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2019 Journal Article Computer modelling and synthesis of deoxy and monohydroxy analogues of a ribitylaminouracil bacterial metabolite that potently activates human T cellsLer, Geraldine J. M., Xu, Weijun, Mak, Jeffrey Y. W., Liu, Ligong, Bernhardt, Paul V. and Fairlie, David P (2019). Computer modelling and synthesis of deoxy and monohydroxy analogues of a ribitylaminouracil bacterial metabolite that potently activates human T cells. Chemistry – A European Journal, 25 (68) chem.201903732, 15594-15608. doi: 10.1002/chem.201903732 |
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2019 Journal Article Protease-activated receptor 2 does not contribute to renal inflammation or fibrosis in the obstructed kidneyMa, Frank Y., Han, Yingjie, Ozols, Elyce, Chew, Phyllis, Vesey, David A., Gobe, Glenda C., Morais, Christudas, Lohman, Rink-Jan, Suen, Jacky Y., Johnson, David W., Fairlie, David P. and Nikolic-Paterson, David J. (2019). Protease-activated receptor 2 does not contribute to renal inflammation or fibrosis in the obstructed kidney. Nephrology, 24 (9) nep.13635, 983-991. doi: 10.1111/nep.13635 |
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2019 Journal Article Diverse MR1-restricted T cells in mice and humansKoay, Hui-Fern, Gherardin, Nicholas A., Xu, Calvin, Seneviratna, Rebecca, Zhao, Zhe, Chen, Zhenjun, Fairlie, David P., McCluskey, James, Pellicci, Daniel G., Uldrich, Adam P. and Godfrey, Dale I. (2019). Diverse MR1-restricted T cells in mice and humans. Nature Communications, 10 (1) 2243, 2243. doi: 10.1038/s41467-019-10198-w |
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2019 Journal Article Crystal structures of protein-bound cyclic peptidesMalde, Alpeshkumar K., Hill, Timothy A., Iyer, Abishek and Fairlie, David P. (2019). Crystal structures of protein-bound cyclic peptides. Chemical Reviews, 119 (17) acs.chemrev.8b00807, 9861-9914. doi: 10.1021/acs.chemrev.8b00807 |
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2019 Journal Article Pharmacological inhibition of protease-activated receptor-2 reduces crescent formation in rat nephrotoxic serum nephritisHan, Yingjie, Tian, Lifang, Ma, Frank, Tesch, Greg, Vesey, David A., Gobe, Glenda C., Lohman, Rink-Jan, Morais, Christudas, Suen, Jacky Y., Fairlie, David P. and Nikolic-Paterson, David J. (2019). Pharmacological inhibition of protease-activated receptor-2 reduces crescent formation in rat nephrotoxic serum nephritis. Clinical and Experimental Pharmacology and Physiology, 46 (5) 1440-1681.13077, 456-464. doi: 10.1111/1440-1681.13077 |
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2019 Journal Article MAIT cells upregulate α4β7 in response to acute simian immunodeficiency virus/simian HIV infection but are resistant to peripheral depletion in pigtail macaquesJuno, Jennifer A., Wragg, Kathleen M., Amarasena, Thakshila, Meehan, Bronwyn S., Mak, Jeffrey Y. W., Liu, Ligong, Fairlie, David P., McCluskey, James, Eckle, Sidonia B. G. and Kent, Stephen J. (2019). MAIT cells upregulate α4β7 in response to acute simian immunodeficiency virus/simian HIV infection but are resistant to peripheral depletion in pigtail macaques. The Journal of Immunology, 202 (7), ji1801405-2120. doi: 10.4049/jimmunol.1801405 |
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2019 Journal Article Oxazole-benzenesulfonamide derivatives inhibit HIV-1 reverse transcriptase interaction with cellular eEF1A and reduce viral replicationRawle, Daniel J., Li, Dongsheng, Wu, Zhonglan, Wang, Lu, Choong, Marcus, Lor, Mary, Reid, Robert C., Fairlie, David P., Harris, Jonathan, Tachedjian, Gilda, Poulsen, Sally-Ann and Harrich, David (2019). Oxazole-benzenesulfonamide derivatives inhibit HIV-1 reverse transcriptase interaction with cellular eEF1A and reduce viral replication. Journal of Virology, 93 (12) e0023919. doi: 10.1128/jvi.00239-19 |
