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2019 Journal Article Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclizationRehm, Fabian B. H., Jackson, Mark A., De Geyter, Ewout, Yap, Kuok, Gilding, Edward K., Durek, Thomas and Craik, David J. (2019). Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclization. Proceedings of the National Academy of Sciences, 116 (16), 7831-7836. doi: 10.1073/pnas.1901807116 |
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2019 Journal Article Amino acid scanning at P5′ within the Bowman–Birk inhibitory loop reveals specificity trends for diverse serine proteasesLi, Choi Yi, de Veer, Simon J., White, Andrew M., Chen, Xingchen, Harris, Jonathan M., Swedberg, Joakim E. and Craik, David J. (2019). Amino acid scanning at P5′ within the Bowman–Birk inhibitory loop reveals specificity trends for diverse serine proteases. Journal of Medicinal Chemistry, 62 (7), 3696-3706. doi: 10.1021/acs.jmedchem.9b00211 |
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2019 Journal Article Toward structure determination of disulfide-rich peptides using chemical shift-based methodsWang, Conan K. and Craik, David J. (2019). Toward structure determination of disulfide-rich peptides using chemical shift-based methods. The Journal of Physical Chemistry B, 123 (9) acs.jpcb.8b10649, 1903-1912. doi: 10.1021/acs.jpcb.8b10649 |
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2019 Journal Article Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitorsPeigneur, Steve, Cheneval, Olivier, Maiti, Mohitosh, Leipold, Enrico, Heinemann, Stefan H., Lescrinier, Eveline, Herdewijn, Piet, De Lima, Maria Elena, Craik, David J., Schroeder, Christina I. and Tytgat, Jan (2019). Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitors. FASEB Journal, 33 (3), 3693-3703. doi: 10.1096/fj.201801909R |
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2019 Journal Article A centipede toxin family defines an ancient class of CSαβ defensinsDash, Thomas S., Shafee, Thomas, Harvey, Peta J., Zhang, Chuchu, Peigneur, Steve, Deuis, Jennifer R., Vetter, Irina, Tytgat, Jan, Anderson, Marilyn A., Craik, David J., Durek, Thomas and Undheim, Eivind A. B. (2019). A centipede toxin family defines an ancient class of CSαβ defensins. Structure, 27 (2), 315-326. doi: 10.1016/j.str.2018.10.022 |
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2019 Journal Article Highly potent and selective plasmin inhibitors based on the sunflower trypsin inhibitor-1 scaffold attenuate fibrinolysis in plasmaSwedberg, Joakim E., Wu, Guojie, Mahatmanto, Tunjung, Durek, Thomas, Caradoc-Davies, Tom T., Whisstock, James C., Law, Ruby H. P. and Craik, David J. (2019). Highly potent and selective plasmin inhibitors based on the sunflower trypsin inhibitor-1 scaffold attenuate fibrinolysis in plasma. Journal of Medicinal Chemistry, 62 (2), 552-560. doi: 10.1021/acs.jmedchem.8b01139 |
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2019 Journal Article Discovery and characterization of cyclic and acyclic trypsin inhibitors from Momordica dioicaDu, Junqiao, Chan, Lai Yue, Poth, Aaron G. and Craik, David J. (2019). Discovery and characterization of cyclic and acyclic trypsin inhibitors from Momordica dioica. Journal of Natural Products, 82 (2) acs.jnatprod.8b00716, 293-300. doi: 10.1021/acs.jnatprod.8b00716 |
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2019 Journal Article Peptide-membrane interactions affect the inhibitory potency and selectivity of spider toxins ProTx-II and GpTx-1Lawrence, Nicole, Wu, Bin, Ligutti, Joseph, Cheneval, Olivier, Agwa, Akello Joanna, Benfield, Aurélie H., Biswas, Kaustav, Craik, David J., Miranda, Les P., Henriques, Sónia Troeira and Schroeder, Christina I. (2019). Peptide-membrane interactions affect the inhibitory potency and selectivity of spider toxins ProTx-II and GpTx-1. ACS Chemical Biology, 14 (1), 118-130. doi: 10.1021/acschembio.8b00989 |
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2019 Journal Article Characterising the subsite specificity of urokinase-type plasminogen activator and tissue-type plasminogen activator using a sequence-defined peptide aldehyde libraryLi, Choi Yi, de Veer, Simon J., Law, Ruby H. P., Whisstock, James C., Craik, David J. and Swedberg, Joakim E. (2019). Characterising the subsite specificity of urokinase-type plasminogen activator and tissue-type plasminogen activator using a sequence-defined peptide aldehyde library. ChemBioChem, 19 (1), 46-50. doi: 10.1002/cbic.201800395 |
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2019 Book Chapter Overview of NMR in the Pharmaceutical SciencesSchirra, Horst Joachim and Craik, David J. (2019). Overview of NMR in the Pharmaceutical Sciences. Modern Magnetic Resonance. (pp. 1195-1202) Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/1-4020-3910-7_128 |
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2019 Journal Article Evaluation of the in vitro antitumor activity of nanostructured cyclotides in polymers of Eudragit (R) L 100-55 and RS 30 DSilva, Osmar N., Pinto, Michelle F. S., Viana, Juliane F. C., Freitas, Camila G., Fensterseifer, Isabel C. M., Craik, David J. and Franco, Octavio L. (2019). Evaluation of the in vitro antitumor activity of nanostructured cyclotides in polymers of Eudragit (R) L 100-55 and RS 30 D. Letters in Drug Design and Discovery, 16 (4), 437-445. doi: 10.2174/1570180815666180801115526 |
