MD Shahriar Hossain

Porous magnetic nanomaterials and nanocomposites for biomedical application

This is a multidisciplinary project for the development of a number of monodispersed, biocompatible and superparamagnetic porous nanoparticles with high surface area and various surface functionalisations suitable for the use in biological (in vitro and in vivo) experiments. Water dispersible magnetite nanoparticles have been synthesized by thermal decomposition method and with a wet technique by forming a micro-emulsion solution and the surface of the nanoparticles has been functionalised by different functional groups such as thiol, amino acid, etc as per specific requirements. Special designed gold-coated magnetic nanoparticles have been prepared for site-specific exosome profiling for the use in cancer diagnostics.

Superconducting materials and discovery of low activation superconducting materials for fusion magnet applications

This highly interdisciplinary project has been initiated in collaborating with the Australian Nuclear Science and Technology Organisation (ANSTO), Australian National University (ANU) and International Thermonuclear Experimental Reactor (ITER), France, CERN, Switzerland, Hyper Tech, USA, QUT and University of Wollongong (UOW) for the development of nano-structured engineered low-activation boron-11 based isotopic high temperature superconductors for the next generation low-cost DEMO fusion reactors. This isotope-based material has been.characterised by a number of state-of-the-art facilities available at UQ, QUT, UOW and ANSTO

A next generation 'smart' superconducting magnet system in persistent mode

This project aims to develop a liquid-helium-free superconducting technology to address the need for more affordable MRI magnets that currently rely on expensive, limited supplies of liquid helium. This project expects to generate a world-first, much needed MRI systems to be operated in persistent mode without a power supply, to obtain high-resolution images and low-cost operation. The expected outcomes include a novel, lightweight, easy-to-operate magnesium diboride superconducting MRI magnet prototype under persistent mode operation. This should provide significant benefits, including reducing the cost associated with conventional liquid helium-dependent technologies and ensuring Australia at the forefront of MRI development worldwide.

Industry partner: HyperTech Inc.

A nanoarchitectured platform for early diagnosis and monitoring of ovarian cancer

Ovarian cancer (OC), a leading cause of cancer-related death in women, demands early and accurate diagnosis for improved outcomes. Exosomes, especially exosomal biomarkers like proteins and miRNAs, are promising candidates for early OC detection. However, existing techniques involve complex processes and specialized laboratories, hindering routine clinical use. To overcome these challenges, this project aims to develop a portable and automated diagnostic device. This device, utilizing novel mesoporous nanostructures, will automatically isolate, purify, and simultaneously detect exosomes and exosomal biomarkers for early OC diagnosis and treatment monitoring. The engineered nanostructures will enhance efficiency, enabling diagnosis in primary healthcare settings. This project promises a robust, cost-effective, and impactful automated device for OC detection and treatment monitoring, offering significant health and economic benefits for patients.