Associate Professor

Peter Noakes

Email: 
Phone: 
+61 7 336 51780
Phone: 
+61 7 336 51640

Availability

Associate Professor Peter Noakes is:
Available for supervision

Fields of research

Biological Sciences Immunology Neurosciences

Research interests

  • RESEARCH AREA 1:

    The cell and molecular mechanisms that underlie developmental motoneuron cell death. This involves examining a number of genetically modified mice that we and our colleagues have created. In each of these mice we have inactivated the genes that encode for synaptic signalling molecules, such as agrin and laminins, or molecules that are needed to cluster ion channels in the postsynaptic membranes of muscles and/or neurones, such as rapsyn and gephyrin.

  • RESEARCH AREA 2:

    The molecular mechanisms that underpin synapse formation and plasticity. This involves exploring the signal transduction mechanisms that are activated when signalling molecules such as neuregulin-1 (ARIA, beta-heregulin 1), or agrin active ErbB or MuSK receptors in the membrane of muscle respectively.

  • RESEARCH AREA 3:

    The biological role of P2X1, 2, 4 and 7 in the living animal. This is big project and involves making tissue inducible gene knockouts of these ion channels. At present we are well on the way to making such mice. However, before we can gain a proper understanding of their role in mice that are missing these ion channel subunits, we need to know their developmental expression profile in the developing mouse. In particular when and where they are expressed in the developing nervous system.

  • RESEARCH AREA 4:

    The biological role of TGFbeta 2 at adult synapses. This will involve looking at mice we are making where we the gene for TGFbeta is knockout out in adult muscle and/or in the adult spinal cord (a tissue inducible knockout out of TGFbeta 2). The mice should be ready sometime next year but no firm dates for this one.

  • RESEARCH AREA 5:

    The Control of synaptic gene expression. This project in the first part is simply a promoter and 3' UTR analysis of some 30 genes that appear at the same time in the postsynaptic region of skeletal muscle. It is aimed at looking for common regulatory elements and or spacing patterns of such elements (enhancers and repressors). It is high risk and involves some biological and mathematical knowledge. The biological part of this project will involve making transgenic mice with test non-coding DNA linked to reporter constructs such as green fluorescent protein (GFP). The aim here is to see if such elements can drive synapse expression of reporter genes (eg GFP)

  • RESEARCH AREA 6:

    The roles of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), as well as insulin. in the proliferation and differentiation of mouse embryonic stem cells. This is not a neurobiology-based project, but is early developmental biology one. It will also have links through our USA collaborators to understanding the role of such growth factors in the proliferation tumor cells within the brain (U87 a nasty brain tumor). In particular, this project is aimed at looking at the signalling pathways that are activated when these growth factors activate their receptors, which are on these stem and tumor cells. We also want to know if these signalling pathways activate proliferation and differentiation. And if so what are the down stream target genes involved.

Search Professor Peter Noakes’s works on UQ eSpace

170 works between 1983 and 2024
All (170) Journal Article (106) Book Chapter (1) Conference Publication (63)

141 - 160 of 170 works

2001

Conference Publication

Suppressor of cytokine signalling-3 is decreased in rapsyn deficient mice

Bartlett, S., Banks, G. B. and Noakes, P. G. (2001). Suppressor of cytokine signalling-3 is decreased in rapsyn deficient mice. 21st Annual Meeting of the Australian Neuroscience Society, Brisbane, 28-31 January 2001. Sydney: Ausrralian Neuroscience Society.

Suppressor of cytokine signalling-3 is decreased in rapsyn deficient mice

2001

Conference Publication

The development of synaptic connections: Genetic analysis in mice

Noakes, P. G. (2001). The development of synaptic connections: Genetic analysis in mice. ComBio 2001, National Convenetion Centre, Canberra, 30 September-4 October 2001. Kent Town, SA: Australian Society for Biochemistry & Molecular Biology.

