|
2024 Journal Article Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestriesZheng, Zhili, Liu, Shouye, Sidorenko, Julia, Wang, Ying, Lin, Tian, Yengo, Loic, Turley, Patrick, Ani, Alireza, Wang, Rujia, Nolte, Ilja M., Snieder, Harold, Aguirre-Gamboa, Raul, Deelen, Patrick, Franke, Lude, Kuivenhoven, Jan A., Lopera Maya, Esteban A., Sanna, Serena, Swertz, Morris A., Vonk, Judith M., Wijmenga, Cisca, Yang, Jian, Wray, Naomi R., Goddard, Michael E., Visscher, Peter M., Zeng, Jian and LifeLines Cohort Study (2024). Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries. Nature Genetics, 56 (5), 1-11. doi: 10.1038/s41588-024-01704-y |
|
2023 Journal Article Joint analysis of GWAS and multi-omics QTL summary statistics reveals a large fraction of GWAS signals shared with molecular phenotypesWu, Yang, Qi, Ting, Wray, Naomi R., Visscher, Peter M., Zeng, Jian and Yang, Jian (2023). Joint analysis of GWAS and multi-omics QTL summary statistics reveals a large fraction of GWAS signals shared with molecular phenotypes. Cell Genomics, 3 (8) 100344, 100344. doi: 10.1016/j.xgen.2023.100344 |
|
2023 Journal Article mBAT-combo: a more powerful test to detect gene-trait associations from GWAS dataLi, Ang, Liu, Shouye, Bakshi, Andrew, Jiang, Longda, Chen, Wenhan, Zheng, Zhili, Sullivan, Patrick F., Visscher, Peter M., Wray, Naomi R., Yang, Jian and Zeng, Jian (2023). mBAT-combo: a more powerful test to detect gene-trait associations from GWAS data. American Journal of Human Genetics, 110 (1), 30-43. doi: 10.1016/j.ajhg.2022.12.006 |
|
2021 Journal Article Widespread signatures of natural selection across human complex traits and functional genomic categoriesZeng, Jian, Xue, Angli, Jiang, Longda, Lloyd-Jones, Luke R., Wu, Yang, Wang, Huanwei, Zheng, Zhili, Yengo, Loic, Kemper, Kathryn E., Goddard, Michael E., Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2021). Widespread signatures of natural selection across human complex traits and functional genomic categories. Nature Communications, 12 (1) 1164, 1-12. doi: 10.1038/s41467-021-21446-3 |
|
2021 Journal Article Correction: Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changesXue, Angli, Jiang, Longda, Zhu, Zhihong, Wray, Naomi R., Visscher, Peter M., Zeng, Jian and Yang, Jian (2021). Correction: Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes. Nature Communications, 12 (1) 988, 988. doi: 10.1038/s41467-021-21294-1 |
|
2019 Journal Article Improved polygenic prediction by Bayesian multiple regression on summary statisticsLloyd-Jones, Luke R., Zeng, Jian, Sidorenko, Julia, Yengo, Loïc, Moser, Gerhard, Kemper, Kathryn E., Wang, Huanwei, Zheng, Zhili, Magi, Reedik, Esko, Tõnu, Metspalu, Andres, Wray, Naomi R., Goddard, Michael E., Yang, Jian and Visscher, Peter M. (2019). Improved polygenic prediction by Bayesian multiple regression on summary statistics. Nature Communications, 10 (1) 5086, 1-10. doi: 10.1038/s41467-019-12653-0 |
|
2018 Journal Article Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetesXue, Angli, Wu, Yang, Zhu, Zhihong, Zhang, Futao, Kemper, Kathryn E., Zheng, Zhili, Yengo, Loic, Lloyd-Jones, Luke R., Sidorenko, Julia, Wu, Yeda, eQTLGen Consortium, McRae, Allan F., Visscher, Peter M., Zeng, Jian and Yang, Jian (2018). Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. Nature Communications, 9 (1) 2941, 2941. doi: 10.1038/s41467-018-04951-w |
|
