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Dr David Klyne
Dr

David Klyne

Email: 
Phone: 
+61 7 336 54569

Overview

Background

David M. Klyne PhD, MSc (MolBiol), DPhty, BAppSc) is a NHMRC Emerging Leadership Fellow and Fulbright Scholar within the Centre for Clinical Research Excellence in Spinal Pain, Injury and Health. There he leads an international team that probe the bio-psycho-social mechanisms that underlie physiological and pathological pain. His niche is in understanding the neuro-immune pathways involved and how they can be targeted with interventions using a blend of basic and clinical sciences and his skills and knowledge gained through his four degrees – neuro-immunology (PhD), molecular biology (Master), physiotherapy (Doctorate) and applied sciences (Bachelor).

David has received numerous national and international research awards that span basic and clinical sciences. These include the premier international award for spine research (ISSLS Prize) on two occasions – in Basic Science (2019) and Clinical Science (2018). In 2019, he was awarded a postdoctoral Fulbright Fellowship to continue his work elucidating the role of sleep in chronic pain at the Lewis Katz School of Medicine (Temple University), in the USA. He was also one of ten Australian scientists to attend the Lindau Nobel Laureate Meeting in 2019 and again in 2023, and has received more than $100K in research prize money and $17.5M in research funding.

Availability

Dr David Klyne is:
Available for supervision
Media expert

Qualifications

  • Bachelor of Applied Science, unknown
  • Doctor of Philosophy of Physiotherapy Studies, Bond University
  • Masters (Coursework), The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Acute to chronic pain

  • Neuro-immunology

  • Sleep

  • Chronic pain prevention and rehabilitation

Research impacts

Klyne's research has attracted 17.5M ($8.5M as CIA/PI) from local, national and international funding bodies, been adopted by the world’s leading forum on pain (IASP) in the form of an online Fact Sheet (2021; >50K online visits), informed clinical guidelines and policies relating to the management of pain (e.g., American Academy of Orthopaedic Manual Physical Therapists), and formed the basis of a chapter in one of the world’s leading physiotherapy textbooks – Grieve's (2024). His reputation is exemplified by his >40 national/international presentations (>20 funded invited and/or Keynote) and invitations to provide expertise on global matters such as at the 2019 Opioid Epidemic Consortium in Kentucky, USA. The significance of Klyne's program of research to the broader public is evidenced by features in the media, including 9 News Australia (interview), the Sydney Morning Herald and Australian Academy of Science. In 2021, 9 News released a mini-documentary about Klyne's work on sleep and pain, which ranked in the top 5 stories nationally on NineMSN. From this program of work, Klyne is consitently ranked in the top 1% of experts globally in back pain (Expertscape).

Works

Search Professor David Klyne’s works on UQ eSpace

41 works between 2012 and 2024

1 - 20 of 41 works

2024

Journal Article

Should cognitive behavioral therapy for insomnia be considered for preventing and managing chronic pain? 

Klyne, David M., Smith, Simon S. and Hall, Michelle (2024). Should cognitive behavioral therapy for insomnia be considered for preventing and managing chronic pain? . Sleep. doi: 10.1093/sleep/zsae177

Should cognitive behavioral therapy for insomnia be considered for preventing and managing chronic pain? 

2024

Book Chapter

Biological Contributors to Musculoskeletal Pain and Disability

Farrell, Scott F., deZoete, Rutger M.J., Klyne, David M., Schmid, Annina B., Polli, Andrea, Nijs, Jo and Sterling, Michele (2024). Biological Contributors to Musculoskeletal Pain and Disability. Grieve's Modern Musculoskeletal Physiotherapy. (pp. 22-35) edited by Deborah Falla, Jeremy Lewis, Christopher McCarthy, Chad E. Cook and Michele Sterling. London, United Kingdom: Elsevier.

Biological Contributors to Musculoskeletal Pain and Disability

2024

Conference Publication

The Additive Effects Of Aerobic Activity To Strengthening Exercise For Hip Osteoarthritis: A Randomized Controlled Trial

Hall, Michelle, Allison, Kim, Knox, Gabrielle, Hinman, Rana S., Bennell, Kim, Spiers, Libby, Plinsinga, Melanie, Klyne, David, McManus, Fiona, De Silva, Anurika, Da Costa, Ricardo, Murphy, Nicholas and Dobson, Fiona (2024). The Additive Effects Of Aerobic Activity To Strengthening Exercise For Hip Osteoarthritis: A Randomized Controlled Trial. 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria, 18-21 April 2024. London, United Kingdom: Elsevier. doi: 10.1016/j.joca.2024.03.098

The Additive Effects Of Aerobic Activity To Strengthening Exercise For Hip Osteoarthritis: A Randomized Controlled Trial

