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2026 Journal Article Progress and Challenges in the Biosynthesis and Chemical Synthesis of Lasso PeptidesKhatri, Bhavesh, Lay, Travis and Craik, David J. (2026). Progress and Challenges in the Biosynthesis and Chemical Synthesis of Lasso Peptides. Journal of the American Chemical Society, 148 (5) jacs.5c10593, 4777-4790. doi: 10.1021/jacs.5c10593 |
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2026 Journal Article uPA-mediated remodeling of CCL21 gradients regulates lymphatic migration of dendritic cellsCollado-Diaz, Victor, Christakopoulou, Maria-Nefeli, Schineis, Philipp, Blatter, Katharina, Laubender, David, Trzebanski, Sébastien, Thoma, Marina, Gadient, Yves, Tatliadim, Hazal, Gkelis, Konstantinos, Friess, Mona C., Purvanov, Vladimir, Samson, Guerric P.B., Artinger, Marc, Bisoendial, Radjesh, Yepes, Manuel, de Veer, Simon J., Craik, David, Behrendt, Niels, Silina, Karina, Legler, Daniel F. and Halin, Cornelia (2026). uPA-mediated remodeling of CCL21 gradients regulates lymphatic migration of dendritic cells. Journal of Cell Biology, 225 (3) e202412190. doi: 10.1083/jcb.202412190 |
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2026 Journal Article Recent advances in structural and functional diversities of cancer lncRNA-encoded peptides: current opportunities and challenges for enhancing cancer diagnosis and treatmentGuo, Aimin, Wang, Shanshan, Huang, Linan, He, Yanping, Xi, Qing, Craik, David J. and Zhang, Jun (2026). Recent advances in structural and functional diversities of cancer lncRNA-encoded peptides: current opportunities and challenges for enhancing cancer diagnosis and treatment. Cancer Cell International, 26 (1) 67. doi: 10.1186/s12935-025-04158-2 |
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2025 Journal Article Deep learning-driven discovery and mechanism of action study of a minimalist conopeptide targeting α7 nicotinic acetylcholine receptorZhang, Jinghui, Yin, Zhengji, Li, Yue, Ge, Cheng, Zhang, Zixuan, Yuan, Pu, Jiang, Tao, Craik, David J., Zhao, Yan and Yu, Rilei (2025). Deep learning-driven discovery and mechanism of action study of a minimalist conopeptide targeting α7 nicotinic acetylcholine receptor. Acta Pharmaceutica Sinica B. doi: 10.1016/j.apsb.2025.12.035 |
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2025 Journal Article Discovery of insecticidal cyclotides from the African plants Allexis batangae and Allexis obanensisKhatibi, Negin, Eteme, Olivier Ndogo, Wang, Conan K., Gilding, Edward K., Zondegoumba, Ernestine Nkwengoua, Colgrave, Michelle L., Huang, Yen-Hua and Craik, David J. (2025). Discovery of insecticidal cyclotides from the African plants Allexis batangae and Allexis obanensis. Industrial Crops and Products, 237 122073, 1-9. doi: 10.1016/j.indcrop.2025.122073 |
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2025 Journal Article Nickel-catalyzed cascade C-H alkynylation/hydroamination of free benzylamines for the synthesis of substituted 1H-isoindoles using a transient directing group strategyCai, Xinghao, Lu, Wei, Ma, Chen, Kang, Ying, Ren, Yuqiang, Meng, Xue, Craik, David J., Fan, Shiming, Chan, Lai Yue and Liu, Shouxin (2025). Nickel-catalyzed cascade C-H alkynylation/hydroamination of free benzylamines for the synthesis of substituted 1H-isoindoles using a transient directing group strategy. Chinese Journal of Chemistry, 43 (23) cjoc.70222, 3171-3177. doi: 10.1002/cjoc.70222 |
