Overview
Background
Dr Axayacatl Gonzalez completed his bachelors in 2010 in Chemical Engineering /Biotechnology at the Interdisciplinary Unit for Biotechnology (UPIBI, IPN, Mexico). He obtained his Master’s degree in 2012, where he specialised in metabolic modelling and bioprocessing. In 2013, he moved to Australia where he completed his PhD studies at the Australian Institute for Bioengineering and Nanotechnology (AIBN) at The University of Queensland (UQ).
Dr Gonzalez has been involved in the ARC-Training Centre for Biopharmaceutical Innovation (ARCT-CBI, 2018), the Queensland Strain Factory (QSF, 2019), ARC Centre of Excellence in Synthetic Biology (COESB, 2021) and is currently the Facility Manager and Senior Bioprocess Engineer for the Integrated Design Environment for Advanced biomanufacturing (IDEA bio) at AIBN-UQ.
Complementary to his role at IDEA Bio, Dr Gonzalez research focuses on a) Development of bioprocess strategies to improve productivities. b) Identification of metabolic changes in bacterial strains associated with selective pressure. c) Design, construction and evaluation of synthetic genetic circuits in microbial hosts. d) Development of strategies to screen, isolate, characterise and propagate soil microorganism for agricultural practices.
Availability
- Dr Axa Gonzalez is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Research interests
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Bioprocess development and scale up
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Development of microbial cell factories
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Assemble and assessment of synthetic microbial communities for agriculture
Research impacts
Dr Axayacatl González leads research that delivers tangible benefits to agriculture, industry, and Australia’s growing bioeconomy. His work combines microbial engineering, fermentation, and soil microbiome science to create technologies that improve environmental sustainability and support new high-value manufacturing pathways.
Dr González has produced high-quality research recognised nationally and internationally, with 33 peer-reviewed publications and over 900 citations. His research has directly informed the development of microbial platforms for rare sugar production, supporting innovation within Queensland’s sugar industry through a $1.5M collaboration with MSF Sugar.
His environmental research has advanced understanding of the microbial drivers of nitrous oxide emissions, one of agriculture’s most damaging greenhouse gases. This work, supported by GRDC, DAF and the ARC Centre of Excellence in Synthetic Biology, provides evidence-based strategies to reduce emissions and improve soil health.
Beyond academic impact, Dr González has secured over $1.7M in competitive research funding and facilitated major industry partnerships with companies such as Windfall Bio, SQM, Manildra Group and Eden Brew. His leadership at IDEA Bio has also contributed to securing $20M in national research infrastructure funding, strengthening Australia’s capacity in synthetic biology and biomanufacturing.
Works
Search Professor Axa Gonzalez’s works on UQ eSpace
2020
Journal Article
Adaptive laboratory evolution of native methanol assimilation in Saccharomyces cerevisiae
Espinosa, Monica I., Gonzalez-Garcia, Ricardo A., Valgepea, Kaspar, Plan, Manuel R., Scott, Colin, Pretorius, Isak S., Marcellin, Esteban, Paulsen, Ian T. and Williams, Thomas C. (2020). Adaptive laboratory evolution of native methanol assimilation in Saccharomyces cerevisiae. Nature Communications, 11 (1) 5564, 5564. doi: 10.1038/s41467-020-19390-9
2020
Conference Publication
Revamping the model CO-fermenting acetogen, Clostridium autoethanogenum, as a CO2-valorisation platform
Heffernan, James, Valgepea, Kaspar, de Souza Pinto Lemgruber, Renato, Casini, Isabella, Plan, Manuel, Tappel, Ryan, Simpson, Sean D., Köpke, Michael, Gonzalez-Garcia, Ricardo A., Nielsen, Lars K. and Marcellin, Esteban (2020). Revamping the model CO-fermenting acetogen, Clostridium autoethanogenum, as a CO2-valorisation platform. International Chain Elongation Conference 2020, Virtual, 26-27 October 2020. Wageningen, Germany: Wageningen University and Research. doi: 10.18174/icec2020.18019
