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Dr Leon Hugo
Dr

Leon Hugo

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Overview

Background

Dr Leon Hugo is a medical entomologist conducting research into the biology of mosquitoes, host-parasite interactions and the development of novel control strategies against arthropod-borne viruses (arboviruses). Dr Hugo is an Honorary Associate Professor through the School of Biomedical Sciences and is also the Academic Lead of the Mosquito Control Laboratory at QIMR Berghofer medical research institute, Brisbane. Dr Hugo has developed and applied experimental mosquito models of arbovirus infection for over 15 years to establish the risk of arbovirus transmission in Australia and new biological controls. Dr Hugo works with physical containment/biosecurity level (PC/BSL) 2 and 3 arboviruses, including dengue, Zika, Japanese encephalitis and chikungunya viruses and performs fundamental research on Wolbachia bacteria and Insect-specific virus (ISV) microbial control agents. Dr Hugo has published 60+ research articles with over 160 collaborators, from academic, medical, government and corporate sectors, across 18 countries. Topic areas his publications have had greatest impact were Japanese Encephalitis and Socioeconomic Impact, Wolbachia’s Role in Mosquito Population Replacement and Insecticide Resistance Mechanisms in Aedes aegypti.

Dr Hugo’s team maintains a living library of native and exotic mosquito species and conducts infection and transmission studies in state-of-the-art PC2 and PC3 insectaries. Research themes including mosquito vector competence, climate change impacts on mosquito-borne disease transmission risk, mosquito and arbovirus surveillance and genomics and novel control strategies, including biological control and the use of endectocides.

Availability

Dr Leon Hugo is:
Available for supervision

Qualifications

  • Doctor of Philosophy, The University of Queensland

Research impacts

Seven of Dr Hugo's publications have attracted over 40 citations in policy documents across 8+ countries from agencies including the WHO, State of Hawaii and the OECD.

Works

Search Professor Leon Hugo’s works on UQ eSpace

69 works between 2003 and 2025

21 - 40 of 69 works

2022

Journal Article

Persistence of antibodies, boostability, and interchangeability of Japanese encephalitis vaccines: A systematic review and dose-response meta-analysis

Islam, Nazmul, Xu, Chang, Lau, Colleen L., Mills, Deborah J., Clark, Justin, Devine, Gregor J., Hugo, Leon E., Gyawali, Narayan, Thalib, Lukman and Furuya-Kanamori, Luis (2022). Persistence of antibodies, boostability, and interchangeability of Japanese encephalitis vaccines: A systematic review and dose-response meta-analysis. Vaccine, 40 (26), 3546-3555. doi: 10.1016/j.vaccine.2022.04.079

Persistence of antibodies, boostability, and interchangeability of Japanese encephalitis vaccines: A systematic review and dose-response meta-analysis

2022

Journal Article

The emergence of Japanese encephalitis in Australia and the implications for a vaccination strategy

Furuya-Kanamori, Luis, Gyawali, Narayan, Mills, Deborah J., Hugo, Leon E., Devine, Gregor J. and Lau, Colleen L. (2022). The emergence of Japanese encephalitis in Australia and the implications for a vaccination strategy. Tropical Medicine and Infectious Disease, 7 (6) 85, 85. doi: 10.3390/tropicalmed7060085

The emergence of Japanese encephalitis in Australia and the implications for a vaccination strategy

2022

Journal Article

The distinguishing NS5-M114V mutation in American Zika virus isolates has negligible impacts on virus replication and transmission potential

Peng, Nias Y. G., Amarilla, Alberto A., Hugo, Leon E., Modhiran, Naphak, Sng, Julian D. J., Slonchak, Andrii, Watterson, Daniel, Setoh, Yin Xiang and Khromykh, Alexander A. (2022). The distinguishing NS5-M114V mutation in American Zika virus isolates has negligible impacts on virus replication and transmission potential. PLoS Neglected Tropical Diseases, 16 (5) e0010426, 1-17. doi: 10.1371/journal.pntd.0010426

