Overview
Background
I received PhD (with distinction) in 2014 from The Institute of Biotechnology at The University of Helsinki, Finland, studying membrane traffickign using advanced imaging techniques. In 2015, I relocated to The Queensland Brain Institute (QBI) at The University of Queensland (UQ), Brisbane, Australia for postdoctoral training and changed my research field from basic cell biology to neuroscience and super-resolution imaging. I was awarded a 3-year Academy of Finland Postdoctoral Fellowship (2016) and an ARC DECRA Award (2019) to study the role of a lipid modifying enzyme on neuronal function. In 2022, I became a UQ Amplify Fellow and Group Leader in a joint Australian Institute for Bioengineering and Nanotechnology (AIBN) and QBI. My lab aims to understand two central biological questions: how lipid metabolism in the brain supports cognition, learning and memory, and how bidirectional modulation of neuronal lipid functions can be used as a therapeutic strategy for inherited neurodevelopmental disorders, neuroparalytic disorders caused by bacterial toxins and infectious diseases cause by neurotropic and respiratory viruses.
Availability
- Dr Merja Joensuu is:
- Available for supervision
Qualifications
- Doctor of Philosophy, University of Helsinki*
Research impacts
My laboratory focuses on how lipids and proteins affect cellular and neuronal membrane trafficking and energy metabolism, and how neurotoxins and viruses exploit cellular endocytic machinery to gain access into cells. We use in vitro cell and primary neuron cultures as our main model system, allowing us to address the effects of pharmacological perturbations and genetic disease conditions on cellular functions. My team uses a combination of imaging techniques, including electron microscopy, confocal imaging and live-cell super-resolution microscopy, as well as molecular approaches, to understand how cells function in health and disease, which is critical for discovering novel therapeutic strategies for the treatment of disease, viral infections and neurointoxication pathologies.
Works
Search Professor Merja Joensuu’s works on UQ eSpace
2019
Journal Article
Phospholipases in neuronal function: a role in learning and memory?
Joensuu, Merja, Wallis, Tristan P., Saber, Saber H. and Meunier, Frédéric A. (2019). Phospholipases in neuronal function: a role in learning and memory?. Journal of Neurochemistry, 153 (3) jnc.14918, e14918-333. doi: 10.1111/jnc.14918
2019
Journal Article
GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation
Witkos, Tomasz M., Chan, Wing Lee, Joensuu, Merja, Rhiel, Manuel, Pallister, Ed, Thomas-Oates, Jane, Mould, A. Paul, Mironov, Alex A., Biot, Christophe, Guerardel, Yann, Morelle, Willy, Ungar, Daniel, Wieland, Felix T., Jokitalo, Eija, Tassabehji, May, Kornak, Uwe and Lowe, Martin (2019). GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation. Nature Communications, 10 (1) 127, 127. doi: 10.1038/s41467-018-08044-6
2019
Journal Article
VAMP2 Binding to Munc18-1 Domain 3a Controls the Nanoscale Reorganization of the Plasma Membrane and Vesicle Interface During Vesicular Priming
Kasula, Ravikiran, Blum, Ailisa, Salla-Martret, Merce, Chai, Ye Jin, Jiang, Anmin, Wallis, Tristan P., Gormal, Rachel S., Brouillet, Julie Z., Padmanabhan, Pranesh, Weeratunga, Saroja K., Livingstone, Emma K., Mollazade, Mahdie, Joensuu, Merja, Martínez-Mármol, Ramón, Collins, Brett M. and Meunier, Frederic (2019). VAMP2 Binding to Munc18-1 Domain 3a Controls the Nanoscale Reorganization of the Plasma Membrane and Vesicle Interface During Vesicular Priming. SSRN Electronic Journal. doi: 10.2139/ssrn.3362260
2018
Journal Article
Dendritic spine actin cytoskeleton in autism spectrum disorder
Joensuu, Merja, Lanoue, Vanessa and Hotulainen, Pirta (2018). Dendritic spine actin cytoskeleton in autism spectrum disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 84 (Pt B), 362-381. doi: 10.1016/j.pnpbp.2017.08.023
2018
Conference Publication
Super-resolving botulinum neurotoxin type A molecules: from surface landing to internalization in synaptic vesicles
Joensuu, Merja, Blum, Ailisa, Mollazade, Mahdie, Lanoue, Vanessa, Padmanabhan, Pranesh, Small, Christopher, Mahrhold, Stefan, Krez, Nadja, Rummel, Andreas and Meunier, Frederic A. (2018). Super-resolving botulinum neurotoxin type A molecules: from surface landing to internalization in synaptic vesicles. TOXINS 2019: Basic Science and Clinical Aspects of Botulinum and Other Neurotoxins, Copenhagen, Denmark, 16-19 January 2019. Kidlington, Oxford, United Kingdom: Pergamon Press. doi: 10.1016/j.toxicon.2018.11.122
2017
Journal Article
Visualizing endocytic recycling and trafficking in live neurons by subdiffractional tracking of internalized molecules
Joensuu, Merja, Martinez-Marmol, Ramon, Padmanabhan, Pranesh, Glass, Nick R., Durisic, Nela, Pelekanos, Matthew, Mollazade, Mahdie, Balistreri, Giuseppe, Amor, Rumelo, Cooper-White, Justin J., Goodhill, Geoffrey J. and Meunier, Frederic A. (2017). Visualizing endocytic recycling and trafficking in live neurons by subdiffractional tracking of internalized molecules. Nature Protocols, 12 (12), 2590-2622. doi: 10.1038/nprot.2017.116
