Overview
Background
Dr Jian Zeng is a statistical geneticist and NHMRC Emerging Leadership Fellow at the Institute for Molecular Bioscience (IMB) at the University of Queensland (UQ). He received his PhD in animal breeding and genetics at Iowa State University and joined the Program in Complex Trait Genomics (PCTG) at UQ in 2016. His research focuses on the development and application of innovative statistical methods for estimating the genetic architecture and evolutionary signals in complex traits, identifying genetic variants, genes and other molecular intermediates associated with phenotype variation, and predicting trait phenotypes using genome sequence data. In 2019, he was awarded an NHMRC Investigator Emerging Leadership Grant to develop statistical methods and software tools for best predict an individual’s disease risk using genomic and omics data. He was an invited speaker at the prestigious Gordon Research Conference in 2019.
Availability
- Dr Jian Zeng is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, University of Iowa
Research interests
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Understanding genetic architecture and evolution of complex traits
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Prediction of polygenic scores of complex traits and diseases
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Mapping causal variants, genes and regulatory elements using multi-omics data
Works
Search Professor Jian Zeng’s works on UQ eSpace
Featured
2023
Journal Article
HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function
Friedman, Clayton E., Cheetham, Seth W., Negi, Sumedha, Mills, Richard J., Ogawa, Masahito, Redd, Meredith A., Chiu, Han Sheng, Shen, Sophie, Sun, Yuliangzi, Mizikovsky, Dalia, Bouveret, Romaric, Chen, Xiaoli, Voges, Holly K., Paterson, Scott, De Angelis, Jessica E., Andersen, Stacey B., Cao, Yuanzhao, Wu, Yang, Jafrani, Yohaann M.A., Yoon, Sohye, Faulkner, Geoffrey J., Smith, Kelly A., Porrello, Enzo, Harvey, Richard P., Hogan, Benjamin M., Nguyen, Quan, Zeng, Jian, Kikuchi, Kazu, Hudson, James E. and Palpant, Nathan J. (2023). HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function. Developmental Cell, 59 (1), 91-107.e1. doi: 10.1016/j.devcel.2023.11.012
2023
Journal Article
Developing flexible models for genetic evaluations in smallholder crossbred dairy farms
Costilla, R., Zeng, J., Al Kalaldeh, M., Swaminathan, M., Gibson, J.P., Ducrocq, V. and Hayes, B.J. (2023). Developing flexible models for genetic evaluations in smallholder crossbred dairy farms. Journal of Dairy Science, 106 (12), 9125-9135. doi: 10.3168/jds.2022-23135
2023
Journal Article
Learning functional conservation between human and pig to decipher evolutionary mechanisms underlying gene expression and complex traits
Li, Jinghui, Zhao, Tianjing, Guan, Dailu, Pan, Zhangyuan, Bai, Zhonghao, Teng, Jinyan, Zhang, Zhe, Zheng, Zhili, Zeng, Jian, Zhou, Huaijun, Fang, Lingzhao and Cheng, Hao (2023). Learning functional conservation between human and pig to decipher evolutionary mechanisms underlying gene expression and complex traits. Cell Genomics, 3 (10) 100390. doi: 10.1016/j.xgen.2023.100390
2023
Conference Publication
Advances In Polygenic Score Methods And Applications In Psychiatric Genetics
Vilhjalmsson, Bjarni, Zeng, Jian and Wray, Naomi (2023). Advances In Polygenic Score Methods And Applications In Psychiatric Genetics. World Congress of Psychiatric Genetics WCPG 2023, Montreal, QC Canada, 10-14 October 2023. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2023.08.062
2023
Conference Publication
IDENTIFICATION OF CELL TYPES AND CELLULAR DYNAMICS GENETICALLY ASSOCIATED WITH BRAIN DISORDERS AND COGNITIVE TRAITS
Yao, Shuyang, Harder, Arvid, Darki, Fahimeh, Li, Ang, Zeng, Jian, Nikouei, Kasra, Lundstrom, Johan, Wray, Naomi, Lu, Yi, Sullivan, Patrick and Hjerling-Leffler, Jens (2023). IDENTIFICATION OF CELL TYPES AND CELLULAR DYNAMICS GENETICALLY ASSOCIATED WITH BRAIN DISORDERS AND COGNITIVE TRAITS. World Congress of Psychiatric Genetics (WCPG), Montreal Canada, Oct 10-14, 2023. AMSTERDAM: ELSEVIER. doi: 10.1016/j.euroneuro.2023.08.160
2023
Conference Publication
Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries
Zeng, Jian, Zheng, Zhili, Liu, Shouye, Sidorenko, Julia, Yengo, Loic, Turley, Patrick, Ani, Alireza, Wang, Rujia, Nolte, Ilja, Snieder, Harold, Yang, Jian, Wray, Naomi, Goddard, Michael and Visscher, Peter (2023). Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries. World Congress of Psychiatric Genetics (WCPG), Montreal, ON, Canada, 10 - 14 October 2023. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/j.euroneuro.2023.08.063