2018 Journal Article Signatures of negative selection in the genetic architecture of human complex traitsZeng, Jian, de Vlaming, Ronald, Wu, Yang, Robinson, Matthew R., Lloyd-Jones, Luke R., Yengo, Loic, Yap, Chloe X., Xue, Angli, Sidorenko, Julia, McRae, Allan F., Powell, Joseph E., Montgomery, Grant W., Metspalu, Andres, Esko, Tonu, Gibson, Greg, Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2018). Signatures of negative selection in the genetic architecture of human complex traits. Nature Genetics, 50 (5), 746-753. doi: 10.1038/s41588-018-0101-4 |
|
2018 Journal Article Integrative analysis of omics summary data reveals putative mechanisms underlying complex traitsWu, Yang, Zeng, Jian, Zhang, Futao, Zhu, Zhihong, Qi, Ting, Zheng, Zhili, Lloyd-Jones, Luke R., Marioni, Riccardo E., Martin, Nicholas G., Montgomery, Grant W., Deary, Ian J., Wray, Naomi R., Visscher, Peter M., McRae, Allan F. and Yang, Jian (2018). Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits. Nature Communications, 9 (918) 918, 918. doi: 10.1038/s41467-018-03371-0 |
|
2026 Journal Article Sleep chart of biological ageing clocks in middle and late lifeThe MULTI Consortium, O’Toole, Cliodhna Kate, Song, Zhiyuan, Anagnostakis, Filippos, Yang, Zhijian, Tian, Ye Ella, Duggan, Michael R., Zou, Chunrui, Leng, Yue, Cai, Yi, Bai, Wenjia, Fu, Cynthia H. Y., Rafii, Michael S., Aisen, Paul, Wang, Gao, De Jager, Philip L., Zeng, Jian, Oh, Hamilton Se-Hwee, Zhou, Xia, Walker, Keenan A., Belsky, Daniel W., Zalesky, Andrew, Simonsick, Eleanor M., Resnick, Susan M., Ferrucci, Luigi, Davatzikos, Christos and Wen, Junhao (2026). Sleep chart of biological ageing clocks in middle and late life. Nature, 1-11. doi: 10.1038/s41586-026-10524-5 |
|
2026 Journal Article Empirical evaluation of analytic validity of polygenic scoresLin, Tian, Zeng, Jian, Gordon, Scott D., Wallace, Leanne, Ziser, Laura, Shah, Sonia, Pain, Oliver, Nolte, Ilja M., Snieder, Harold, Lifelines Cohort Study, Aguirre-Gamboa, Raul, Deelen, Patrick, Franke, Lude, Kuivenhoven, Jan A, Lopera Maya, Esteban A, Sanna, Serena, Swertz, Morris A, Vonk, Judith M, Wijmenga, Cisca, James, Paul A., Martin, Nicholas G., Visscher, Peter M., Lee, Eric, Yengo, Loic, Henders, Anjali K. and Wray, Naomi R. (2026). Empirical evaluation of analytic validity of polygenic scores. Genome Medicine. doi: 10.1186/s13073-026-01654-6 |
|
2026 Journal Article Multi-ancestry genome-wide association analyses of refractive error augment genetic discovery and polygenic predictionCheng, Fei-Fei, Liu, Xiaoxi, Mi, Hao, Wang, Lizhong, Ma, Ruilei, Guo, Yazhou, Sidorenko, Julia, Jiang, Chen, Islam, Tania, Meguro, Akira, Hikino, Keiko, Ishikawa, Yuki, Tang, Senwei, Li, Teng, Chen, Ruoyan, Wang, Likun, Mägi, Reedik, Metspalu, Andres, Estonian Biobank Research Team, Milani, Lili, Esko, Tõnu, Nelis, Mari, Hudjashov, Georgi, 23andMe Research Team, Auton, Adam, Kwong, Alan, Shastri, Anjali J., Hicks, Barry, Weldon, Catherine H. ... Yang, Jian (2026). Multi-ancestry genome-wide association analyses of refractive error augment genetic discovery and polygenic prediction. Nature Genetics, 58 (5), 1030-1039. doi: 10.1038/s41588-026-02576-0 |
|
2026 Journal Article Genome-wide fine-mapping improves identification of causal variantsWu, Yang, Zheng, Zhili, Thibaut, Loic, Lin, Tian, Feng, Qian, Cheng, Hao, Yengo, Loic, Goddard, Michael E., Wray, Naomi R., Visscher, Peter M. and Zeng, Jian (2026). Genome-wide fine-mapping improves identification of causal variants. Nature Genetics, 58 (4), 940-951. doi: 10.1038/s41588-026-02549-3 |
|
