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Dr Nick Hudson
Dr

Nick Hudson

Email: 
Phone: 
+61 7 54601 521

Overview

Background

Nick is interested in fostering efficient, environmentally friendly animal production enterprises. He uses the data and capabilities provided by modern 'omics technologies to help improve breeding decisions and to inform other types of 'on farm' intervention.

Nick has a parallel interest in the development, physiology, metabolism and conservation of native Australian species, particularly frogs and butterflies.

Nick is a metabolic biochemist by training with research expertise in a) the handling and biological interpretation of large, complex data sets b) molecular technologies c) mitochondrial physiology and d) metabolic flux.

Nick enjoys teaching various aspects of biochemistry and molecular biology to both undergraduate and postgraduate students. He highlights the main themes using the comparative method and illustrates their importance through applied examples from agriculture and other areas of human endeavour.

Before taking his current position as a Teaching and Research academic in the School of Agriculture and Food Sustainability (AGFS) Nick worked for the CSIRO in a research intensive multi-disciplinary Systems Biology group.

Through this group he helped develop and apply bioinformatic methods that used metabolite, protein, RNA and DNA biotech to understand, model and predict phenotypes of commercial importance in cattle, sheep, pigs and chickens.

A research highlight from this time was the co-invention of a universal method for inferring causal molecules from genome-wide gene expression data (Hudson et al 2009. PLoS Comp Biol e1000382). This method has been applied across a diverse range of model systems including human kidney cancer and commercial traits in various agricultural species.

Following an undergraduate degree in Animal Biology at the University of St.Andrews, Nick was awarded his PhD through what was then the Zoology department of the University of Queensland, after travelling from England on a Britain-Australia Society funded Northcote Scholarship.

Availability

Dr Nick Hudson is:
Available for supervision
Media expert

Qualifications

  • Doctor of Philosophy, The University of Queensland

Research interests

  • Productive, efficient farm animals

  • Wildlife biology of butterflies and frogs

  • Mitochondrial physiology

  • Metabolism

  • Flux analysis

  • Agricultural resource utilisation

Research impacts

Nick is an active science communicator whose research has been disseminated through print, radio and television media.

He hopes to make an impact on agricultural resource utilisation through a better understanding of production animal feed efficiency, and to sustainable agriculture through an understanding of agro-ecology and wildlife biology.

Nick has a very active national and international network of collaborators from academe, government agencies and industry.

This collaborative network has provided stimulating insights into industrial problems and how novel technologies and innovative concepts may inspire creative solutions.

Works

Search Professor Nick Hudson’s works on UQ eSpace

92 works between 2000 and 2024

61 - 80 of 92 works

2012

Journal Article

Beyond differential expression: the quest for causal mutations and effector molecules

Hudson, Nicholas J., Dalrymple, Brian P. and Reverter, Antonio (2012). Beyond differential expression: the quest for causal mutations and effector molecules. BMC Genomics, 13 (1) 356. doi: 10.1186/1471-2164-13-356

Beyond differential expression: the quest for causal mutations and effector molecules

2011

Journal Article

Eukaryotic evolutionary transitions are associated with extreme codon bias in functionally-related proteins

Hudson, Nicholas J., Gu, Quan, Nagaraj, Shivashankar H., Ding, Yong-Sheng, Dalrymple, Brian P. and Reverter, Antonio (2011). Eukaryotic evolutionary transitions are associated with extreme codon bias in functionally-related proteins. PLoS ONE, 6 (9) e25457, e25457. doi: 10.1371/journal.pone.0025457

Eukaryotic evolutionary transitions are associated with extreme codon bias in functionally-related proteins

2011

Journal Article

Chronic exposure to anabolic steroids induces the muscle expression of oxytocin and a more than fiftyfold increase in circulating oxytocin in cattle

De Jager, Nadia, Hudson, Nicolas J., Reverter, Antonio, Wang, Yong-Hong, Nagaraj, Shivashankar H., Cafe, Linda M., Greenwood, Paul L., Barnard, Ross T., Kongsuwan, Kritaya P. and Dalrymple, Brian P. (2011). Chronic exposure to anabolic steroids induces the muscle expression of oxytocin and a more than fiftyfold increase in circulating oxytocin in cattle. Physiological Genomics, 43 (9), 467-478. doi: 10.1152/physiolgenomics.00226.2010

Chronic exposure to anabolic steroids induces the muscle expression of oxytocin and a more than fiftyfold increase in circulating oxytocin in cattle

2011

Journal Article

Musical beauty and information compression: complex to the ear but simple to the mind?