2024

Journal Article

Characterization of pain-related behaviors in a rat model of acute-to-chronic low back pain: single vs. multi-level disc injury

Barbe, Mary F., Chen, Frank Liu, Loomis, Regina H., Harris, Michele Y., Kim, Brandon M., Xie, Kevin, Hilliard, Brendan A., McGonagle, Elizabeth R., Bailey, Taylor D., Gares, Ryan P., Van Der Bas, Megan, Kalicharan, Betsy A., Holt-Bright, Lewis, Stone, Laura S., Hodges, Paul W. and Klyne, David M. (2024). Characterization of pain-related behaviors in a rat model of acute-to-chronic low back pain: single vs. multi-level disc injury. Frontiers in Pain Research, 5 1394017, 1-23. doi: 10.3389/fpain.2024.1394017

Characterization of pain-related behaviors in a rat model of acute-to-chronic low back pain: single vs. multi-level disc injury

2024

Journal Article

Coordination of hip and spine in individuals with acute low back pain during unstable sitting

Alshehri, Mansour Abdullah, van den Hoorn, Wolbert, Klyne, David M. and Hodges, Paul W. (2024). Coordination of hip and spine in individuals with acute low back pain during unstable sitting. The Spine Journal, 24 (5), 768-782. doi: 10.1016/j.spinee.2023.12.001

Coordination of hip and spine in individuals with acute low back pain during unstable sitting

2024

Journal Article

Is sleep the new treatment for pain? Two issues need resolving before deciding

Klyne, David M and Hall, Michelle (2024). Is sleep the new treatment for pain? Two issues need resolving before deciding. SLEEP, 47 (6) zsae089. doi: 10.1093/sleep/zsae089

Is sleep the new treatment for pain? Two issues need resolving before deciding

2024

Journal Article

Poor lumbar spine coordination in acute low back pain predicts persistent long-term pain and disability

Alshehri, Mansour Abdullah, van den Hoorn, Wolbert, Klyne, David M., van Dieën, Jaap H., Cholewicki, Jacek and Hodges, Paul W. (2024). Poor lumbar spine coordination in acute low back pain predicts persistent long-term pain and disability. European Spine Journal, 33 (6), 2380-2394. doi: 10.1007/s00586-024-08205-w

Poor lumbar spine coordination in acute low back pain predicts persistent long-term pain and disability

2024

Journal Article

Poor sleep versus exercise: A duel to decide whether pain resolves or persists after injury

Klyne, David M., Hilliard, Brendan A., Harris, Michele Y., Amin, Mamta, Hall, Michelle, Besomi, Manuela, Mustafa, Sanam, Farrell, Scott F., Rawashdeh, Oliver, Han, Felicity Y., Hodges, Paul W., Frara, Nagat and Barbe, Mary F. (2024). Poor sleep versus exercise: A duel to decide whether pain resolves or persists after injury. Brain, Behavior, & Immunity - Health, 35 100714, 100714. doi: 10.1016/j.bbih.2023.100714

Poor sleep versus exercise: A duel to decide whether pain resolves or persists after injury

2024

Journal Article

Trunk postural control during unstable sitting among individuals with and without low back pain: A systematic review with an individual participant data meta-analysis

Alshehri, Mansour Abdullah, Alzahrani, Hosam, van den Hoorn, Wolbert, Klyne, David M., Vette, Albert H., Hendershot, Brad D., Roberts, Brad W. R., Larivière, Christian, Barbado, David, Vera-Garcia, Francisco J., van Dieen, Jaap H., Cholewicki, Jacek, Nussbaum, Maury A., Madigan, Michael L., Reeves, Norman Peter, Silfies, Sheri P., Brown, Stephen H. M. and Hodges, Paul W. (2024). Trunk postural control during unstable sitting among individuals with and without low back pain: A systematic review with an individual participant data meta-analysis. PLoS One, 19 (1) e0296968, 1-42. doi: 10.1371/journal.pone.0296968

Trunk postural control during unstable sitting among individuals with and without low back pain: A systematic review with an individual participant data meta-analysis

2023

Journal Article

Low back pain and osteoarthritis pain: a perspective of estrogen

Pang, Huiwen, Chen, Shihui, Klyne, David M., Harrich, David, Ding, Wenyuan, Yang, Sidong and Han, Felicity Y. (2023). Low back pain and osteoarthritis pain: a perspective of estrogen. Bone Research, 11 (1) 42, 42. doi: 10.1038/s41413-023-00280-x

Low back pain and osteoarthritis pain: a perspective of estrogen

2023

Journal Article

Neurobiology of osteoarthritis: a systematic review and activation likelihood estimation meta-analysis