The development of synaptic connections: Genetic analysis in mice

2000

Conference Publication

Agrin is needed to build an organised basal lamina over developing skeletal muscle

Roberston, L. and Noakes, P. G. (2000). Agrin is needed to build an organised basal lamina over developing skeletal muscle. 20th Annual Meeting of the Australian Neuroscience Society, Melbourne, Australia, Jan 30 - Feb 2, 2000.

Agrin is needed to build an organised basal lamina over developing skeletal muscle

2000

Conference Publication

Altered motoneuron death in rapsyn deficient mice

Banks, G., Bartlett, S. E. and Noakes, P.G. (2000). Altered motoneuron death in rapsyn deficient mice. 20th Annual meeting: Australian Neuroscience Society Annual Conference, Melbourne, Australia, 30 Jan 30 - 2 Feb, 2000. Australian Neuroscience Society.

Altered motoneuron death in rapsyn deficient mice

2000

Conference Publication

The regulatory role of neuregulin in acetylcholine receptor clustering at the neuromuscular synapse

Ngo, S. T., Phillips, W. D. and Noakes P. G. (2000). The regulatory role of neuregulin in acetylcholine receptor clustering at the neuromuscular synapse. Society for Neuroscience Annual Meeting 2000, New Orleans, Louisiana, 4-9 November, 2000. Online: Society for Neuroscience.

The regulatory role of neuregulin in acetylcholine receptor clustering at the neuromuscular synapse

2000

Conference Publication

Functional analysis of beta 2-laminin deficient synapses

Noakes, P. G., Kim, D., Knight, D. and Lavidis, N. A. (2000). Functional analysis of beta 2-laminin deficient synapses. 20th Annual Meeting of the Australian Neuroscience Society, Melbourne, Australia, 30 Jan - 2 Feb, 2000. Australia: Australian Neuroscience Society.

Functional analysis of beta 2-laminin deficient synapses

2000

Journal Article

Alterations in ciliary neurotrophic factor signaling in rapsyn deficient mice

Bartlett, S. E., Banks, G. B. and Noakes P. G. (2000). Alterations in ciliary neurotrophic factor signaling in rapsyn deficient mice. Journal of Neuroscience Research, 64 (6), 575-581.

Alterations in ciliary neurotrophic factor signaling in rapsyn deficient mice

2000

Conference Publication

Promotion of motoneuron survival and branching in rapsyn mutant mice

Banks, G., Bartlett, S.E. and Noakes P.G. (2000). Promotion of motoneuron survival and branching in rapsyn mutant mice. Annual Meeting of the Society for Neuroscience, New Orleans, Louisiana, United States, 4-9 November, 2000. Washington, D.C., United States: Society for Neuroscience (SfN).

Promotion of motoneuron survival and branching in rapsyn mutant mice

1999

Journal Article

Over expression of rapsyn inhibits agrin-induced acetylcholine receptor clustering in muscle cells

Han, Hong, Noakes, Peter G. and Phillips, William D. (1999). Over expression of rapsyn inhibits agrin-induced acetylcholine receptor clustering in muscle cells. Journal of neurocytology, 28 (9), 763-775. doi: 10.1023/A:1007098406748

Over expression of rapsyn inhibits agrin-induced acetylcholine receptor clustering in muscle cells

1999

Journal Article

Expression and localisation of dynamin and syntaxin during neural development and neuromuscular synapse formation

Noakes, P. G., Chin, D., Kim, S. S., Liang, S. and Phillips, W. D. (1999). Expression and localisation of dynamin and syntaxin during neural development and neuromuscular synapse formation. Journal of Comparative Neurology, 410 (4), 531-540. doi: 10.1002/(SICI)1096-9861(19990809)410:43.0.CO;2-C

Expression and localisation of dynamin and syntaxin during neural development and neuromuscular synapse formation

1999

Conference Publication

Molecular and function changes at the developing beta-2 laminin mutant neuromuscular synapse

Noakes P. G., Bartlett, S. E., Kim, D., Knight, D. and Lavidis, N. A. (1999). Molecular and function changes at the developing beta-2 laminin mutant neuromuscular synapse. Annual Meeting of the Society for Neuroscience, Miami Beach, Florida, USA, 23-28 October, 1999. Bethesda, MD: Society for Neuroscience.