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2025 Journal Article Combining bioactive cell-penetrating peptides and vemurafenib to produce peptide-drug conjugates with activity against drug-resistant melanoma cellsPalombi, Isabella R., White, Andrew M., Koda, Yasuko, Craik, David J., Troeira Henriques, Sónia, Lawrence, Nicole and Malins, Lara R. (2025). Combining bioactive cell-penetrating peptides and vemurafenib to produce peptide-drug conjugates with activity against drug-resistant melanoma cells. Journal of Medicinal Chemistry, 68 (21), 23459-23471. doi: 10.1021/acs.jmedchem.5c02367 |
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2025 Conference Publication Recombinant production of an antimalarial peptide in Nicotiana benthamianaNguyen, Linh T.T., Harding, Maxim D., Healy, Wing L., Thanthrige, Nipuni P., Ninh, Thao T., Jackson, Mark A., Gilding, Edward K., Lawrence, Nicole and Craik, David (2025). Recombinant production of an antimalarial peptide in Nicotiana benthamiana. The 16th Australian Peptide Conference, Launceston, TAS, Australia, 12-17 October 2025. |
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2025 Journal Article Design of Bicyclic peptide tandems mimicking the homodimeric GDF15 protein to inhibit GDF15–GFRaL–RET complex cell signalingNoisier, Anaïs F. M., Sandmark, Jenny, Edfeldt, Fredrik, Backmark, Anna, Broddefalk, Johan, Wandzik, Joanna, Jurva, Ulrik, Ek, Margareta, Johansson, Carina A., Barlind, Louise, Gunnarsson, Jenny, Bigalke, Janna M., Xue, Yafeng, Frolov, Andrey I., Kankkonen, Cecilia, Roth, Robert G., Fritsch, Maria, Watcham, Sophie, van Rietschoten, Katerine, Mudd, Gemma E., Harrison, Helen, Chen, Liuhong, Skynner, Michael J., Craik, David J., Chankeshwara, Sunay V. and Lemurell, Malin (2025). Design of Bicyclic peptide tandems mimicking the homodimeric GDF15 protein to inhibit GDF15–GFRaL–RET complex cell signaling. Journal of Medicinal Chemistry, 68 (20), 21441-21457. doi: 10.1021/acs.jmedchem.5c01378 |
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2025 Journal Article Where have you been? Backtracking microplastic to its source using the biomolecular composition of the ecocoronaDawson, Amanda L., Bose, Utpal, Escobar-Correas, Sophia, Yap, Kuok, Craik, David J. and Pegg, Cassandra L. (2025). Where have you been? Backtracking microplastic to its source using the biomolecular composition of the ecocorona. Environmental Science and Technology, 59 (41), 22227-22238. doi: 10.1021/acs.est.5c09277 |
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2025 Journal Article AEP-mediated backbone cyclization of cyclotides—a chemoenzymatic method for cyclotide productionZhou, Yan, de Veer, Simon J., Durek, Thomas and Craik, David J. (2025). AEP-mediated backbone cyclization of cyclotides—a chemoenzymatic method for cyclotide production. Methods in Enzymology, 723, 71-90. doi: 10.1016/bs.mie.2025.09.001 |
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2025 Journal Article Mixed-chirality prohibitin peptide: D-(RLARLAR)2 enhances stability and in vivo effects on obesityChan, Lai Yue, Weger, Benjamin D., Weger, Meltem, Du, Junqiao, Lawrence, Nicole, Cardoso, Marlon H., de Rezende, Samilla B., Muller, Jéssica A.I., Yap, Kuok, Tse, Brian W−C., Sokolowski, Kamil A., Sullivan, Robert K.P., Gunter, Jennifer, Franco, Octávio L., Gachon, Frédéric and Craik, David J. (2025). Mixed-chirality prohibitin peptide: D-(RLARLAR)2 enhances stability and in vivo effects on obesity. Journal of the American Chemical Society, 147 (28), 24628-24642. doi: 10.1021/jacs.5c05536 |
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2025 Journal Article Asparaginyl ligases with engineered substrate specificity for controlled, sequential transpeptidation reactionsZhou, Yan, de Veer, Simon J., Tyler, Tristan J., Chen, Yufei, Durek, Thomas, Craik, David J. and Rehm, Fabian B. H. (2025). Asparaginyl ligases with engineered substrate specificity for controlled, sequential transpeptidation reactions. Journal of the American Chemical Society, 147 (25), 21824-21831. doi: 10.1021/jacs.5c04693 |
