Overview
Availability
- Dr James Humphries is:
- Available for supervision
Qualifications
- PhD, The University of Queensland
Works
Search Professor James Humphries’s works on UQ eSpace
2025
Journal Article
Nanobody-mediated cellular uptake maximizes the potency of polylysine dendrimers while preserving solid tumor penetration
Yuen, Daniel, Feeney, Orlagh M., Noi, Leo, Shengule, Sudhir, McLeod, Victoria M., Reitano, Pauline, Tsegay, Sammi, Hufton, Richard, Houston, Zachary H., Fletcher, Nicholas L., Humphries, James, Thurecht, Kristofer J., Cullinane, Carleen, Owen, David J., Porter, Christopher J.H. and Johnston, Angus P.R. (2025). Nanobody-mediated cellular uptake maximizes the potency of polylysine dendrimers while preserving solid tumor penetration. ACS Nano, 19 (6), 6044-6057. doi: 10.1021/acsnano.4c10851
2025
Journal Article
Multiplexing label-free polymeric nanocarriers via antipolymer antibodies
Humphries, James, Hobson-Peters, Jody, Ghosh, Saikat, Howard, Christopher B., Huda, Pie, Bell, Craig A., Fletcher, Nicholas L., Kempe, Kristian and Thurecht, Kristofer J. (2025). Multiplexing label-free polymeric nanocarriers via antipolymer antibodies. ACS Sensors, 10 (2), 1280-1288. doi: 10.1021/acssensors.4c03184
2024
Journal Article
A first-in-class dual-chelator theranostic agent designed for use with imaging-therapy radiometal pairs of different elements
Wood, James Liam, Ghosh, Saikat, Houston, Zachary, Fletcher, Nicholas, Humphries, James, Mardon, Karine, Akhter, Dewan T., Tieu, William, Ivashkevich, Alesia, Wheatcroft, Michael P., Thurecht, Kristofer J. and Codd, Rachel (2024). A first-in-class dual-chelator theranostic agent designed for use with imaging-therapy radiometal pairs of different elements. Chemical Science, 15 (30), 11748-11760. doi: 10.1039/d4sc02851a
2024
Journal Article
Mitigating the effects of persistent antipolymer immune reactions in nanomedicine: Evaluating materials-based approaches using molecular imaging
Humphries, James, Fletcher, Nicholas L., Sonderegger, Stefan E., Bell, Craig A., Kempe, Kristian and Thurecht, Kristofer J. (2024). Mitigating the effects of persistent antipolymer immune reactions in nanomedicine: Evaluating materials-based approaches using molecular imaging. ACS Nano, 18 (30), 19890-19904. doi: 10.1021/acsnano.4c07317
2023
Journal Article
Abstract A147: a HER2 targeted polylysine dendrimer nanoparticle radiotheranostic demonstrates excellent tumor accumulation, rapid clearance from circulation, and promising performance in PET-CT imaging
Johnstone, Cameron N., Heery, Graham P., Kelly, Brian D, Humphries, James, Akhter, Dewan T., Thurecht, Kristofer J., Yuen, Daniel, Giannis, Michael, Yong, Ken, Chadwick, Gareth, Barker, Helena, Cargill, Anne, Eglezos, Anthony, Castellarnau, Alex, Paull, Jeremy R. A. and Hufton, Richard (2023). Abstract A147: a HER2 targeted polylysine dendrimer nanoparticle radiotheranostic demonstrates excellent tumor accumulation, rapid clearance from circulation, and promising performance in PET-CT imaging. Molecular Cancer Therapeutics, 22 (12_Supplement), A147-A147. doi: 10.1158/1535-7163.targ-23-a147
2023
Other Outputs
Understanding immunogenicity in nanomedicine
Humphries, James (2023). Understanding immunogenicity in nanomedicine. PhD Thesis, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland. doi: 10.14264/28b468b
2023
Journal Article
Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporation
Huda, Pie, Humphries, James, Fletcher, Nicholas L., Howard, Christopher B., Thurecht, Kristofer J. and Bell, Craig A. (2023). Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporation. Chemistry–Methods, 4 (2) e202300036. doi: 10.1002/cmtd.202300036
2022
Journal Article
Probing the biocompatibility and immune cell association of chiral, water-soluble, bottlebrush poly(2-oxazoline)s
Pizzi, David, Humphries, James, Morrow, Joshua P., Mahmoud, Ayaat M., Fletcher, Nicholas L., Sonderegger, Stefan E., Bell, Craig A., Thurecht, Kristofer J. and Kempe, Kristian (2022). Probing the biocompatibility and immune cell association of chiral, water-soluble, bottlebrush poly(2-oxazoline)s. Biomacromolecules, 24 (1), 246-257. doi: 10.1021/acs.biomac.2c01105
2022
Journal Article
Modulating macrophage clearance of nanoparticles: comparison of small-molecule and biologic drugs as pharmacokinetic modifiers of soft nanomaterials
Mills, Jessica A., Humphries, James, Simpson, Joshua D., Sonderegger, Stefan E., Thurecht, Kristofer J. and Fletcher, Nicholas L. (2022). Modulating macrophage clearance of nanoparticles: comparison of small-molecule and biologic drugs as pharmacokinetic modifiers of soft nanomaterials. Molecular Pharmaceutics, 19 (11), 4080-4097. doi: 10.1021/acs.molpharmaceut.2c00528
2022
Journal Article
Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearance
Fletcher, N. L., Prior, A., Choy, O., Humphries, J., Huda, P., Ghosh, S., Houston, Z. H., Bell, C. A. and Thurecht, K. J. (2022). Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearance. Chemical Communications, 58 (57), 7912-7915. doi: 10.1039/d2cc02443h
2022
Journal Article
Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruption
Janowicz, Phillip W., Houston, Zachary H., Bunt, Jens, Fletcher, Nicholas L., Bell, Craig A., Cowin, Gary, Howard, Christopher B., Taslima, Dewan, Westra van Holthe, Nicholas, Prior, Amber, Soh, Vanessa, Ghosh, Saikat, Humphries, James, Huda, Pie, Mahler, Stephen M., Richards, Linda J. and Thurecht, Kristofer J. (2022). Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruption. Biomaterials, 283 121416, 121416. doi: 10.1016/j.biomaterials.2022.121416
2021
Journal Article
Poly(2-ethyl-2-oxazoline) bottlebrushes: How nanomaterial dimensions can influence biological interactions
Pizzi, David, Mahmoud, Ayaat M., Klein, Tobias, Morrow, Joshua P., Humphries, James, Houston, Zachary H., Fletcher, Nicholas L., Bell, Craig A., Thurecht, Kristofer J. and Kempe, Kristian (2021). Poly(2-ethyl-2-oxazoline) bottlebrushes: How nanomaterial dimensions can influence biological interactions. European Polymer Journal, 151 110447, 1-9. doi: 10.1016/j.eurpolymj.2021.110447
2020
Journal Article
Hyperbranched Poly(2-oxazoline)s and Poly(ethylene glycol): A structure–activity comparison of biodistribution
Humphries, James, Pizzi, David, Sonderegger, Stefan E., Fletcher, Nicholas L., Houston, Zachary H., Bell, Craig A., Kempe, Kristian and Thurecht, Kristofer J. (2020). Hyperbranched Poly(2-oxazoline)s and Poly(ethylene glycol): A structure–activity comparison of biodistribution. Biomacromolecules, 21 (8) acs.biomac.0c00765, 3318-3331. doi: 10.1021/acs.biomac.0c00765
2019
Journal Article
Poly(2-oxazoline) macromonomers as building blocks for functional and biocompatible polymer architectures
Pizzi, David, Humphries, James, Morrow, Joshua P., Fletcher, Nicholas L., Bell, Craig A., Thurecht, Kristofer J. and Kempe, Kristian (2019). Poly(2-oxazoline) macromonomers as building blocks for functional and biocompatible polymer architectures. European Polymer Journal, 121 109258, 109258. doi: 10.1016/j.eurpolymj.2019.109258
Supervision
Availability
- Dr James Humphries is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Development of novel gene therapy strategies for treating brain cancer
Associate Advisor
Other advisors: Professor Kristofer Thurecht
-
Doctor Philosophy
Development of site-specific radiopharmaceuticals using nanotechnology
Associate Advisor
Other advisors: Dr Craig Bell, Dr Nick Fletcher, Professor Kristofer Thurecht
Media
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