Molecular and function changes at the developing beta-2 laminin mutant neuromuscular synapse

1999

Conference Publication

Altered motor neuron programmed cell death in Rapsyn deficient mice: A role of neurotrophic factors

Banks, G., Bartlett, S. and Noakes, P. G. (1999). Altered motor neuron programmed cell death in Rapsyn deficient mice: A role of neurotrophic factors. ComBio 99, Conrad Jupiters, Gold Coast, Qld., 27-30 September 1999. Kent Town, S.A.: Australian Society for Biochemistry and Molecular Biology.

Altered motor neuron programmed cell death in Rapsyn deficient mice: A role of neurotrophic factors

1999

Conference Publication

Analysis of skeletal muscle basal lamina in wild-type and agrin-deficient mice

Robertson, L. N. and Noakes, P. G. (1999). Analysis of skeletal muscle basal lamina in wild-type and agrin-deficient mice. ComBio 99, Conrad Jupiters, Gold Coast, Qld., 27 - 30 September, 1999. Kent Town, S.A.: Australian Society for Biochemistry and Molecular Biology.

Analysis of skeletal muscle basal lamina in wild-type and agrin-deficient mice

1999

Conference Publication

The Role of Neurotrophins at Developing Synapses of b2-Laminin Mutant Mice

Bartlett, S. and Noakes, P. G. (1999). The Role of Neurotrophins at Developing Synapses of b2-Laminin Mutant Mice. 17th Biennial Meeting of the International Society for Neurochemists, Berlin, Germany, 8 -14 Aug1999. USA: Lippiniott Williams & Wilkins.

The Role of Neurotrophins at Developing Synapses of b2-Laminin Mutant Mice

1998

Conference Publication

Development of the neuromuscular junction: Genetic analysis in mice

Sanes, Joshua R., Apel, Elizabeth D., Burgess, Robert W., Emerson, Ronald B., Feng, Guoping, Gautam, Medha, Glass, David, Grady, R. Mark, Krejci, Eric, Lichtman, Jeff W., Lu, Jonathan T., Massoulié, Jean, Miner, Jeffrey H., Moscoso, Lisa M., Nguyen, Quyen, Nichol, Mia, Noakes, Peter G., Patton, Bruce L., Son, Young-Jin, Yancopoulos, George D. and Zhou, Heather (1998). Development of the neuromuscular junction: Genetic analysis in mice. Elsevier Masson SAS. doi: 10.1016/S0928-4257(98)80004-1

Development of the neuromuscular junction: Genetic analysis in mice

1998

Journal Article

Role of rapsyn in agrin-mediated acetylcholine receptor clustering

Han, H, Noakes, PG and Phillips, WD (1998). Role of rapsyn in agrin-mediated acetylcholine receptor clustering. Journal of Neurochemistry, 70, S36-S36.

Role of rapsyn in agrin-mediated acetylcholine receptor clustering

1997

Journal Article

Rapsyn and agrin slow the metabolic degradation of the acetylcholine receptor

Phillips, William D., Vladeta, Daniel, Han, Hong and Noakes, Peter G. (1997). Rapsyn and agrin slow the metabolic degradation of the acetylcholine receptor. Molecular and Cellular Neuroscience, 10 (1-2), 16-26. doi: 10.1006/mcne.1997.0634

Rapsyn and agrin slow the metabolic degradation of the acetylcholine receptor

1996

Journal Article

Defective neuromuscular synaptogenesis in agrin-deficient mutant mice

Gautam, M., Noakes, P.G., Moscoso, L., Rupp, F., Scheller, R.H., Merlie, J.P. and Sanes, (1996). Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Cell, 85 (4), 525-535. doi: 10.1016/S0092-8674(00)81253-2

