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2024 Journal Article Improving cognition without clearing amyloid: effects of tau and ultrasound neuromodulationLeinenga, Gerhard, Padmanabhan, Pranesh and Götz, Jürgen (2024). Improving cognition without clearing amyloid: effects of tau and ultrasound neuromodulation. Journal of Alzheimer's Disease, 100 (s1), S211-S222. doi: 10.3233/jad-240616 |
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2024 Journal Article Correction: Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reductionLeinenga, Gerhard, To, Xuan Vinh, Bodea, Liviu-Gabriel, Yousef, Jumana, Richter-Stretton, Gina, Palliyaguru, Tishila, Chicoteau, Antony, Dagley, Laura, Nasrallah, Fatima and Götz, Jürgen (2024). Correction: Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction. Molecular Psychiatry, 29 (12), 3968-3970. doi: 10.1038/s41380-024-02616-3 |
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2024 Journal Article Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reductionLeinenga, Gerhard, To, Xuan Vinh, Bodea, Liviu-Gabriel, Yousef, Jumana, Richter-Stretton, Gina, Palliyaguru, Tishila, Chicoteau, Antony, Dagley, Laura, Nasrallah, Fatima and Götz, Jürgen (2024). Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction. Molecular Psychiatry, 29 (8), 1-16. doi: 10.1038/s41380-024-02509-5 |
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2022 Journal Article Transcriptional signature in microglia isolated from an Alzheimer's disease mouse model treated with scanning ultrasoundLeinenga, Gerhard, Bodea, Liviu‐Gabriel, Schröder, Jan, Sun, Giuzhi, Zhou, Yichen, Song, Jae, Grubman, Alexandra, Polo, Jose M. and Götz, Jürgen (2022). Transcriptional signature in microglia isolated from an Alzheimer's disease mouse model treated with scanning ultrasound. Bioengineering & Translational Medicine, 8 (1) e10329, e10329. doi: 10.1002/btm2.10329 |
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2022 Journal Article A sporadic Alzheimer’s blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodiesWasielewska, Joanna M., Chaves, Juliana C.S., Johnston, Rebecca L., Milton, Laura A., Hernández, Damián, Chen, Liyu, Song, Jae, Lee, Wendy, Leinenga, Gerhard, Nisbet, Rebecca M., Pébay, Alice, Götz, Jürgen, White, Anthony R. and Oikari, Lotta E. (2022). A sporadic Alzheimer’s blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies. Theranostics, 12 (16), 6826-6847. doi: 10.7150/thno.72685 |
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2022 Journal Article Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier modelChen, Liyu, Sutharsan, Ratneswary, Lee, Jonathan L. F., Cruz, Esteban, Asnicar, Blaise, Palliyaguru, Tishila, Wasielewska, Joanna M., Gaudin, Arnaud, Song, Jae, Leinenga, Gerhard and Götz, Jürgen (2022). Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model. Theranostics, 12 (5), 1952-1970. doi: 10.7150/thno.65539 |
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2021 Journal Article A comparative study of the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in the APP23 mouse model of Alzheimer diseaseLeinenga, Gerhard, Koh, Wee Kiat and Götz, Jürgen (2021). A comparative study of the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in the APP23 mouse model of Alzheimer disease. Alzheimer's Research and Therapy, 13 (1) 76, 1-14. doi: 10.1186/s13195-021-00809-4 |
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2020 Journal Article Delivery of antibodies into the brain using focused scanning ultrasoundLeinenga, Gerhard, Bodea, Liviu-Gabriel, Koh, Wee Kiat, Nisbet, Rebecca M. and Götz, Jürgen (2020). Delivery of antibodies into the brain using focused scanning ultrasound. Journal of Visualized Experiments, 2020 (161) e61372, 1-13. doi: 10.3791/61372 |
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2019 Journal Article Scanning ultrasound in the absence of blood-brain barrier opening is not sufficient to clear β-amyloid plaques in the APP23 mouse model of Alzheimer's diseaseLeinenga, Gerhard, Koh, Wee Kiat and Götz, Jürgen (2019). Scanning ultrasound in the absence of blood-brain barrier opening is not sufficient to clear β-amyloid plaques in the APP23 mouse model of Alzheimer's disease. Brain Research Bulletin, 153, 8-14. doi: 10.1016/j.brainresbull.2019.08.002 |