The distinguishing NS5-M114V mutation in American Zika virus isolates has negligible impacts on virus replication and transmission potential

2021

Journal Article

Releasing incompatible males drives strong suppression across populations of wild and Wolbachia-carrying Aedes aegypti in Australia

Beebe, Nigel W., Pagendam, Dan, Trewin, Brendan J., Boomer, Andrew, Bradford, Matt, Ford, Andrew, Liddington, Catherine, Bondarenco, Artiom, de Barro, Paul J., Gilchrist, Joshua, Paton, Christopher, Staunton, Kyran M., Johnson, Brian, Maynard, Andrew J., Devine, Gregor J., Hugo, Leon E., Rasic, Gordana, Cook, Helen, Massaro, Peter, Snoad, Nigel, Crawford, Jacob E., White, Bradley J., Xi, Zhiyong and Ritchie, Scott A. (2021). Releasing incompatible males drives strong suppression across populations of wild and Wolbachia-carrying Aedes aegypti in Australia. Proceedings of the National Academy of Sciences of the United States of America, 118 (41) e2106828118, e2106828118. doi: 10.1073/pnas.2106828118

Releasing incompatible males drives strong suppression across populations of wild and Wolbachia-carrying Aedes aegypti in Australia

2021

Journal Article

The structure of an infectious immature flavivirus redefines viral architecture and maturation

Newton, Natalee D., Hardy, Joshua M., Modhiran, Naphak, Hugo, Leon E., Amarilla, Alberto A., Bibby, Summa, Venugopal, Hariprasad, Harrison, Jessica J., Traves, Renee J., Hall, Roy A., Hobson-Peters, Jody, Coulibaly, Fasséli and Watterson, Daniel (2021). The structure of an infectious immature flavivirus redefines viral architecture and maturation. Science Advances, 7 (20) eabe4507, 1-12. doi: 10.1126/sciadv.abe4507

The structure of an infectious immature flavivirus redefines viral architecture and maturation

2021

Journal Article

The presence of knockdown resistance mutations reduces male mating competitiveness in the major arbovirus vector, Aedes aegypti

Rigby, Lisa M., Johnson, Brian J., Rašić, Gordana, Peatey, Christopher L., Hugo, Leon E., Beebe, Nigel W., Hartel, Gunter F. and Devine, Gregor J. (2021). The presence of knockdown resistance mutations reduces male mating competitiveness in the major arbovirus vector, Aedes aegypti. PLoS Neglected Tropical Diseases, 15 (2) e0009121, 1-13. doi: 10.1371/journal.pntd.0009121

The presence of knockdown resistance mutations reduces male mating competitiveness in the major arbovirus vector, Aedes aegypti

2020

Journal Article

Effect of serotype and strain diversity on dengue virus replication in Australian mosquito vectors

Ekwudu, O’mezie, Marquart, Louise, Webb, Lachlan, Lowry, Kym S., Devine, Gregor J., Hugo, Leon E. and Frentiu, Francesca D. (2020). Effect of serotype and strain diversity on dengue virus replication in Australian mosquito vectors. Pathogens, 9 (8) 668, 668-14. doi: 10.3390/pathogens9080668

Effect of serotype and strain diversity on dengue virus replication in Australian mosquito vectors

2020

Journal Article

A micro-PRNT for the detection of Ross River virus antibodies in mosquito blood meals: A useful tool for inferring transmission pathways

Gyawali, Narayan, Murphy, Amanda K., Hugo, Leon E. and Devine, Gregor J. (2020). A micro-PRNT for the detection of Ross River virus antibodies in mosquito blood meals: A useful tool for inferring transmission pathways. PLoS One, 15 (7) e0229314, 1-13. doi: 10.1371/journal.pone.0229314

A micro-PRNT for the detection of Ross River virus antibodies in mosquito blood meals: A useful tool for inferring transmission pathways

2020

Journal Article

Identifying the fitness costs of a pyrethroid-resistant genotype in the major arboviral vector Aedes aegypti

Rigby, Lisa M., Rašić, Gordana, Peatey, Christopher L., Hugo, Leon E., Beebe, Nigel W. and Devine, Gregor J. (2020). Identifying the fitness costs of a pyrethroid-resistant genotype in the major arboviral vector Aedes aegypti. Parasites & Vectors, 13 (1) 358, 358. doi: 10.1186/s13071-020-04238-4

Identifying the fitness costs of a pyrethroid-resistant genotype in the major arboviral vector Aedes aegypti

2020

Conference Publication

Zika Virus sfRNA plays an essential role in the infection of insects and mammals

Slonchak, Andrii, Hugo, Leon E., Freney, Morgan, Amarilla, Alberto A., Hall-Mendelin, Sonja, Yan, Kexin, Torres, Francisco, Setoh, Yin Xiang, Peng, Nias, Chaggar, Harman K., Hurk, Andrew Van Den, Wolvetang, Ernst, Suhrbier, Andreas, Devine, Gregor J. and Khromykh, Alexander A. (2020). Zika Virus sfRNA plays an essential role in the infection of insects and mammals. Viruses 2020—Novel Concepts in Virology, Barcelona, Spain, 5–7 February 2020. Basel, Switzerland: MDPI. doi: 10.3390/proceedings2020050112

Zika Virus sfRNA plays an essential role in the infection of insects and mammals

2020

Journal Article

Australian Aedes aegypti mosquitoes are susceptible to infection with a highly divergent and sylvatic strain of dengue virus type 2 but are unlikely to transmit it

Pickering, Paul, Hugo, Leon E., Devine, Gregor J., Aaskov, John G. and Liu, Wenjun (2020). Australian Aedes aegypti mosquitoes are susceptible to infection with a highly divergent and sylvatic strain of dengue virus type 2 but are unlikely to transmit it. Parasites and Vectors, 13 (1) 240, 1-7. doi: 10.1186/s13071-020-04091-5

Australian Aedes aegypti mosquitoes are susceptible to infection with a highly divergent and sylvatic strain of dengue virus type 2 but are unlikely to transmit it

Featured

2020

Journal Article

Zika virus noncoding RNA suppresses apoptosis and is required for virus transmission by mosquitoes

Slonchak, Andrii, Hugo, Leon E., Freney, Morgan E., Hall-Mendelin, Sonja, Amarilla, Alberto A., Torres, Francisco J., Setoh, Yin Xiang, Peng, Nias Y. G., Sng, Julian D. J., Hall, Roy A., van den Hurk, Andrew F., Devine, Gregor J. and Khromykh, Alexander A. (2020). Zika virus noncoding RNA suppresses apoptosis and is required for virus transmission by mosquitoes. Nature Communications, 11 (1) 2205, 2205. doi: 10.1038/s41467-020-16086-y

Zika virus noncoding RNA suppresses apoptosis and is required for virus transmission by mosquitoes

2020

Journal Article

Mosquito age grading and vector-control programmes

Johnson, Brian J., Hugo, Leon E., Churcher, Thomas S., Ong, Oselyne T. W. and Devine, Gregor J. (2020). Mosquito age grading and vector-control programmes. Trends in Parasitology, 36 (1), 39-51. doi: 10.1016/j.pt.2019.10.011

Mosquito age grading and vector-control programmes

2020

Conference Publication

Dengue virus defective interfering particles in mosquitoes

Hugo, Leon E., Graham, Melissa C., Hussain, Malik, Lowry, Kym, Devine, Gregor J. and Aaskov, John G. (2020). Dengue virus defective interfering particles in mosquitoes. 68th Annual Meeting of the American Society for Tropical Medicine and Hygiene (ASTMH), National Harbor, MD United States, 20-24 November 2019. Deerfield, IL United States: American Society of Tropical Medicine and Hygiene. doi: 10.4269/ajtmh.abstract2019

