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2026 Journal Article Biotechnological approaches for producing therapeutic peptides in plantsThanthrige, Nipuni, Lawrence, Nicole and Craik, David J. (2026). Biotechnological approaches for producing therapeutic peptides in plants. npj Science of Plants, 2 (1) 12. doi: 10.1038/s44383-026-00021-z |
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2026 Journal Article Enzyme‐assisted synthesis and in vitro characterization of bifunctional PCSK9 inhibitorsZhang, Yuhui, Wang, Li, Corcilius, Leo, Reji, Amal K., Payne, Richard J., Hong, Bin, Durek, Thomas, Wang, Conan K. and Craik, David J. (2026). Enzyme‐assisted synthesis and in vitro characterization of bifunctional PCSK9 inhibitors. ChemBioChem, 27 (7) e202500972, e202500972. doi: 10.1002/cbic.202500972 |
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2026 Journal Article Cofilin hyperphosphorylation triggers TDP-43 pathology in sporadic amyotrophic lateral sclerosisJagaraj, Cyril Jones, Saravanabavan, Sayanthooran, Parakh, Sonam, Jayakumar, Mrithulabashini, Kashani, Sara Assar, Shadfar, Sina, Mehta, Prachi, Gautam, Shashi, Farzana, Fabiha, Suchowerska, Alexandra K, Yap, Kuok, Vidal, Marta, Ragagnin, Audrey M G, Jamali, Md Shafi, Yang, Shu, Fath, Thomas, Craik, David and Atkin, Julie D (2026). Cofilin hyperphosphorylation triggers TDP-43 pathology in sporadic amyotrophic lateral sclerosis. Brain awag096. doi: 10.1093/brain/awag096 |
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2026 Journal Article α-Conotoxin LvID, an antagonist of α7 nicotinic acetylcholine receptor, mitigates Alzheimer-associated phenotypes by inhibiting Aβ deposition and reactive astrogliosisYue, Song, Xing, Haonan, Du, Xiaoxue, Wang, Yufei, Qin, Runtian, He, Jinsheng, Yu, Jinpeng, Zhangsun, Dongting, Craik, David J., Mcintosh, J. Michael, Wu, Yili, Zhu, Xiaopeng and Luo, Sulan (2026). α-Conotoxin LvID, an antagonist of α7 nicotinic acetylcholine receptor, mitigates Alzheimer-associated phenotypes by inhibiting Aβ deposition and reactive astrogliosis. International Journal of Biological Macromolecules, 349 150933, 1-15. doi: 10.1016/j.ijbiomac.2026.150933 |
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2026 Journal Article Rational design of plant-derived protein ligases with altered substrate specificityZhou, Yan, de Veer, Simon J., Tyler, Tristan J., Durek, Thomas, Rehm, Fabian B. H. and Craik, David J. (2026). Rational design of plant-derived protein ligases with altered substrate specificity. Biochemistry, 65 (5) acs.biochem.5c00808, 571-578. doi: 10.1021/acs.biochem.5c00808 |
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2026 Journal Article Progress and challenges in the biosynthesis and chemical synthesis of lasso peptidesKhatri, Bhavesh, Lay, Travis and Craik, David J. (2026). Progress and challenges in the biosynthesis and chemical synthesis of lasso peptides. Journal of the American Chemical Society, 148 (5), 4777-4790. doi: 10.1021/jacs.5c10593 |
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2026 Journal Article uPA-mediated remodeling of CCL21 gradients regulates lymphatic migration of dendritic cellsCollado-Diaz, Victor, Christakopoulou, Maria-Nefeli, Schineis, Philipp, Blatter, Katharina, Laubender, David, Trzebanski, Sébastien, Thoma, Marina, Gadient, Yves, Tatliadim, Hazal, Gkelis, Konstantinos, Friess, Mona C., Purvanov, Vladimir, Samson, Guerric P.B., Artinger, Marc, Bisoendial, Radjesh, Yepes, Manuel, de Veer, Simon J., Craik, David, Behrendt, Niels, Silina, Karina, Legler, Daniel F. and Halin, Cornelia (2026). uPA-mediated remodeling of CCL21 gradients regulates lymphatic migration of dendritic cells. Journal of Cell Biology, 225 (3) e202412190. doi: 10.1083/jcb.202412190 |
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2026 Journal Article Recent advances in structural and functional diversities of cancer lncRNA-encoded peptides: current opportunities and challenges for enhancing cancer diagnosis and treatmentGuo, Aimin, Wang, Shanshan, Huang, Linan, He, Yanping, Xi, Qing, Craik, David J. and Zhang, Jun (2026). Recent advances in structural and functional diversities of cancer lncRNA-encoded peptides: current opportunities and challenges for enhancing cancer diagnosis and treatment. Cancer Cell International, 26 (1) 67. doi: 10.1186/s12935-025-04158-2 |
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2025 Journal Article Nickel-catalyzed cascade C-H alkynylation/hydroamination of free benzylamines for the synthesis of substituted 1H-isoindoles using a transient directing group strategyCai, Xinghao, Lu, Wei, Ma, Chen, Kang, Ying, Ren, Yuqiang, Meng, Xue, Craik, David J., Fan, Shiming, Chan, Lai Yue and Liu, Shouxin (2025). Nickel-catalyzed cascade C-H alkynylation/hydroamination of free benzylamines for the synthesis of substituted 1H-isoindoles using a transient directing group strategy. Chinese Journal of Chemistry, 43 (23) cjoc.70222, 3171-3177. doi: 10.1002/cjoc.70222 |
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2025 Journal Article Discovery of insecticidal cyclotides from the African plants Allexis batangae and Allexis obanensisKhatibi, Negin, Eteme, Olivier Ndogo, Wang, Conan K., Gilding, Edward K., Zondegoumba, Ernestine Nkwengoua, Colgrave, Michelle L., Huang, Yen-Hua and Craik, David J. (2025). Discovery of insecticidal cyclotides from the African plants Allexis batangae and Allexis obanensis. Industrial Crops and Products, 237 122073, 1-9. doi: 10.1016/j.indcrop.2025.122073 |
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2025 Journal Article Combining bioactive cell-penetrating peptides and vemurafenib to produce peptide-drug conjugates with activity against drug-resistant melanoma cellsPalombi, Isabella R., White, Andrew M., Koda, Yasuko, Craik, David J., Troeira Henriques, Sónia, Lawrence, Nicole and Malins, Lara R. (2025). Combining bioactive cell-penetrating peptides and vemurafenib to produce peptide-drug conjugates with activity against drug-resistant melanoma cells. Journal of Medicinal Chemistry, 68 (21), 23459-23471. doi: 10.1021/acs.jmedchem.5c02367 |
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2025 Conference Publication Recombinant production of an antimalarial peptide in Nicotiana benthamianaNguyen, Linh T.T., Harding, Maxim D., Healy, Wing L., Thanthrige, Nipuni P., Ninh, Thao T., Jackson, Mark A., Gilding, Edward K., Lawrence, Nicole and Craik, David (2025). Recombinant production of an antimalarial peptide in Nicotiana benthamiana. The 16th Australian Peptide Conference, Launceston, TAS, Australia, 12-17 October 2025. |
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2025 Journal Article Design of Bicyclic peptide tandems mimicking the homodimeric GDF15 protein to inhibit GDF15–GFRaL–RET complex cell signalingNoisier, Anaïs F. M., Sandmark, Jenny, Edfeldt, Fredrik, Backmark, Anna, Broddefalk, Johan, Wandzik, Joanna, Jurva, Ulrik, Ek, Margareta, Johansson, Carina A., Barlind, Louise, Gunnarsson, Jenny, Bigalke, Janna M., Xue, Yafeng, Frolov, Andrey I., Kankkonen, Cecilia, Roth, Robert G., Fritsch, Maria, Watcham, Sophie, van Rietschoten, Katerine, Mudd, Gemma E., Harrison, Helen, Chen, Liuhong, Skynner, Michael J., Craik, David J., Chankeshwara, Sunay V. and Lemurell, Malin (2025). Design of Bicyclic peptide tandems mimicking the homodimeric GDF15 protein to inhibit GDF15–GFRaL–RET complex cell signaling. Journal of Medicinal Chemistry, 68 (20), 21441-21457. doi: 10.1021/acs.jmedchem.5c01378 |
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2025 Journal Article Where have you been? Backtracking microplastic to its source using the biomolecular composition of the ecocoronaDawson, Amanda L., Bose, Utpal, Escobar-Correas, Sophia, Yap, Kuok, Craik, David J. and Pegg, Cassandra L. (2025). Where have you been? Backtracking microplastic to its source using the biomolecular composition of the ecocorona. Environmental Science and Technology, 59 (41), 22227-22238. doi: 10.1021/acs.est.5c09277 |
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2025 Journal Article AEP-mediated backbone cyclization of cyclotides—a chemoenzymatic method for cyclotide productionZhou, Yan, de Veer, Simon J., Durek, Thomas and Craik, David J. (2025). AEP-mediated backbone cyclization of cyclotides—a chemoenzymatic method for cyclotide production. Methods in Enzymology, 723, 71-90. doi: 10.1016/bs.mie.2025.09.001 |
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2025 Journal Article Mixed-chirality prohibitin peptide: D-(RLARLAR)2 enhances stability and in vivo effects on obesityChan, Lai Yue, Weger, Benjamin D., Weger, Meltem, Du, Junqiao, Lawrence, Nicole, Cardoso, Marlon H., de Rezende, Samilla B., Muller, Jéssica A.I., Yap, Kuok, Tse, Brian W−C., Sokolowski, Kamil A., Sullivan, Robert K.P., Gunter, Jennifer, Franco, Octávio L., Gachon, Frédéric and Craik, David J. (2025). Mixed-chirality prohibitin peptide: D-(RLARLAR)2 enhances stability and in vivo effects on obesity. Journal of the American Chemical Society, 147 (28), 24628-24642. doi: 10.1021/jacs.5c05536 |
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2025 Journal Article Asparaginyl ligases with engineered substrate specificity for controlled, sequential transpeptidation reactionsZhou, Yan, de Veer, Simon J., Tyler, Tristan J., Chen, Yufei, Durek, Thomas, Craik, David J. and Rehm, Fabian B. H. (2025). Asparaginyl ligases with engineered substrate specificity for controlled, sequential transpeptidation reactions. Journal of the American Chemical Society, 147 (25), 21824-21831. doi: 10.1021/jacs.5c04693 |
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2025 Journal Article High-throughput enrichment of functional disulfide-rich peptides by droplet microfluidicsXie, Jing, Yap, Kuok, de Veer, Simon J., Edwardraja, Selvakumar, Durek, Thomas, Trau, Matt, Craik, David J. and Wang, Conan K. (2025). High-throughput enrichment of functional disulfide-rich peptides by droplet microfluidics. Lab on a Chip, 25 (14), 3525-3536. doi: 10.1039/d5lc00261c |
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2025 Journal Article Cyclization of the analgesic α‐Conotoxin Vc1.1 with a non‐natural linker: effects on structure, stability, and bioactivityZhang, Yuhui, Tae, Han Shen, Adams, David J., Durek, Thomas and Craik, David J. (2025). Cyclization of the analgesic α‐Conotoxin Vc1.1 with a non‐natural linker: effects on structure, stability, and bioactivity. Journal of Peptide Science, 31 (6) e70017, 1-10. doi: 10.1002/psc.70017 |
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2025 Journal Article Exploring use of a protein cage system for producing bioactive peptides in Escherichia coliHarding, Maxim D., Jackson, Mark A., Gilding, Edward K., Yap, Kuok, Craik, David J., Sainsbury, Frank and Lawrence, Nicole (2025). Exploring use of a protein cage system for producing bioactive peptides in Escherichia coli. Microbial Biotechnology, 18 (6) e70158, 1-14. doi: 10.1111/1751-7915.70158 |
