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2014

Journal Article

Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis

Wang, Conan K., Gruber, Christian W., Cemazar, Masa, Siatskas, Christopher, Tagore, Prascilla, Payne, Natalie, Sun, Guizhi, Wang, Shunhe, Bernard, Claude C. and Craik, David J. (2014). Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis. ACS Chemical Biology, 9 (1), 156-163. doi: 10.1021/cb400548s

Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis

2013

Journal Article

The Future of Peptide-based Drugs

Craik, David J., Fairlie, David P., Liras, Spiros and Price, David (2013). The Future of Peptide-based Drugs. Chemical Biology and Drug Design, 81 (1), 136-147. doi: 10.1111/cbdd.12055

The Future of Peptide-based Drugs

2012

Journal Article

Protein folding: Turbo-charged crosslinking

Craik, David J. (2012). Protein folding: Turbo-charged crosslinking. Nature Chemistry, 4 (8), 600-602. doi: 10.1038/nchem.1417

Protein folding: Turbo-charged crosslinking

2012

Journal Article

Cyclotides associate with leaf vasculature and are the products of a novel precursor in Petunia (Solanaceae)

Poth, Aaron G., Mylne, Joshua S., Grassl, Julia, Lyons, Russell E., Millar, A. Harvey, Colgrave, Michelle L. and Craik, David J. (2012). Cyclotides associate with leaf vasculature and are the products of a novel precursor in Petunia (Solanaceae). Journal of Biological Chemistry, 287 (32), 27033-27046. doi: 10.1074/jbc.M112.370841

Cyclotides associate with leaf vasculature and are the products of a novel precursor in Petunia (Solanaceae)

2011

Journal Article

The chemistry of cyclotides

Craik, David J. and Conibear, Anne C. (2011). The chemistry of cyclotides. Journal of Organic Chemistry, 76 (12), 4805-4817. doi: 10.1021/jo200520v

The chemistry of cyclotides

2011

Journal Article

Albumins and their processing machinery are hijacked for cyclic peptides in sunflower

Mylne, Joshua S., Colgrave, Michelle L., Daly, Norelle L., Chanson, Aurelie H., Elliott, Alysha G., McCallum, Emily J., Jones, Alun and Craik, David J. (2011). Albumins and their processing machinery are hijacked for cyclic peptides in sunflower. Nature Chemical Biology, 7 (5), 257-259. doi: 10.1038/nchembio.542

Albumins and their processing machinery are hijacked for cyclic peptides in sunflower

2011

Journal Article

Discovery of cyclotides in the Fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins

Poth, Aaron G., Colgrave, Michelle L., Philip, Reynold, Kerenga, Bomai, Daly, Norelle L., Anderson, Marilyn A. and Craik, David J. (2011). Discovery of cyclotides in the Fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins. ACS Chemical Biology, 6 (4), 345-355. doi: 10.1021/cb100388j

Discovery of cyclotides in the Fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins

2009

Journal Article

Circling the enemy: cyclic proteins in plant defence

Craik, David J. (2009). Circling the enemy: cyclic proteins in plant defence. Trends in Plant Science, 14 (6), 328-335. doi: 10.1016/j.tplants.2009.03.003

Circling the enemy: cyclic proteins in plant defence

2009

Journal Article

Conotoxins: natural product drug leads

Halai, Reena and Craik, David J. (2009). Conotoxins: natural product drug leads. Natural Product Reports, 26 (4), 526-536. doi: 10.1039/b819311h

Conotoxins: natural product drug leads

2008

Journal Article

Distribution and evolution of circular miniproteins in flowering plants

Gruber, Christian W., Elliott, Alysha G., Ireland, David C., Delprete, Piero G., Dessein, Steven, Goransson, Ulf, Trabi, Manuela, Wang, Conan K., Kinghorn, Andrew B., Robbrecht, Elmar and Craik, David J. (2008). Distribution and evolution of circular miniproteins in flowering plants. The Plant Cell, 20 (9), 2471-2483. doi: 10.1105/tpc.108.062331

Distribution and evolution of circular miniproteins in flowering plants

2006

Journal Article

Chemistry - Seamless proteins tie up their loose ends

Craik, D. J. (2006). Chemistry - Seamless proteins tie up their loose ends. Science, 311 (5767), 1563-1564. doi: 10.1126/science.1125248

Chemistry - Seamless proteins tie up their loose ends

2026

Journal Article

Minidomains from evolution for scaffold engineering

Devnath, Hiron Saraj, Xie, Jing, Craik, David J. and Wang, Conan K. (2026). Minidomains from evolution for scaffold engineering. Biotechnology Advances, 90 108904, 1-19. doi: 10.1016/j.biotechadv.2026.108904