Hudson, Nicholas J. (2011). Musical beauty and information compression: complex to the ear but simple to the mind?. BMC Research Notes, 4 (1) 9. doi: 10.1186/1756-0500-4-9

Musical beauty and information compression: complex to the ear but simple to the mind?

2011

Journal Article

Genome-wide patterns of promoter sharing and co-expression in bovine skeletal muscle

Gu, Quan, Nagaraj, Shivashankar H., Hudson, Nicholas J., Dalrymple, Brian P. and Reverter, Antonio (2011). Genome-wide patterns of promoter sharing and co-expression in bovine skeletal muscle. BMC Genomics, 12 (1) 23, 23.1-23.13. doi: 10.1186/1471-2164-12-23

Genome-wide patterns of promoter sharing and co-expression in bovine skeletal muscle

2010

Journal Article

Enzyme activity in the aestivating Green-striped burrowing frog (Cyclorana alboguttata)

Mantle, Beth L., Guderley, Helga, Hudson, Nicholas J. and Franklin, Craig E. (2010). Enzyme activity in the aestivating Green-striped burrowing frog (Cyclorana alboguttata). Journal of Comparative Physiology B-biochemical Systemic And Environmental Physiology, 180 (7), 1033-1043. doi: 10.1007/s00360-010-0471-0

Enzyme activity in the aestivating Green-striped burrowing frog (Cyclorana alboguttata)

2010

Journal Article

Activity, abundance, distribution and expression of Na+/K+-ATPase in the salt glands of Crocodylus porosus following chronic saltwater acclimation

Cramp, Rebecca L., Hudson, Nicholas J. and Franklin, Craig E. (2010). Activity, abundance, distribution and expression of Na+/K+-ATPase in the salt glands of Crocodylus porosus following chronic saltwater acclimation. Journal of Experimental Biology, 213 (8), 1301-1308. doi: 10.1242/jeb.039305

Activity, abundance, distribution and expression of Na+/K+-ATPase in the salt glands of Crocodylus porosus following chronic saltwater acclimation

2010

Journal Article

Regulatory impact factors: unraveling the transcriptional regulation of complex traits from expression data

Reverter, Antonio, Hudson, Nicholas J., Nagaraj, Shivashankar H., Perez-Enciso, Miguel and Dalrymple, Brian P. (2010). Regulatory impact factors: unraveling the transcriptional regulation of complex traits from expression data. Bioinformatics, 26 (7) btq051, 896-904. doi: 10.1093/bioinformatics/btq051

Regulatory impact factors: unraveling the transcriptional regulation of complex traits from expression data

2009

Journal Article

Skeletal muscle atrophy occurs slowly and selectively during prolonged aestivation in Cyclorana alboguttata (Gunther 1867)

Mantle, Beth L., Hudson, Nicholas J., Harper, Gregory S., Cramp, Rebecca L. and Franklin, Craig E. (2009). Skeletal muscle atrophy occurs slowly and selectively during prolonged aestivation in Cyclorana alboguttata (Gunther 1867). Journal of Experimental Biology, 212 (22), 3664-3672. doi: 10.1242/jeb.033688

Skeletal muscle atrophy occurs slowly and selectively during prolonged aestivation in Cyclorana alboguttata (Gunther 1867)

2009

Journal Article

Inferring the transcriptional landscape of bovine skeletal muscle by integrating co-expression networks

Hudson, Nicholas J., Reverter, Antonio, Wang, YongHong, Greenwood, Paul L. and Dalrymple, Brian P. (2009). Inferring the transcriptional landscape of bovine skeletal muscle by integrating co-expression networks. PLoS ONE, 4 (10) e7249, e7249. doi: 10.1371/journal.pone.0007249

Inferring the transcriptional landscape of bovine skeletal muscle by integrating co-expression networks

2009

Journal Article

Surviving the drought: Burrowing frogs save energy by increasing mitochondrial coupling

Kayes, Sara M., Cramp, Rebecca L., Hudson, Nicholas J. and Franklin, Craig E. (2009). Surviving the drought: Burrowing frogs save energy by increasing mitochondrial coupling. Journal of Experimental Biology, 212 (14), 2248-2253. doi: 10.1242/jeb.028233

Surviving the drought: Burrowing frogs save energy by increasing mitochondrial coupling

2009

Journal Article

Symmorphosis and livestock bioenergetics: production animal muscle has low mitochondrial volume fractions

