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2016 Journal Article Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffoldWang, Conan K., Northfield, Susan E., Huang, Yen-Hua, Ramos, Mariana C. and Craik, David J. (2016). Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffold. European Journal of Medicinal Chemistry, 109, 342-349. doi: 10.1016/j.ejmech.2016.01.006 |
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2016 Journal Article Membrane-binding properties of gating modifier and pore-blocking toxins: membrane interaction is not a prerequisite for modification of channel gatingDeplazes, Evelyne, Troeira Henriques, Sonia, Smith, Jennifer J., King, Glenn F., Craik, David J., Mark, Alan E. and Schroeder, Christina I. (2016). Membrane-binding properties of gating modifier and pore-blocking toxins: membrane interaction is not a prerequisite for modification of channel gating. Biochimica et Biophysica Acta - Biomembranes, 1858 (4), 872-882. doi: 10.1016/j.bbamem.2016.02.002 |
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2016 Journal Article Chlorotoxin: structure, activity, and potential uses in cancer therapyOjeda, Paola G., Wang, Conan K. and Craik, David J. (2016). Chlorotoxin: structure, activity, and potential uses in cancer therapy. Biopolymers - Peptide Science, 106 (1), 25-36. doi: 10.1002/bip.22748 |
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2016 Journal Article Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclizationConibear, Anne C., Chaousis, Stephanie, Durek, Thomas, Rosengren, K. Johan, Craik, David J. and Schroeder, Christina I. (2016). Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization. Biopolymers, 106 (1), 89-100. doi: 10.1002/bip.22767 |
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2016 Journal Article Using the MCoTI-II cyclotide scaffold to design a stable cyclic peptide antagonist of SET, a protein overexpressed in human cancerD'Souza, Charlotte, Henriques, Sonia Troeira, Wang, Conana K., Cheneval, Olivier, Chan, Lai Yue, Bokil, Nilesh J., Sweet, Matthew J. and Craik, David J. (2016). Using the MCoTI-II cyclotide scaffold to design a stable cyclic peptide antagonist of SET, a protein overexpressed in human cancer. Biochemistry, 55 (2), 396-405. doi: 10.1021/acs.biochem.5b00529 |
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2016 Conference Publication Probing voltage-dependent structural changes of the VSD in mammalian Nav with LRETKubota, Tomoya, Durek, Thomas, Finol-Urdaneta, Rocio K., Craik, David J., French, Robert J., Bezanilla, Francisco and Correa, Ana M. (2016). Probing voltage-dependent structural changes of the VSD in mammalian Nav with LRET. 60th Annual Meeting of the Biophysical Society, Los Angeles, United States, Feb 27-Mar 02, 2016. St. Louis, United States: Cell Press. doi: 10.1016/j.bpj.2015.11.665 |
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2016 Conference Publication Membrane-binding properties of gating-modifier and pore blocking toxins: membrane interaction is not a prerequisite for modification of channel gatingDeplazes, Evelyne, Henriques, Sonia Troeira, King, Glenn F., Craik, David J., Mark, Alan E. and Schroeder, Christina I. (2016). Membrane-binding properties of gating-modifier and pore blocking toxins: membrane interaction is not a prerequisite for modification of channel gating. 60th Annual Meeting of the Biophysical-Society, Los Angeles, United States, February 27- March 2 2016. St Louis, United States: Cell Press. doi: 10.1016/j.bpj.2015.11.220 |
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2016 Conference Publication Inhibitory Effects of Substrate-Based Bcr-Abl1 Kinase Inhibitors On the Growth of Chronic Myeloid Leukemia Cell Line K562Huang, Y. -H., Henriques, S. Troeira, Lawrence, N., Kaas, Q. and Craik, D. J. (2016). Inhibitory Effects of Substrate-Based Bcr-Abl1 Kinase Inhibitors On the Growth of Chronic Myeloid Leukemia Cell Line K562. 34th European Peptide Symposium, Leipzig, Germany, 4‐9 September 2016. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2950 |
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2016 Conference Publication Cyclotides, stable drug scaffolds and delivery systems to target intracellular cancer pathwaysHenriques, S. Troeira, Huang, Y. -H. and Craik, D. (2016). Cyclotides, stable drug scaffolds and delivery systems to target intracellular cancer pathways. 34th European Peptide Symposium, Leipzig, Germany, 4-9 September 2016. Oxford, United Kingdom: John Wiley & Sons. |
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2016 Journal Article Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High Voltage-Activated Calcium Channels via GABAB Receptor Activation Reveal a Minimal Functional MotifCarstens, Bodil B., Berecki, Geza, Daniel, James T., Lee, Han Siean, Jackson, Kathryn A. V., Tae, Han-Shen, Sadeghi, Mahsa, Castro, Joel, O'Donnell, Tracy, Deiteren, Annemie, Brierley, Stuart M., Craik, David J., Adams, David J. and Clark, Richard J. (2016). Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High Voltage-Activated Calcium Channels via GABAB Receptor Activation Reveal a Minimal Functional Motif. Angewandte Chemie - International Edition, 55 (15), 4692-4696. doi: 10.1002/anie.201600297 |