Minidomains from evolution for scaffold engineering

2026

Journal Article

Direct Heterologous Expression of Cyclic Conotoxin [G22N]Vc1.1 in Yeast

Xie, Jing, Yap, Kuok, Wang, Conan K., Durek, Thomas and Craik, David J. (2026). Direct Heterologous Expression of Cyclic Conotoxin [G22N]Vc1.1 in Yeast. ACS Chemical Biology. doi: 10.1021/acschembio.6c00509

Direct Heterologous Expression of Cyclic Conotoxin [G22N]Vc1.1 in Yeast

2026

Journal Article

Bacteriophage <scp>P22</scp> Virus‐Like Particles as Nanoscale Protein Scaffolds for Plant Synthetic Biology

Harding, Maxim D., Jackson, Mark A., Gilding, Edward K., Craik, David J., Sainsbury, Frank and Lawrence, Nicole (2026). Bacteriophage P22 Virus‐Like Particles as Nanoscale Protein Scaffolds for Plant Synthetic Biology. Plant Biotechnology Journal pbi.70735. doi: 10.1111/pbi.70735

Bacteriophage <scp>P22</scp> Virus‐Like Particles as Nanoscale Protein Scaffolds for Plant Synthetic Biology

2026

Journal Article

Cyclotides as sustainable biopesticides: structure, function and agricultural potential

Shambhawi, Zhang, Mengbai, Chan, Lai Yue and Craik, David J. (2026). Cyclotides as sustainable biopesticides: structure, function and agricultural potential. Phytochemistry Reviews, 1-31. doi: 10.1007/s11101-026-10289-9

Cyclotides as sustainable biopesticides: structure, function and agricultural potential

2026

Journal Article

Deep learning-driven discovery and mechanism of action study of a minimalist conopeptide targeting α7 nicotinic acetylcholine receptor

Zhang, Jinghui, Yin, Zhengji, Li, Yue, Ge, Cheng, Zhang, Zixuan, Yuan, Pu, Jiang, Tao, Craik, David J., Zhao, Yan and Yu, Rilei (2026). Deep learning-driven discovery and mechanism of action study of a minimalist conopeptide targeting α7 nicotinic acetylcholine receptor. Acta Pharmaceutica Sinica B, 16 (7), 4147-4165. doi: 10.1016/j.apsb.2025.12.035

Deep learning-driven discovery and mechanism of action study of a minimalist conopeptide targeting α7 nicotinic acetylcholine receptor

2026

Journal Article

Applying therapeutic peptide design principles to agricultural peptides

Cobon, Jack H., Craik, David J. and Wang, Conan K. (2026). Applying therapeutic peptide design principles to agricultural peptides. Nature Reviews Bioengineering, 4 (8), 705-707. doi: 10.1038/s44222-026-00461-3

Applying therapeutic peptide design principles to agricultural peptides

2026

Journal Article

Bacteriophage P22 virus-like particles as nanoscale protein scaffolds for plant synthetic biology

Harding, Maxim D., Jackson, Mark A., Gilding, Edward K., Craik, David J., Sainsbury, Frank and Lawrence, Nicole (2026). Bacteriophage P22 virus-like particles as nanoscale protein scaffolds for plant synthetic biology. doi: 10.64898/2026.05.14.725278

Bacteriophage P22 virus-like particles as nanoscale protein scaffolds for plant synthetic biology

2026

Journal Article

Computer-aided design of Plasmodium chabaudi -derived peptides with dual antibiofilm and anti-inflammatory activities

Quigua Orozco, Raquel M., Santos, Alexandre D. O., Rossetto, Joelma P., Madalozzo, Elisângela S., Luchi, Lívia V., Rezende, Samilla B., Chan, Lai Yue, Buccini, Danieli F., Macedo, Maria L. R., Mehta, Angela, Craik, David J., Franco, Octávio L. and Cardoso, Marlon H. (2026). Computer-aided design of Plasmodium chabaudi -derived peptides with dual antibiofilm and anti-inflammatory activities. ACS Medicinal Chemistry Letters, 17 (5) acsmedchemlett.6c00007, 1057-1066. doi: 10.1021/acsmedchemlett.6c00007

Computer-aided design of Plasmodium chabaudi -derived peptides with dual antibiofilm and anti-inflammatory activities

2026

Journal Article

Site-specific protein and peptide modification by redeploying an asparaginyl ligase for noncanonical reactions

de Veer, Simon J., Zhou, Yan, Rehm, Fabian B. H., Durek, Thomas and Craik, David J. (2026). Site-specific protein and peptide modification by redeploying an asparaginyl ligase for noncanonical reactions. Nature Protocols. doi: 10.1038/s41596-026-01348-8

Site-specific protein and peptide modification by redeploying an asparaginyl ligase for noncanonical reactions