Hudson, Nicholas J. (2009). Symmorphosis and livestock bioenergetics: production animal muscle has low mitochondrial volume fractions. Journal of Animal Physiology and Animal Nutrition, 93 (1), 1-6. doi: 10.1111/j.1439-0396.2007.00791.x

Symmorphosis and livestock bioenergetics: production animal muscle has low mitochondrial volume fractions

2009

Conference Publication

Burrowing frog metabolism: maximising energy savings during dormancy

Kayes, Sara M., Cramp, Rebecca L., Hudson, Nicholas J. and Franklin, Craig E. (2009). Burrowing frog metabolism: maximising energy savings during dormancy. Annual Meeting of the Society for Experimental Biology, Glasgow Scotland, 28June-01 July 2009. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.cbpa.2009.04.126

Burrowing frog metabolism: maximising energy savings during dormancy

2008

Journal Article

Epigenetic silencers are enriched in dormant desert frog muscle

Hudson, Nicholas J., Lonhienne, T. G. A,, Franklin, Craig E., Harper, Gregory S. and Lehnert, S. A. (2008). Epigenetic silencers are enriched in dormant desert frog muscle. Journal of Comparative Physiology B Biochemical, Systems, and Environmental Physiology, 178 (6), 729-734. doi: 10.1007/s00360-008-0261-0

Epigenetic silencers are enriched in dormant desert frog muscle

2008

Journal Article

Obese humans as economically designed feed converters: symmorphosis and low oxidative capacity skeletal muscle

Hudson, Nicholas J., Lehnert, Sigrid A. and Harper, Gregory S. (2008). Obese humans as economically designed feed converters: symmorphosis and low oxidative capacity skeletal muscle. Medical Hypotheses, 70 (3), 693-697. doi: 10.1016/j.mehy.2007.05.042

Obese humans as economically designed feed converters: symmorphosis and low oxidative capacity skeletal muscle

2008

Journal Article

Role of calcium and vesicle-docking proteins in remobilising dormant neuromuscular junctions in desert frogs

Lavidis, N. A., Hudson, N. J., Choy, P. T., Lehnert, S. A. and Franklin, C. E. (2008). Role of calcium and vesicle-docking proteins in remobilising dormant neuromuscular junctions in desert frogs. Journal of Comparative Physiology A: Neuroethology Sensory Neural and Behavioral Physiology, 194 (1), 27-37. doi: 10.1007/s00359-007-0284-0

Role of calcium and vesicle-docking proteins in remobilising dormant neuromuscular junctions in desert frogs

2008

Conference Publication

Opioids as triggers for metabolic depression in the frog, Cyclorana alboguttata

Kayes, S., Hudson, N. and Franklin, C. (2008). Opioids as triggers for metabolic depression in the frog, Cyclorana alboguttata. Annual Meeting of the Society-for-Experimental-Biology, Marseille, France, 6-10 July, 2008. New York, U.S.: Elsevier. doi: 10.1016/j.cbpa.2008.04.202

Opioids as triggers for metabolic depression in the frog, Cyclorana alboguttata

2007

Journal Article

The effects of saltwater acclimation on neurotransmitters in the lingual salt glands of the estuarine crocodile, Crocodylus porosus

Cramp, Rebecca L., Hudson, Nicholas J., Holmberg, Anna, Holmgren, Susanne and Franklin, Craig E. (2007). The effects of saltwater acclimation on neurotransmitters in the lingual salt glands of the estuarine crocodile, Crocodylus porosus. Regulatory Peptides, 140 (1-2), 55-64. doi: 10.1016/j.regpep.2006.11.011

The effects of saltwater acclimation on neurotransmitters in the lingual salt glands of the estuarine crocodile, Crocodylus porosus

2007

Journal Article

Skeletal muscle extracellular matrix remodelling after aestivation in the green striped burrowing frog, Cyclorana alboguttata

Hudson, Nicholas J, Harper, Gregory S., Allingham, Peter G., Franklin, Craig E., Barris, W. and Lehnert, Sigrid A. (2007). Skeletal muscle extracellular matrix remodelling after aestivation in the green striped burrowing frog, Cyclorana alboguttata. Comparative Biochemistry And Physiology A-Molecular & Integrative Physiology, 146 (3), 440-445. doi: 10.1016/j.cbpa.2006.12.023

Skeletal muscle extracellular matrix remodelling after aestivation in the green striped burrowing frog, Cyclorana alboguttata

2007

Journal Article

Gene expression studies of developing bovine longissimus muscle from two different beef cattle breeds

