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2017 Journal Article Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signalingPlisson, Fabien, Hill, Timothy A., Mitchell, Justin M., Hoang, Huy N., de Araujo, Aline D., Xu, Weijun, Cotterell, Adam, Edmonds, David J., Stanton, Robert V., Derksen, David R., Loria, Paula M., Griffith, David A., Price, David A., Liras, Spiros and Fairlie, David P. (2017). Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling. European Journal of Medicinal Chemistry, 127, 703-714. doi: 10.1016/j.ejmech.2016.10.044 |
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2017 Journal Article Alpha helix nucleation by a simple cyclic tetrapeptideHoang, Huy N., Wu, Chongyang, Beyer, Renee L., Hill, Timothy A. and Fairlie, David P. (2017). Alpha helix nucleation by a simple cyclic tetrapeptide. Australian Journal of Chemistry, 70 (2), 213-219. doi: 10.1071/CH16591 |
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2017 Journal Article Histone deacetylases (HDAC) in physiological and pathological bone remodellingCantley, M. D., Zannettino, A. C. W., Bartold, P. M., Fairlie, D. P. and Haynes, D. R. (2017). Histone deacetylases (HDAC) in physiological and pathological bone remodelling. Bone, 95, 162-174. doi: 10.1016/j.bone.2016.11.028 |
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2017 Journal Article Total synthesis of the Mycobacterium tuberculosis dideoxymycobactin-838 and stereoisomers: diverse CD1a-restricted T cells display a common hierarchy of lipopeptide recognitionCheng, Janice, Liu, Ligong, Pellicci, Daniel, Reddiex, Scott J.J., Cotton, Rachel, Cheng, Tan-Yun, Young, David, Van Rhijn, Ildiko, Moody, Branch, Rossjohn, Jamie, Fairlie, David, Godfrey, Dale and Williams, Spencer John (2017). Total synthesis of the Mycobacterium tuberculosis dideoxymycobactin-838 and stereoisomers: diverse CD1a-restricted T cells display a common hierarchy of lipopeptide recognition. Chemistry - A European Journal, 23 (7), 1694-1701. doi: 10.1002/chem.201605287 |
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2017 Journal Article An HDAC6 inhibitor confers protection and selectively inhibits B-cell infiltration in DSS-induced colitis in miceDo, Anh, Reid, Robert C., Lohman, Rink-Jan, Sweet, Matthew J., Fairlie, David P. and Iyer, Abishek (2017). An HDAC6 inhibitor confers protection and selectively inhibits B-cell infiltration in DSS-induced colitis in mice. The Journal of Pharmacology and Experimental Therapeutics, 360 (1), 140-151. doi: 10.1124/jpet.116.236711 |
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2017 Journal Article Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signalChen, Z., Wang, H., D'Souza, C., Sun, S., Kostenko, L., Eckle, S. B. G, Meehan, B. S., Jackson, D.C., Strugnell, R. A., Cao, H., Wang, N., Fairlie, David, Liu, L., Godfrey, D. I., Rossjohn, J., McCluskey, J. and Corbett, A. J. (2017). Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signal. Mucosal Immunology, 10 (1), 58-68. doi: 10.1038/mi.2016.39 |
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2016 Journal Article Product release is rate-limiting for catalytic processing by the Dengue virus proteaseShannon, A. E., Pedroso, M. M., Chappell, K. J., Watterson, D., Liebscher, S., Kok, W. M., Fairlie, D. P., Schenk, G. and Young, P. R. (2016). Product release is rate-limiting for catalytic processing by the Dengue virus protease. Scientific Reports, 6 (1) 37539, 37539. doi: 10.1038/srep37539 |
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2016 Journal Article Correction: Downsizing the BAD BH3 peptide to small constrained alpha-helices with improved ligand efficiency (vol 14, pg 10939, 2016)Shepherd, Nicholas E., Harrison, Rosemary S., Ruiz-Gomez, Gloria, Abbenante, Giovanni, Mason, Jody M. and Fairlie, David P. (2016). Correction: Downsizing the BAD BH3 peptide to small constrained alpha-helices with improved ligand efficiency (vol 14, pg 10939, 2016). Organic & Biomolecular Chemistry, 14 (48), 11525-11525. doi: 10.1039/c6ob90178f |
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2016 Journal Article Downsizing the BAD BH3 peptide to small contrained alpha-helices with improved ligand efficiencyShepherd, Nicholas E., Harrison, Rosemary S., Ruiz-Gomez, Gloria, Abbenante, Giovanni, Mason, Jody M. and Fairlie, David P. (2016). Downsizing the BAD BH3 peptide to small contrained alpha-helices with improved ligand efficiency. Organic and Biomolecular Chemistry, 46 (14), 10939-10945. doi: 10.1039/C6OB02185A |
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2016 Journal Article A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineageKoay, Hui-Fern, Gherardin, Nicholas A., Enders, Anselm, Loh, Liyen, Mackay, Laura K., Almeida, Catarina F., Russ, Brendan E., Nold-Petry, Claudia A., Nold, Marcel F., Bedoui, Sammy, Chen, Zhenjun, Corbett, Alexandra J., Eckle, Sidonia B. G., Meehan, Bronwyn, D'Udekem, Yves, Konstantinov, Igor E., Lappas, Martha, Liu, Ligong, Goodnow, Chris C., Fairlie, David P., Rossjohn, Jamie, Chong, Mark M., Kedzierska, Katherine, Berzins, Stuart P., Belz, Gabrielle T., McCluskey, James, Uldrich, Adam P., Godfrey, Dale I. and Pellicci, Daniel G. (2016). A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage. Nature Immunology, 17 (11), 1300-1311. doi: 10.1038/ni.3565 |
