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2023

Journal Article

Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation

Chen, Zhian, Cui, Yanfang, Yao, Yin, Liu, Bo, Yunis, Joseph, Gao, Xin, Wang, Naiqi, Cañete, Pablo F., Tuong, Zewen Kelvin, Sun, Hongjian, Wang, Hao, Yang, Siling, Wang, Runli, Leong, Yew Ann, Simon Davis, David, Qin, Jiahuan, Liang, Kaili, Deng, Jun, Wang, Conan K., Huang, Yen-Hua, Roco, Jonathan A., Nettelfield, Sam, Zhu, Huaming, Xu, Huajun, Yu, Zhijia, Craik, David, Liu, Zheng, Qi, Hai, Parish, Christopher and Yu, Di (2023). Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation. Science Immunology, 8 (80) eadd1728, 1-17. doi: 10.1126/sciimmunol.add1728

Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation

2023

Journal Article

Discovery, characterization, and engineering of LvIC, an α4/4-conotoxin that selectively blocks rat α6/α3β4 nicotinic acetylcholine receptors

Zhu, Xiaopeng, Wang, Shuai, Kaas, Quentin, Yu, Jinpeng, Wu, Yong, Harvey, Peta J., Zhangsun, Dongting, Craik, David J. and Luo, Sulan (2023). Discovery, characterization, and engineering of LvIC, an α4/4-conotoxin that selectively blocks rat α6/α3β4 nicotinic acetylcholine receptors. Journal of Medicinal Chemistry, 66 (3), 2020-2031. doi: 10.1021/acs.jmedchem.2c01786

Discovery, characterization, and engineering of LvIC, an α4/4-conotoxin that selectively blocks rat α6/α3β4 nicotinic acetylcholine receptors

2023

Other Outputs

Ct_HiC3 assembly and analysis data

Gilding, Edward and Craik, David (2023). Ct_HiC3 assembly and analysis data. The University of Queensland. (Dataset) doi: 10.48610/757738c

Ct_HiC3 assembly and analysis data

2022

Journal Article

Sex-specific expression of pheromones and other signals in gravid starfish

Jönsson, Mathias, Morin, Marie, Wang, Conan K., Craik, David J., Degnan, Sandie M. and Degnan, Bernard M. (2022). Sex-specific expression of pheromones and other signals in gravid starfish. BMC Biology, 20 (1) 288, 1-18. doi: 10.1186/s12915-022-01491-0

Sex-specific expression of pheromones and other signals in gravid starfish

2022

Journal Article

Cancer-related micropeptides encoded by ncRNAs: Promising drug targets and prognostic biomarkers

Setrerrahmane, Sarra, Li, Mengwei, Zoghbi, Abdelmoumin, Lv, Xue, Zhang, Sen, Zhao, Wenjing, Lu, Jingjing, Craik, David J. and Xu, Hanmei (2022). Cancer-related micropeptides encoded by ncRNAs: Promising drug targets and prognostic biomarkers. Cancer Letters, 547 215723, 1-12. doi: 10.1016/j.canlet.2022.215723

Cancer-related micropeptides encoded by ncRNAs: Promising drug targets and prognostic biomarkers

2022

Journal Article

Structural analysis of the complex of human transthyretin with 3′,5′-dichlorophenylanthranilic acid at 1.5 Å resolution

Cody, Vivian, Truong, Jia Q., Holdsworth, Bruce A., Holien, Jessica K., Richardson, Samantha J., Chalmers, David K. and Craik, David J. (2022). Structural analysis of the complex of human transthyretin with 3′,5′-dichlorophenylanthranilic acid at 1.5 Å resolution. Molecules, 27 (21) 7206, 1-11. doi: 10.3390/molecules27217206

Structural analysis of the complex of human transthyretin with 3′,5′-dichlorophenylanthranilic acid at 1.5 Å resolution

2022

Journal Article

A designed cyclic analogue of gomesin has potent activity against Staphylococcus aureus biofilms

Dias, Susana A., Pinto, Sandra N., Silva-Herdade, Ana S., Cheneval, Olivier, Craik, David J., Coutinho, Ana, Castanho, Miguel A. R. B., Henriques, Sónia T. and Veiga, Ana Salomé (2022). A designed cyclic analogue of gomesin has potent activity against Staphylococcus aureus biofilms. Journal of Antimicrobial Chemotherapy, 77 (12), 3256-3264. doi: 10.1093/jac/dkac309

A designed cyclic analogue of gomesin has potent activity against Staphylococcus aureus biofilms

2022

Journal Article

µ-Conotoxins targeting the human voltage-gated sodium channel subtype NaV1.7

McMahon, Kirsten L., Tran, Hue N. T., Deuis, Jennifer R., Craik, David J., Vetter, Irina and Schroeder, Christina I. (2022). µ-Conotoxins targeting the human voltage-gated sodium channel subtype NaV1.7. Toxins, 14 (9) 600, 1-16. doi: 10.3390/toxins14090600

µ-Conotoxins targeting the human voltage-gated sodium channel subtype NaV1.7

2022

Journal Article

Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox

Xie, Jing, Robinson, Samuel D., Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Rehm, Fabian B.H., Yap, Kuok, Ragnarsson, Lotten, Chan, Lai Yue, Hamilton, Brett R., Harvey, Peta J., Craik, David J., Vetter, Irina and Durek, Thomas (2022). Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox. Journal of Biological Chemistry, 298 (8) 102218, 1-12. doi: 10.1016/j.jbc.2022.102218

Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox

2022

Conference Publication

Activating the p53 pathway with peptide conjugates: synthesis, structure, activity and cellular uptake

