
Overview
Background
Nick is interested in fostering efficient, environmentally friendly animal production enterprises. He uses the data and capabilities provided by modern 'omics technologies to help improve breeding decisions and to inform other types of 'on farm' intervention.
Nick has a parallel interest in the development, physiology, metabolism and conservation of native Australian species, particularly frogs and butterflies.
Nick is a metabolic biochemist by training with research expertise in a) the handling and biological interpretation of large, complex data sets b) molecular technologies c) mitochondrial physiology and d) metabolic flux.
Nick enjoys teaching various aspects of biochemistry and molecular biology to both undergraduate and postgraduate students. He highlights the main themes using the comparative method and illustrates their importance through applied examples from agriculture and other areas of human endeavour.
Before taking his current position as a Teaching and Research academic in the School of Agriculture and Food Sustainability (AGFS) Nick worked for the CSIRO in a research intensive multi-disciplinary Systems Biology group.
Through this group he helped develop and apply bioinformatic methods that used metabolite, protein, RNA and DNA biotech to understand, model and predict phenotypes of commercial importance in cattle, sheep, pigs and chickens.
A research highlight from this time was the co-invention of a universal method for inferring causal molecules from genome-wide gene expression data (Hudson et al 2009. PLoS Comp Biol e1000382). This method has been applied across a diverse range of model systems including human kidney cancer and commercial traits in various agricultural species.
Following an undergraduate degree in Animal Biology at the University of St.Andrews, Nick was awarded his PhD through what was then the Zoology department of the University of Queensland, after travelling from England on a Britain-Australia Society funded Northcote Scholarship.
Availability
- Dr Nick Hudson is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Research interests
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Productive, efficient farm animals
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Wildlife biology of butterflies and frogs
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Mitochondrial physiology
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Metabolism
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Flux analysis
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Agricultural resource utilisation
Research impacts
Nick is an active science communicator whose research has been disseminated through print, radio and television media.
He hopes to make an impact on agricultural resource utilisation through a better understanding of production animal feed efficiency, and to sustainable agriculture through an understanding of agro-ecology and wildlife biology.
Nick has a very active national and international network of collaborators from academe, government agencies and industry.
This collaborative network has provided stimulating insights into industrial problems and how novel technologies and innovative concepts may inspire creative solutions.
Works
Search Professor Nick Hudson’s works on UQ eSpace
2013
Journal Article
Effect of opioids on tissue metabolism in aestivating and active Green-Striped Burrowing Frogs, Cyclorana alboguttata
Kayes, Sara M., Cramp, Rebecca L., Hudson, Nicholas J. and Franklin, Craig E. (2013). Effect of opioids on tissue metabolism in aestivating and active Green-Striped Burrowing Frogs, Cyclorana alboguttata. Journal of Herpetology, 47 (2), 369-377. doi: 10.1670/12-039
2012
Journal Article
An Always Correlated gene expression landscape for ovine skeletal muscle, lessons learnt from comparison with an "equivalent" bovine landscape
Sun, Wei, Hudson, Nicholas J., Reverter, Antonio, Waardenberg, Ashley J., Tellam, Ross L., Vuocolo, Tony, Byrne, Keren and Dalrymple, Brian P. (2012). An Always Correlated gene expression landscape for ovine skeletal muscle, lessons learnt from comparison with an "equivalent" bovine landscape. BMC Research Notes, 5 (1) 632. doi: 10.1186/1756-0500-5-632
2012
Journal Article
Porcine tissue-specific regulatory networks derived from meta-analysis of the transcriptome
Perez-Montarelo, Dafne, Hudson, Nicholas J., Fernandez, Ana I., Ramayo-Caldas, Yuliaxis, Dalrymple, Brian P. and Reverter, Antonio (2012). Porcine tissue-specific regulatory networks derived from meta-analysis of the transcriptome. PLoS ONE, 7 (9) e46159, e46159. doi: 10.1371/journal.pone.0046159
2012
Journal Article
Mitochondrial treason: a driver of pH decline rate in post-mortem muscle?
