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2007 Journal Article (-)Adrenaline elicits positive inotropic,lusitropic, and biochemical effects through ß2-adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consisten with Gs coupling but not with Gi coupling.Molenaar, P., Savarimuthu, S. M., Sarsero, D., Chen, L., Semmler, A. B. T., Carle, A., Yang, I., Bartel, S., Vetter, D., Beyerdorfer, I., Krause,E-G. and Kaumann, A. J. (2007). (-)Adrenaline elicits positive inotropic,lusitropic, and biochemical effects through ß2-adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consisten with Gs coupling but not with Gi coupling.. Naunyn-Schmiedeberg's Archives of Pharmocolgy, 375 (1), 11-28. doi: 10.1007/s00210-007-0138-x |
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2006 Conference Publication Carvedilol causes a greater increase in heart function in idiopathic dilated cardiomyopathy patients with ARG389-compared to GLY389 Beta1-adrenoceptorsMolenaar, P., Chen, Lu, Meyers, E., Javorsky, G., Burstow, M., Lucas, P., Lolekha, J., Atherton, A., Semmler, A. B., Savarimuthu, S., Fong, K. M., Yang, I. A., Galbraith, A. and Parsonage, W. A. (2006). Carvedilol causes a greater increase in heart function in idiopathic dilated cardiomyopathy patients with ARG389-compared to GLY389 Beta1-adrenoceptors. The Australian Health and Medical Research Congress, Melbourn, Australia, 26th November - 1st December, 2006. Australia: Australian Govenment NHMRC. |
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2006 Conference Publication Contractile responses through Gs-coupled receptors are reduced by phosphodiesterase3 activity in human isolated myocardiumChrist, T., Molenaar, P., Galindo-Tovar, A., Ravens, U. and Kaumann, A. J. (2006). Contractile responses through Gs-coupled receptors are reduced by phosphodiesterase3 activity in human isolated myocardium. Compartmentalization of cyclic AMP signalling, Cambridge, U.K., 29-30 March, 2006. |
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2006 Journal Article Cardiac implications for the use of beta(2)-adrenoceptor agonists for the management of muscle wastingMolenaar, Peter, Chen, Lu and Parsonage, William A. (2006). Cardiac implications for the use of beta(2)-adrenoceptor agonists for the management of muscle wasting. British Journal of Pharmacology, 147 (6), 583-586. doi: 10.1038/sj.bjp.0706670 |
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2006 Conference Publication Beta1-adrenoceptor (AR) Arg389Gly polymorphisms affect responses to carvedilol in patients with idiopathic dilated cardiomyopathyChen, L., Meyers, D., Semmler, A.B., Yang, I., Pakorn, L., Lucas, M., Jovarsky, G., Savarimuthu, S., Galbraith, A., Parsonage, W. and Molenaar, P. (2006). Beta1-adrenoceptor (AR) Arg389Gly polymorphisms affect responses to carvedilol in patients with idiopathic dilated cardiomyopathy. 15th World Congress of Pharmacology, Beijing, China, 2nd - 7th July, 2006. China: Chinese Pharmacological Society. |
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2006 Journal Article Carvedilol blocks beta(2)- more than beta(1)-adrenoceptors in human heartMolenaar, Peter, Christ, Torsten, Ravens, Ursula and Kaumann, Alberto (2006). Carvedilol blocks beta(2)- more than beta(1)-adrenoceptors in human heart. Cardiovascular Research, 69 (1), 128-139. doi: 10.1016/j.cardiores.2005.08.024 |
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2006 Conference Publication Human heart Beta-adrenoceptors:-Beta1-adrenoceptor diversification through 'affinity states' and polymorphismMolenaar, P., Chen, Lu, Semmler, A. B., Parsonage, W. A. and Kaumann, A. (2006). Human heart Beta-adrenoceptors:-Beta1-adrenoceptor diversification through 'affinity states' and polymorphism. The Australian Health & Medical Research Congress, Melbourne, Australia, 26 November - 1 December, 2006. Australia: Australian Govenment NHMRC. |
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2006 Conference Publication Human heart beta1-adrenoceptor heterogeneity - diversification through 'affinity states' and polymorphismMolenaar, P., Chen, L., Semmler, A. B., Parsonage, W. A. and Kaumann, A. (2006). Human heart beta1-adrenoceptor heterogeneity - diversification through 'affinity states' and polymorphism. 15th World Congress of Pharmacology, Beijing, China, 7 - 9 July, 2006. China: Institute of Vascular Medicine. |
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2005 Journal Article Fundamental considerations of beta-adrenoceptor subtypes in human heart failureMolenaar, P and Parsonage, WA (2005). Fundamental considerations of beta-adrenoceptor subtypes in human heart failure. Trends In Pharmacological Sciences, 26 (7), 368-375. doi: 10.1016/j.tips.2005.05.005 |