2017
Conference Publication
Nanoscale imaging of botulinum neurotoxin type a retrograde axonal trafficking
Harper, Callista B., Wang, Tong, Joensuu, Merja, Papadopulos, Andreas and Meunier, Frederic A. (2017). Nanoscale imaging of botulinum neurotoxin type a retrograde axonal trafficking. TOXINS: Basic Science and Clinical Aspects of Botulinum and other Neurotoxins, Madrid, Spain, 18-21 January 2017. Oxford, United Kingdom: Pergamon Press. doi: 10.1016/j.toxicon.2016.11.106
2016
Journal Article
Subdiffractional tracking of internalized molecules reveals heterogeneous motion states of synaptic vesicles
Joensuu, Merja, Padmanabhan, Pranesh, Durisic, Nela, Bademosi, Adekunle T. D., Cooper-Williams, Elizabeth, Morrow, Isabel C., Harper, Callista B., Jung, WooRam, Parton, Robert G., Goodhill, Geoffrey J., Papadopulos, Andreas and Meunier, Frederic A. (2016). Subdiffractional tracking of internalized molecules reveals heterogeneous motion states of synaptic vesicles. Journal of Cell Biology, 215 (2), 277-292. doi: 10.1083/jcb.201604001
2016
Journal Article
NOGO-A/RTN4A and NOGO-B/RTN4B are simultaneously expressed in epithelial, fibroblast and neuronal cells and maintain ER morphology
Ramo, Olli, Kumar, Darshan, Gucciardo, Erika, Joensuu, Merja, Saarekas, Maiju, Vihinen, Helena, Belevich, Ilya, Smolander, Olli-Pekka, Qian, Kui, Auvinen, Petri and Jokitalo, Eija (2016). NOGO-A/RTN4A and NOGO-B/RTN4B are simultaneously expressed in epithelial, fibroblast and neuronal cells and maintain ER morphology. Scientific Reports, 6 (1) 35969. doi: 10.1038/srep35969
2016
Journal Article
Microscopy image browser: a platform for segmentation and analysis of multidimensional datasets
Belevich, Ilya, Joensuu, Merja, Kumar, Darshan, Vihinen, Helena and Jokitalo, Eija (2016). Microscopy image browser: a platform for segmentation and analysis of multidimensional datasets. PLoS Biology, 14 (1) e1002340, e1002340. doi: 10.1371/journal.pbio.1002340
2015
Journal Article
ER sheet-tubule balance is regulated by an array of actin filaments and microtubules
Joensuu, Merja and Jokitalo, Eija (2015). ER sheet-tubule balance is regulated by an array of actin filaments and microtubules. Experimental Cell Research, 337 (2), 170-178. doi: 10.1016/j.yexcr.2015.04.009
2015
Journal Article
Genome-wide RNAi screen for nuclear actin reveals a network of cofilin regulators
Dopie, Joseph, Rajakyla, Eeva K., Joensuu, Merja S., Huet, Guillaume, Ferrantelli, Evelina, Xie, Tiao, Jaalinoja, Harri, Jokitalo, Eija and Vartiainen, Maria K. (2015). Genome-wide RNAi screen for nuclear actin reveals a network of cofilin regulators. Journal of Cell Science, 128 (13), 2388-2400. doi: 10.1242/jcs.169441
2014
Journal Article
ER sheet persistence is coupled to myosin 1c-regulated dynamic actin filament arrays
Joensuu, Merja, Belevich, Ilya, Ramo, Olli, Nevzorov, Ilya, Vihinen, Helena, Puhka, Maija, Witkos, Tomasz M., Lowe, Martin, Vartiainen, Maria K. and Jokitalo, Eija (2014). ER sheet persistence is coupled to myosin 1c-regulated dynamic actin filament arrays. Molecular Biology of the Cell, 25 (7), 1111-1126. doi: 10.1091/mbc.E13-12-0712
2012
Journal Article
Progressive sheet-to-tubule transformation is a general mechanism for endoplasmic reticulum partitioning in dividing mammalian cells
Puhka, Maija, Joensuu, Merja, Vihinen, Helena, Belevich, Ilya and Jokitalo, Eija (2012). Progressive sheet-to-tubule transformation is a general mechanism for endoplasmic reticulum partitioning in dividing mammalian cells. Molecular Biology of the Cell, 23 (13), 2424-2432. doi: 10.1091/mbc.E10-12-0950
2007
Journal Article
Endoplasmic reticulum remains continuous and undergoes sheet-to-tubule transformation during cell division in mammalian cells
Puhka, Maija, Vihinen, Helena, Joensuu, Merja and Jokitalo, Eija (2007). Endoplasmic reticulum remains continuous and undergoes sheet-to-tubule transformation during cell division in mammalian cells. Journal of Cell Biology, 179 (5), 895-909. doi: 10.1083/jcb.200705112
Funding
Past funding
Supervision
Availability
- Dr Merja Joensuu is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Secretory pathway membrane trafficking and lipid metabolism in health and disease
Principal Advisor
-
Doctor Philosophy
The role of saturated free fatty acids in learning and memory
Principal Advisor
Completed supervision
-
2022
Doctor Philosophy
Characterization and role of lateral trapping and nanocluster organization of the endocytic machinery
Associate Advisor
Other advisors: Professor Frederic Meunier
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2022
Doctor Philosophy
Identifying Key Changes in Brain Free Fatty Acids Associated with Memory in Health, Ageing and Disease: A Mechanistic Study
Associate Advisor
Other advisors: Dr Tristan Wallis, Professor Frederic Meunier
Media
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