Lehnert, SA, Reverter, A, Byrne, KA, Wang, Y, Nattrass, GS, Hudson, NJ and Greenwood, PL (2007). Gene expression studies of developing bovine longissimus muscle from two different beef cattle breeds. Bmc Developmental Biology, 7 (1) 95. doi: 10.1186/1471-213x-7-95

Gene expression studies of developing bovine longissimus muscle from two different beef cattle breeds

Funding

Current funding

  • 2023 - 2024
    Innate immune response to Ross River virus infection in horses
    Research Donation Generic
    Open grant
  • 2022 - 2026
    LESTR Low Emission Saliva Test for Ruminants
    Meat & Livestock Australia
    Open grant

Past funding

  • 2019 - 2020
    Understanding the Mechanisms of West Nile virus (WNV) induced lesions in the Australian saltwater crocodile (Crocodylus porosus)
    Research Donation Generic
    Open grant
  • 2019 - 2022
    How do brains become lateralised? (ARC Discovery Project administered by Macquarie University)
    Macquarie University
    Open grant
  • 2019 - 2022
    Increased pasture intake and reduced supplement requirements of sheep/cattle
    Meat & Livestock Australia
    Open grant
  • 2018 - 2020
    The gateway to selecting for nutrient efficient livestock - ''Better doers'' (Meat and Livestock Australia grant administered by NSW Department of Primary Industries)
    New South Wales Department of Primary Industries
    Open grant
  • 2017
    Towards a high-throughput metabolic phenotyping capability for production animals and plants
    UQ Major Equipment and Infrastructure
    Open grant

Supervision

Availability

Dr Nick Hudson is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Mitochondria and livestock feed efficiency

    Some production animals utilise feed more efficiently for production than others, while some are able to maintain muscle mass, liveweight and productivity under periods of nutritional and environmental stress.

    Why is this? The successful applicant will focus their research on the biology of the mitochondria and its role in determining metabolic efficiency in cattle.

  • Frog and butterfly ecology

    Projects regarding the fundamental biology and ecology of both frogs and butterflies are available.

    Fieldwork will be based at Hiddenvale Research Station (https://hiddenvalewildlife.uq.edu.au/). There is a lot of scope for flexibility in project development so if you have any ideas - or even just a passion for - these two groups of animals please get in touch.

  • Metabolism across species

    Are you interested in growth, development and metabolism? Students are encouraged to get in touch with any of their own ideas in the broad area of animal biology. Projects can be developed collaboratively with other academics within and beyond AGFS so there is lots of scope for diversity and inter-disciplinary research.

    We encourage students to develope their own ideas and projects. In our lab we use a range of metabolic and molecular tools such as gene expression, metabolic flux analysis and SNP genotyping that can be readily applied across species and biological circumstances.

    You can learn how to handle and quantitate DNA and RNA, run an agarose gel, estimate gene expression by quantitative PCR and phenotype animal and plant cells in the state of the art XFe24 Flux analyser.

    Remember, a new discovery is just round the corner!

  • The interface between genomes and diet in ruminant farm animals

    Livestock products provide a nutritious source of protein (and a range of other molecules including bioavailable iron and vitamin B12). More efficient production may be required to meet not only increasing demand but also greater awareness over welfare issues and environmental footprint.

    Breeds and individual cattle and sheep can show substantial differences in how they respond to diets, with some animals more productive than others. The proposed research will investigate which parts of the genome underpin productivity in cattle and sheep.

    Biochemical pathways relevant to the new science of nutrigenomics will be uncovered primarily through investigation of genome-wide gene expression data sets available for metabolically important tissues such as muscle, fat and liver.

    Cutting edge bioinformatics tools including the latest approaches from network science will be deployed. This knowledge may help us understand why some animals fare better than others under given nutritional circumstances and perhaps inform decisions regarding diet formulation.

Supervision history

Current supervision

  • Doctor Philosophy

    Cellular oxidative damage and ruminant feed efficiency

    Principal Advisor

    Other advisors: Associate Professor Marina Fortes

  • Doctor Philosophy

    Using Systems Biology to understand the genetic basis of bull fertility phenotypes and their covariance

    Associate Advisor

    Other advisors: Associate Professor Marina Fortes

Completed supervision

Media

Enquiries

Contact Dr Nick Hudson directly for media enquiries about:

  • feed efficiency
  • flux analysis
  • functional genomics
  • mitochondria
  • muscle growth
  • production animals

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au