analysis pipelines
Associate Advisor
Other advisors: Dr Quan Nguyen, Associate Professor Nathan Palpant
Media
Enquiries
For media enquiries about Dr Woo Jun Shim's areas of expertise, story ideas and help finding experts, contact our Media team: