Overview
Background
Andrew Kotze is an Adjunct Professor in the School of Veterinary Science at The University of Queensland, and co-Editor-in-Chief of the International Journal for Parasitology: Drugs and Drug Resistance. He is also on the editorial boards of several other parasitology journals. He has led research projects focusing on the control of nematode parasites of sheep, cattle, humans and companion animals. He has also led research projects on the control of the sheep blowfly. Research areas include drug resistance mechanisms, assays for detecting anthelmintic resistance, identifying new drug targets for the control of worms and blowflies, and exploring biochemical and molecular aspects of host-parasite interactions.
Availability
- Adjunct Professor Andrew Kotze is:
- Not available for supervision
Qualifications
- Bachelor of Agricultural Science, University of Sydney
- Doctor of Philosophy, University of Sydney
Works
Search Professor Andrew Kotze’s works on UQ eSpace
2015
Journal Article
Histone deacetylase enzymes as drug targets for the control of the sheep blowfly, Lucilia cuprina
Kotze, Andrew C., Hines, Barney M., Bagnall, Neil H., Anstead, Clare A., Gupta, Praveer, Reid, Robert C., Ruffell, Angela P. and Fairlie, David P. (2015). Histone deacetylase enzymes as drug targets for the control of the sheep blowfly, Lucilia cuprina. International Journal for Parasitology: Drugs and Drug Resistance, 5 (3), 201-208. doi: 10.1016/j.ijpddr.2015.09.003
2015
Journal Article
Suspected ivermectin resistance in a south-east Queensland Parascaris equorum population
Beasley, A., Coleman, G. and Kotze, A. C. (2015). Suspected ivermectin resistance in a south-east Queensland Parascaris equorum population. Australian Veterinary Journal, 93 (9), 305-307. doi: 10.1111/avj.12352
2015
Journal Article
Effects of third generation P-glycoprotein inhibitors on the sensitivity of drug-resistant and -susceptible isolates of Haemonchus contortus to anthelmintics in vitro
Raza, Ali, Kopp, Steven R., Jabbar, Abdul and Kotze, Andrew C. (2015). Effects of third generation P-glycoprotein inhibitors on the sensitivity of drug-resistant and -susceptible isolates of Haemonchus contortus to anthelmintics in vitro. Veterinary Parasitology, 211 (1-2), 80-88. doi: 10.1016/j.vetpar.2015.04.025
2015
Journal Article
In vitro levamisole selection pressure on larval stages of Haemonchus contortus over nine generations gives rise to drug resistance and target site gene expression changes specific to the early larval stages only
Sarai, Ranbir S., Kopp, Steven R., Knox, Malcolm R., Coleman, Glen T. and Kotze, Andrew C. (2015). In vitro levamisole selection pressure on larval stages of Haemonchus contortus over nine generations gives rise to drug resistance and target site gene expression changes specific to the early larval stages only. Veterinary Parasitology, 211 (1-2), 45-53. doi: 10.1016/j.vetpar.2015.05.002
2015
Journal Article
Lucilia cuprina genome unlocks parasitic fly biology to underpin future interventions
Anstead, Clare A, Korhonen, Pasi K, Young, Neil D, Hall, Ross S, Jex, Aaron R, Murali, Shwetha C, Hughes, Daniel S.T, Lee, Siu F, Perry, Trent, Stroehlein, Andreas J, Ansell, Brendan R.E, Breugelmans, Bert, Hofmann, Andreas, Qu, Jiaxin, Dugan, Shannon, Lee, Sandra L, Chao, Hsu, Dinh, Huyen, Han, Yi, Doddapaneni, Harsha V, Worley, Kim C, Muzny, Donna M, Ioannidis, Panagiotis, Waterhouse, Robert M, Zdobnov, Evgeny M, James, Peter J, Bagnall, Neil H, Kotze, Andrew C, Gibbs, Richard A ... Gasser, Robin B (2015). Lucilia cuprina genome unlocks parasitic fly biology to underpin future interventions. Nature Communications, 6 (7344) 7344, 1-11. doi: 10.1038/ncomms8344
2014
Journal Article
Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions
Kotze, Andrew C., Hunt, Peter W., Skuce, Philip, von Samson-Himmelstjerna, Georg, Martin, Richard J., Sager, Heinz, Kruecken, Juergen, Hodgkinson, Jane, Lespine, Anne, Jex, Aaron R., Gilleard, John S., Beech, Robin N., Wolstenholme, Adrian J., Demeler, Janina, Robertson, Alan P., Charvet, Claude L., Neveu, Cedric, Kaminsky, Ronald, Rufener, Lucien, Alberich, Melanie, Menez, Cecile and Prichard, Roger K. (2014). Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions. International Journal for Parasitology-Drugs and Drug Resistance, 4 (3), 164-184. doi: 10.1016/j.ijpddr.2014.07.007
2014
Journal Article
Phenobarbital Induction and Chemical Synergism Demonstrate the Role of UDP-Glucuronosyltransferases in Detoxification of Naphthalophos by <i>Haemonchus contortus</i> Larvae
Kotze, Andrew C., Ruffell, Angela P. and Ingham, Aaron B. (2014). Phenobarbital Induction and Chemical Synergism Demonstrate the Role of UDP-Glucuronosyltransferases in Detoxification of Naphthalophos by Haemonchus contortus Larvae. Antimicrobial Agents and Chemotherapy, 58 (12), 7475-7483. doi: 10.1128/AAC.03333-14
2014
Journal Article
Cloning, recombinant expression and inhibitor profiles of dihydrofolate reductase from the Australian sheep blow fly, <i>Lucilia cuprina</i>
Kotze, A. C., Bagnall, N. H., Ruffell, A. P. and Pearson, R. (2014). Cloning, recombinant expression and inhibitor profiles of dihydrofolate reductase from the Australian sheep blow fly, Lucilia cuprina. Medical and Veterinary Entomology, 28 (3), 297-306. doi: 10.1111/mve.12041
2014
Journal Article
Drug-efflux and target-site gene expression patterns in Haemonchus contortus larvae able to survive increasing concentrations of levamisole in vitro
Sarai, Ranbir S., Kopp, Steven R., Coleman, Glen T. and Kotze, Andrew C. (2014). Drug-efflux and target-site gene expression patterns in Haemonchus contortus larvae able to survive increasing concentrations of levamisole in vitro. International Journal for Parasitology: Drugs and Drug Resistance, 4 (2), 77-84. doi: 10.1016/j.ijpddr.2014.02.001
2014
Journal Article
Relative potency of macrocyclic lactones in <i>in vitro</i> assays with larvae of susceptible and drug-resistant Australian isolates of <i>Haemonchus contortus</i> and <i>H-placei</i>
Kotze, Andrew C., Ruffell, Angela P., Knox, Malcolm R. and Kelly, Gareth A. (2014). Relative potency of macrocyclic lactones in in vitro assays with larvae of susceptible and drug-resistant Australian isolates of Haemonchus contortus and H-placei. Veterinary Parasitology, 203 (3-4), 294-302. doi: 10.1016/j.vetpar.2014.04.005
2014
Journal Article
Application of a Poisson distribution quality control measure to the analysis of two human hookworm drug treatment studies in Ghana
Kotze, Andrew C., Dobson, Robert J., Humphries, Debbie, Wilson, Michael and Cappello, Michael (2014). Application of a Poisson distribution quality control measure to the analysis of two human hookworm drug treatment studies in Ghana. International Journal for Parasitology-Drugs and Drug Resistance, 4 (1), 64-70. doi: 10.1016/j.ijpddr.2014.01.001
2014
Journal Article
Assessment of Anthelmintic Efficacy of Mebendazole in School Children in Six Countries Where Soil-Transmitted Helminths Are Endemic
Levecke, Bruno, Montresor, Antonio, Albonico, Marco, Ame, Shaali M., Behnke, Jerzy M., Bethony, Jeffrey M., Noumedem, Calvine D., Engels, Dirk, Guillard, Bertrand, Kotze, Andrew C., Krolewiecki, Alejandro J., McCarthy, James S., Mekonnen, Zeleke, Periago, Maria V., Sopheak, Hem, Tchuem-Tchuenté, Louis-Albert, Duong, Tran Thanh, Huong, Nguyen Thu, Zeynudin, Ahmed and Vercruysse, Jozef (2014). Assessment of Anthelmintic Efficacy of Mebendazole in School Children in Six Countries Where Soil-Transmitted Helminths Are Endemic. PLoS Neglected Tropical Diseases, 8 (10) ARTN e3204, e3204. doi: 10.1371/journal.pntd.0003204
2013
Journal Article
Australian plants show anthelmintic activity toward equine cyathostomins <i>in vitro</i>
Payne, S. E., Kotze, A. C., Durmic, Z. and Vercoe, P. E. (2013). Australian plants show anthelmintic activity toward equine cyathostomins in vitro. Veterinary Parasitology, 196 (1-2), 153-160. doi: 10.1016/j.vetpar.2013.01.012
2013
Journal Article
Acetylcholine receptor subunit and P-glycoprotein transcription patterns in levamisole-susceptible and -resistant Haemonchus contortus
Sarai, Ranbir S., Kopp, Steven R., Coleman, Glen T. and Kotze, Andrew C. (2013). Acetylcholine receptor subunit and P-glycoprotein transcription patterns in levamisole-susceptible and -resistant Haemonchus contortus. International Journal For Parasitology: Drugs and Drug Resistance, 3, 51-58. doi: 10.1016/j.ijpddr.2013.01.002
2012
Journal Article
Relative level of thiabendazole resistance associated with the E198A and F200Y SNPs in larvae of a multi-drug resistant isolate of Haemonchus contortus
Kotze, Andrew C., Cowling, Katie, Bagnall, Neil H., Hines, Barney M., Ruffell, Angela P., Hunt, Peter W. and Coleman, Glen T. (2012). Relative level of thiabendazole resistance associated with the E198A and F200Y SNPs in larvae of a multi-drug resistant isolate of Haemonchus contortus. International Journal For Parasitology: Drugs and Drug Resistance, 2, 92-97. doi: 10.1016/j.ijpddr.2012.02.003
2012
Journal Article
A reappraisal of the relative sensitivity of nematode pharyngeal and somatic musculature to macrocyclic lactone drugs
Kotze, Andrew C., Hines, Barney M. and Ruffell, Angela P. (2012). A reappraisal of the relative sensitivity of nematode pharyngeal and somatic musculature to macrocyclic lactone drugs. International Journal for Parasitology-Drugs and Drug Resistance, 2, 29-35. doi: 10.1016/j.ijpddr.2011.10.002
2012
Journal Article
Molecular cloning and characterisation of ovine dual oxidase 2
Lees, M. S., Nagaraj, Shivashankar H., Piedrafita, D. M., Kotze, A. C. and Ingham, A. B. (2012). Molecular cloning and characterisation of ovine dual oxidase 2. Gene, 500 (1), 40-46. doi: 10.1016/j.gene.2012.03.052
2012
Journal Article
Target-based and whole-worm screening approaches to anthelmintic discovery
Kotze, A. C. (2012). Target-based and whole-worm screening approaches to anthelmintic discovery. Veterinary Parasitology, 186 (1-2), 118-123. doi: 10.1016/j.vetpar.2011.11.052
2012
Journal Article
Silencing of essential genes by RNA interference in <i>Haemonchus contortus</i>
Zawadzki, J. L., Kotze, A. C., Fritz, J. -A., Johnson, N. M., Hemsworth, J. E., Hines, B. M. and Behm, C. A. (2012). Silencing of essential genes by RNA interference in Haemonchus contortus. Parasitology, 139 (5), 613-629. doi: 10.1017/S0031182012000121
2012
Journal Article
Trichostrongylus colubriformis larvae induce necrosis and release of IL33 from intestinal epithelial cells in vitro: Implications for gastrointestinal nematode vaccine design
Andronicos, Nicholas M., McNally, Jody, Kotze, Andrew C., Hunt, Peter W. and Ingham, Aaron (2012). Trichostrongylus colubriformis larvae induce necrosis and release of IL33 from intestinal epithelial cells in vitro: Implications for gastrointestinal nematode vaccine design. International Journal for Parasitology, 42 (3), 295-304. doi: 10.1016/j.ijpara.2012.01.007
Funding
Past funding
Supervision
Availability
- Adjunct Professor Andrew Kotze is:
- Not available for supervision
Supervision history
Completed supervision
-
2021
Doctor Philosophy
Detecting Haemonchus contortus infection in sheep using infrared spectroscopy
Associate Advisor
Other advisors: Dr Maggy Lord, Dr Anne Beasley
-
2021
Doctor Philosophy
Arthropod venoms in antiparasitic drug discovery: isolation and biological characterisation of venom-derived anthelmintic compounds
Associate Advisor
Other advisors: Professor Glenn King
-
2017
Doctor Philosophy
THE ROLE OF DRUG EFFLUX SYSTEMS IN ANTHELMINTIC RESISTANCE IN PARASITIC NEMATODES
Associate Advisor
Other advisors: Dr Steven Kopp
-
2010
Doctor Philosophy
The mode of action of cyclotides: Functional studies of the prototypic cyclotide kalata B1
Associate Advisor
Other advisors: Professor David Craik
-
2010
Doctor Philosophy
Antigen presenting cell involvement in Th2 response
Associate Advisor
Other advisors: Professor Matt Sweet
-
2008
Doctor Philosophy
Pyrantel resistance in the canine hookworm, ancylostoma caninum
Associate Advisor
Media
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