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Dr Axa Gonzalez
Dr

Axa Gonzalez

Email: 
Phone: 
+61 7 334 63159

Overview

Background

Dr Axayacatl Gonzalez completed his bachelors in 2010 in Chemical Engineering /Biotechnology at the Interdisciplinary Unit for Biotechnology (UPIBI, IPN, Mexico). He obtained his Master’s degree in 2012, where he specialised in metabolic modelling and bioprocessing. In 2013, he moved to Australia where he completed his PhD studies at the Australian Institute for Bioengineering and Nanotechnology (AIBN) at The University of Queensland (UQ).

Dr Gonzalez has been involved in the ARC-Training Centre for Biopharmaceutical Innovation (ARCT-CBI, 2018), the Queensland Strain Factory (QSF, 2019), ARC Centre of Excellence in Synthetic Biology (COESB, 2021) and is currently the Facility Manager and Senior Bioprocess Engineer for the Integrated Design Environment for Advanced biomanufacturing (IDEA bio) at AIBN-UQ.

Complementary to his role at IDEA Bio, Dr Gonzalez research focuses on a) Development of bioprocess strategies to improve productivities. b) Identification of metabolic changes in bacterial strains associated with selective pressure. c) Design, construction and evaluation of synthetic genetic circuits in microbial hosts. d) Development of strategies to screen, isolate, characterise and propagate soil microorganism for agricultural practices.

Availability

Dr Axa Gonzalez is:
Available for supervision

Qualifications

  • Doctor of Philosophy, The University of Queensland

Research interests

  • Bioprocess development and scale up

  • Development of microbial cell factories

  • Assemble and assessment of synthetic microbial communities for agriculture

Research impacts

Dr Axayacatl González leads research that delivers tangible benefits to agriculture, industry, and Australia’s growing bioeconomy. His work combines microbial engineering, fermentation, and soil microbiome science to create technologies that improve environmental sustainability and support new high-value manufacturing pathways.

Dr González has produced high-quality research recognised nationally and internationally, with 33 peer-reviewed publications and over 900 citations. His research has directly informed the development of microbial platforms for rare sugar production, supporting innovation within Queensland’s sugar industry through a $1.5M collaboration with MSF Sugar.

His environmental research has advanced understanding of the microbial drivers of nitrous oxide emissions, one of agriculture’s most damaging greenhouse gases. This work, supported by GRDC, DAF and the ARC Centre of Excellence in Synthetic Biology, provides evidence-based strategies to reduce emissions and improve soil health.

Beyond academic impact, Dr González has secured over $1.7M in competitive research funding and facilitated major industry partnerships with companies such as Windfall Bio, SQM, Manildra Group and Eden Brew. His leadership at IDEA Bio has also contributed to securing $20M in national research infrastructure funding, strengthening Australia’s capacity in synthetic biology and biomanufacturing.

Works

Search Professor Axa Gonzalez’s works on UQ eSpace

38 works between 2011 and 2026

21 - 38 of 38 works

2020

Journal Article

Adaptive laboratory evolution of native methanol assimilation in Saccharomyces cerevisiae

Espinosa, Monica I., Gonzalez-Garcia, Ricardo A., Valgepea, Kaspar, Plan, Manuel R., Scott, Colin, Pretorius, Isak S., Marcellin, Esteban, Paulsen, Ian T. and Williams, Thomas C. (2020). Adaptive laboratory evolution of native methanol assimilation in Saccharomyces cerevisiae. Nature Communications, 11 (1) 5564, 5564. doi: 10.1038/s41467-020-19390-9

Adaptive laboratory evolution of native methanol assimilation in Saccharomyces cerevisiae

2020

Conference Publication

Revamping the model CO-fermenting acetogen, Clostridium autoethanogenum, as a CO2-valorisation platform

Heffernan, James, Valgepea, Kaspar, de Souza Pinto Lemgruber, Renato, Casini, Isabella, Plan, Manuel, Tappel, Ryan, Simpson, Sean D., Köpke, Michael, Gonzalez-Garcia, Ricardo A., Nielsen, Lars K. and Marcellin, Esteban (2020). Revamping the model CO-fermenting acetogen, Clostridium autoethanogenum, as a CO2-valorisation platform. International Chain Elongation Conference 2020, Virtual, 26-27 October 2020. Wageningen, Germany: Wageningen University and Research. doi: 10.18174/icec2020.18019

Revamping the model CO-fermenting acetogen, Clostridium autoethanogenum, as a CO2-valorisation platform

2020

Journal Article

A pan-genome guided metabolic network reconstruction of five Propionibacterium species reveals extensive metabolic diversity

McCubbin, Tim, Gonzalez-Garcia, R. Axayacatl, Palfreyman, Robin W., Stowers, Chris, Nielsen, Lars K. and Marcellin, Esteban (2020). A pan-genome guided metabolic network reconstruction of five Propionibacterium species reveals extensive metabolic diversity. Genes, 11 (10) 1115, 1-26. doi: 10.3390/genes11101115

A pan-genome guided metabolic network reconstruction of five Propionibacterium species reveals extensive metabolic diversity