Philippe, Gregoire, Huang, Yen-Hua, Mittermeier, Anna, Brown, Christopher, Wang, Conan, Kaas, Quentin, Lawrence, Nicole, Condon, Nicholas, Lane, David, Loewer, Alexander, Craik, David and Henriques, Sonia (2022). Activating the p53 pathway with peptide conjugates: synthesis, structure, activity and cellular uptake. 36th European Peptide Symposium 12th International Peptide Symposium, Barcelona, Spain, 28 August - 2 September 2022. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.3445

Activating the p53 pathway with peptide conjugates: synthesis, structure, activity and cellular uptake

2022

Journal Article

Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides

Dang, Tien T., Harvey, Peta J., Chan, Lai Yue, Huang, Yen-Hua, Kaas, Quentin and Craik, David J. (2022). Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides. Peptide Science, 114 (6) e24284. doi: 10.1002/pep2.24284

Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides

2022

Journal Article

Antinociceptive peptides from venomous arthropods

Muller, Jessica A. I., Chan, Lai Y., Toffoli-Kadri, Monica C., Mortari, Marcia R., Craik, David J. and Koehbach, Johannes (2022). Antinociceptive peptides from venomous arthropods. Toxin Reviews, 42 (1), 1-20. doi: 10.1080/15569543.2022.2065510

Antinociceptive peptides from venomous arthropods

2022

Journal Article

Cystine knot peptides with tuneable activity and mechanism

Li, Choi Yi, Rehm, Fabian B. H., Yap, Kuok, Zdenek, Christina N., Harding, Maxim D., Fry, Bryan G., Durek, Thomas, Craik, David J. and Veer, Simon J. (2022). Cystine knot peptides with tuneable activity and mechanism. Angewandte Chemie, 61 (19) e202200951, e202200951. doi: 10.1002/ange.202200951

Cystine knot peptides with tuneable activity and mechanism

2022

Journal Article

Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA

Jakob, Valentin, Zoller, Ben G. E., Rinkes, Julia, Wu, Yingwen, Kiefer, Alexander F., Hust, Michael, Polten, Saskia, White, Andrew M., Harvey, Peta J., Durek, Thomas, Craik, David J., Siebert, Andreas, Kazmaier, Uli and Empting, Martin (2022). Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA. European Journal of Medicinal Chemistry, 231 114148, 114148. doi: 10.1016/j.ejmech.2022.114148

Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA

2022

Journal Article

An N-capping asparagine–lysine–proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffold

Cardoso, Marlon H., Chan, Lai Y., Cândido, Elizabete S., Buccini, Danieli F., Rezende, Samilla B., Torres, Marcelo D. T., Oshiro, Karen G. N., Silva, Ítala C., Gonçalves, Sónia, Lu, Timothy K., Santos, Nuno C., de la Fuente-Nunez, Cesar, Craik, David J. and Franco, Octávio L. (2022). An N-capping asparagine–lysine–proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffold. Chemical Science, 13 (32), 9410-9424. doi: 10.1039/d1sc06998e

An N-capping asparagine–lysine–proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffold

2022

Book Chapter

Scalable and efficient In planta biosynthesis of sunflower trypsin inhibitor-1 (SFTI) peptide therapeutics

Handley, Thomas N. G., Jackson, Mark A. and Craik, David J. (2022). Scalable and efficient In planta biosynthesis of sunflower trypsin inhibitor-1 (SFTI) peptide therapeutics. Peptide macrocycles: methods and protocols. (pp. 117-142) edited by Matthew B. Coppock and Alexander J. Winton. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-1689-5_7

Scalable and efficient In planta biosynthesis of sunflower trypsin inhibitor-1 (SFTI) peptide therapeutics

2022

Other Outputs

De novo design of peptide-small molecule ligands of the kappa-opioid receptors

Muratspahic, E., Muttenthaler, M., Jadhav, K. B., Baker, D., Che, T., Spetea, M., Craik, D. and Gruber, C. W. (2022). De novo design of peptide-small molecule ligands of the kappa-opioid receptors. EP22193238.

De novo design of peptide-small molecule ligands of the kappa-opioid receptors

2022

Journal Article

ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (CaV2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activation

Yousuf, Arsalan, Wu, Xiaosa, Bony, Anuja R., Sadeghi, Mahsa, Huang, Yen-Hua, Craik, David J. and Adams, David J. (2022). ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (CaV2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activation. Journal of Neurochemistry, 160 (2), 154-171. doi: 10.1111/jnc.15535

ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (CaV2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activation

2022

Book Chapter

Cyclotides—cyclic and disulfide-knotted polypeptides

Craik, David J., Zhang, Yuhui, Zhou, Yan, Kaas, Quentin and Kan, Meng-Wei (2022). Cyclotides—cyclic and disulfide-knotted polypeptides. Topological polymer chemistry: concepts and practices. (pp. 135-147) Singapore, Singapore: Springer Singapore. doi: 10.1007/978-981-16-6807-4_9

Cyclotides—cyclic and disulfide-knotted polypeptides

2021

Conference Publication

An N-capping asparagine-lysine-proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffold

Silva Cardoso, Marlon Henrique E., Chan, Lai Yue, Candido, Elizabete De Souza, Torres, Marcelo D. T., Oshiro, Karen G. N., Silva, Itala C., Goncalves, S., Buccini, Danieli Fernanda, Lu, Timothy K., Santos, Nuno C., De la Fuente-Nunez, Cesar, Craik, David J. and Franco, Octavio L. (2021). An N-capping asparagine-lysine-proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffold. 20th IUPAB International Congress, 45th SBBf Congress and 50th Annual Meeting of SBBq, Online, 4-8 October 2021. London, United Kingdom: Springer.

An N-capping asparagine-lysine-proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffold