Overview
Background
Dr Leon Hugo is a medical entomologist conducting research into the biology of mosquitoes, host-parasite interactions and the development of novel control strategies against arthropod-borne viruses (arboviruses). Dr Hugo is an Honorary Associate Professor through the School of Biomedical Sciences and is also the Academic Lead of the Mosquito Control Laboratory at QIMR Berghofer medical research institute, Brisbane. Dr Hugo has developed and applied experimental mosquito models of arbovirus infection for over 15 years to establish the risk of arbovirus transmission in Australia and new biological controls. Dr Hugo works with physical containment/biosecurity level (PC/BSL) 2 and 3 arboviruses, including dengue, Zika, Japanese encephalitis and chikungunya viruses and performs fundamental research on Wolbachia bacteria and Insect-specific virus (ISV) microbial control agents. Dr Hugo has published 60+ research articles with over 160 collaborators, from academic, medical, government and corporate sectors, across 18 countries. Topic areas his publications have had greatest impact were Japanese Encephalitis and Socioeconomic Impact, Wolbachia’s Role in Mosquito Population Replacement and Insecticide Resistance Mechanisms in Aedes aegypti.
Dr Hugo’s team maintains a living library of native and exotic mosquito species and conducts infection and transmission studies in state-of-the-art PC2 and PC3 insectaries. Research themes including mosquito vector competence, climate change impacts on mosquito-borne disease transmission risk, mosquito and arbovirus surveillance and genomics and novel control strategies, including biological control and the use of endectocides.
Availability
- Dr Leon Hugo is:
- Available for supervision
Qualifications
- Doctor of Philosophy, The University of Queensland
Research impacts
Seven of Dr Hugo's publications have attracted over 40 citations in policy documents across 8+ countries from agencies including the WHO, State of Hawaii and the OECD.
Works
Search Professor Leon Hugo’s works on UQ eSpace
2018
Journal Article
Suppression of the pelo protein by Wolbachia and its effect on dengue virus in Aedes aegypti
Asad, Sultan, Hussain, Mazhar, Hugo, Leon, Osei-Amo, Solomon, Zhang, Guangmei, Watterson, Daniel and Asgari, Sassan (2018). Suppression of the pelo protein by Wolbachia and its effect on dengue virus in Aedes aegypti. PLoS Neglected Tropical Diseases, 12 (4) e0006405, e0006405. doi: 10.1371/journal.pntd.0006405
2018
Conference Publication
Characterization of Wolbachia infections from native Australian mosquito vectors
Wu, Chen, Fernandes, Jill, Devine, Greg and Hugo, Leon (2018). Characterization of Wolbachia infections from native Australian mosquito vectors. 67th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTHM), New Orleans, Los Angeles, 28 October - 1 November 2018. Deerfield, IL, United States: American Society of Tropical Medicine and Hygiene.
2018
Conference Publication
Relative vector competence of Aedes aegypti and Ae. albopictus for an epidemic strain of Zika virus under simulated field conditions
Hugo, Leon, Stassen, Liesel, Devine, Gregor and Frentiu, Francesca (2018). Relative vector competence of Aedes aegypti and Ae. albopictus for an epidemic strain of Zika virus under simulated field conditions. 67th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTHM), New Orleans, LA, United States, 28 October - 1 November 2018. Arlington, VA, United States: American Society of Tropical Medicine and Hygiene.
2018
Conference Publication
A novel quantitative PCR assay for the detection of Ross River virus
Kuzma, Rebecca, Grant, Jessica, Pilotte, Nils, Hugo, Leon, Devine, Gregor, Lau, Colleen and Williams, Steven (2018). A novel quantitative PCR assay for the detection of Ross River virus. 67th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTHM), New Orleans, LA, United States, 28 October - 1 November 2018. Arlington, VA, United States: American Society of Tropical Medicine and Hygiene.
2017
Conference Publication
Detection of mammalian antibodies against Ross River virus in mosquito blood meals and potential for arbovirus surveillance
Hugo, Leon E., Darbro, Jonathan, Kho, Elise, Gyawali, Narayan and Devine, Greg (2017). Detection of mammalian antibodies against Ross River virus in mosquito blood meals and potential for arbovirus surveillance. 65th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, GA, United States, 13 - 16 November 2016. Arlington, VA, United States: American Society of Tropical Medicine and Hygiene.
2017
Journal Article
De novo generation and characterization of new Zika virus isolate using sequence data from a microcephaly case
Setoh, Yin Xiang, Prow, Natalie A., Peng, Nias, Hugo, Leon E., Devine, Gregor, Hazlewood, Jessamine E., Suhrbier, Andreas and Khromykh, Alexander A. (2017). De novo generation and characterization of new Zika virus isolate using sequence data from a microcephaly case. mSphere, 2 (3) e00190-17, 1-11. doi: 10.1128/mSphereDirect.00190-17
2017
Conference Publication
Next generation mosquito surveillance technique: the near infra-red spectroscopy
Sikulu-Lord, Maggy, Wirtz, Robert, Hugo, Leon, Ulrich, Jill, Devine, Gregor, Masabho, Milali P., de Freitas, Rafael and Dowell, Floyd (2017). Next generation mosquito surveillance technique: the near infra-red spectroscopy. 66th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Baltimore, Maryland USA, 05-09 November 2017. Deerfield, IL United States: American Society of Tropical Medicine and Hygiene.