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2019 Journal Article Structure-activity relationships of wollamide cyclic hexapeptides with activity against drug-resistant and intracellularKhalil, Zeinab G., Hill, Timothy A., De Leon Rodriguez, Luis M., Lohman, Rink-Jan, Hoang, Huy N., Reiling, Norbert, Hillemann, Doris, Brimble, Margaret A., Fairlie, David, Blumenthal, Antje and Capon, Robert J. (2019). Structure-activity relationships of wollamide cyclic hexapeptides with activity against drug-resistant and intracellular. Antimicrobial Agents and Chemotherapy, 63 (3) e01773-18. doi: 10.1128/AAC.01773-18 |
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2019 Journal Article Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitroAlgate, Kent, Haynes, David, Fitzsimmons, Tracy, Romeo, Ornella, Wagner, Florence, Holson, Edward, Reid, Robert, Fairlie, David, Bartold, Peter and Cantley, Melissa (2019). Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro. Journal of Cellular Biochemistry, 121 (1) jcb.29137, 244-258. doi: 10.1002/jcb.29137 |
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2018 Journal Article Complement C3a and C5a receptors promote GVHD by suppressing mitophagy in recipient dendritic cellsNguyen, Hung, Kuril, Sandeepkumar, Bastian, David, Kim, Jisun, Zhang, Mengmeng, Vaena, Silvia G., Dany, Mohammed, Dai, Min, Heinrichs, Jessica Lauren, Daenthanasanmak, Anusara, Iamsawat, Supinya, Schutt, Steven, Fu, Jianing, Wu, Yongxia, Fairlie, David P., Atkinson, Carl, Ogretmen, Besim, Tomlinson, Stephen and Yu, Xue-Zhong (2018). Complement C3a and C5a receptors promote GVHD by suppressing mitophagy in recipient dendritic cells. JCI Insight, 3 (24) e121697. doi: 10.1172/jci.insight.121697 |
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2018 Journal Article MAIT cells protect against pulmonary Legionella longbeachae infectionWang, Huimeng, D’Souza, Criselle, Lim, Xin Yi, Kostenko, Lyudmila, Pediongco, Troi J., Eckle, Sidonia B. G., Meehan, Bronwyn S., Shi, Mai, Wang, Nancy, Li, Shihan, Liu, Ligong, Mak, Jeffrey Y. W., Fairlie, David P., Iwakura, Yoichiro, Gunnersen, Jennifer M., Stent, Andrew W., Godfrey, Dale I., Rossjohn, Jamie, Westall, Glen P., Kjer-Nielsen, Lars, Strugnell, Richard A., McCluskey, James, Corbett, Alexandra J., Hinks, Timothy S. C. and Chen, Zhenjun (2018). MAIT cells protect against pulmonary Legionella longbeachae infection. Nature Communications, 9 (1) 3350, 3350. doi: 10.1038/s41467-018-05202-8 |
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2018 Journal Article Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genesRamnath, Divya, Irvine, Katharine M., Lukowski, Samuel W., Horsfall, Leigh U., Loh, Zhixuan, Clouston, Andrew D., Patel, Preya J., Fagan, Kevin J., Iyer, Abishek, Lampe, Guy, Stow, Jennifer L., Schroder, Kate, Fairlie, David P., Powell, Joseph E., Powell, Elizabeth E. and Sweet, Matthew J. (2018). Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes. JCI Insight, 3 (14) e120274. doi: 10.1172/jci.insight.120274 |
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2018 Journal Article Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasisKim, Soo-Hyun, Redvers, Richard P., Chi, Lap Hing, Ling, Xiawei, Lucke, Andrew J., Reid, Robert C., Fairlie, David P., Baptista Moreno Martin, Ana Carolina, Anderson, Robin L., Denoyer, Delphine and Pouliot, Normand (2018). Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis. Disease Models and Mechanisms, 11 (7) Y, DMM034850. doi: 10.1242/dmm.034850 |
