Skip to menu Skip to content Skip to footer
Dr Fleur Garton
Dr

Fleur Garton

Email: 

Overview

Background

Fleur Garton is a researcher focused on improving outcomes for those with a neurological disease. She completed a Bachelor of Applied Science (Hons I) in 2008 at the University of Sydney. Pursing an interest in the molecular basis of skeletal muscle function she completed her honours and PhD at the Institute of Neuroscience and Muscle research at the Children’s Hospital Westmead. Fleur spent two-years as post-doctoral researcher at the Murdoch Childrens Research Institute, Melbourne. She was responsible for modelling the effect of gene dosage using rAAV vectors while helping to contribute to studies on human performance and health. In 2016, Fleur moved to work with Professor Naomi Wray at the Program in Complex Trait Genomics team at the University of Queensland. She was awarded a Bill Gole MND Postdoctoral fellowship from MNDRA in 2016, an NHMRC Early Career Researcher Fellowship (2017-2022) and is now the Scott Sullivan MND Research Fellow (2022). Her research program aims to further understand the genetic mechanisms of motor neurone disease (MND/ALS) using novel genomics analyses. This includes investigations into the use of cell-free DNA and other 'omic data to improve diagnosis and treatment. Fleur currently has research projects running at the Royal Brisbane Womens Hospital and the Mater Hospital together with local and international collaborators. Any potential participants or collaborators are encouraged to contact her on email about these projects.

Availability

Dr Fleur Garton is:
Available for supervision
Media expert

Qualifications

  • Doctor of Philosophy, University of Sydney

Research interests

  • Motor Neurone Disease

  • Genetic variants influencing performance

  • Neuromuscular Disease

Works

Search Professor Fleur Garton’s works on UQ eSpace

44 works between 2009 and 2025

21 - 40 of 44 works

2018

Journal Article

The Effect of ACTN3 Gene Doping on Skeletal Muscle Performance

Garton, Fleur C., Houweling, Peter J., Vukcevic, Damjan, Meehan, Lyra R., Lee, Fiona X.Z., Lek, Monkol, Roeszler, Kelly N., Hogarth, Marshall W., Tiong, Chrystal F., Zannino, Diana, Yang, Nan, Leslie, Stephen, Gregorevic, Paul, Head, Stewart I., Seto, Jane T. and North, Kathryn N. (2018). The Effect of ACTN3 Gene Doping on Skeletal Muscle Performance. American Journal of Human Genetics, 102 (5), 845-857. doi: 10.1016/j.ajhg.2018.03.009

The Effect of ACTN3 Gene Doping on Skeletal Muscle Performance

2018

Journal Article

Human cerebral evolution and the clinical syndrome of amyotrophic lateral sclerosis

Henderson, Robert D., Garton, Fleur C., Kiernan, Matthew C., Turner, Martin R. and Eisen, Andrew (2018). Human cerebral evolution and the clinical syndrome of amyotrophic lateral sclerosis. JNNP Online, 90 (5), jnnp-2017. doi: 10.1136/jnnp-2017-317245

Human cerebral evolution and the clinical syndrome of amyotrophic lateral sclerosis

2018

Journal Article

No association between ACTN3 R577X and ACE I/D polymorphisms and endurance running times in 698 Caucasian athletes

Papadimitriou, Ioannis D., Lockey, Sarah J., Voisin, Sarah, Herbert, Adam J., Garton, Fleur, Houweling, Peter J., Cieszczyk, Pawel, Maciejewska-Skrendo, Agnieszka, Sawczuk, Marek, Massidda, Myosotis, Calò, Carla Maria, Astratenkova, Irina V., Kouvatsi, Anastasia, Druzhevskaya, Anastasiya M., Jacques, Macsue, Ahmetov, Ildus I., Stebbings, Georgina K., Heffernan, Shane, Day, Stephen H., Erskine, Robert, Pedlar, Charles, Kipps, Courtney, North, Kathryn N., Williams, Alun G. and Eynon, Nir (2018). No association between ACTN3 R577X and ACE I/D polymorphisms and endurance running times in 698 Caucasian athletes. BMC Genomics, 19 (1) 13, 1-9. doi: 10.1186/s12864-017-4412-0

No association between ACTN3 R577X and ACE I/D polymorphisms and endurance running times in 698 Caucasian athletes

2018

Conference Publication

Allelic Variation in Key Fitness Genes is Linked with Increased Severity of Obesity in Overweight/obese Youth

Saner, Christoph, Harcourt, Brooke E., Juonala, Markus, Kao, Kung-Ting, Houweling, Peter, Garton, Fleur, North, Kathryn N. and Sabin, Matthew A. (2018). Allelic Variation in Key Fitness Genes is Linked with Increased Severity of Obesity in Overweight/obese Youth. BASEL: KARGER.