2020

Journal Article

Heterologous production of 6-deoxyerythronolide B in Escherichia coli through the wood werkman cycle

Gonzalez-Garcia, R. Axayacatl, Nielsen, Lars K. and Marcellin, Esteban (2020). Heterologous production of 6-deoxyerythronolide B in Escherichia coli through the wood werkman cycle. Metabolites, 10 (6) 228, 228. doi: 10.3390/metabo10060228

Heterologous production of 6-deoxyerythronolide B in Escherichia coli through the wood werkman cycle

2020

Journal Article

Engineering Escherichia coli for propionic acid production through the Wood‐Werkman cycle

Gonzalez‐Garcia, R. A., McCubbin, T., Turner, M. S., Nielsen, L. K. and Marcellin, E. (2020). Engineering Escherichia coli for propionic acid production through the Wood‐Werkman cycle. Biotechnology and Bioengineering, 117 (1), 167-183. doi: 10.1002/bit.27182

Engineering Escherichia coli for propionic acid production through the Wood‐Werkman cycle

2020

Book Chapter

Hydrogen and Polyhidroxybutyrate (PHB) Production by a Photoheterotrophic Mixed Culture

García-Peña, E. I. and Gonzalez-Garcia, R. A. (2020). Hydrogen and Polyhidroxybutyrate (PHB) Production by a Photoheterotrophic Mixed Culture. Encyclopedia of Plant Science. (pp. 575-588) Hauppauge, NY United States: Nova Science Publishers.

Hydrogen and Polyhidroxybutyrate (PHB) Production by a Photoheterotrophic Mixed Culture

2019

Journal Article

A TetR-family protein (CAETHG_0459) activates transcription from a new promoter motif associated with essential genes for autotrophic growth in acetogens

Lemgruber, Renato de Souza Pinto, Valgepea, Kaspar, Garcia, Ricardo Axayacatl Gonzalez, de Bakker, Christopher, Palfreyman, Robin William, Tappel, Ryan, Kopke, Michael, Simpson, Sean Dennis, Nielsen, Lars Keld and Marcellin, Esteban (2019). A TetR-family protein (CAETHG_0459) activates transcription from a new promoter motif associated with essential genes for autotrophic growth in acetogens. Frontiers in Microbiology, 10 2549, 2549. doi: 10.3389/fmicb.2019.02549

A TetR-family protein (CAETHG_0459) activates transcription from a new promoter motif associated with essential genes for autotrophic growth in acetogens

2018

Other Outputs

Metabolic engineering of propionibacteria’s Wood Werkman cycle in Escherichia coli and Saccharomyces cerevisiae

Gonzalez Garcia, Ricardo Axayacatl (2018). Metabolic engineering of propionibacteria’s Wood Werkman cycle in Escherichia coli and Saccharomyces cerevisiae. PhD Thesis, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland. doi: 10.14264/716822

Metabolic engineering of propionibacteria’s Wood Werkman cycle in Escherichia coli and Saccharomyces cerevisiae

2018

Journal Article

Hydrogen production by a mixed photoheterotrophic culture: Correlation between gene expression analysis and physiological behavior

Jurado-Marban, V. H., Tapia-Bustos, M. A., Gonzalez-Garcia, R. A., Salgado-Manjarrez, E. and García-Peña, E. I. (2018). Hydrogen production by a mixed photoheterotrophic culture: Correlation between gene expression analysis and physiological behavior. International Journal of Hydrogen Energy, 44 (2), 641-651. doi: 10.1016/j.ijhydene.2018.10.197

Hydrogen production by a mixed photoheterotrophic culture: Correlation between gene expression analysis and physiological behavior

2017

Journal Article

Genome-scale model guided design of Propionibacterium for enhanced propionic acid production

Navone, Laura, McCubbin, Tim, Gonzalez-Garcia, Ricardo A., Nielsen, Lars K. and Marcellin, Esteban (2017). Genome-scale model guided design of Propionibacterium for enhanced propionic acid production. Metabolic Engineering Communications, 6, 1-12. doi: 10.1016/j.meteno.2017.11.001

Genome-scale model guided design of Propionibacterium for enhanced propionic acid production

2017

Journal Article

Awakening sleeping beauty: production of propionic acid in Escherichia coli through the sbm operon requires the activity of a methylmalonyl-CoA epimerase

Gonzalez-Garcia, Ricardo Axayacatl, McCubbin, Tim, Wille, Annalena, Plan, Manuel, Nielsen, Lars Keld and Marcellin, Esteban (2017). Awakening sleeping beauty: production of propionic acid in Escherichia coli through the sbm operon requires the activity of a methylmalonyl-CoA epimerase. Microbial Cell Factories, 16 (1) 121, 121. doi: 10.1186/s12934-017-0735-4

Awakening sleeping beauty: production of propionic acid in Escherichia coli through the sbm operon requires the activity of a methylmalonyl-CoA epimerase