2020
Journal Article
A pan-genome guided metabolic network reconstruction of five Propionibacterium species reveals extensive metabolic diversity
McCubbin, Tim, Gonzalez-Garcia, R. Axayacatl, Palfreyman, Robin W., Stowers, Chris, Nielsen, Lars K. and Marcellin, Esteban (2020). A pan-genome guided metabolic network reconstruction of five Propionibacterium species reveals extensive metabolic diversity. Genes, 11 (10) 1115, 1-26. doi: 10.3390/genes11101115
2020
Journal Article
Heterologous production of 6-deoxyerythronolide B in Escherichia coli through the wood werkman cycle
Gonzalez-Garcia, R. Axayacatl, Nielsen, Lars K. and Marcellin, Esteban (2020). Heterologous production of 6-deoxyerythronolide B in Escherichia coli through the wood werkman cycle. Metabolites, 10 (6) 228, 228. doi: 10.3390/metabo10060228
2020
Journal Article
Engineering Escherichia coli for propionic acid production through the Wood‐Werkman cycle
Gonzalez‐Garcia, R. A., McCubbin, T., Turner, M. S., Nielsen, L. K. and Marcellin, E. (2020). Engineering Escherichia coli for propionic acid production through the Wood‐Werkman cycle. Biotechnology and Bioengineering, 117 (1), 167-183. doi: 10.1002/bit.27182
2020
Book Chapter
Hydrogen and Polyhidroxybutyrate (PHB) Production by a Photoheterotrophic Mixed Culture
García-Peña, E. I. and Gonzalez-Garcia, R. A. (2020). Hydrogen and Polyhidroxybutyrate (PHB) Production by a Photoheterotrophic Mixed Culture. Encyclopedia of Plant Science. (pp. 575-588) Hauppauge, NY United States: Nova Science Publishers.
2019
Journal Article
A TetR-family protein (CAETHG_0459) activates transcription from a new promoter motif associated with essential genes for autotrophic growth in acetogens
Lemgruber, Renato de Souza Pinto, Valgepea, Kaspar, Garcia, Ricardo Axayacatl Gonzalez, de Bakker, Christopher, Palfreyman, Robin William, Tappel, Ryan, Kopke, Michael, Simpson, Sean Dennis, Nielsen, Lars Keld and Marcellin, Esteban (2019). A TetR-family protein (CAETHG_0459) activates transcription from a new promoter motif associated with essential genes for autotrophic growth in acetogens. Frontiers in Microbiology, 10 2549, 2549. doi: 10.3389/fmicb.2019.02549
2018
Other Outputs
Metabolic engineering of propionibacteria’s Wood Werkman cycle in Escherichia coli and Saccharomyces cerevisiae
Gonzalez Garcia, Ricardo Axayacatl (2018). Metabolic engineering of propionibacteria’s Wood Werkman cycle in Escherichia coli and Saccharomyces cerevisiae. PhD Thesis, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland. doi: 10.14264/716822
2018
Journal Article
Hydrogen production by a mixed photoheterotrophic culture: Correlation between gene expression analysis and physiological behavior
Jurado-Marban, V. H., Tapia-Bustos, M. A., Gonzalez-Garcia, R. A., Salgado-Manjarrez, E. and García-Peña, E. I. (2018). Hydrogen production by a mixed photoheterotrophic culture: Correlation between gene expression analysis and physiological behavior. International Journal of Hydrogen Energy, 44 (2), 641-651. doi: 10.1016/j.ijhydene.2018.10.197
2017
Journal Article
Genome-scale model guided design of Propionibacterium for enhanced propionic acid production
Navone, Laura, McCubbin, Tim, Gonzalez-Garcia, Ricardo A., Nielsen, Lars K. and Marcellin, Esteban (2017). Genome-scale model guided design of Propionibacterium for enhanced propionic acid production. Metabolic Engineering Communications, 6, 1-12. doi: 10.1016/j.meteno.2017.11.001
2017
Journal Article
Awakening sleeping beauty: production of propionic acid in Escherichia coli through the sbm operon requires the activity of a methylmalonyl-CoA epimerase
Gonzalez-Garcia, Ricardo Axayacatl, McCubbin, Tim, Wille, Annalena, Plan, Manuel, Nielsen, Lars Keld and Marcellin, Esteban (2017). Awakening sleeping beauty: production of propionic acid in Escherichia coli through the sbm operon requires the activity of a methylmalonyl-CoA epimerase. Microbial Cell Factories, 16 (1) 121, 121. doi: 10.1186/s12934-017-0735-4
2017
Journal Article
Microbial Propionic Acid Production