Defective neuromuscular synaptogenesis in agrin-deficient mutant mice

1995

Journal Article

Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle

Moscoso, Lisa M., Chu, Gerald C., Gautam, Medha, Noakes, Peter G., Merlie, John P. and Sanes, Joashua R. (1995). Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle. Developmental Biology, 172 (1), 158-169. doi: 10.1006/dbio.1995.0012

Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle

1995

Journal Article

Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice

Gautam, Medha, Noakes, Peter G., Mudd, Jacqueline, Nichol, Mia, Chu, Gerald C., Sanes, Joshua R. and Merlie John P. (1995). Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice. Nature, 377 (6546), 232-236. doi: 10.1038/377232a0

Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice

Current funding

  • 2024 - 2027
    Mechanisms that promote the health of the motor unit in MND
    Cure for MND Foundation - Discovery Research Grants
    Open grant
  • 2022 - 2025
    Developing treatments for Duchenne Muscular Dystrophy
    Muscular Dystrophy Association
    Open grant

Past funding

  • 2023 - 2024
    Stabilizing Neuromuscular Signaling in Motor Neuron Disease
    Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
    Open grant
  • 2020
    Molecular analyses of pre-synaptic compartments in diseased human and mouse brains
    Brain Foundation Research Gift
    Open grant
  • 2020 - 2023
    Fine tuning metabolic flux: Modulating substrate oxidation as a therapeutic strategy in motor neuron disease (MND)
    NHMRC IDEAS Grants
    Open grant
  • 2020 - 2023
    Towards the treatment of Duchenne Muscular Dystrophy
    NHMRC Development Grant
    Open grant
  • 2020 - 2024
    Understanding neuromuscular synaptic loss in Motor Neuron Disease
    NHMRC IDEAS Grants
    Open grant
  • 2018 - 2019
    Targeting the molecular basis of muscle weakness in motor neuron disease.
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2017 - 2018
    Targeting neuromuscular stability in motor neuron disease
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2016 - 2017
    Exploiting the opposing actions of complement receptors C3aR and C5aR1 in the treatment of MND
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2016
    A state-of-the-art facility for simulataneous photo-stimulation, high speed imaging and electrophysiological recording of multiple neurons in brain tissue and living organisms
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    A state-of-the-art spinning disc confocal microscope for high speed imaging of live cells and super resolution microscopy
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    The role of altered neuromuscular activity and mRNA transport in modifying the progression of Motor Neuron Disease
    Royal Brisbane and Women's Hospital Foundation
    Open grant
  • 2015
    The role of altered neuromuscular activity and mRNA transport in modifying the progression of Motor Neuron Disease
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2015
    The role of altered neuronal activity and mRNA transport in modifying the progression Motor Neuron Disease (MND)
    Royal Brisbane and Women's Hospital Foundation
    Open grant
  • 2014 - 2015
    The role of altered neuromuscular signaling in ALS: factors that modify the course of MND
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2014 - 2016
    The role of neuronal hyperactivity and neurotrophic factor signalling in synaptogenesis, dendrogenesis and neuron death in motor neuron disease
    NHMRC Project Grant
    Open grant
  • 2014 - 2016
    Understanding the role of TDP-43 in motor neuron disease.
    NHMRC Project Grant
    Open grant
  • 2012
    Establishment of Integrated Small Animal Metabolic and Physiology Assessment Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Building UQ's analytical capacity in biomedical sciences
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    Dual channel electrophysiological recordings
    NHMRC Equipment Grant
    Open grant
  • 2010
    Establishment of a digital Scanscope system for virtual microscopy
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    In Situ Hybridization Suite for Biomedical Science Researchers
    NHMRC Equipment Grant
    Open grant
  • 2009 - 2012
    Development of a new method of motor unit number estimation for use in motor neurone disease