Allelic Variation in Key Fitness Genes is Linked with Increased Severity of Obesity in Overweight/obese Youth

2017

Journal Article

Whole-exome sequencing in amyotrophic lateral sclerosis suggests NEK1 is a risk gene in Chinese

Gratten, Jacob, Zhao, Qiongyi, Benyamin, Beben, Garton, Fleur, He, Ji, Leo, Paul J., Mangelsdorf, Marie, Anderson, Lisa, Zhang, Zong-Hong, Chen, Lu, Chen, Xiang-Ding, Cremin, Katie, Deng, Hong-Weng, Edson, Janette, Han, Ying-Ying, Harris, Jessica, Henders, Anjali K., Jin, Zi-Bing, Li, Zhongshan, Lin, Yong, Liu, Xiaolu, Marshall, Mhairi, Mowry, Bryan J., Ran, Shu, Reutens, David C., Song, Sharon, Tan, Li-Jun, Tang, Lu, Wallace, Robyn H. ... Fan, Dongsheng (2017). Whole-exome sequencing in amyotrophic lateral sclerosis suggests NEK1 is a risk gene in Chinese. Genome Medicine, 9 (97) 97, 97. doi: 10.1186/s13073-017-0487-0

Whole-exome sequencing in amyotrophic lateral sclerosis suggests NEK1 is a risk gene in Chinese

2017

Journal Article

Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis

Benyamin, Beben, He, Ji, Zhao, Qiongyi, Gratten, Jacob, Garton, Fleur, Leo, Paul J., Liu, Zhijun, Mangelsdorf, Marie, Al-Chalabi, Ammar, Anderson, Lisa, Butler, Timothy J., Chen, Lu, Chen, Xiang-Ding, Cremin, Katie, Deng, Hong-Weng, Devine, Matthew, Edson, Janette, Fifita, Jennifer A., Furlong, Sarah, Han, Ying-Ying, Harris, Jessica, Henders, Anjali K., Jeffree, Rosalind L., Jin, Zi-Bing, Li, Zhongshan, Li, Ting, Li, Mengmeng, Lin, Yong, Liu, Xiaolu ... Fan, Dongsheng (2017). Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis. Nature Communications, 8 (1) 611, 611. doi: 10.1038/s41467-017-00471-1

Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis

2017

Journal Article

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

Willems, Sara M., Wright, Daniel J., Day, Felix R., Trajanoska, Katerina, Joshi, Peter K., Morris, John A., Matteini, Amy M., Garton, Fleur C., Grarup, Niels, Oskolkov, Nikolay, Thalamuthu, Anbupalam, Mangino, Massimo, Liu, Jun, Demirkan, Ayse, Lek, Monkol, Xu, Liwen, Wang, Guan, Oldmeadow, Christopher, Gaulton, Kyle J., Lotta, Luca A., Miyamoto-Mikami, Eri, Rivas, Manuel A., White, Tom, Loh, Po-Ru, Aadahl, Mette, Amin, Najaf, Attia, John R., Austin, Krista, Benyamin, Beben ... Ohlsson, Claes (2017). Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness. Nature Communications, 8 (1) 16015, 16015. doi: 10.1038/ncomms16015

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

2017

Journal Article

Whole exome sequencing and DNA methylation analysis in a clinical amyotrophic lateral sclerosis cohort

Garton, Fleur C., Benyamin, Beben, Zhao, Qiongyi, Liu, Zhijun, Gratten, Jacob, Henders, Anjali K., Zhang, Zong-Hong, Edson, Janette, Furlong, Sarah, Morgan, Sarah, Heggie, Susan, Thorpe, Kathryn, Pfluger, Casey, Mather, Karen A., Sachdev, Perminder S., McRae, Allan F., Robinson, Matthew R., Shah, Sonia, Visscher, Peter M., Mangelsdorf, Marie, Henderson, Robert D., Wray, Naomi R. and McCombe, Pamela A. (2017). Whole exome sequencing and DNA methylation analysis in a clinical amyotrophic lateral sclerosis cohort. Molecular Genetics and Genomic Medicine, 5 (4), 418-428. doi: 10.1002/mgg3.302

