Overview
Background
Dr Leon Hugo is a medical entomologist conducting research into the biology of mosquitoes, host-parasite interactions and the development of novel control strategies against arthropod-borne viruses (arboviruses). Dr Hugo is an Honorary Associate Professor through the School of Biomedical Sciences and is also the Academic Lead of the Mosquito Control Laboratory at QIMR Berghofer medical research institute, Brisbane. Dr Hugo has developed and applied experimental mosquito models of arbovirus infection for over 15 years to establish the risk of arbovirus transmission in Australia and new biological controls. Dr Hugo works with physical containment/biosecurity level (PC/BSL) 2 and 3 arboviruses, including dengue, Zika, Japanese encephalitis and chikungunya viruses and performs fundamental research on Wolbachia bacteria and Insect-specific virus (ISV) microbial control agents. Dr Hugo has published 60+ research articles with over 160 collaborators, from academic, medical, government and corporate sectors, across 18 countries. Topic areas his publications have had greatest impact were Japanese Encephalitis and Socioeconomic Impact, Wolbachia’s Role in Mosquito Population Replacement and Insecticide Resistance Mechanisms in Aedes aegypti.
Dr Hugo’s team maintains a living library of native and exotic mosquito species and conducts infection and transmission studies in state-of-the-art PC2 and PC3 insectaries. Research themes including mosquito vector competence, climate change impacts on mosquito-borne disease transmission risk, mosquito and arbovirus surveillance and genomics and novel control strategies, including biological control and the use of endectocides.
Availability
- Dr Leon Hugo is:
- Available for supervision
Qualifications
- Doctor of Philosophy, The University of Queensland
Research impacts
Seven of Dr Hugo's publications have attracted over 40 citations in policy documents across 8+ countries from agencies including the WHO, State of Hawaii and the OECD.
Works
Search Professor Leon Hugo’s works on UQ eSpace
2022
Journal Article
Persistence of antibodies, boostability, and interchangeability of Japanese encephalitis vaccines: A systematic review and dose-response meta-analysis
Islam, Nazmul, Xu, Chang, Lau, Colleen L., Mills, Deborah J., Clark, Justin, Devine, Gregor J., Hugo, Leon E., Gyawali, Narayan, Thalib, Lukman and Furuya-Kanamori, Luis (2022). Persistence of antibodies, boostability, and interchangeability of Japanese encephalitis vaccines: A systematic review and dose-response meta-analysis. Vaccine, 40 (26), 3546-3555. doi: 10.1016/j.vaccine.2022.04.079
2022
Journal Article
The emergence of Japanese encephalitis in Australia and the implications for a vaccination strategy
Furuya-Kanamori, Luis, Gyawali, Narayan, Mills, Deborah J., Hugo, Leon E., Devine, Gregor J. and Lau, Colleen L. (2022). The emergence of Japanese encephalitis in Australia and the implications for a vaccination strategy. Tropical Medicine and Infectious Disease, 7 (6) 85, 85. doi: 10.3390/tropicalmed7060085
2022
Journal Article
The distinguishing NS5-M114V mutation in American Zika virus isolates has negligible impacts on virus replication and transmission potential
Peng, Nias Y. G., Amarilla, Alberto A., Hugo, Leon E., Modhiran, Naphak, Sng, Julian D. J., Slonchak, Andrii, Watterson, Daniel, Setoh, Yin Xiang and Khromykh, Alexander A. (2022). The distinguishing NS5-M114V mutation in American Zika virus isolates has negligible impacts on virus replication and transmission potential. PLoS Neglected Tropical Diseases, 16 (5) e0010426, 1-17. doi: 10.1371/journal.pntd.0010426
2021
Journal Article
Releasing incompatible males drives strong suppression across populations of wild and Wolbachia-carrying Aedes aegypti in Australia
Beebe, Nigel W., Pagendam, Dan, Trewin, Brendan J., Boomer, Andrew, Bradford, Matt, Ford, Andrew, Liddington, Catherine, Bondarenco, Artiom, de Barro, Paul J., Gilchrist, Joshua, Paton, Christopher, Staunton, Kyran M., Johnson, Brian, Maynard, Andrew J., Devine, Gregor J., Hugo, Leon E., Rasic, Gordana, Cook, Helen, Massaro, Peter, Snoad, Nigel, Crawford, Jacob E., White, Bradley J., Xi, Zhiyong and Ritchie, Scott A. (2021). Releasing incompatible males drives strong suppression across populations of wild and Wolbachia-carrying Aedes aegypti in Australia. Proceedings of the National Academy of Sciences of the United States of America, 118 (41) e2106828118, e2106828118. doi: 10.1073/pnas.2106828118
2021