Hall, Michelle, Dobson, Fiona, Klyne, David Murray, Zheng, Carmen Jiamin, Lima, Yuri Lopes and Egorova-Brumley, Natalia (2023). Neurobiology of osteoarthritis: a systematic review and activation likelihood estimation meta-analysis. Scientific Reports, 13 (1) 12442. doi: 10.1038/s41598-023-39245-9

Neurobiology of osteoarthritis: a systematic review and activation likelihood estimation meta-analysis

2023

Journal Article

Pain-related cognitions and emotional distress are not associated with conditioned pain modulation: an explorative analysis of 1142 participants with acute, subacute, and chronic pain

Plinsinga, Melanie Louise, Vuvan, Viana, Maclachlan, Liam, Klyne, David, Graven-Nielsen, Thomas, Vicenzino, Bill, Hodges, Paul and Bjarke Vaegter, Henrik (2023). Pain-related cognitions and emotional distress are not associated with conditioned pain modulation: an explorative analysis of 1142 participants with acute, subacute, and chronic pain. Pain, 164 (7), 1593-1599. doi: 10.1097/j.pain.0000000000002864

Pain-related cognitions and emotional distress are not associated with conditioned pain modulation: an explorative analysis of 1142 participants with acute, subacute, and chronic pain

2023

Journal Article

Genetic impact of blood C-reactive protein levels on chronic spinal and widespread pain

Farrell, Scott F., Sterling, Michele, Klyne, David M., Mustafa, Sanam, Campos, Adrián I., Kho, Pik-Fang, Lundberg, Mischa, Rentería, Miguel E., Ngo, Trung Thanh and Cuéllar-Partida, Gabriel (2023). Genetic impact of blood C-reactive protein levels on chronic spinal and widespread pain. European Spine Journal, 32 (6), 2078-2085. doi: 10.1007/s00586-023-07711-7

Genetic impact of blood C-reactive protein levels on chronic spinal and widespread pain

2023

Conference Publication

Neurobiology of Osteoarthritis - A Systematic Review and Activation Likelihood Estimation Meta-analysis

Hall, M., Dobson, F., Klyne, D., Zheng, C., Lima, Y. and Egorova-Brumley, N. (2023). Neurobiology of Osteoarthritis - A Systematic Review and Activation Likelihood Estimation Meta-analysis. World Congress of Osteoarthritis Research Society International (OARSI), Denver, CO United States, 17-20 March 2023. London, United Kingdom: Elsevier.

Neurobiology of Osteoarthritis - A Systematic Review and Activation Likelihood Estimation Meta-analysis

2023

Journal Article

How do nonsurgical interventions improve pain and physical function in people with osteoarthritis? A scoping review of mediation analysis studies

Lima, Yuri Lopes, Lee, Hopin, Klyne, David M., Dobson, Fiona L., Hinman, Rana S., Bennell, Kim L. and Hall, Michelle (2023). How do nonsurgical interventions improve pain and physical function in people with osteoarthritis? A scoping review of mediation analysis studies. Arthritis Care and Research, 75 (3), 467-481. doi: 10.1002/acr.24983

How do nonsurgical interventions improve pain and physical function in people with osteoarthritis? A scoping review of mediation analysis studies

2023

Conference Publication

Neurobiology Of Osteoarthritis - A Systematic Review And Activation Likelihood Estimation Meta-Analysis

Hall, M., Dobson, F., Klyne, D., Zheng, C., Lima, Y. and Egorova-Brumley, N. (2023). Neurobiology Of Osteoarthritis - A Systematic Review And Activation Likelihood Estimation Meta-Analysis. 2023 OARSI World Congress on Osteoarthritis, Denver, CO United States, 17-20 March 2023. London, United Kingdom: Elsevier. doi: 10.1016/j.joca.2023.01.431

Neurobiology Of Osteoarthritis - A Systematic Review And Activation Likelihood Estimation Meta-Analysis

2022

Journal Article

Effects of adding aerobic physical activity to strengthening exercise on hip osteoarthritis symptoms: protocol for the PHOENIX randomised controlled trial

Hall, Michelle, Allison, Kim, Hinman, Rana S., Bennell, Kim L., Spiers, Libby, Knox, Gabrielle, Plinsinga, Melanie, Klyne, David M., McManus, Fiona, Lamb, Karen E., Da Costa, Ricardo, Murphy, Nicholas J. and Dobson, Fiona L. (2022). Effects of adding aerobic physical activity to strengthening exercise on hip osteoarthritis symptoms: protocol for the PHOENIX randomised controlled trial. BMC Musculoskeletal Disorders, 23 (1) 361. doi: 10.1186/s12891-022-05282-0

Effects of adding aerobic physical activity to strengthening exercise on hip osteoarthritis symptoms: protocol for the PHOENIX randomised controlled trial

2022

Journal Article

Balance control in unstable sitting in individuals with an acute episode of low back pain

van den Hoorn, Wolbert, Meroni, Roberto, Klyne, David M., Alshehri, Mansour Abdullah and Hodges, Paul W. (2022). Balance control in unstable sitting in individuals with an acute episode of low back pain. Gait and Posture, 95, 15-21. doi: 10.1016/j.gaitpost.2022.03.014

Balance control in unstable sitting in individuals with an acute episode of low back pain

2022

Journal Article

Postural control of the trunk in individuals with and without low back pain during unstable sitting: A protocol for a systematic review with an individual participant data meta-analysis

Alshehri, Mansour Abdullah, van den Hoorn, Wolbert, Klyne, David M. and Hodges, Paul W. (2022). Postural control of the trunk in individuals with and without low back pain during unstable sitting: A protocol for a systematic review with an individual participant data meta-analysis. PLoS One, 17 (5) e0268381, 1-14. doi: 10.1371/journal.pone.0268381

Postural control of the trunk in individuals with and without low back pain during unstable sitting: A protocol for a systematic review with an individual participant data meta-analysis

2022

Journal Article

Risk factors for low back pain outcome: Does it matter when they are measured?

Klyne, David Murray, Hall, Leanne Marie, Nicholas, Michael K. and Hodges, Paul William (2022). Risk factors for low back pain outcome: Does it matter when they are measured?. European Journal of Pain, 26 (4), 835-854. doi: 10.1002/ejp.1911

Risk factors for low back pain outcome: Does it matter when they are measured?

Funding

Current funding

  • 2024 - 2028
    Comparative effectiveness of exercise, cognitive behavioural therapy, and their combination for people with chronic musculoskeletal pain and poor sleep
    United States Congressionally Directed Medical Research Programs - Chronic Pain Management Research Program
    Open grant
  • 2024 - 2028
    The role of sleep, physical activity and central sensitisation in chronic back pain development
    NHMRC Investigator Grants
    Open grant
  • 2023 - 2028
    PRioRTI: PReventing chronic pain after whiplash Road Traffic Injury
    NHMRC MRFF CTA - Clinical Trials Activity
    Open grant
  • 2022 - 2027
    What causes low back pain to flare: Has a major opportunity to understand back pain been missed?
    United States National Institutes of Health
    Open grant
  • 2021 - 2026
    Biomarkers of Tissue Tolerance and Behavior in a Rat Model (NIH Grant administered by Temple Unviersity)
    Temple University
    Open grant

Past funding

  • 2020 - 2024
    Understanding Acute to Chronic Back Pain Pathways and Testing New Solutions
    United States Congressionally Directed Medical Research Programs - Chronic Pain Management Research Program
    Open grant

Supervision

Availability

Dr David Klyne is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Disentangling the relationship between sleep and pain

    We are seeking PhD students with a background in biomedical and/or rehabilitative sciences to join our team to contribute to a body of work that aims to identify if and how sleep influences pain. Projects will involve the measurement and analysis of sleep in the “real world” to understand how daily variations in sleep – one of the most important, yet modifiable health behaviors – drive the day-to-day “waxing and waning” of back pain. The work will involve a multidisciplinary team to address this challenging issue.

    Essential criteria: An undergraduate degree with first or second class division 1 Honours in biomedical science, physiotherapy or a related discipline; eligibility for admission to the PhD program at The University of Queensland; knowledge of pain physiology; experience with statistical programs for data analysis; excellent communication skills (written and verbal) in English.

  • Unravelling the molecular mechanisms that explain how exercise programs improve chronic pain

    Physical activity and sleep are two of the most modifiable “every day” behaviours that we are learning to target with interventions to prevent and manage chronic diseases. This fully funded PhD will focus on unravelling the molecular mechanisms that explain how physical activity/exercise programs benefit people with chronic hip pain, and how sleep may influence this relationship. Outcomes will guide the refinement and development of new exercise and sleep interventions for improved chronic pain management and prevention. The successful PhD candidate will join Dr Klyne’s team at The University of Queensland and be co-supervised by A/Prof Michelle Hall at The University of Sydney.

    Essential criteria: An undergraduate degree in biomedical science, physiotherapy, human movement or a related discipline; eligibility for admission to the PhD program at The University of Queensland; knowledge of pain physiology; experience with statistical programs for data analysis; excellent communication skills (written and verbal) in English. Previous research experience and/or coursework in molecular biology is highly desirable.

    Interested applicants should email Dr David Klyne with the subject line “PhD student application”. In your email, please briefly describe your research interests, career ambitions, qualifications and career groups. Please also include a PDF of your CV. Applications will be reviewed as soon as they are received and will continue to be accepted until the position is filled.

Supervision history

Current supervision

Media

Enquiries

Contact Dr David Klyne directly for media enquiries about:

  • Chronic Pain
  • Pain
  • Physical Activity
  • Sleep

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au