Whole exome sequencing and DNA methylation analysis in a clinical amyotrophic lateral sclerosis cohort

2016

Journal Article

ACTN3 R577X and ACE I/D gene variants influence performance in elite sprinters: a multi-cohort study

Papadimitriou, Ioannis D., Lucia, Alejandro, Pitsiladis, Yannis P., Pushkarev, Vladimir P., Dyatlov, Dmitry A., Orekhov, Evgeniy F., Artioli, Guilherme G., Guilherme, João Paulo L.F., Lancha, Antonio H., Ginevičiene, Valentina, Cieszczyk, Pawel, Maciejewska-Karlowska, Agnieszka, Sawczuk, Marek, Muniesa, Carlos A., Kouvatsi, Anastasia, Massidda, Myosotis, Calò, Carla Maria, Garton, Fleur, Houweling, Peter J., Wang, Guan, Austin, Krista, Druzhevskaya, Anastasiya M., Astratenkova, Irina V., Ahmetov, Ildus I., Bishop, David J., North, Kathryn N. and Eynon, Nir (2016). ACTN3 R577X and ACE I/D gene variants influence performance in elite sprinters: a multi-cohort study. BMC Genomics, 17 (1) 285. doi: 10.1186/s12864-016-2462-3

ACTN3 R577X and ACE I/D gene variants influence performance in elite sprinters: a multi-cohort study

2016

Journal Article

Analysis of the ACTN3 heterozygous genotype suggests that α-actinin-3 controls sarcomeric composition and muscle function in a dose-dependent fashion

Hogarth, Marshall W., Garton, Fleur C., Houweling, Peter J., Tukiainen, Taru, Lek, Monkol, Macarthur, Daniel G., Seto, Jane T., Quinlan, Kate G.R., Yang, Nan, Head, Stewart I. and North, Kathryn N. (2016). Analysis of the ACTN3 heterozygous genotype suggests that α-actinin-3 controls sarcomeric composition and muscle function in a dose-dependent fashion. Human Molecular Genetics, 25 (5), 866-877. doi: 10.1093/hmg/ddv613

Analysis of the ACTN3 heterozygous genotype suggests that α-actinin-3 controls sarcomeric composition and muscle function in a dose-dependent fashion

2016

Journal Article

Athlome project consortium: a concerted effort to discover genomic and other "omic" markers of athletic performance

Pitsiladis, Yannis P., Tanaka, Masashi, Eynon, Nir, Bouchard, Claude, North, Kathryn N., Williams, Alun G., Collins, Malcolm, Moran, Colin N., Britton, Steven L., Fuku, Noriyuki, Ashley, Euan A., Klissouras, Vassilis, Lucia, Alejandro, Ahmetov, Ildus I., De Geus, Eco, Alsayrafi, Mohammed, Webborn, Nick, Wang, Guan, Bishop, David J., Papadimitriou, Ioannis, Yan, Xu, Tirosh, Oren, Kuang, Jujiao, Rankinen, Tuomo, Sarzinsky, Mark, Mikael Mattsson, C., Wheeler, Matthew, Waggott, Daryl, Byrne, Nuala M. ... Pushkarev, Vladimir P. (2016). Athlome project consortium: a concerted effort to discover genomic and other "omic" markers of athletic performance. Physiological Genomics, 48 (3), 183-190. doi: 10.1152/physiolgenomics.00105.2015

Athlome project consortium: a concerted effort to discover genomic and other "omic" markers of athletic performance

2016

Journal Article

The effect of heterozygosity for the ACTN3 null allele on human muscle performance

Garton, Fleur C. and North, Kathryn N. (2016). The effect of heterozygosity for the ACTN3 null allele on human muscle performance. Medicine and Science in Sports and Exercise, 48 (3), 509-520. doi: 10.1249/MSS.0000000000000784

The effect of heterozygosity for the ACTN3 null allele on human muscle performance

2016

Journal Article

Rodent models for resolving extremes of exercise and health

Garton, Fleur C., North, Kathryn N., Koch, Lauren G., Britton, Steven L., Nogales-Gadea, Gisela and Lucia, Alejandro (2016). Rodent models for resolving extremes of exercise and health. Physiological Genomics, 48 (2), 82-92. doi: 10.1152/physiolgenomics.00077.2015

Rodent models for resolving extremes of exercise and health

2016

Journal Article

No evidence of a common DNA variant profile specific to world class endurance athletes