Journal Article
The structure of an infectious immature flavivirus redefines viral architecture and maturation
Newton, Natalee D., Hardy, Joshua M., Modhiran, Naphak, Hugo, Leon E., Amarilla, Alberto A., Bibby, Summa, Venugopal, Hariprasad, Harrison, Jessica J., Traves, Renee J., Hall, Roy A., Hobson-Peters, Jody, Coulibaly, Fasséli and Watterson, Daniel (2021). The structure of an infectious immature flavivirus redefines viral architecture and maturation. Science Advances, 7 (20) eabe4507, 1-12. doi: 10.1126/sciadv.abe4507
2021
Journal Article
The presence of knockdown resistance mutations reduces male mating competitiveness in the major arbovirus vector, Aedes aegypti
Rigby, Lisa M., Johnson, Brian J., Rašić, Gordana, Peatey, Christopher L., Hugo, Leon E., Beebe, Nigel W., Hartel, Gunter F. and Devine, Gregor J. (2021). The presence of knockdown resistance mutations reduces male mating competitiveness in the major arbovirus vector, Aedes aegypti. PLoS Neglected Tropical Diseases, 15 (2) e0009121, 1-13. doi: 10.1371/journal.pntd.0009121
2020
Journal Article
Effect of serotype and strain diversity on dengue virus replication in Australian mosquito vectors
Ekwudu, O’mezie, Marquart, Louise, Webb, Lachlan, Lowry, Kym S., Devine, Gregor J., Hugo, Leon E. and Frentiu, Francesca D. (2020). Effect of serotype and strain diversity on dengue virus replication in Australian mosquito vectors. Pathogens, 9 (8) 668, 668-14. doi: 10.3390/pathogens9080668
2020
Journal Article
A micro-PRNT for the detection of Ross River virus antibodies in mosquito blood meals: A useful tool for inferring transmission pathways
Gyawali, Narayan, Murphy, Amanda K., Hugo, Leon E. and Devine, Gregor J. (2020). A micro-PRNT for the detection of Ross River virus antibodies in mosquito blood meals: A useful tool for inferring transmission pathways. PLoS One, 15 (7) e0229314, 1-13. doi: 10.1371/journal.pone.0229314
2020
Journal Article
Identifying the fitness costs of a pyrethroid-resistant genotype in the major arboviral vector Aedes aegypti
Rigby, Lisa M., Rašić, Gordana, Peatey, Christopher L., Hugo, Leon E., Beebe, Nigel W. and Devine, Gregor J. (2020). Identifying the fitness costs of a pyrethroid-resistant genotype in the major arboviral vector Aedes aegypti. Parasites & Vectors, 13 (1) 358, 358. doi: 10.1186/s13071-020-04238-4
2020
Conference Publication
Zika Virus sfRNA plays an essential role in the infection of insects and mammals
Slonchak, Andrii, Hugo, Leon E., Freney, Morgan, Amarilla, Alberto A., Hall-Mendelin, Sonja, Yan, Kexin, Torres, Francisco, Setoh, Yin Xiang, Peng, Nias, Chaggar, Harman K., Hurk, Andrew Van Den, Wolvetang, Ernst, Suhrbier, Andreas, Devine, Gregor J. and Khromykh, Alexander A. (2020). Zika Virus sfRNA plays an essential role in the infection of insects and mammals. Viruses 2020—Novel Concepts in Virology, Barcelona, Spain, 5–7 February 2020. Basel, Switzerland: MDPI. doi: 10.3390/proceedings2020050112
2020
Journal Article
Australian Aedes aegypti mosquitoes are susceptible to infection with a highly divergent and sylvatic strain of dengue virus type 2 but are unlikely to transmit it
Pickering, Paul, Hugo, Leon E., Devine, Gregor J., Aaskov, John G. and Liu, Wenjun (2020). Australian Aedes aegypti mosquitoes are susceptible to infection with a highly divergent and sylvatic strain of dengue virus type 2 but are unlikely to transmit it. Parasites and Vectors, 13 (1) 240, 1-7. doi: 10.1186/s13071-020-04091-5
Featured
2020
Journal Article
Zika virus noncoding RNA suppresses apoptosis and is required for virus transmission by mosquitoes
Slonchak, Andrii, Hugo, Leon E., Freney, Morgan E., Hall-Mendelin, Sonja, Amarilla, Alberto A., Torres, Francisco J., Setoh, Yin Xiang, Peng, Nias Y. G., Sng, Julian D. J., Hall, Roy A., van den Hurk, Andrew F., Devine, Gregor J. and Khromykh, Alexander A. (2020). Zika virus noncoding RNA suppresses apoptosis and is required for virus transmission by mosquitoes. Nature Communications, 11 (1) 2205, 2205. doi: 10.1038/s41467-020-16086-y
2020
Journal Article
Mosquito age grading and vector-control programmes
Johnson, Brian J., Hugo, Leon E., Churcher, Thomas S., Ong, Oselyne T. W. and Devine, Gregor J. (2020). Mosquito age grading and vector-control programmes. Trends in Parasitology, 36 (1), 39-51. doi: 10.1016/j.pt.2019.10.011
2020
Conference Publication
Dengue virus defective interfering particles in mosquitoes