2017

Journal Article

Microbial Propionic Acid Production

Gonzalez Garcia, Ricardo Axayacatl, McCubbin, Timothy, Navone, Laura, Stowers, Chris, Nielsen, Lars K. and Marcellin Saldana, Esteban Stefane (2017). Microbial Propionic Acid Production. Fermentation, 3 (2) 3020021, 1-20. doi: 10.3390/fermentation3020021

Microbial Propionic Acid Production

2017

Journal Article

Metabolic pathway and flux analysis of H2 production by an anaerobic mixed culture

Gonzalez-Garcia, R. A., Aispuro-Castro, R., Salgado-Manjarrez, E., Aranda-Barradas, J. and Garcia-Pena, E. I. (2017). Metabolic pathway and flux analysis of H2 production by an anaerobic mixed culture. International Journal of Hydrogen Energy, 42 (7), 4069-4082. doi: 10.1016/j.ijhydene.2017.01.043

Metabolic pathway and flux analysis of H2 production by an anaerobic mixed culture

2016

Journal Article

Continuous two-staged co-digestion process for biohydrogen production from agro-industrial wastes

Gomez-Romero, J., Gonzalez-Garcia, R. A., Chairez, I., Torres, L. and Garcia-Pena, E. I. (2016). Continuous two-staged co-digestion process for biohydrogen production from agro-industrial wastes. International Journal of Energy Research, 40 (2), 257-272. doi: 10.1002/er.3466

Continuous two-staged co-digestion process for biohydrogen production from agro-industrial wastes

2015

Book Chapter

Hydrogen and polyhidroxybutyrate (PHB) production by a photoheterotrophic mixed culture

Garcia-Pena, E. I. and Gonzalez-Garcia, R. A. (2015). Hydrogen and polyhidroxybutyrate (PHB) production by a photoheterotrophic mixed culture. Microalgae and other phototrophic bacteria: culture, processing, recovery and new products. (pp. 111-124) Hauppauge, NY, United States: Nova Science Publishers.

Hydrogen and polyhidroxybutyrate (PHB) production by a photoheterotrophic mixed culture

2014

Journal Article

Selective adaptation of an anaerobic microbial community: biohydrogen production by co-digestion of cheese whey and vegetables fruit waste

Gomez-Romero, J., Gonzalez-Garcia, A., Chairez, I., Torres, L. and García-Peña, E.I. (2014). Selective adaptation of an anaerobic microbial community: biohydrogen production by co-digestion of cheese whey and vegetables fruit waste. International Journal of Hydrogen Energy, 39 (24), 12541-12550. doi: 10.1016/j.ijhydene.2014.06.050

Selective adaptation of an anaerobic microbial community: biohydrogen production by co-digestion of cheese whey and vegetables fruit waste

2013

Journal Article

Metabolic flux distribution and thermodynamic analysis of green fluorescent protein production in recombinant Escherichia coli: the effect of carbon source and CO2 partial pressure

González-García, R. Axayácatl, Garcia-Peña, E. Ines, Salgado-Manjarrez, Edgar and Aranda-Barradas, Juan S. (2013). Metabolic flux distribution and thermodynamic analysis of green fluorescent protein production in recombinant Escherichia coli: the effect of carbon source and CO2 partial pressure. Biotechnology and Bioprocess Engineering, 18 (6), 1049-1061. doi: 10.1007/s12257-013-0277-5

Metabolic flux distribution and thermodynamic analysis of green fluorescent protein production in recombinant Escherichia coli: the effect of carbon source and CO2 partial pressure

2011

Journal Article

A simple metabolic flux balance analysis of biomass and bioethanol production in Saccharomyces cerevisiae fed-batch cultures

Barrera-Martínez, Iliana, Axayácatl González-García, R., Salgado-Manjarrez, Edgar and Aranda-Barradas, Juan S. (2011). A simple metabolic flux balance analysis of biomass and bioethanol production in Saccharomyces cerevisiae fed-batch cultures. Biotechnology and Bioprocess Engineering, 16 (1), 13-22. doi: 10.1007/s12257-010-0176-y

A simple metabolic flux balance analysis of biomass and bioethanol production in Saccharomyces cerevisiae fed-batch cultures

Funding

Current funding

  • 2024 - 2027
    Production of rare sugars
    Trailblazer Universities Program
    Open grant
  • 2024 - 2028
    Integrated Design Environment for Advanced Biomanufacturing (IDEA Bio) - Bioplatforms Australia (BPA) NCRIS 2022
    Bioplatforms Australia Ltd
    Open grant
  • 2023 - 2026
    Understanding and resolving the biological bottlenecks of recombinant dairy protein production in host microorganisms
    Trailblazer Universities Program
    Open grant
  • 2020 - 2027
    ARC Centre of Excellence in Synthetic Biology (ARC Centre of Excellence administered by Macquarie University)
    Macquarie University
    Open grant

Past funding

  • 2023 - 2025
    Assessing the potential of engineered microbial communities to reduce nitrous oxide (N2O) emissions from agricultural soils
    Grains Research & Development Corporation
    Open grant

Supervision

Availability

Dr Axa Gonzalez is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Media

Enquiries

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