2026 Journal Article Distinct genetic profiles influence body mass index between infancy and adolescenceWang, Geng, McEwan, Samuel, Zeng, Jian, Haile-Mariam, Mekonnen, Yengo, Loic, Goddard, Michael E., Kemper, Kathryn E. and Warrington, Nicole M. (2026). Distinct genetic profiles influence body mass index between infancy and adolescence. Nature Communications, 17 (1) 1594, 1-13. doi: 10.1038/s41467-026-69310-6 |
|
2026 Journal Article Multi-organ AI endophenotypes chart the heterogeneity of brain, eye and heart pan-diseaseBoquet-Pujadas, Aleix, MULTI Consortium,, Anagnostakis, Filippos, Yang, Zhijian, Tian, Ye Ella, Duggan, Michael R., Erus, Guray, Srinivasan, Dhivya, Joynes, Cassandra M., Bai, Wenjia, Patel, Praveen J., Walker, Keenan A., Zalesky, Andrew, Davatzikos, Christos, Wen, Junhao, Rafii, Michael S., Aisen, Paul, Ferrucci, Luigi and Zeng, Jian (2026). Multi-organ AI endophenotypes chart the heterogeneity of brain, eye and heart pan-disease. Nature Mental Health, 4 (2), 203-230. doi: 10.1038/s44220-025-00560-x |
|
2026 Journal Article Progress in understanding the biological basis of polygenic disordersWray, Naomi R., Lin, Tian, Li, A., de Almeida, Valéria Correia, Ziller, Michael Johannes and Zeng, Jian (2026). Progress in understanding the biological basis of polygenic disorders. Current Opinion in Genetics and Development, 97 102433. doi: 10.1016/j.gde.2025.102433 |
|
2026 Journal Article Author Correction: Genome-wide fine-mapping improves identification of causal variants (Nature Genetics, (2026), 58, 4, (940-951), 10.1038/s41588-026-02549-3)Wu, Yang, Zheng, Zhili, Thibaut, Loic, Lin, Tian, Feng, Qian, Cheng, Hao, Yengo, Loic, Goddard, Michael E., Wray, Naomi R., Visscher, Peter M. and Zeng, Jian (2026). Author Correction: Genome-wide fine-mapping improves identification of causal variants (Nature Genetics, (2026), 58, 4, (940-951), 10.1038/s41588-026-02549-3). Nature Genetics. doi: 10.1038/s41588-026-02627-6 |
|
2025 Journal Article Estimation and mapping of the missing heritability of human phenotypesWainschtein, Pierrick, Zhang, Yuanxiang, Schwartzentruber, Jeremy, Kassam, Irfahan, Sidorenko, Julia, Fiziev, Petko P., Wang, Huanwei, McRae, Jeremy, Border, Richard, Zaitlen, Noah, Sankararaman, Sriram, Goddard, Michael E., Zeng, Jian, Visscher, Peter M., Farh, Kyle Kai-How and Yengo, Loic (2025). Estimation and mapping of the missing heritability of human phenotypes. Nature, 649 (8099), 1219-1227. doi: 10.1038/s41586-025-09720-6 |
|
2025 Journal Article Conserved facultative heterochromatin across cell types identify regulatory sequences underpinning cell identity and diseaseSinniah, Enakshi, Mizikovsky, Dalia, Shim, Woo Jun, Chow, Chris Siu Yeung, Souilmi, Yassine, Cheng, Fei-Fei, Zeng, Zhili, Laurie, Jordan, Foster, Matthew, Shah, Sonia, Bodén, Mikael, Zeng, Jian, Llamas, Bastien and Palpant, Nathan J. (2025). Conserved facultative heterochromatin across cell types identify regulatory sequences underpinning cell identity and disease. Nucleic Acids Research, 53 (20) gkaf971, 1-23. doi: 10.1093/nar/gkaf971 |
|
2025 Journal Article Brain–heart–eye axis revealed by multi-organ imaging genetics and proteomicsZeng, Jian, Aisen, Paul, Rafii, Michael S., Bai, Wenjia, Ferrucci, Luigi, Tian, Ye Ella, Zalesky, Andrew, Boquet-Pujadas, Aleix, Anagnostakis, Filippos, Duggan, Michael R., Joynes, Cassandra M., Toga, Arthur W., Yang, Zhijian, Walker, Keenan A., Davatzikos, Christos and Wen, Junhao (2025). Brain–heart–eye axis revealed by multi-organ imaging genetics and proteomics. Nature Biomedical Engineering. doi: 10.1038/s41551-025-01506-5 |