Gonzalez Garcia, Ricardo Axayacatl, McCubbin, Timothy, Navone, Laura, Stowers, Chris, Nielsen, Lars K. and Marcellin Saldana, Esteban Stefane (2017). Microbial Propionic Acid Production. Fermentation, 3 (2) 3020021, 1-20. doi: 10.3390/fermentation3020021
2017
Journal Article
Metabolic pathway and flux analysis of H2 production by an anaerobic mixed culture
Gonzalez-Garcia, R. A., Aispuro-Castro, R., Salgado-Manjarrez, E., Aranda-Barradas, J. and Garcia-Pena, E. I. (2017). Metabolic pathway and flux analysis of H2 production by an anaerobic mixed culture. International Journal of Hydrogen Energy, 42 (7), 4069-4082. doi: 10.1016/j.ijhydene.2017.01.043
2016
Journal Article
Continuous two-staged co-digestion process for biohydrogen production from agro-industrial wastes
Gomez-Romero, J., Gonzalez-Garcia, R. A., Chairez, I., Torres, L. and Garcia-Pena, E. I. (2016). Continuous two-staged co-digestion process for biohydrogen production from agro-industrial wastes. International Journal of Energy Research, 40 (2), 257-272. doi: 10.1002/er.3466
2015
Book Chapter
Hydrogen and polyhidroxybutyrate (PHB) production by a photoheterotrophic mixed culture
Garcia-Pena, E. I. and Gonzalez-Garcia, R. A. (2015). Hydrogen and polyhidroxybutyrate (PHB) production by a photoheterotrophic mixed culture. Microalgae and other phototrophic bacteria: culture, processing, recovery and new products. (pp. 111-124) Hauppauge, NY, United States: Nova Science Publishers.
2014
Journal Article
Selective adaptation of an anaerobic microbial community: biohydrogen production by co-digestion of cheese whey and vegetables fruit waste
Gomez-Romero, J., Gonzalez-Garcia, A., Chairez, I., Torres, L. and García-Peña, E.I. (2014). Selective adaptation of an anaerobic microbial community: biohydrogen production by co-digestion of cheese whey and vegetables fruit waste. International Journal of Hydrogen Energy, 39 (24), 12541-12550. doi: 10.1016/j.ijhydene.2014.06.050
2013
Journal Article
Metabolic flux distribution and thermodynamic analysis of green fluorescent protein production in recombinant Escherichia coli: the effect of carbon source and CO2 partial pressure
González-García, R. Axayácatl, Garcia-Peña, E. Ines, Salgado-Manjarrez, Edgar and Aranda-Barradas, Juan S. (2013). Metabolic flux distribution and thermodynamic analysis of green fluorescent protein production in recombinant Escherichia coli: the effect of carbon source and CO2 partial pressure. Biotechnology and Bioprocess Engineering, 18 (6), 1049-1061. doi: 10.1007/s12257-013-0277-5
2011
Journal Article
A simple metabolic flux balance analysis of biomass and bioethanol production in Saccharomyces cerevisiae fed-batch cultures
Barrera-Martínez, Iliana, Axayácatl González-García, R., Salgado-Manjarrez, Edgar and Aranda-Barradas, Juan S. (2011). A simple metabolic flux balance analysis of biomass and bioethanol production in Saccharomyces cerevisiae fed-batch cultures. Biotechnology and Bioprocess Engineering, 16 (1), 13-22. doi: 10.1007/s12257-010-0176-y
Supervision
Availability
- Dr Axa Gonzalez is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Isolation and optimisation of phosphate-solubilising fungi for agricultural applications
Associate Advisor
Other advisors: Professor Susanne Schmidt, Professor Esteban Marcellin
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Doctor Philosophy
Engineering biology of yeast for sustainable fragrance production through precision fermentation
Associate Advisor
Other advisors: Professor Esteban Marcellin, Dr Huadong Peng
Completed supervision
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2025
Doctor Philosophy
Pathway engineering and systems biology for optimised isobutanol production in gas-fermenting acetogens: From strain enrichment to identification of metabolic limitations
Associate Advisor
Other advisors: Professor Lars Nielsen, Professor Gary Schenk, Dr James Heffernan, Professor Esteban Marcellin
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2023
Doctor Philosophy
Sustainable fuel and chemical production via Gas Fermentation: exploring CO2 metabolism by Clostridium autoethanogenum
Associate Advisor
Other advisors: Professor Lars Nielsen, Professor Esteban Marcellin
Media
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