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2018 Journal Article An overview on the identification of MAIT cell antigensKjer-Nielsen, Lars, Corbett, Alexandra J., Chen, Zhenjun, Liu, Ligong, Mak, Jeffrey Y. W., Godfrey, Dale I., Rossjohn, Jamie, Fairlie, David P., McCluskey, James and Eckle, Sidonia B. G. (2018). An overview on the identification of MAIT cell antigens. Immunology and Cell Biology, 96 (6), 573-587. doi: 10.1111/imcb.12057 |
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2018 Journal Article Bicyclic helical peptides as dual inhibitors selective for Bcl2A1 and Mcl-1 proteinsde Araujo, Aline D., Lim, Junxian, Wu, Kai-Chen, Xiang, Yibin, Good, Andrew C., Skerlj, Renato and Fairlie, David P. (2018). Bicyclic helical peptides as dual inhibitors selective for Bcl2A1 and Mcl-1 proteins. Journal of Medicinal Chemistry, 61 (7), 2962-2972. doi: 10.1021/acs.jmedchem.8b00010 |
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Featured 2018 Journal Article Recipient mucosal-associated invariant T cells control GVHD within the colonVarelias, Antiopi, Bunting, Mark D., Ormerod, Kate L., Koyama, Motoko, Olver, Stuart D., Straube, Jasmin, Kuns, Rachel D., Robb, Renee J., Henden, Andrea S., Cooper, Leanne, Lachner, Nancy, Gartlan, Kate H., Lantz, Olivier, Kjer-Nielsen, Lars, Mak, Jeffrey Y. W., Fairlie, David P., Clouston, Andrew D., McCluskey, James, Rossjohn, Jamie, Lane, Steven W., Hugenholtz, Philip and Hill, Geoffrey R. (2018). Recipient mucosal-associated invariant T cells control GVHD within the colon. Journal of Clinical Investigation, 128 (5), 1919-1936. doi: 10.1172/JCI91646 |
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2018 Journal Article Lysine deacetylases and regulated glycolysis in macrophagesShakespear, Melanie R., Iyer, Abishek, Cheng, Catherine Youting, Das Gupta, Kaustav, Singhal, Amit, Fairlie, David P. and Sweet, Matthew J. (2018). Lysine deacetylases and regulated glycolysis in macrophages. Trends in Immunology, 39 (6), 473-488. doi: 10.1016/j.it.2018.02.009 |
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2018 Journal Article Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed multiple myelomaGherardin, Nicholas A, Loh, Liyen, Admojo, Lorenztino, Davenport, Alexander J, Richardson, Kelden, Rogers, Amy, Darcy, Phillip K, Jenkins, Misty R., Prince, H. Miles, Harrison, Simon J., Quach, Hang, Fairlie, David P., Kedzierska, Katherine, McCluskey, James, Uldrich, Adam P, Neeson, Paul J., Ritchie, David S. and Godfrey, Dale I. (2018). Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed multiple myeloma. Scientific reports, 8 (1) 4159, 4159. doi: 10.1038/s41598-018-22130-1 |
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2018 Journal Article Chemically Diverse Helix-Constrained Peptides Using Selenocysteine CrosslinkingDantas de Araujo, Aline, Perry, Samuel R. and Fairlie, David P. (2018). Chemically Diverse Helix-Constrained Peptides Using Selenocysteine Crosslinking. Organic Letters, 20 (5), 1453-1456. doi: 10.1021/acs.orglett.8b00233 |
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2018 Journal Article Human blood MAIT cell subsets defined using MR1 tetramersGherardin, Nicholas A., Souter, Michael N. T., Koay, Hui-Fern, Mangas, Kirstie M., Seemann, Torsten, Stinear, Timothy P., Eckle, Sidonia B. G., Berzins, Stuart P., d'Udekem, Yves, Konstantinov, Igor E., Fairlie, David P., Ritchie, David S., Neeson, Paul J., Pellicci, Daniel G., Uldrich, Adam P., McCluskey, James and Godfrey, Dale I. (2018). Human blood MAIT cell subsets defined using MR1 tetramers. Immunology and Cell Biology, 96 (5), 507-525. doi: 10.1111/imcb.12021 |