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2005 Conference Publication Carvedilol causes greater persistent blockage of beta2- than beta1-adrenoceptors in human failing myocardiumKaumann, A. J., Christ, T., Ravens, U. and Molenaar, P. (2005). Carvedilol causes greater persistent blockage of beta2- than beta1-adrenoceptors in human failing myocardium. BPS Summer Meeting 2005, Cambridge, U.K., July, 2005. |
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2005 Journal Article Cardiovascular actions of the venom from the Irukandji (Carukia barnesi) jellyfish: Effects in human, rat and guinea-pig tissues in vitro and in pigs in vivoWinkel, KD, Tibballs, J, Molenaar, P, Lambert, G, Coles, P, Ross-Smith, M, Wiltshire, C, Fenner, PJ, Gershwin, LA, Hawdon, GM, Wright, CE and Angus, JA (2005). Cardiovascular actions of the venom from the Irukandji (Carukia barnesi) jellyfish: Effects in human, rat and guinea-pig tissues in vitro and in pigs in vivo. Clinical And Experimental Pharmacology And Physiology, 32 (9), 777-788. doi: 10.1111/j.1440-1681.2005.04258.x |
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2005 Conference Publication Rationale for treatment of heart failure by blockade of ventricular serotonin receptors appearing in heart failureQvigstad, E., Brattelid, T., Sjaastad, I., Molenaar, P., Birkeland, J. A., Andressen, K. W., Krobert, K. A., Sejersted, O. M., Skomedal, T., Osnes, J-B., Kaumann, A. J. and Levy, F. O. (2005). Rationale for treatment of heart failure by blockade of ventricular serotonin receptors appearing in heart failure. International Soc for Heart Research, European Section Mtg, Norway, 21-25 Jun, 2005. Italy: Medimond International. |
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2005 Journal Article Activation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin IILi, J., Wang, J. C., Russell, F. D. and Molenaar, P. (2005). Activation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin II. British Journal of Pharmacology, 145 (4), 432-440. doi: 10.1038/sj.bjp.0706217 |
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2005 Conference Publication Carvedilol blocks beta2-adrenoceptors more than beta1-adrenoceptors in human atriumKaumann, A. J. and Molenaar, P. (2005). Carvedilol blocks beta2-adrenoceptors more than beta1-adrenoceptors in human atrium. BPS Summer Meeting 2005, Cambridge, U.K., July, 2005. |
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2005 Conference Publication Carvedilol blocks beta2- more than beta1-adrenoceptors in human heartMolenaar, P., Christ, T., Ravens, U., Chen, L. and Kaumann, A. (2005). Carvedilol blocks beta2- more than beta1-adrenoceptors in human heart. Joint Meeting of ASCEPT & APSA, Melbourne, Australia, 4 - 7 Dec, 2005. Australia: ASCEPT. |
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2004 Journal Article Cardiovascular actions of human urotensin II - considerations for hypertensionRussell, F. D. and Molenaar, P. (2004). Cardiovascular actions of human urotensin II - considerations for hypertension. Naunyn-Schmiedebergs Archives of Pharmacology, 369 (3), 271-273. doi: 10.1007/s00210-004-0876-y |
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2004 Conference Publication Investigation of urotensin-II converting enzyme activity in human cells and bloodKearns, P., Russell, F. D., Toth, I. and Molenaar, P. (2004). Investigation of urotensin-II converting enzyme activity in human cells and blood. 8th Annual Scientific Sessions of the Latin American Section of the International-Society for Heart Research, Brisbane, Qld, Australia, 7th - 11th August, 2004. United Kingdom: Academic Press. doi: 10.1016/j.yjmcc.2004.05.003 |
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2004 Conference Publication Regulatory myosin light chain signaling pathways in urotensin-II-mediated positive inotropic effect in human right atriumRussell, F. D. and Molenaar, P. (2004). Regulatory myosin light chain signaling pathways in urotensin-II-mediated positive inotropic effect in human right atrium. 2004 ISHR World Congress Meeting, Brisbane, Qld, Australia, 7 - 11 August, 2004. London, England: Academic Press. doi: 10.1016/j.yjmcc.2004.05.003 |
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2004 Journal Article Investigation of signaling pathways that mediate the inotropic effect of urotensin-II in human heartRussell, FD and Molenaar, P (2004). Investigation of signaling pathways that mediate the inotropic effect of urotensin-II in human heart. Cardiovascular Research, 63 (4), 673-681. doi: 10.1016/j.cardiores.2004.05.009 |
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2004 Journal Article Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failureBrattelid, T, Qvigstad, E, Lynham, JA, Molenaar, P, Aass, H, Geiran, O, Skomedal, T, Osnes, JB, Levy, FO and Kaumann, AJ (2004). Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure. Naunyn-Schmiedeberg's Arch Pharmacol, 370 (3), 157-166. doi: 10.1007/s00210-004-0963-0 |