2023
Conference Publication
Highlighting human brain cell types and regions for the genetic risk of schizophrenia and other psychiatric disorders
Yao, Shuyang, Harder, Arvid, Darki, Fahimeh, Li, Ang, Zeng, Jian, Nikouei, Kasra, Lundström, Johan, Wray, Naomi, Lu, Yi, Sullivan, Patrick and Hjerling-Leffler, Jens (2023). Highlighting human brain cell types and regions for the genetic risk of schizophrenia and other psychiatric disorders. World Congress of Psychiatric Genetics (WCPG) 2023, Montreal, Canada, 10-14 October 2023. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2023.08.161
2023
Journal Article
Leveraging base-pair mammalian constraint to understand genetic variation and human disease
Sullivan, Patrick F., Meadows, Jennifer R. S., Gazal, Steven, Phan, BaDoi N., Li, Xue, Genereux, Diane P., Dong, Michael X., Bianchi, Matteo, Andrews, Gregory, Sakthikumar, Sharadha, Nordin, Jessika, Roy, Ananya, Christmas, Matthew J., Marinescu, Voichita D., Wang, Chao, Wallerman, Ola, Xue, James, Yao, Shuyang, Sun, Quan, Szatkiewicz, Jin, Wen, Jia, Huckins, Laura M., Lawler, Alyssa, Keough, Kathleen C., Zheng, Zhili, Zeng, Jian, Wray, Naomi R., Li, Yun, Johnson, Jessica ... Zoonomia Consortium§ (2023). Leveraging base-pair mammalian constraint to understand genetic variation and human disease. Science, 380 (6643) eabn2937, 1-12. doi: 10.1126/science.abn2937
2022
Journal Article
Genetic control of RNA splicing and its distinct role in complex trait variation
Qi, Ting, Wu, Yang, Fang, Hailing, Zhang, Futao, Liu, Shouye, Zeng, Jian and Yang, Jian (2022). Genetic control of RNA splicing and its distinct role in complex trait variation. Nature Genetics, 54 (9), 1355-1363. doi: 10.1038/s41588-022-01154-4
2022
Journal Article
Extend mixed models to multilayer neural networks for genomic prediction including intermediate omics data
Zhao, Tianjing, Zeng, Jian and Cheng, Hao (2022). Extend mixed models to multilayer neural networks for genomic prediction including intermediate omics data. Genetics, 221 (1) iyac034. doi: 10.1093/genetics/iyac034
2022
Journal Article
Comparative Analysis Reveals Novel Changes in Plasma Metabolites and Metabolomic Networks of Infants With Retinopathy of Prematurity
Yang, Yuhang, Yang, Qian, Luo, Sisi, Zhang, Yinsheng, Lian, Chaohui, He, Honghui, Zeng, Jian and Zhang, Guoming (2022). Comparative Analysis Reveals Novel Changes in Plasma Metabolites and Metabolomic Networks of Infants With Retinopathy of Prematurity. Investigative Ophthalmology & Visual Science, 63 (1) 28. doi: 10.1167/iovs.63.1.28
2021
Journal Article
A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts
Ni, Guiyan, Zeng, Jian, Revez, Joana A., Wang, Ying, Zheng, Zhili, Ge, Tian, Restuadi, Restuadi, Kiewa, Jacqueline, Nyholt, Dale R., Coleman, Jonathan R.I., Smoller, Jordan W., Yang, Jian, Visscher, Peter M. and Wray, Naomi R. (2021). A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts. Biological Psychiatry, 90 (9), 611-620. doi: 10.1016/j.biopsych.2021.04.018
2021
Journal Article
Tumor mutational burden is polygenic and genetically associated with complex traits and diseases
Sun, Xiwei, Xue, Angli, Qi, Ting, Chen, Dan, Shi, Dandan, Wu, Yang, Zheng, Zhili, Zeng, Jian and Yang, Jian (2021). Tumor mutational burden is polygenic and genetically associated with complex traits and diseases. Cancer Research, 81 (5) canres.3459.2020, 12230-1239. doi: 10.1158/0008-5472.can-20-3459
2021
Journal Article
Analysis of common genetic variation and rare CNVs in the Australian Autism Biobank
Yap, Chloe X., Alvares, Gail A., Henders, Anjali K., Lin, Tian, Wallace, Leanne, Farrelly, Alaina, McLaren, Tiana, Berry, Jolene, Vinkhuyzen, Anna A. E., Trzaskowski, Maciej, Zeng, Jian, Yang, Yuanhao, Cleary, Dominique, Grove, Rachel, Hafekost, Claire, Harun, Alexis, Holdsworth, Helen, Jellett, Rachel, Khan, Feroza, Lawson, Lauren, Leslie, Jodie, Levis Frenk, Mira, Masi, Anne, Mathew, Nisha E., Muniandy, Melanie, Nothard, Michaela, Visscher, Peter M., Dawson, Paul A., Dissanayake, Cheryl ... Gratten, Jacob (2021). Analysis of common genetic variation and rare CNVs in the Australian Autism Biobank. Molecular Autism, 12 (1) 12, 12. doi: 10.1186/s13229-020-00407-5
2021
Journal Article
Effect of veneer initial moisture content on the performance of polyethylene film reinforced decorative veneer