Hugo, Leon E., Graham, Melissa C., Hussain, Malik, Lowry, Kym, Devine, Gregor J. and Aaskov, John G. (2020). Dengue virus defective interfering particles in mosquitoes. 68th Annual Meeting of the American Society for Tropical Medicine and Hygiene (ASTMH), National Harbor, MD United States, 20-24 November 2019. Deerfield, IL United States: American Society of Tropical Medicine and Hygiene. doi: 10.4269/ajtmh.abstract2019
2019
Journal Article
Identification of the source of blood meals in mosquitoes collected from north-eastern Australia
Gyawali, Narayan, Taylor-Robinson, Andrew W., Bradbury, Richard S., Huggins, David W., Hugo, Leon E., Lowry, Kym and Aaskov, John G. (2019). Identification of the source of blood meals in mosquitoes collected from north-eastern Australia. Parasites and Vectors, 12 (1) 198, 198. doi: 10.1186/s13071-019-3455-2
2019
Journal Article
Vector competence of Australian Aedes aegypti and Aedes albopictus for an epidemic strain of Zika virus
Hugo, Leon E., Stassen, Liesel, La, Jessica, Gosden, Edward, Ekwudu, O'mezie, Winterford, Clay, Viennet, Elvina, Faddy, Helen M., Devine, Gregor J. and Frentiu, Francesca D. (2019). Vector competence of Australian Aedes aegypti and Aedes albopictus for an epidemic strain of Zika virus. PLoS Neglected Tropical Diseases, 13 (4) e0007281, e0007281. doi: 10.1371/journal.pntd.0007281
2019
Journal Article
Treatment of pigs with endectocides as a complementary tool for combating malaria transmission by Anopheles farauti (s.s.) in Papua New Guinea
Pasay, Cielo J., Yakob, Laith, Meredith, Hannah R., Stewart, Romal, Mills, Paul C., Dekkers, Milou H., Ong, Oselyne, Llewellyn, Stacey, Hugo, R. Leon E., McCarthy, James S. and Devine, Gregor J. (2019). Treatment of pigs with endectocides as a complementary tool for combating malaria transmission by Anopheles farauti (s.s.) in Papua New Guinea. Parasites and Vectors, 12 (1) 124. doi: 10.1186/s13071-019-3392-0
2018
Journal Article
Proteomics of Anopheles Vectors of Malaria
Hugo, R. Leon E. and Birrell, Geoff W. (2018). Proteomics of Anopheles Vectors of Malaria. Trends in Parasitology, 34 (11), 961-981. doi: 10.1016/j.pt.2018.08.009
2018
Journal Article
First report on the application of near-infrared spectroscopy to predict the age of Aedes albopictus Skuse
Sikulu-Lord, Maggy T., Devine, Gregor J., Hugo, Leon E. and Dowell, Floyd E. (2018). First report on the application of near-infrared spectroscopy to predict the age of Aedes albopictus Skuse. Scientific Reports, 8 (1) 9590, 9590. doi: 10.1038/s41598-018-27998-7
2018
Journal Article
Wolbachia-induced transcription factor GATA4 suppresses ovary-specific genes blastoderm-specific protein 25D and imaginal disc growth factor
Osei-Amo, S, Hussein, M, Asad, S, Hugo, L and Asgari, S (2018). Wolbachia-induced transcription factor GATA4 suppresses ovary-specific genes blastoderm-specific protein 25D and imaginal disc growth factor. Insect Molecular Biology, 27 (3), 295-304. doi: 10.1111/imb.12371
Supervision
Availability
- Dr Leon Hugo is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Investigation of factors affecting the maternal transmission of Insect-specific viruses by mosquitoes
Principal Advisor
Other advisors: Associate Professor Jody Peters
-
Doctor Philosophy
Insect-specific viruses as tools for the downregulation of mosquito vector competence for arboviruses
Principal Advisor
Other advisors: Associate Professor Jody Peters
-
Doctor Philosophy
Exploring the development of a malaria refractory Anopheles farauti
Associate Advisor
Other advisors: Professor Sassan Asgari, Professor Nigel Beebe
-
Doctor Philosophy
Engineering chimeric viruses as protective and safe vaccines against mosquito-borne viral disease
Associate Advisor
Other advisors: Professor Alexander Khromykh, Dr Andrii Slonchak, Associate Professor Jody Peters
Completed supervision
-
2023
Doctor Philosophy
New tools for managing Aedes-borne diseases in Bangladesh
Associate Advisor
Other advisors: Professor Nigel Beebe
-
2021
Doctor Philosophy
The biological costs and benefits associated with a pyrethroid-resistant genotype of Aedes aegypti
Associate Advisor
Other advisors: Professor Nigel Beebe
-
2020
Doctor Philosophy
Interaction between flaviviruses and the vector Aedes aegypti, an overview into replication and microRNAs
Associate Advisor
Other advisors: Professor Nigel Beebe, Professor Sassan Asgari
-
2020
Doctor Philosophy
Characterization of Wolbachia infections from native Australian mosquitoes
Associate Advisor
Other advisors: Professor Sassan Asgari
Media
Enquiries
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