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2016 Journal Article Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites (vol 5, pg 117, 2015)Engel, Jessica A., Jones, Amy J., Avery, Vicky M., Sumanadasa, Subathdrage D. M., Ng, Susanna S., Fairlie, David P., Skinner-Adams, Tina and Andrews, Katherine T. (2016). Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites (vol 5, pg 117, 2015). International Journal for Parasitology-Drugs and Drug Resistance, 6 (3), 287-287. doi: 10.1016/j.ijpddr.2016.05.001 |
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2016 Journal Article The intracellular pathway for the presentation of vitamin B–related antigens by the antigen-presenting molecule MR1McWilliam, Hamish E. G., Eckle, Sidonia B. G., Theodossis, Alex, Liu, Ligong, Chen, Zhenjun, Wubben, Jacinta M., Fairlie, David P., Strugnell, Richard A., Mintern, Justine D., McCluskey, James, Rossjohn, Jamie and Villadangos, Jose A. (2016). The intracellular pathway for the presentation of vitamin B–related antigens by the antigen-presenting molecule MR1. Nature Immunology, 17 (5), 531-537. doi: 10.1038/ni.3416 |
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2016 Journal Article Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonistsSeow, Vernon, Lim, Junxian, Cotterell, Adam J., Yau, Mei-Kwan, Xu, Weijun, Lohman, Rink-Jan, Kok, W. Mei, Stoermer, Martin J., Sweet, Matthew J., Reid, Robert C., Suen, Jacky Y. and Farilie, David P. (2016). Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists. Scientific Reports, 6 (1) 24575, 24575.1-24575.12. doi: 10.1038/srep24575 |
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2016 Journal Article Protease activated receptor 2 (PAR2) modulators: a patent review (2010–2015)Yau, Mei-Kwan, Lim, Junxian, Liu, Ligong and Fairlie, David P. (2016). Protease activated receptor 2 (PAR2) modulators: a patent review (2010–2015). Expert Opinion on Therapeutic Patents, 26 (4), 471-483. doi: 10.1517/13543776.2016.1154540 |
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2016 Journal Article Histone deacetylase inhibitors promote mitochondrial reactive oxygen species production and bacterial clearance by human macrophagesAriffin, Juliana K., das Gupta, Kaustav, Kapetanovic, Ronan, Iyer, Abishek, Reid, Robert C., Fairlie, David P. and Sweet, Matthew J. (2016). Histone deacetylase inhibitors promote mitochondrial reactive oxygen species production and bacterial clearance by human macrophages. Antimicrobial Agents and Chemotherapy, 60 (3), 1521-1529. doi: 10.1128/AAC.01876-15 |
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2016 Journal Article Differential anti-inflammatory activity of HDAC inhibitors in human macrophages and rat arthritisLohman, Rink-Jan, Iyer, Abishek, Fairlie, Thomas J., Cotterell, Adam, Gupta, Praveer, Reid, Robert C., Vesey, David A., Sweet, Matthew J. and Fairlie, David P. (2016). Differential anti-inflammatory activity of HDAC inhibitors in human macrophages and rat arthritis. Journal of Pharmacology and Experimental Therapeutics, 356 (2), 387-396. doi: 10.1124/jpet.115.229328 |
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2016 Journal Article Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activityYau, Mei-Kwan, Liu, Ligong, Lim, Junxian, Lohman, Rink-Jan, Cotterell, Adam J., Suen, Jacky Y., Vesey, David A., Reid, Robert C. and Fairlie, David P. (2016). Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity. Bioorganic and Medicinal Chemistry Letters, 26 (3), 986-991. doi: 10.1016/j.bmcl.2015.12.048 |
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2016 Journal Article Histone deacetylases in monocyte/macrophage development, activation and metabolism: refining HDAC targets for inflammatory and infectious diseasesDas Gupta, Kaustav, Melanie Shakespear R., Iyer, Abishek, Fairlie, David P. and Sweet, Matthew J. (2016). Histone deacetylases in monocyte/macrophage development, activation and metabolism: refining HDAC targets for inflammatory and infectious diseases. Clinical and Translational Immunology, 5 (1) e62, e62. doi: 10.1038/cti.2015.46 |
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2016 Journal Article Diversity of T cells restricted by the MHC class I-related molecule MR1 facilitates differential antigen recognitionGherardin, Nicholas A., Keller, Andrew N., Woolley, Rachel E., Le Nours, Jerome, Ritchie, David S., Neeson, Paul J., Birkinshaw, Richard W., Eckle, Sidonia B. G., Waddington, John N., Liu, Ligong, Fairlie, David P., Uldrich, Adam P., Pellicci, Daniel G., McCluskey, James, Godfrey, Dale I and Rossjohn, Jamie (2016). Diversity of T cells restricted by the MHC class I-related molecule MR1 facilitates differential antigen recognition. Immunity, 44 (1), 32-45. doi: 10.1016/j.immuni.2015.12.005 |
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2016 Journal Article PAR2 modulators derived from GB88Yau, Mei-Kwan, Liu, Ligong, Suen, Jacky Y., Lim, Junxian, Lohman, Rink-Jan, Jiang, Yuhong, Cotterell, Adam J., Barry, Grant D., Mak, Jeffrey Y. W., Vesey, David A., Reid, Robert C. and Fairlie, David P. (2016). PAR2 modulators derived from GB88. ACS Medicinal Chemistry Letters, 7 (12), 1179-1184. doi: 10.1021/acsmedchemlett.6b00306 |
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2016 Journal Article Potent small agonists of protease activated receptor 2Yau, Mei-Kwan, Suen, Jacky Y., Xu, Weijun, Lim, Junxian, Liu, Ligong, Adams, Mark N., He, Yaowu, Hooper, John D., Reid, Robert C. and Fairlie, David P. (2016). Potent small agonists of protease activated receptor 2. ACS Medicinal Chemistry Letters, 7 (1), 105-110. doi: 10.1021/acsmedchemlett.5b00429 |
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2016 Journal Article Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactionsPhilippe, Gregoire, Huang, Yen-Hua, Cheneval, Olivier, Lawrence, Nicole, Zhang, Zhen, Fairlie, David P., Craik, David J., Dantas De Araujo, Aline and Troeira Henriques, Sonia (2016). Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions. Biopolymers - Peptide Science, 106 (6), 853-863. doi: 10.1002/bip.22893 |
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2015 Journal Article Recognition of Vitamin B precursors and byproducts by Mucosal Associated Invariant T cellsEckle, Sidonia B.G., Corbett, Alexandra J., Keller, Andrew, Chen, Zhenjun, Godfrey, Dale I., Liu, Ligong, Mak, Jeffrey Y. W., Fairlie, David P., Rossjohn, Jamie and McCluskey, James (2015). Recognition of Vitamin B precursors and byproducts by Mucosal Associated Invariant T cells. The Journal of Biological Chemistry, 290 (51), 30204-30211. doi: 10.1074/jbc.R115.685990 |
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2015 Journal Article Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasitesEngel, Jessica A., Jones, Amy J., Avery, Vicky M., Sumanadasa, Subathdrage D. M., Ng, Susanna S., Fairlie, David P., Adams, Tina S. and Andrews, Katherine T. (2015). Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites. International Journal for Parasitology: Drugs and Drug Resistance, 5 (3), 117-126. doi: 10.1016/j.ijpddr.2015.05.004 |
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2015 Journal Article Potent complement C3a receptor agonists derived from oxazole amino acids: structure-activity relationshipsSingh, Ranee, Reed, Anthony N., Chu, Peifei, Scully, Conor C. G., Yau, Mei-Kwan, Suen, Jacky Y., Durek, Thomas, Reid, Robert C. and Fairlie, David P. (2015). Potent complement C3a receptor agonists derived from oxazole amino acids: structure-activity relationships. Bioorganic and Medicinal Chemistry Letters, 25 (23), 5604-5608. doi: 10.1016/j.bmcl.2015.10.038 |
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2015 Journal Article Histone deacetylase enzymes as drug targets for the control of the sheep blowfly, Lucilia cuprinaKotze, Andrew C., Hines, Barney M., Bagnall, Neil H., Anstead, Clare A., Gupta, Praveer, Reid, Robert C., Ruffell, Angela P. and Fairlie, David P. (2015). Histone deacetylase enzymes as drug targets for the control of the sheep blowfly, Lucilia cuprina. International Journal for Parasitology: Drugs and Drug Resistance, 5 (3), 201-208. doi: 10.1016/j.ijpddr.2015.09.003 |
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2015 Journal Article Simultaneous uncoupled expression and purification of the Dengue virus NS3 protease and NS2B co-factor domain.Shannon, A. E, Chappell, K. J., Stoermer, M. J., Chow, S. Y., Kok, W. M., Fairlie, D. P. and Young, P. R. (2015). Simultaneous uncoupled expression and purification of the Dengue virus NS3 protease and NS2B co-factor domain.. Protein Expression and Purification, 119, 124-129. doi: 10.1016/j.pep.2015.11.022 |
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2015 Journal Article Flexibility versus rigidity for orally bioavailable cyclic hexapeptidesNielsen, Daniel S., Lohman, Rink-Jan, Hoang, Huy Ngoc, Hill, Timothy A., Jones, Alun, Lucke, Andrew J. and Fairlie, David P. (2015). Flexibility versus rigidity for orally bioavailable cyclic hexapeptides. Chembiochem, 16 (16), 2289-2293. doi: 10.1002/cbic.201500441 |
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2015 Journal Article Repurposing Registered Drugs as Antagonists for Protease-Activated Receptor 2Xu, Weijun, Lim, Junxian, Goh, Chai-Yeen, Suen, Jacky Y., Jiang, Yuhong, Yau, Mei-Kwan, Wu, Kai-Chen, Liu, Ligong and Fairlie, David P. (2015). Repurposing Registered Drugs as Antagonists for Protease-Activated Receptor 2. Journal of Chemical Information and Modeling, 55 (10), 2079-2084. doi: 10.1021/acs.jcim.5b00500 |
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2015 Journal Article Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonistsSwedberg, Joakim E., Schroeder, Christina I., Mitchell, Justin M., Durek, Thomas, Fairlie, David P., Edmonds, David J., Griffith, David A., Ruggeri, Roger B., Derksen, David R., Loria, Paula M., Liras, Spiros, Price, David A. and Craik, David J. (2015). Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists. European Journal of Medicinal Chemistry, 103, 175-184. doi: 10.1016/j.ejmech.2015.08.046 |
