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2014 Journal Article Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosisWang, Conan K., Gruber, Christian W., Cemazar, Masa, Siatskas, Christopher, Tagore, Prascilla, Payne, Natalie, Sun, Guizhi, Wang, Shunhe, Bernard, Claude C. and Craik, David J. (2014). Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis. ACS Chemical Biology, 9 (1), 156-163. doi: 10.1021/cb400548s |
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2013 Journal Article The Future of Peptide-based DrugsCraik, David J., Fairlie, David P., Liras, Spiros and Price, David (2013). The Future of Peptide-based Drugs. Chemical Biology and Drug Design, 81 (1), 136-147. doi: 10.1111/cbdd.12055 |
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2012 Journal Article Protein folding: Turbo-charged crosslinkingCraik, David J. (2012). Protein folding: Turbo-charged crosslinking. Nature Chemistry, 4 (8), 600-602. doi: 10.1038/nchem.1417 |
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2012 Journal Article Cyclotides associate with leaf vasculature and are the products of a novel precursor in Petunia (Solanaceae)Poth, Aaron G., Mylne, Joshua S., Grassl, Julia, Lyons, Russell E., Millar, A. Harvey, Colgrave, Michelle L. and Craik, David J. (2012). Cyclotides associate with leaf vasculature and are the products of a novel precursor in Petunia (Solanaceae). Journal of Biological Chemistry, 287 (32), 27033-27046. doi: 10.1074/jbc.M112.370841 |
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2011 Journal Article The chemistry of cyclotidesCraik, David J. and Conibear, Anne C. (2011). The chemistry of cyclotides. Journal of Organic Chemistry, 76 (12), 4805-4817. doi: 10.1021/jo200520v |
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2011 Journal Article Albumins and their processing machinery are hijacked for cyclic peptides in sunflowerMylne, Joshua S., Colgrave, Michelle L., Daly, Norelle L., Chanson, Aurelie H., Elliott, Alysha G., McCallum, Emily J., Jones, Alun and Craik, David J. (2011). Albumins and their processing machinery are hijacked for cyclic peptides in sunflower. Nature Chemical Biology, 7 (5), 257-259. doi: 10.1038/nchembio.542 |
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2011 Journal Article Discovery of cyclotides in the Fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteinsPoth, Aaron G., Colgrave, Michelle L., Philip, Reynold, Kerenga, Bomai, Daly, Norelle L., Anderson, Marilyn A. and Craik, David J. (2011). Discovery of cyclotides in the Fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins. ACS Chemical Biology, 6 (4), 345-355. doi: 10.1021/cb100388j |
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2009 Journal Article Circling the enemy: cyclic proteins in plant defenceCraik, David J. (2009). Circling the enemy: cyclic proteins in plant defence. Trends in Plant Science, 14 (6), 328-335. doi: 10.1016/j.tplants.2009.03.003 |
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2009 Journal Article Conotoxins: natural product drug leadsHalai, Reena and Craik, David J. (2009). Conotoxins: natural product drug leads. Natural Product Reports, 26 (4), 526-536. doi: 10.1039/b819311h |
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2008 Journal Article Distribution and evolution of circular miniproteins in flowering plantsGruber, Christian W., Elliott, Alysha G., Ireland, David C., Delprete, Piero G., Dessein, Steven, Goransson, Ulf, Trabi, Manuela, Wang, Conan K., Kinghorn, Andrew B., Robbrecht, Elmar and Craik, David J. (2008). Distribution and evolution of circular miniproteins in flowering plants. The Plant Cell, 20 (9), 2471-2483. doi: 10.1105/tpc.108.062331 |
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2006 Journal Article Chemistry - Seamless proteins tie up their loose endsCraik, D. J. (2006). Chemistry - Seamless proteins tie up their loose ends. Science, 311 (5767), 1563-1564. doi: 10.1126/science.1125248 |
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2026 Journal Article α-Conotoxin LvID, an antagonist of α7 nicotinic acetylcholine receptor, mitigates Alzheimer-associated phenotypes by inhibiting Aβ deposition and reactive astrogliosisYue, Song, Xing, Haonan, Du, Xiaoxue, Wang, Yufei, Qin, Runtian, He, Jinsheng, Yu, Jinpeng, Zhangsun, Dongting, Craik, David J., Mcintosh, J. Michael, Wu, Yili, Zhu, Xiaopeng and Luo, Sulan (2026). α-Conotoxin LvID, an antagonist of α7 nicotinic acetylcholine receptor, mitigates Alzheimer-associated phenotypes by inhibiting Aβ deposition and reactive astrogliosis. International Journal of Biological Macromolecules, 349 150933, 150933. doi: 10.1016/j.ijbiomac.2026.150933 |