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2019 Journal Article Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibodyJanowicz, Phillip W., Leinenga, Gerhard, Götz, Jürgen and Nisbet, Rebecca M. (2019). Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody. Scientific Reports, 9 (1) 9255, 9255. doi: 10.1038/s41598-019-45577-2 |
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2019 Journal Article Repeated ultrasound treatment of tau transgenic mice clears neuronal tau by autophagy and improves behavioral functionsPandit, Rucha, Leinenga, Gerhard and Gotz, Jurgen (2019). Repeated ultrasound treatment of tau transgenic mice clears neuronal tau by autophagy and improves behavioral functions. Theranostics, 9 (13), 3754-3767. doi: 10.7150/thno.34388 |
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2018 Journal Article Modeling ultrasound propagation through material of increasing geometrical complexityOdabaee, Maryam, Odabaee, Mostafa, Pelekanos, Matthew, Leinenga, Gerhard and Götz, Jürgen (2018). Modeling ultrasound propagation through material of increasing geometrical complexity. Ultrasonics, 90, 52-62. doi: 10.1016/j.ultras.2018.05.014 |
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2018 Journal Article Safety and Efficacy of Scanning Ultrasound Treatment of Aged APP23 MiceLeinenga, Gerhard and Gotz, Jurgen (2018). Safety and Efficacy of Scanning Ultrasound Treatment of Aged APP23 Mice. Frontiers in Neuroscience, 12 (FEB) 55, 1-10. doi: 10.3389/fnins.2018.00055 |
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2018 Journal Article Establishing sheep as an experimental species to validate ultrasound-mediated blood-brain barrier opening for potential therapeutic interventionsPelekanos, Matthew, Leinenga, Gerhard, Odabaee, Mostafa, Odabaee, Maryam, Saifzadeh, Siamak, Steck, Roland and Götz, Jürgen (2018). Establishing sheep as an experimental species to validate ultrasound-mediated blood-brain barrier opening for potential therapeutic interventions. Theranostics, 8 (9), 2583-2602. doi: 10.7150/thno.22852 |
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2017 Journal Article Ultrasound as a treatment modality for neurological diseasesLeinenga, Gerhard, Nisbet, Rebecca M. and Gotz, Jurgen (2017). Ultrasound as a treatment modality for neurological diseases. Medical Journal of Australia, 206 (11), 470-471. doi: 10.5694/mja16.01013 |
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2017 Journal Article Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse modelNisbet, Rebecca M., Van der Jeugd, Ann, Leinenga, Gerhard, Evans, Harrison T., Janowicz, Phillip W. and Goetz, Juergen (2017). Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model. Brain, 140 (5), 1220-1230. doi: 10.1093/brain/awx052 |
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2016 Journal Article Scanning ultrasound (SUS) causes no changes to neuronal excitability and prevents age-related reductions in hippocampal CA1 dendritic structure in wild-type miceHatch, Robert John, Leinenga, Gerhard and Götz, Jürgen (2016). Scanning ultrasound (SUS) causes no changes to neuronal excitability and prevents age-related reductions in hippocampal CA1 dendritic structure in wild-type mice. PloS One, 11 (10) e0164278, e0164278. doi: 10.1371/journal.pone.0164278 |
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2016 Journal Article Ultrasound treatment of neurological diseases — current and emerging applicationsLeinenga, Gerhard, Langton, Christian, Nisbet, Rebecca and Gotz, Jurgen (2016). Ultrasound treatment of neurological diseases — current and emerging applications. Nature Reviews Neurology, 12 (3), 161-174. doi: 10.1038/nrneurol.2016.13 |
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2015 Journal Article Scanning ultrasound removes amyloid-beta and restores memory in an Alzheimer's disease mouse modelLeinenga, Gerhard and Götz, Jürgen (2015). Scanning ultrasound removes amyloid-beta and restores memory in an Alzheimer's disease mouse model. Science Translational Medicine, 7 (278) 278ra33, 278ra33.1-278ra33.12. doi: 10.1126/scitranslmed.aaa2512 |
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2013 Journal Article What renders TAU toxicGoetz, Juergen, Xia, Di, Leinenga, Gerhard, Chew, Yee Lian and Nicholas, Hannah R. (2013). What renders TAU toxic. Frontiers in Neurology, 4 Article 72, 72.1-72.10. doi: 10.3389/fneur.2013.00072 |