Rankinen, Tuomo, Fuku, Noriyuki, Wolfarth, Bernd, Wang, Guan, Sarzynski, Mark A., Alexeev, Dmitry G., Ahmetov, Ildus I., Boulay, Marcel R., Cieszczyk, Pawel, Eynon, Nir, Filipenko, Maxim L., Garton, Fleur C., Generozov, Edward V., Govorun, Vadim M., Houweling, Peter J., Kawahara, Takashi, Kostryukova, Elena S., Kulemin, Nickolay A., Larin, Andrey K., Maciejewska-Karlowska, Agnieszka, Miyachi, Motohiko, Muniesa, Carlos A., Murakami, Haruka, Ospanova, Elena A., Padmanabhan, Sandosh, Pavlenko, Alexander V., Pyankova, Olga N., Santiago, Catalina, Sawczuk, Marek ... Bouchard, Claude (2016). No evidence of a common DNA variant profile specific to world class endurance athletes. PLoS ONE, 11 (1) e0147330, e0147330. doi: 10.1371/journal.pone.0147330

No evidence of a common DNA variant profile specific to world class endurance athletes

2015

Journal Article

Direct-to-consumer genetic testing for predicting sports performance and talent identification: Consensus statement

Webborn, Nick, Williams, Alun, McNamee, Mike, Bouchard, Claude, Pitsiladis, Yannis, Ahmetov, Ildus, Ashley, Euan, Byrne, Nuala, Camporesi, Silvia, Collins, Malcolm, Dijkstra, Paul, Eynon, Nir, Fuku, Noriyuki, Garton, Fleur C., Hoppe, Nils, Holm, Søren, Kaye, Jane, Klissouras, Vassilis, Lucia, Alejandro, Maase, Kamiel, Moran, Colin, North, Kathryn N., Pigozzi, Fabio and Wang, Guan (2015). Direct-to-consumer genetic testing for predicting sports performance and talent identification: Consensus statement. British Journal of Sports Medicine, 49 (23), 1486-1491. doi: 10.1136/bjsports-2015-095343

Direct-to-consumer genetic testing for predicting sports performance and talent identification: Consensus statement

2015

Conference Publication

A gene for speed: the influence of ACTN3 on muscle performance in health and disease

Houweling, P., Seto, J., Garton, F., Quinlan, K., Head, S. and North, K. (2015). A gene for speed: the influence of ACTN3 on muscle performance in health and disease. 20th International Congress of the World Muscle Society, Brighton, United Kingdom, 30 September-4 October 2015. London, United Kingdom: Elsevier. doi: 10.1016/j.nmd.2015.06.011

A gene for speed: the influence of ACTN3 on muscle performance in health and disease

2014

Journal Article

α-Actinin-3 deficiency alters muscle adaptation in response to denervation and immobilization

Garton, F. C., Seto, J. T., Quinlan, K. G. R., Yang, N., Houweling, P. J. and North, K. N. (2014). α-Actinin-3 deficiency alters muscle adaptation in response to denervation and immobilization. Human Molecular Genetics, 23 (7), 1879-1893. doi: 10.1093/hmg/ddt580

α-Actinin-3 deficiency alters muscle adaptation in response to denervation and immobilization

2014

Journal Article

NF1 is a critical regulator of muscle development and metabolism

Sullivan, Kate, El-hoss, Jad, Quinlan, Kate G.R., Deo, Nikita, Garton, Fleur, Seto, Jane T.C., Gdalevitch, Marie, Turner, Nigel, Cooney, Gregory J., Kolanczyk, Mateusz, North, Kathryn N., Little, David G. and Schindeler, Aaron (2014). NF1 is a critical regulator of muscle development and metabolism. Human Molecular Genetics, 23 (5) ddt515, 1250-1259. doi: 10.1093/hmg/ddt515

NF1 is a critical regulator of muscle development and metabolism

2013

Journal Article

ACTN3 genotype infuences muscle performance through the regulation of calcineurin signaling

Seto, Jane T., Quinlan, Kate G. R., Lek, Monkol, Zheng, Xi Fiona, Garton, Fleur, Macarthur, Daniel G., Hogarth, Marshall W., Houweling, Peter J., Gregorevic, Paul, Turner, Nigel, Cooney, Gregory J., Yang, Nan and North, Kathryn N. (2013). ACTN3 genotype infuences muscle performance through the regulation of calcineurin signaling. Journal of Clinical Investigation, 123 (10), 4255-4263. doi: 10.1172/JCI67691