    NHMRC Project Grant
    Open grant
  • 2009 - 2012
    Molecular mechanisms that help organise effective synaptic transmission.
    NHMRC Project Grant
    Open grant
  • 2009
    Quantitative Histological Core Facility
    UQ School/Centre Co-Funding
    Open grant
  • 2009 - 2011
    The role of neuronal hyper-excitability in an animal model of motor neuron disease
    NHMRC Project Grant
    Open grant
  • 2008 - 2009
    The molecular basis of hyper-exactability in corticospinal neurons in a novel mouse model of amyotrophic lateral sclerosis
    Brain Foundation
    Open grant
  • 2008 - 2009
    High Speed Fluorescence Imaging coupled with Total Internal Reflection Microscopy and Fluorescence Recovery After Photobleaching System
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2008
    Olympus disk-spinning confocal microscope system capable of simutaneously imaging a ratiometric (UV) non-ratiometric (visible range) dye
    Ramaciotti Foundation
    Open grant
  • 2008
    The molecular and functional basis of motor neuron hyper-excitability in an animal model of motor neuron disease.
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2008
    The role of synaptic laminins in the organisation of pre- and post-synaptic specializations at the neuromuscular synapse
    UQ External Support Enabling Grant
    Open grant
  • 2007 - 2009
    Evaluation of orally active anti-inflammatory C5a receptor antagonists in a transgenic rat motor neurone disease model
    NHMRC Project Grant
    Open grant
  • 2006 - 2008
    Phenotypic studies of the NaSi-1 transporter knock-out mouse
    NHMRC Project Grant
    Open grant
  • 2006 - 2008
    The role of central and peripheral synaptic activity in the developmental death of motoneurons.
    NHMRC Project Grant
    Open grant
  • 2005
    The effectiveness of C5a receptor antagonists in the treatment of motor neuron disease
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2003 - 2004
    A transgenic analysis of the physiologic roles of signaling domains in the growth hormone receptor
    NHMRC Project Grant
    Open grant
  • 2003
    The Role of TGFB2 In Maintaining the Function and Viability of Adult Motor Neurons
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2002
    Cell and molecular mechanisms that maintain and promote motoneuron survival: analysis of MuSK, agrin and rapsyn mutant lines of mice
    Ramaciotti Foundation
    Open grant
  • 2002 - 2004
    Role of synaptogenesis in development motoneuron cell death
    NHMRC Project Grant
    Open grant
  • 2000
    High-resolution, high quality digital time-lapse microscopy system
    NHMRC Equipment Grant
    Open grant
  • 1999 - 2001
    A Transgenic Analysis of the Basis for Growth Signalling by the Growth Hormone Receptor
    NHMRC Project Grant
    Open grant
  • 1999
    Functional analysis of neuromuscular synapses in mice that carry specific postsynaptic deletions
    Ramaciotti Foundation
    Open grant
  • 1999
    How neurotrophic factors modulate synaptic connections during development
    ARC Australian Research Council (Small grants)
    Open grant
  • 1999 - 2001
    Molecular Mechanisms Involved in the Formation, Maintenance and Viability of Synapses
    NHMRC Project Grant
    Open grant
  • 1999
    Molecular mechanisms of how motor nerve connections are maintained
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 1999
    Network for brain research in mental disorders (Gene Targeting Consortium)
    Monash University
    Open grant
  • 1999
    Network for Brain Research into Mental Disorders (Gene Targeting Consortium)
    University of Melbourne
    Open grant
  • 1998 - 2000
    Synaptic Development in the Absence of á2-laminin, Agrin and Rapsyn
    NHMRC Project Grant
    Open grant
  • 1997
    Analysis of mutations affecting the formation and function of neuromuscular synapses
    NHMRC Project Grant
    Open grant
  • 1997
    Analysis of synapse formation in S/á2-laminin deficient mice
    University of Queensland New Staff Research Grant
    Open grant
  • 1997
    Neuronal cell death in the rapsyn deficient mouse
    UQ Foundation
    Open grant
  • 1997
    Pre-synaptic differentiation in S/beta2-Laminin deficient mice
    Ramaciotti Foundation
    Open grant

Availability

Associate Professor Peter Noakes is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

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