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2016 Journal Article Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactionsPhilippe, Gregoire, Huang, Yen-Hua, Cheneval, Olivier, Lawrence, Nicole, Zhang, Zhen, Fairlie, David P., Craik, David J., Dantas De Araujo, Aline and Troeira Henriques, Sonia (2016). Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions. Biopolymers - Peptide Science, 106 (6), 853-863. doi: 10.1002/bip.22893 |
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2016 Journal Article The radish defensins RsAFP1 and RsAFP2 act synergistically with caspofungin against Candida albicans biofilmsVriens, Kim, Cools, Tanne L., Harvey, Peta J., Craik, David J., Braem, Annabel, Vleugels, Jozef, Coninck, Barbara De, Cammue, Bruno P. A. and Thevissen, Karin (2016). The radish defensins RsAFP1 and RsAFP2 act synergistically with caspofungin against Candida albicans biofilms. Peptides, 75, 71-79. doi: 10.1016/j.peptides.2015.11.001 |
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2016 Conference Publication Modulation of colonic sensory signaling by novel alpha-conotoxin Vc1.1 analogues in miceDeiteren, A., Castro, J., O'Donnell, T., Craik, D. J., Adams, D. J. and Brierley, S. M. (2016). Modulation of colonic sensory signaling by novel alpha-conotoxin Vc1.1 analogues in mice. 2nd Federation of Neurogastroenterology and Motility Meeting, San Francisco, California, United States, 25-28 August, 2016. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/nmo.12881 |
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2016 Conference Publication Towards An Understanding of A- Conotoxin Receptor SpecificityKaas, Q. and Craik, D. J. (2016). Towards An Understanding of A- Conotoxin Receptor Specificity. HOBOKEN: Wiley. |
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2016 Conference Publication Structure-Activity Relationship Studies Reveal that the Spider Toxin Protx-II has Unusual Membrane-Binding Properties and Inhibits NAV1.7 Channel at the Membrane SurfaceHenriques, Sonia Troeira, Craik, David J. and Schroeder, Christina I. (2016). Structure-Activity Relationship Studies Reveal that the Spider Toxin Protx-II has Unusual Membrane-Binding Properties and Inhibits NAV1.7 Channel at the Membrane Surface. 60th Annual Meeting of the Biophysical-Society, Los Angeles, CA, United States, Feb 27-Mar 02, 2016. CAMBRIDGE: CELL PRESS. |
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2016 Journal Article Natural structural diversity within a conserved cyclic peptide scaffoldElliott, Alysha G., Franke, Bastian, Armstrong, David A., Craik, David J., Mylne, Joshua S. and Rosengren, K. Johan (2016). Natural structural diversity within a conserved cyclic peptide scaffold. Amino Acids, 49 (1), 1-14. doi: 10.1007/s00726-016-2333-x |
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2016 Conference Publication Design and plant-based production of therapeutic cyclic peptidesCraik, D., Oguis, G. K., Smithies, B., Qu, H., Gilding, E. K. and Jackson, M. A. (2016). Design and plant-based production of therapeutic cyclic peptides. 34th European Peptide Symposium, Leipzig, Germany, 4‐9 September 2016. Oxford, United Kingdom: John Wiley & Sons. |
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2015 Journal Article Effects of Cyclization on Peptide Backbone DynamicsWang, Conan K., Swedberg, Joakim E., Northfield, Susan E. and Craik, David J. (2015). Effects of Cyclization on Peptide Backbone Dynamics. Journal of Physical Chemistry B, 119 (52), 15821-15830. doi: 10.1021/acs.jpcb.5b11085 |
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2015 Journal Article Cyclic thrombospondin-1 mimetics: grafting of a thrombospondin sequence into circular disulfide-rich frameworks to inhibit endothelial cell migrationChan, Lai Yue, Craik, David J. and Daly, Norelle L. (2015). Cyclic thrombospondin-1 mimetics: grafting of a thrombospondin sequence into circular disulfide-rich frameworks to inhibit endothelial cell migration. Bioscience Reports, 35 (6) e00270, e00270-e00270. doi: 10.1042/BSR20150210 |
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2015 Journal Article Transforming conotoxins into cyclotides: backbone cyclization of P-superfamily conotoxinsAkcan, Muharrem, Clark, Richard J., Daly, Norelle L., Conibear, Anne C., de Faoite, Andrew, Heghinian, Mari D., Sahil, Talwar, Adams, David J., Mari, Frank and Craik, David J. (2015). Transforming conotoxins into cyclotides: backbone cyclization of P-superfamily conotoxins. Peptide Science, 104 (6), 682-692. doi: 10.1002/bip.22699 |