Hudson, Nicholas J. (2012). Mitochondrial treason: a driver of pH decline rate in post-mortem muscle?. Animal Production Science, 52 (12), 1107-1110. doi: 10.1071/AN12171
2012
Journal Article
Beyond differential expression: the quest for causal mutations and effector molecules
Hudson, Nicholas J., Dalrymple, Brian P. and Reverter, Antonio (2012). Beyond differential expression: the quest for causal mutations and effector molecules. BMC Genomics, 13 (1) 356. doi: 10.1186/1471-2164-13-356
2011
Journal Article
Eukaryotic evolutionary transitions are associated with extreme codon bias in functionally-related proteins
Hudson, Nicholas J., Gu, Quan, Nagaraj, Shivashankar H., Ding, Yong-Sheng, Dalrymple, Brian P. and Reverter, Antonio (2011). Eukaryotic evolutionary transitions are associated with extreme codon bias in functionally-related proteins. PLoS ONE, 6 (9) e25457, e25457. doi: 10.1371/journal.pone.0025457
2011
Journal Article
Chronic exposure to anabolic steroids induces the muscle expression of oxytocin and a more than fiftyfold increase in circulating oxytocin in cattle
De Jager, Nadia, Hudson, Nicolas J., Reverter, Antonio, Wang, Yong-Hong, Nagaraj, Shivashankar H., Cafe, Linda M., Greenwood, Paul L., Barnard, Ross T., Kongsuwan, Kritaya P. and Dalrymple, Brian P. (2011). Chronic exposure to anabolic steroids induces the muscle expression of oxytocin and a more than fiftyfold increase in circulating oxytocin in cattle. Physiological Genomics, 43 (9), 467-478. doi: 10.1152/physiolgenomics.00226.2010
2011
Journal Article
Musical beauty and information compression: complex to the ear but simple to the mind?
Hudson, Nicholas J. (2011). Musical beauty and information compression: complex to the ear but simple to the mind?. BMC Research Notes, 4 (1) 9. doi: 10.1186/1756-0500-4-9
2011
Journal Article
Genome-wide patterns of promoter sharing and co-expression in bovine skeletal muscle
Gu, Quan, Nagaraj, Shivashankar H., Hudson, Nicholas J., Dalrymple, Brian P. and Reverter, Antonio (2011). Genome-wide patterns of promoter sharing and co-expression in bovine skeletal muscle. BMC Genomics, 12 (1) 23, 23.1-23.13. doi: 10.1186/1471-2164-12-23
2010
Journal Article
Enzyme activity in the aestivating Green-striped burrowing frog (Cyclorana alboguttata)
Mantle, Beth L., Guderley, Helga, Hudson, Nicholas J. and Franklin, Craig E. (2010). Enzyme activity in the aestivating Green-striped burrowing frog (Cyclorana alboguttata). Journal of Comparative Physiology B-biochemical Systemic And Environmental Physiology, 180 (7), 1033-1043. doi: 10.1007/s00360-010-0471-0
2010
Journal Article
Activity, abundance, distribution and expression of Na+/K+-ATPase in the salt glands of Crocodylus porosus following chronic saltwater acclimation
Cramp, Rebecca L., Hudson, Nicholas J. and Franklin, Craig E. (2010). Activity, abundance, distribution and expression of Na+/K+-ATPase in the salt glands of Crocodylus porosus following chronic saltwater acclimation. Journal of Experimental Biology, 213 (8), 1301-1308. doi: 10.1242/jeb.039305
2010
Journal Article
Regulatory impact factors: unraveling the transcriptional regulation of complex traits from expression data
Reverter, Antonio, Hudson, Nicholas J., Nagaraj, Shivashankar H., Perez-Enciso, Miguel and Dalrymple, Brian P. (2010). Regulatory impact factors: unraveling the transcriptional regulation of complex traits from expression data. Bioinformatics, 26 (7) btq051, 896-904. doi: 10.1093/bioinformatics/btq051
2009
Journal Article
Skeletal muscle atrophy occurs slowly and selectively during prolonged aestivation in Cyclorana alboguttata (Gunther 1867)
Mantle, Beth L., Hudson, Nicholas J., Harper, Gregory S., Cramp, Rebecca L. and Franklin, Craig E. (2009). Skeletal muscle atrophy occurs slowly and selectively during prolonged aestivation in Cyclorana alboguttata (Gunther 1867). Journal of Experimental Biology, 212 (22), 3664-3672. doi: 10.1242/jeb.033688
2009
Journal Article
Inferring the transcriptional landscape of bovine skeletal muscle by integrating co-expression networks
Hudson, Nicholas J., Reverter, Antonio, Wang, YongHong, Greenwood, Paul L. and Dalrymple, Brian P. (2009). Inferring the transcriptional landscape of bovine skeletal muscle by integrating co-expression networks. PLoS ONE, 4 (10) e7249, e7249. doi: 10.1371/journal.pone.0007249
2009
Journal Article
Surviving the drought: Burrowing frogs save energy by increasing mitochondrial coupling
Kayes, Sara M., Cramp, Rebecca L., Hudson, Nicholas J. and Franklin, Craig E. (2009). Surviving the drought: Burrowing frogs save energy by increasing mitochondrial coupling. Journal of Experimental Biology, 212 (14), 2248-2253. doi: 10.1242/jeb.028233
2009
Journal Article
Symmorphosis and livestock bioenergetics: production animal muscle has low mitochondrial volume fractions
Hudson, Nicholas J. (2009). Symmorphosis and livestock bioenergetics: production animal muscle has low mitochondrial volume fractions. Journal of Animal Physiology and Animal Nutrition, 93 (1), 1-6. doi: 10.1111/j.1439-0396.2007.00791.x
2009
Conference Publication
Burrowing frog metabolism: maximising energy savings during dormancy
Kayes, Sara M., Cramp, Rebecca L., Hudson, Nicholas J. and Franklin, Craig E. (2009). Burrowing frog metabolism: maximising energy savings during dormancy. Annual Meeting of the Society for Experimental Biology, Glasgow Scotland, 28June-01 July 2009. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.cbpa.2009.04.126
2008
Journal Article
Epigenetic silencers are enriched in dormant desert frog muscle
Hudson, Nicholas J., Lonhienne, T. G. A,, Franklin, Craig E., Harper, Gregory S. and Lehnert, S. A. (2008). Epigenetic silencers are enriched in dormant desert frog muscle. Journal of Comparative Physiology B Biochemical, Systems, and Environmental Physiology, 178 (6), 729-734. doi: 10.1007/s00360-008-0261-0
2008
Journal Article
Role of calcium and vesicle-docking proteins in remobilising dormant neuromuscular junctions in desert frogs
Lavidis, N. A., Hudson, N. J., Choy, P. T., Lehnert, S. A. and Franklin, C. E. (2008). Role of calcium and vesicle-docking proteins in remobilising dormant neuromuscular junctions in desert frogs. Journal of Comparative Physiology A: Neuroethology Sensory Neural and Behavioral Physiology, 194 (1), 27-37. doi: 10.1007/s00359-007-0284-0
2008
Conference Publication
Opioids as triggers for metabolic depression in the frog, Cyclorana alboguttata
Kayes, S., Hudson, N. and Franklin, C. (2008). Opioids as triggers for metabolic depression in the frog, Cyclorana alboguttata. Annual Meeting of the Society-for-Experimental-Biology, Marseille, France, 6-10 July, 2008. New York, U.S.: Elsevier. doi: 10.1016/j.cbpa.2008.04.202
Funding
Current funding
Past funding
Supervision
Availability
- Dr Nick Hudson is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Mitochondria and livestock feed efficiency
Some production animals utilise feed more efficiently for production than others, while some are able to maintain muscle mass, liveweight and productivity under periods of nutritional and environmental stress.
Why is this? The successful applicant will focus their research on the biology of the mitochondria and its role in determining metabolic efficiency in cattle.
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Frog and butterfly ecology
Projects regarding the fundamental biology and ecology of both frogs and butterflies are available.
Fieldwork will be based at Hiddenvale Research Station (https://hiddenvalewildlife.uq.edu.au/). There is a lot of scope for flexibility in project development so if you have any ideas - or even just a passion for - these two groups of animals please get in touch.
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Metabolism across species
Are you interested in growth, development and metabolism? Students are encouraged to get in touch with any of their own ideas in the broad area of animal biology. Projects can be developed collaboratively with other academics within and beyond AGFS so there is lots of scope for diversity and inter-disciplinary research.
We encourage students to develope their own ideas and projects. In our lab we use a range of metabolic and molecular tools such as gene expression, metabolic flux analysis and SNP genotyping that can be readily applied across species and biological circumstances.
You can learn how to handle and quantitate DNA and RNA, run an agarose gel, estimate gene expression by quantitative PCR and phenotype animal and plant cells in the state of the art XFe24 Flux analyser.