2017
Conference Publication
Investigating the activity of the macrocyclic lactones ivermectin and moxidectin against malaria vectors
Pasay, Cielo, Mills, Paul, Dekkers, Milou, Stewart, Romal, Hugo, Leon, Ong, Oselyne, Wu, Chen, Devine, Greg and McCarthy, James (2017). Investigating the activity of the macrocyclic lactones ivermectin and moxidectin against malaria vectors. 66th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Baltimore, MA United States, 5-9 November 2017. McLean, VA, United States: American Society of Tropical Medicine and Hygiene.
2016
Journal Article
Safety and reproducibility of a clinical trial system using induced blood stage Plasmodium vivax infection and its potential as a model to evaluate malaria transmission
Griffin, Paul, Pasay, Cielo, Elliott, Suzanne, Sekuloski, Silvana, Sikulu, Maggy, Hugo, Leon, Khoury, David, Cromer, Deborah, Davenport, Miles, Sattabongkot, Jetsumon, Ivinson, Karen, Ockenhouse, Christian and McCarthy, James (2016). Safety and reproducibility of a clinical trial system using induced blood stage Plasmodium vivax infection and its potential as a model to evaluate malaria transmission. PLoS Neglected Tropical Diseases, 10 (12) e0005139, e0005139. doi: 10.1371/journal.pntd.0005139
2016
Journal Article
Chikungunya virus transmission between Aedes albopictus and laboratory mice
Hugo, Leon E., Prow, Natalie A., Tang, Bing, Devine, Greg and Suhrbier, Andreas (2016). Chikungunya virus transmission between Aedes albopictus and laboratory mice. Parasites and Vectors, 9 (1) 555. doi: 10.1186/s13071-016-1838-1
2016
Journal Article
Near-infrared spectroscopy, a rapid method for predicting the age of male and female wild-type and Wolbachia infected Aedes aegypti
Sikulu-Lord, Maggy T., Milali, Masabho P., Henry, Michael, Wirtz, Robert A., Hugo, Leon E., Dowell, Floyd E. and Devine, Gregor J. (2016). Near-infrared spectroscopy, a rapid method for predicting the age of male and female wild-type and Wolbachia infected Aedes aegypti. PLoS Neglected Tropical Diseases, 10 (10) e0005040, e0005040.1-e0005040.11. doi: 10.1371/journal.pntd.0005040
2016
Journal Article
Heat sensitivity of wMel Wolbachia during Aedes aegypti development
Ulrich, Jill N., Beier, John C., Devine, Gregor J. and Hugo, Leon E. (2016). Heat sensitivity of wMel Wolbachia during Aedes aegypti development. PLoS Neglected Tropical Diseases, 10 (7) e0004873, e0004873. doi: 10.1371/journal.pntd.0004873
2016
Journal Article
Effects of Larval Nutrition on Wolbachia-Based Dengue Virus Interference in Aedes aegypti (Diptera: Culicidae)
Kho, Elise A., Hugo, Leon E., Lu, Guangjin, Smith, David D. and Kay, Brian H. (2016). Effects of Larval Nutrition on Wolbachia-Based Dengue Virus Interference in Aedes aegypti (Diptera: Culicidae). Journal of Medical Entomology, 53 (4), 894-901. doi: 10.1093/jme/tjw029
2016
Journal Article
Rapid and non-destructive detection and identification of two strains of Wolbachia in Aedes aegypti by near-infrared spectroscopy
Sikulu-Lord, Maggy T., Maia, Marta F., Milali, Masabho P., Henry, Michael, Mkandawile, Gustav, Kho, Elise A., Wirtz, Robert A., Hugo, Leon E., Dowell, Floyd E. and Devine, Gregor J. (2016). Rapid and non-destructive detection and identification of two strains of Wolbachia in Aedes aegypti by near-infrared spectroscopy. PLoS Neglected Tropical Diseases, 10 (6) e0004759, e0004759. doi: 10.1371/journal.pntd.0004759
2015
Journal Article
Mass spectrometry identification of age-associated proteins from the malaria mosquitoes Anopheles gambiae s.s. and Anopheles stephensi
Sikulu, Maggy T., Monkman, James, Dave, Keyur A., Hastie, Marcus L., Dale, Patricia E., Kitching, Roger L., Killeen, Gerry F., Kay, Brian H., Gorman, Jeffry J. and Hugo, Leon E. (2015). Mass spectrometry identification of age-associated proteins from the malaria mosquitoes Anopheles gambiae s.s. and Anopheles stephensi. Data in Brief, 4, 461-467. doi: 10.1016/j.dib.2015.07.007
2015
Journal Article