Fang, Lu, Zeng, Jian, Zhang, Xinhao and Wang, Dan (2021). Effect of veneer initial moisture content on the performance of polyethylene film reinforced decorative veneer. Forests, 12 (1) 102, 1-9. doi: 10.3390/f12010102
2021
Journal Article
Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes
Xue, Angli, Jiang, Longda, Zhu, Zhihong, Wray, Naomi R., Visscher, Peter M., Zeng, Jian and Yang, Jian (2021). Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes. Nature Communications, 12 (1) 6450, 6450. doi: 10.1038/s41467-020-20237-6
2020
Journal Article
Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data
Wu, Yang, Qi, Ting, Wang, Huanwei, Zhang, Futao, Zheng, Zhili, Phillips-Cremins, Jennifer E., Deary, Ian J., McRae, Allan F., Wray, Naomi R., Zeng, Jian and Yang, Jian (2020). Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data. Nature Communications, 11 (1) 2061, 1-12. doi: 10.1038/s41467-020-15587-0
2020
Journal Article
Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration
Revez, Joana A., Lin, Tian, Qiao, Zhen, Xue, Angli, Holtz, Yan, Zhu, Zhihong, Zeng, Jian, Wang, Huanwei, Sidorenko, Julia, Kemper, Kathryn E., Vinkhuyzen, Anna A. E., Frater, Julanne, Eyles, Darryl, Burne, Thomas H. J., Mitchell, Brittany, Martin, Nicholas G., Zhu, Gu, Visscher, Peter M., Yang, Jian, Wray, Naomi R. and McGrath, John J. (2020). Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration. Nature Communications, 11 (1) 1647, 1-12. doi: 10.1038/s41467-020-15421-7
2019
Journal Article
Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank
Wang, Huanwei, Zhang, Futao, Zeng, Jian, Wu, Yang, Kemper, Kathryn E., Xue, Angli, Zhang, Min, Powell, Joseph E., Goddard, Michael E., Wray, Naomi R., Visscher, Peter M., McRae, Allan F. and Yang, Jian (2019). Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank. Science Advances, 5 (8) eaaw3538, 1-12. doi: 10.1126/sciadv.aaw3538
2019
Journal Article
The effect of X-linked dosage compensation on complex trait variation
Sidorenko, Julia, Kassam, Irfahan, Kemper, Kathryn E., Zeng, Jian, Lloyd-Jones, Luke R., Montgomery, Grant W., Gibson, Greg, Metspalu, Andres, Esko, Tonu, Yang, Jian, McRae, Allan F. and Visscher, Peter M. (2019). The effect of X-linked dosage compensation on complex trait variation. Nature Communications, 10 (1) 3009, 3009. doi: 10.1038/s41467-019-10598-y
Supervision
Availability
- Dr Jian Zeng is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Genetic architecture and evolution of complex traits across populations in humans
Principal Advisor
Other advisors: Professor Peter Visscher, Professor Naomi Wray, Dr Fleur Garton
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Doctor Philosophy
Integrating GWAS and Molecular QTL Data to Dissect the Genetic Architecture and Improve Polygenic Prediction
Principal Advisor
Other advisors: Professor Peter Visscher
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Doctor Philosophy
Spatial transcriptomics and Single-cell Interaction Analysis
Associate Advisor
Other advisors: Dr Laura Grice, Dr Laura Genovesi, Dr Quan Nguyen
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Doctor Philosophy
Using genomic data and epigenetic annotations to identify genetic causes of cell differentiation
Associate Advisor
Other advisors: Professor Nathan Palpant, Dr Amy Hanna
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Doctor Philosophy
Novel methods and data integration to understand the causes of Amyotrophic Lateral Sclerosis
Associate Advisor
Other advisors: Dr Allan McRae, Dr Fleur Garton
Completed supervision
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2024
Doctor Philosophy
Development and application of statistical methods to identify genes and cell types associated with complex traits
Principal Advisor
Other advisors: Professor Naomi Wray
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2024
Doctor Philosophy
The influence of genetic and environmental factors on inter-individual and inter-population variations
Principal Advisor
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2025
Doctor Philosophy
Understanding the pathophysiology of stroke using bioinformatics and statistical genetics
Associate Advisor
Other advisors: Associate Professor Asaduzzaman Khan, Dr Mohammad Ali Moni
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2021
Doctor Philosophy
Identification of genetic and modifiable risk factors for complex diseases
Associate Advisor
Media
Enquiries
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