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2019 Book Chapter Cyclizing disulfide-rich peptides using sortase AAgwa, Akello J., Craik, David J. and Schroeder, Christina I. (2019). Cyclizing disulfide-rich peptides using sortase A. Methods in Molecular Biology. (pp. 29-41) edited by Timo Nuijens and Marcel Schmidt. New York, NY, United States: Humana Press. doi: 10.1007/978-1-4939-9546-2_3 |
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2018 Journal Article Mechanism of bacterial membrane permeabilization of crotalicidin (Ctn) and its fragment Ctn[15-34], antimicrobial peptides from rattlesnake venomPérez-Peinado, Clara, Almeida Dias, Susana, Domingues, Marco M., Benfield, Aurélie H., Freire, João Miguel, Radis-Baptista, Gandhi, Gaspar, Diana, Castanho, Miguel A. R. B., Craik, David J., Henriques, Sonia Troeira, Veiga, Ana S. and Andreu, David (2018). Mechanism of bacterial membrane permeabilization of crotalicidin (Ctn) and its fragment Ctn[15-34], antimicrobial peptides from rattlesnake venom. The Journal of Biological Chemistry, 293 (5), 1536-1549. doi: 10.1074/jbc.RA117.000125 |
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2018 Journal Article Potent, selective, and cell-penetrating inhibitors of Kallikrein-related peptidase 4 based on the cyclic peptide MCoTI-IISwedberg, Joakim E., Ghani, Hafiza Abdul, Harris, Jonathan M., de Veer, Simon J. and Craik, David J. (2018). Potent, selective, and cell-penetrating inhibitors of Kallikrein-related peptidase 4 based on the cyclic peptide MCoTI-II. ACS Medicinal Chemistry Letters, 9 (12) acsmedchemlett.8b00422, 1258-1262. doi: 10.1021/acsmedchemlett.8b00422 |
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2018 Journal Article Synthesis, racemic x-ray crystallographic, and permeability studies of bioactive orbitides from Jatropha speciesRamalho, Suelem D., Wang, Conan K., King, Gordon J., Byriel, Karl A., Huang, Yen-Hua, Bolzani, Vanderlan S. and Craik, David J. (2018). Synthesis, racemic x-ray crystallographic, and permeability studies of bioactive orbitides from Jatropha species. Journal of Natural Products, 81 (11) acs.jnatprod.8b00447, 2436-2445. doi: 10.1021/acs.jnatprod.8b00447 |
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2018 Journal Article Discovery and characterization of cyclotides from Rinorea speciesNiyomploy, Ploypat, Chan, Lai Yue, Harvey, Peta J., Poth, Aaron G., Colgrave, Michelle L. and Craik, David J. (2018). Discovery and characterization of cyclotides from Rinorea species. Journal of Natural Products, 81 (11) acs.jnatprod.8b00572, 2512-2520. doi: 10.1021/acs.jnatprod.8b00572 |
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2018 Journal Article Single amino acid substitution in α-conotoxin TxID reveals a specific α3β4 nicotinic acetylcholine receptor antagonistYu, Jinpeng, Zhu, Xiaopeng, Harvey, Peta J., Kaas, Quentin, Zhangsun, Dongting, Craik, David J. and Luo, Sulan (2018). Single amino acid substitution in α-conotoxin TxID reveals a specific α3β4 nicotinic acetylcholine receptor antagonist. Journal of Medicinal Chemistry, 61 (20), 9256-9265. doi: 10.1021/acs.jmedchem.8b00967 |
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2018 Journal Article NMR structure of µ-conotoxin GIIIC: Leucine 18 induces local repacking of the N-terminus resulting in reduced Nav channel potencyHarvey, Peta J., Kurniawan, Nyoman D., Finol-Urdaneta, Rocio K., McArthur, Jeffrey R., Van Lysebetten, Dorien, Dash, Thomas S., Hill, Justine M., Adams, David J., Durek, Thomas and Craik, David J. (2018). NMR structure of µ-conotoxin GIIIC: Leucine 18 induces local repacking of the N-terminus resulting in reduced Nav channel potency. Molecules, 23 (10) molecules23102715, 2715. doi: 10.3390/molecules23102715 |
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2018 Journal Article A computationally designed peptide derived from Escherichia coli as a potential drug template for antibacterial and antibiofilm therapiesCardoso, Marlon, Cândido, Elizabete, Chan, Lai, Torres, Marcelo Der Torossian, Oshiro, Karen, Rezende, Samilla, Porto, William F., Lu, Timothy K., de la Fuente-Nunez, Cesar, Craik, David J. and Franco, Octávio L. (2018). A computationally designed peptide derived from Escherichia coli as a potential drug template for antibacterial and antibiofilm therapies. ACS Infectious Diseases, 4 (12) acsinfecdis.8b00219, 1727-1736. doi: 10.1021/acsinfecdis.8b00219 |
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2018 Journal Article Targeted delivery of cyclotides via conjugation to a nanobodyKwon, Soohyun, Duarte, Joao N., Li, Zeyang, Ling, Jingjing J., Cheneval, Olivier, Durek, Thomas, Schroeder, Christina I., Craik, David J. and Ploegh, Hidde L. (2018). Targeted delivery of cyclotides via conjugation to a nanobody. ACS Chemical Biology, 13 (10), 2973-2980. doi: 10.1021/acschembio.8b00653 |