Proteomic changes occurring in the malaria mosquitoes Anopheles gambiae and Anopheles stephensi during aging
Sikulu, Maggy T., Monkman, James, Dave, Keyur A., Hastie, Marcus L., Dale, Patricia E., Kitching, Roger L., Killeen, Gerry F., Kay, Brian H., Gorman, Jeffery J. and Hugo, Leon E. (2015). Proteomic changes occurring in the malaria mosquitoes Anopheles gambiae and Anopheles stephensi during aging. Journal of Proteomics, 126, 234-244. doi: 10.1016/j.jprot.2015.06.008
2014
Journal Article
Using a near-infrared spectrometer to estimate the age of Anopheles mosquitoes exposed to pyrethroids
Sikulu, Maggy T., Majambere, Silas, Khatib, Bakar O., Ali, Abdullah S., Hugo, Leon E. and Dowell, Floyd E. (2014). Using a near-infrared spectrometer to estimate the age of Anopheles mosquitoes exposed to pyrethroids. PLoS One, 9 (3) e90657, e90657.1-e90657.6. doi: 10.1371/journal.pone.0090657
2014
Journal Article
Adult Survivorship of the Dengue Mosquito Aedes aegypti Varies Seasonally in Central Vietnam
Hugo, Leon E., Jeffery, Jason A. L., Trewin, Brendan J., Wockner, Leesa F., Nguyen Thi Yen, Nguyen Hoang Le, Le Trung Nghia, Hine, Emma, Ryan, Peter A. and Kay, Brian H. (2014). Adult Survivorship of the Dengue Mosquito Aedes aegypti Varies Seasonally in Central Vietnam. PLoS Neglected Tropical Diseases, 8 (2) e2669, e2669.1-e2669.12. doi: 10.1371/journal.pntd.0002669
2013
Journal Article
Proteomic biomarkers for ageing the mosquito Aedes aegypti to determine risk of pathogen transmission
Hugo, Leon E., Monkman, James, Dave, Keyur A., Wockner, Leesa F., Birrell, Geoff W., Norris, Emma L., Kienzle, Vivian J., Sikulu, Maggy T., Ryan, Peter A., Gorman, Jeffery J. and Kay, Brian H. (2013). Proteomic biomarkers for ageing the mosquito Aedes aegypti to determine risk of pathogen transmission. PLoS One, 8 (3) e58656, e58656.1-e58656.10. doi: 10.1371/journal.pone.0058656
2011
Journal Article
Evaluating RNAlater ® as a preservative for using near-infrared spectroscopy to predict Anopheles gambiae age and species
Sikulu, Maggy, Dowell, Kayla M., Hugo, Leon E., Wirtz, Robert A., Michel, Kristin, Peiris, Kamaranga H. S., Moore, Sarah, Killeen, Gerry F. and Dowell, Floyd E. (2011). Evaluating RNAlater ® as a preservative for using near-infrared spectroscopy to predict Anopheles gambiae age and species. Malaria Journal, 10 (1) 186. doi: 10.1186/1475-2875-10-186
Supervision
Availability
- Dr Leon Hugo is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Insect-specific viruses as tools for the downregulation of mosquito vector competence for arboviruses
Principal Advisor
Other advisors: Associate Professor Jody Peters
-
Doctor Philosophy
Investigation of factors affecting the maternal transmission of Insect-specific viruses by mosquitoes
Principal Advisor
Other advisors: Associate Professor Jody Peters
-
Doctor Philosophy
Exploring the development of a malaria refractory Anopheles farauti
Associate Advisor
Other advisors: Professor Sassan Asgari, Professor Nigel Beebe
-
Doctor Philosophy
Engineering chimeric viruses as protective and safe vaccines against mosquito-borne viral disease
Associate Advisor
Other advisors: Professor Alexander Khromykh, Dr Andrii Slonchak, Associate Professor Jody Peters
Completed supervision
-
2023
Doctor Philosophy
New tools for managing Aedes-borne diseases in Bangladesh
Associate Advisor
Other advisors: Professor Nigel Beebe
-
2021
Doctor Philosophy
The biological costs and benefits associated with a pyrethroid-resistant genotype of Aedes aegypti
Associate Advisor
Other advisors: Professor Nigel Beebe
-
2020
Doctor Philosophy
Interaction between flaviviruses and the vector Aedes aegypti, an overview into replication and microRNAs
Associate Advisor
Other advisors: Professor Nigel Beebe, Professor Sassan Asgari
-
2020
Doctor Philosophy
Characterization of Wolbachia infections from native Australian mosquitoes
Associate Advisor
Other advisors: Professor Sassan Asgari
Media
Enquiries
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