ACTN3 genotype infuences muscle performance through the regulation of calcineurin signaling

2013

Journal Article

Genes for elite power and sprint performance: ACTN3 leads the way

Eynon, Nir, Hanson, Erik D., Lucia, Alejandro, Houweling, Peter J., Garton, Fleur, North, Kathryn N. and Bishop, David J. (2013). Genes for elite power and sprint performance: ACTN3 leads the way. Sports Medicine, 43 (9), 803-817. doi: 10.1007/s40279-013-0059-4

Genes for elite power and sprint performance: ACTN3 leads the way

Funding

Current funding

  • 2025 - 2027
    Proteomic Biomarkers for ALS Disease Prognosis and Progression Monitoring
    United States Congressionally Directed Medical Research Programs - Amyotrophic Lateral Sclerosis Research Program
    Open grant
  • 2023 - 2026
    Organ Transplantation as a Model of Reversible Frailty
    NHMRC IDEAS Grants
    Open grant
  • 2022 - 2025
    Identifying MND risk genes to target novel therapeutic avenues
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2020 - 2025
    From the nucleus to the powerhouse: investigating how TDP-43-mitochondrial interactions wreak havoc in MND
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2020 - 2025
    A novel biomarker for ALS
    Cure for MND Foundation - Impact Grants
    Open grant

Past funding

  • 2023 - 2024
    An Australian Sporadic ALS transcriptome resource
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant
  • 2022 - 2025
    Leveraging medical records to identify patients at risk of neurodegenerative disease
    Boosting Dementia Research Grants (PR4): European Union Joint Program on Neurodegenerative Disease Research (JPND) Call for Multinational Projects
    Open grant
  • 2022 - 2025
    A high-throughput system to identify ALS risk genes from genome-wide association studies
    Cure for MND Foundation - Impact Grants
    Open grant
  • 2021 - 2022
    Dr Fleur Garton - AQ WRAP
    Advance Queensland Women's Research Assistance Program
    Open grant
  • 2021 - 2022
    UQ AWARE - Dr Fleur Garton
    UQ Amplify Women's Academic Research Equity
    Open grant
  • 2019 - 2020
    UQAWARE - Dr Fleur Garton
    UQ Amplify Women's Academic Research Equity
    Open grant
  • 2019 - 2020
    Profiling Cell-free DNA to detect Amyotrophic Lateral Sclerosis
    UQ Early Career Researcher
    Open grant
  • 2018 - 2020
    Cell-free DNA profiling in cases and disease-mimics to develop a biomarker test for Amyotrophic Lateral Sclerosis
    Brain Foundation
    Open grant
  • 2018 - 2019
    Cell-free DNA and ALS; insight into disease mechanisms and Progression (Susie Harris Travel Fellowship)
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2017 - 2018
    Cell-free DNA and ALS; insight into disease mechanisms and progression
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2017 - 2022
    The identification of novel genetic loci and pathways associated with ALS through interrogation of multiple integrated genomics data sets
    NHMRC Early Career Fellowships
    Open grant
  • 2016
    Nina Buscombe Award
    Motor Neurone Disease Association of Victoria
    Open grant
  • 2016
    MND Postdoctotral Fellowship - To identify novel genetic loci and pathways associated with ALS through interrogation of multiple integrated genomics data sets
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant

Supervision

Availability

Dr Fleur Garton is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Novel methods and data integration to understand the causes of Amyotrophic Lateral Sclerosis

    Principal Advisor

    Other advisors: Dr Allan McRae, Dr Jian Zeng

  • Doctor Philosophy

    Investigating the molecular basis of motor neurone disease using cell-free DNA

    Principal Advisor

    Other advisors: Dr Allan McRae, Professor Mark Midwinter

  • Doctor Philosophy

    Cell-free DNA methodology for diagnosis and monitoring progression in Motor Neurone Disease

    Associate Advisor

    Other advisors: Dr Allan McRae

  • Doctor Philosophy

    Genetic architecture and evolution of complex traits across populations in humans

    Associate Advisor

    Other advisors: Professor Peter Visscher, Professor Naomi Wray, Dr Jian Zeng

Media

Enquiries

Contact Dr Fleur Garton directly for media enquiries about:

  • gene tests for athletic ability
  • Genetics of Amyotrophic Lateral Sclerosis
  • Motor Neuron Disease
  • sport genetics

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au