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2026 Journal Article Rational Design of Plant-Derived Protein Ligases with Altered Substrate SpecificityZhou, Yan, de Veer, Simon J., Tyler, Tristan J., Durek, Thomas, Rehm, Fabian B. H. and Craik, David J. (2026). Rational Design of Plant-Derived Protein Ligases with Altered Substrate Specificity. Biochemistry, 65 (5) acs.biochem.5c00808, 571-578. doi: 10.1021/acs.biochem.5c00808 |
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2026 Journal Article Progress and Challenges in the Biosynthesis and Chemical Synthesis of Lasso PeptidesKhatri, Bhavesh, Lay, Travis and Craik, David J. (2026). Progress and Challenges in the Biosynthesis and Chemical Synthesis of Lasso Peptides. Journal of the American Chemical Society, 148 (5) jacs.5c10593, 4777-4790. doi: 10.1021/jacs.5c10593 |
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2026 Journal Article uPA-mediated remodeling of CCL21 gradients regulates lymphatic migration of dendritic cellsCollado-Diaz, Victor, Christakopoulou, Maria-Nefeli, Schineis, Philipp, Blatter, Katharina, Laubender, David, Trzebanski, Sébastien, Thoma, Marina, Gadient, Yves, Tatliadim, Hazal, Gkelis, Konstantinos, Friess, Mona C., Purvanov, Vladimir, Samson, Guerric P.B., Artinger, Marc, Bisoendial, Radjesh, Yepes, Manuel, de Veer, Simon J., Craik, David, Behrendt, Niels, Silina, Karina, Legler, Daniel F. and Halin, Cornelia (2026). uPA-mediated remodeling of CCL21 gradients regulates lymphatic migration of dendritic cells. Journal of Cell Biology, 225 (3) e202412190. doi: 10.1083/jcb.202412190 |
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2026 Journal Article Recent advances in structural and functional diversities of cancer lncRNA-encoded peptides: current opportunities and challenges for enhancing cancer diagnosis and treatmentGuo, Aimin, Wang, Shanshan, Huang, Linan, He, Yanping, Xi, Qing, Craik, David J and Zhang, Jun (2026). Recent advances in structural and functional diversities of cancer lncRNA-encoded peptides: current opportunities and challenges for enhancing cancer diagnosis and treatment. Cancer Cell International, 26 (1) 67, 1. doi: 10.1186/s12935-025-04158-2 |
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2025 Journal Article Nickel-catalyzed cascade C-H alkynylation/hydroamination of free benzylamines for the synthesis of substituted 1H-isoindoles using a transient directing group strategyCai, Xinghao, Lu, Wei, Ma, Chen, Kang, Ying, Ren, Yuqiang, Meng, Xue, Craik, David J., Fan, Shiming, Chan, Lai Yue and Liu, Shouxin (2025). Nickel-catalyzed cascade C-H alkynylation/hydroamination of free benzylamines for the synthesis of substituted 1H-isoindoles using a transient directing group strategy. Chinese Journal of Chemistry, 43 (23) cjoc.70222, 3171-3177. doi: 10.1002/cjoc.70222 |
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2025 Journal Article Deep learning-driven discovery and mechanism of action study of a minimalist conopeptide targeting α7 nicotinic acetylcholine receptorZhang, Jinghui, Yin, Zhengji, Li, Yue, Ge, Cheng, Zhang, Zixuan, Yuan, Pu, Jiang, Tao, Craik, David J., Zhao, Yan and Yu, Rilei (2025). Deep learning-driven discovery and mechanism of action study of a minimalist conopeptide targeting α7 nicotinic acetylcholine receptor. Acta Pharmaceutica Sinica B. doi: 10.1016/j.apsb.2025.12.035 |
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2025 Journal Article Discovery of insecticidal cyclotides from the African plants Allexis batangae and Allexis obanensisKhatibi, Negin, Eteme, Olivier Ndogo, Wang, Conan K., Gilding, Edward K., Zondegoumba, Ernestine Nkwengoua, Colgrave, Michelle L., Huang, Yen-Hua and Craik, David J. (2025). Discovery of insecticidal cyclotides from the African plants Allexis batangae and Allexis obanensis. Industrial Crops and Products, 237 122073, 1-9. doi: 10.1016/j.indcrop.2025.122073 |
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2025 Journal Article Combining bioactive cell-penetrating peptides and vemurafenib to produce peptide-drug conjugates with activity against drug-resistant melanoma cellsPalombi, Isabella R., White, Andrew M., Koda, Yasuko, Craik, David J., Troeira Henriques, Sónia, Lawrence, Nicole and Malins, Lara R. (2025). Combining bioactive cell-penetrating peptides and vemurafenib to produce peptide-drug conjugates with activity against drug-resistant melanoma cells. Journal of Medicinal Chemistry, 68 (21), 23459-23471. doi: 10.1021/acs.jmedchem.5c02367 |