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2016 Journal Article Review stapling peptides using cysteine crosslinkingFairlie, David P. and Dantas de Araujo, Aline (2016). Review stapling peptides using cysteine crosslinking. Biopolymers, 106 (6), 843-852. doi: 10.1002/bip.22877 |
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2016 Journal Article Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activationLoh, Liyen, Wang, Zhongfang, Sant, Sneha, Koutsakos, Marios, Jegaskanda, Sinthujan, Corbett, Alexandra J., Liu, Ligong, Fairlie, David P., Crowe, Jane, Rossjohn, Jamie, Xu, Jianqing, Doherty, Peter C., McCluskey, James and Kedzierska, Katherine (2016). Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation. Proceedings of the National Academy of Sciences, 113 (36), 10133-10138. doi: 10.1073/pnas.1610750113 |
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2016 Journal Article Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2Lieu, T., Savage, E., Zhao, P., Edgington-Mitchell, L., Barlow, N., Bron, R., Poole, D. P., Mclean, P., Lohman, R. -J., Fairlie, D. P. and Bunnett, N. W. (2016). Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2. British Journal of Pharmacology, 173 (18), 2752-2765. doi: 10.1111/bph.13554 |
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2016 Journal Article Truncated glucagon-like peptide-1 and exendin-4 α-conotoxin pl14a peptide chimeras maintain potency and α-helicity and reveal interactions vital for cAMP signaling in vitroSwedberg, Joakim E., Schroeder, Christina I., Mitchell, Justin M., Fairlie, David P., Edmonds, David J., Griffith, David A., Ruggeri, Roger B., Derksen, David R., Loria, Paula M., Price, David A., Liras, Spiros and Craik, David J. (2016). Truncated glucagon-like peptide-1 and exendin-4 α-conotoxin pl14a peptide chimeras maintain potency and α-helicity and reveal interactions vital for cAMP signaling in vitro. Journal of Biological Chemistry, 291 (30), 15778-15787. doi: 10.1074/jbc.M116.724542 |
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2016 Journal Article Helix nucleation by the smallest known α-helix in waterHoang, Huy N., Driver, Russell W., Beyer, Renee L., Hill, Timothy A., de Araujo, Aline D., Plisson, Fabien, Harrison, Rosemary S., Goedecke, Lena, Shepherd, Nicholas E. and Fairlie, David P. (2016). Helix nucleation by the smallest known α-helix in water. Angewandte Chemie (International Edition), 55 (29), 8275-8279. doi: 10.1002/anie.201602079 |
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2016 Journal Article Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites (vol 5, pg 117, 2015)Engel, Jessica A., Jones, Amy J., Avery, Vicky M., Sumanadasa, Subathdrage D. M., Ng, Susanna S., Fairlie, David P., Skinner-Adams, Tina and Andrews, Katherine T. (2016). Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites (vol 5, pg 117, 2015). International Journal for Parasitology-Drugs and Drug Resistance, 6 (3), 287-287. doi: 10.1016/j.ijpddr.2016.05.001 |
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2016 Journal Article The intracellular pathway for the presentation of vitamin B–related antigens by the antigen-presenting molecule MR1McWilliam, Hamish E. G., Eckle, Sidonia B. G., Theodossis, Alex, Liu, Ligong, Chen, Zhenjun, Wubben, Jacinta M., Fairlie, David P., Strugnell, Richard A., Mintern, Justine D., McCluskey, James, Rossjohn, Jamie and Villadangos, Jose A. (2016). The intracellular pathway for the presentation of vitamin B–related antigens by the antigen-presenting molecule MR1. Nature Immunology, 17 (5), 531-537. doi: 10.1038/ni.3416 |
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2016 Journal Article Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonistsSeow, Vernon, Lim, Junxian, Cotterell, Adam J., Yau, Mei-Kwan, Xu, Weijun, Lohman, Rink-Jan, Kok, W. Mei, Stoermer, Martin J., Sweet, Matthew J., Reid, Robert C., Suen, Jacky Y. and Farilie, David P. (2016). Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists. Scientific Reports, 6 (1) 24575, 24575.1-24575.12. doi: 10.1038/srep24575 |
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2016 Journal Article Protease activated receptor 2 (PAR2) modulators: a patent review (2010–2015)Yau, Mei-Kwan, Lim, Junxian, Liu, Ligong and Fairlie, David P. (2016). Protease activated receptor 2 (PAR2) modulators: a patent review (2010–2015). Expert Opinion on Therapeutic Patents, 26 (4), 471-483. doi: 10.1517/13543776.2016.1154540 |
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2016 Journal Article Histone deacetylase inhibitors promote mitochondrial reactive oxygen species production and bacterial clearance by human macrophagesAriffin, Juliana K., das Gupta, Kaustav, Kapetanovic, Ronan, Iyer, Abishek, Reid, Robert C., Fairlie, David P. and Sweet, Matthew J. (2016). Histone deacetylase inhibitors promote mitochondrial reactive oxygen species production and bacterial clearance by human macrophages. Antimicrobial Agents and Chemotherapy, 60 (3), 1521-1529. doi: 10.1128/AAC.01876-15 |