Remember, a new discovery is just round the corner!
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The interface between genomes and diet in ruminant farm animals
Livestock products provide a nutritious source of protein (and a range of other molecules including bioavailable iron and vitamin B12). More efficient production may be required to meet not only increasing demand but also greater awareness over welfare issues and environmental footprint.
Breeds and individual cattle and sheep can show substantial differences in how they respond to diets, with some animals more productive than others. The proposed research will investigate which parts of the genome underpin productivity in cattle and sheep.
Biochemical pathways relevant to the new science of nutrigenomics will be uncovered primarily through investigation of genome-wide gene expression data sets available for metabolically important tissues such as muscle, fat and liver.
Cutting edge bioinformatics tools including the latest approaches from network science will be deployed. This knowledge may help us understand why some animals fare better than others under given nutritional circumstances and perhaps inform decisions regarding diet formulation.
Supervision history
Current supervision
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Doctor Philosophy
Developing genomic resources to enable better breeding decisions for Rufous bettongs, Aepyprymnus rufescens.
Principal Advisor
Other advisors: Dr Loan Nguyen
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Doctor Philosophy
Cellular oxidative damage and ruminant feed efficiency
Principal Advisor
Other advisors: Associate Professor Marina Fortes
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Doctor Philosophy
Using Systems Biology to understand the genetic basis of bull fertility phenotypes and their covariance
Associate Advisor
Other advisors: Associate Professor Marina Fortes
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Doctor Philosophy
Extrinsic and intrinsic factors that influence the meat quality of goat fresh meat and products.
Associate Advisor
Other advisors: Dr Angela Lees, Dr Anne Beasley, Associate Professor Daniel Cozzolino, Professor Louw Hoffman
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Doctor Philosophy
Investigating the genetics of industry-relevant indicator traits for bull fertility
Associate Advisor
Other advisors: Associate Professor Marina Fortes
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Doctor Philosophy
Genome wide association and machine learning approaches for the understanding of the genetic basis of bull fertility traits.
Associate Advisor
Other advisors: Associate Professor Marina Fortes
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Doctor Philosophy
Maternal-foetal programming of stress resilience in Merino sheep
Associate Advisor
Other advisors: Professor Alan Tilbrook
Completed supervision
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2022
Doctor Philosophy
Disturbance and fragmentation impacts movement ecology of a habitat specialist: conservation implications for red pandas
Principal Advisor
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2025
Doctor Philosophy
Investigating the genetics of industry-relevant indicator traits for bull fertility
Associate Advisor
Other advisors: Associate Professor Marina Fortes
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2024
Doctor Philosophy
Pathogenesis and Epidemiology of Zoonotic Mosquito-borne Diseases in Horses
Associate Advisor
Other advisors: Dr Lee McMichael, Professor Joerg Henning, Dr Albert Sole Guitart
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2022
Doctor Philosophy
Unpacking food systems: A systems approach to food packaging reduction
Associate Advisor
Other advisors: Dr Russell Richards, Professor Ammar Abdul Aziz
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2021
Doctor Philosophy
Intake regulation in ruminants consuming nutrient deficient diets
Associate Advisor
Other advisors: Associate Professor Stephen Anderson
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2012
Doctor Philosophy
GENE EXPRESSION STUDIES IN BOVINE SKELETAL MUSCLE: INVESTIGATIONS INTO THE EFFECTS OF HORMONE GROWTH PROMOTANT TREATMENT, ENVIRONMENT AND TENDERNESS GENOTYPE ASSOCIATED WITH TENDERNESS AND MARBLING
Associate Advisor
Other advisors: Emeritus Professor Ross Barnard
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2010
Doctor Philosophy
Metabolic depression in Cyclorana alboguttata and the potential role of the endogenous opioid system and thyroid axis as regulators of aestivation
Associate Advisor
Other advisors: Professor Craig Franklin
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2008
Doctor Philosophy
Effect of Prolonged Aestivation on Muscle Morphology and Biochemistry in the Green-Striped Burrowing Frog, Cyclorana Alboguttata
Associate Advisor
Other advisors: Professor Craig Franklin
Media
Enquiries
Contact Dr Nick Hudson directly for media enquiries about:
- feed efficiency
- flux analysis
- functional genomics
- mitochondria
- muscle growth
- production animals
Need help?
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