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2025 Journal Article High-throughput enrichment of functional disulfide-rich peptides by droplet microfluidicsXie, Jing, Yap, Kuok, de Veer, Simon J., Edwardraja, Selvakumar, Durek, Thomas, Trau, Matt, Craik, David J. and Wang, Conan K. (2025). High-throughput enrichment of functional disulfide-rich peptides by droplet microfluidics. Lab on a Chip, 25 (14), 3525-3536. doi: 10.1039/d5lc00261c |
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2025 Journal Article Exploring use of a protein cage system for producing bioactive peptides in Escherichia coliHarding, Maxim D., Jackson, Mark A., Gilding, Edward K., Yap, Kuok, Craik, David J., Sainsbury, Frank and Lawrence, Nicole (2025). Exploring use of a protein cage system for producing bioactive peptides in Escherichia coli. Microbial Biotechnology, 18 (6) e70158, 1-14. doi: 10.1111/1751-7915.70158 |
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2025 Journal Article Cyclization of the analgesic α‐Conotoxin Vc1.1 with a non‐natural linker: effects on structure, stability, and bioactivityZhang, Yuhui, Tae, Han Shen, Adams, David J., Durek, Thomas and Craik, David J. (2025). Cyclization of the analgesic α‐Conotoxin Vc1.1 with a non‐natural linker: effects on structure, stability, and bioactivity. Journal of Peptide Science, 31 (6) e70017, 1-10. doi: 10.1002/psc.70017 |
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2025 Journal Article An orthogonal protection strategy for the synthesis of conotoxins containing three disulfide bondsZhang, Hengyu, Chan, Lai Yue, Zhang, Huanhuan, Jiang, Tao, Craik, David J., Cai, Wenqing and Yu, Rilei (2025). An orthogonal protection strategy for the synthesis of conotoxins containing three disulfide bonds. Marine Drugs, 23 (4) 168, 1-11. doi: 10.3390/md23040168 |
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2025 Journal Article Anticoagulation during Extracorporeal Membrane Oxygenation (ECMO): A Selective Inhibitor of Activated Factor XII Compared to Heparin in an Ex Vivo ModelGandini, Lucia, de Veer, Simon J., Chan, Chris H. H., Passmore, Margaret R., Liu, Keibun, Lundon, Brooke, Rachakonda, Reema, White, Nicole, Rhodes, Madeleine, Shanahan, Emma, Yap, Kuok, See Hoe, Louise E., Semenzin, Clayton, Li Bassi, Gianluigi, Fraser, John F., Craik, David J. and Suen, Jacky Y. (2025). Anticoagulation during Extracorporeal Membrane Oxygenation (ECMO): A Selective Inhibitor of Activated Factor XII Compared to Heparin in an Ex Vivo Model. ACS Pharmacology & Translational Science, 8 (5), 1260-1269. doi: 10.1021/acsptsci.4c00352 |
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2025 Journal Article Selective inhibition of Rat α7 nicotinic acetylcholine receptors by LvID, a newly characterized α4/7-conotoxin from Conus lividusGuo, Man, Zhu, Xiaopeng, Ma, Tao, Xu, Chenxing, Zhangsun, Dongting, Yu, Jinpeng, Kaas, Quentin, Harvey, Peta J., McIntosh, J. Michael, Craik, David J. and Luo, Sulan (2025). Selective inhibition of Rat α7 nicotinic acetylcholine receptors by LvID, a newly characterized α4/7-conotoxin from Conus lividus. Journal of Medicinal Chemistry, 68 (8), 8163-8173. doi: 10.1021/acs.jmedchem.4c02810 |
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2025 Journal Article Cell-penetrating cyclic and disulfide-rich peptides are privileged molecular scaffolds for intracellular targetingTroeira Henriques, Sónia, Lawrence, Nicole, Kan, Meng-Wei, Malins, Lara R. and Craik, David J. (2025). Cell-penetrating cyclic and disulfide-rich peptides are privileged molecular scaffolds for intracellular targeting. Biochemistry, 64 (7), 1437-1449. doi: 10.1021/acs.biochem.4c00845 |