Dengue virus defective interfering particles in mosquitoes

2019

Journal Article

Identification of the source of blood meals in mosquitoes collected from north-eastern Australia

Gyawali, Narayan, Taylor-Robinson, Andrew W., Bradbury, Richard S., Huggins, David W., Hugo, Leon E., Lowry, Kym and Aaskov, John G. (2019). Identification of the source of blood meals in mosquitoes collected from north-eastern Australia. Parasites and Vectors, 12 (1) 198, 198. doi: 10.1186/s13071-019-3455-2

Identification of the source of blood meals in mosquitoes collected from north-eastern Australia

2019

Journal Article

Vector competence of Australian Aedes aegypti and Aedes albopictus for an epidemic strain of Zika virus

Hugo, Leon E., Stassen, Liesel, La, Jessica, Gosden, Edward, Ekwudu, O'mezie, Winterford, Clay, Viennet, Elvina, Faddy, Helen M., Devine, Gregor J. and Frentiu, Francesca D. (2019). Vector competence of Australian Aedes aegypti and Aedes albopictus for an epidemic strain of Zika virus. PLoS Neglected Tropical Diseases, 13 (4) e0007281, e0007281. doi: 10.1371/journal.pntd.0007281

Vector competence of Australian Aedes aegypti and Aedes albopictus for an epidemic strain of Zika virus

2019

Journal Article

Treatment of pigs with endectocides as a complementary tool for combating malaria transmission by Anopheles farauti (s.s.) in Papua New Guinea

Pasay, Cielo J., Yakob, Laith, Meredith, Hannah R., Stewart, Romal, Mills, Paul C., Dekkers, Milou H., Ong, Oselyne, Llewellyn, Stacey, Hugo, R. Leon E., McCarthy, James S. and Devine, Gregor J. (2019). Treatment of pigs with endectocides as a complementary tool for combating malaria transmission by Anopheles farauti (s.s.) in Papua New Guinea. Parasites and Vectors, 12 (1) 124. doi: 10.1186/s13071-019-3392-0

Treatment of pigs with endectocides as a complementary tool for combating malaria transmission by Anopheles farauti (s.s.) in Papua New Guinea

2018

Journal Article

Proteomics of Anopheles Vectors of Malaria

Hugo, R. Leon E. and Birrell, Geoff W. (2018). Proteomics of Anopheles Vectors of Malaria. Trends in Parasitology, 34 (11), 961-981. doi: 10.1016/j.pt.2018.08.009

Proteomics of Anopheles Vectors of Malaria

2018

Journal Article

First report on the application of near-infrared spectroscopy to predict the age of Aedes albopictus Skuse

Sikulu-Lord, Maggy T., Devine, Gregor J., Hugo, Leon E. and Dowell, Floyd E. (2018). First report on the application of near-infrared spectroscopy to predict the age of Aedes albopictus Skuse. Scientific Reports, 8 (1) 9590, 9590. doi: 10.1038/s41598-018-27998-7

First report on the application of near-infrared spectroscopy to predict the age of Aedes albopictus Skuse

2018

Journal Article

Wolbachia-induced transcription factor GATA4 suppresses ovary-specific genes blastoderm-specific protein 25D and imaginal disc growth factor

Osei-Amo, S, Hussein, M, Asad, S, Hugo, L and Asgari, S (2018). Wolbachia-induced transcription factor GATA4 suppresses ovary-specific genes blastoderm-specific protein 25D and imaginal disc growth factor. Insect Molecular Biology, 27 (3), 295-304. doi: 10.1111/imb.12371

Wolbachia-induced transcription factor GATA4 suppresses ovary-specific genes blastoderm-specific protein 25D and imaginal disc growth factor

Supervision

Availability

Dr Leon Hugo is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Media

Enquiries

For media enquiries about Dr Leon Hugo's areas of expertise, story ideas and help finding experts, contact our Media team:

communications@uq.edu.au