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2018

Journal Article

Correction to: lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling

Zannas, Anthony S., Arloth, Janine, Carrillo-Roa, Tania, Iurato, Stella, Röh, Simone, Ressler, Kerry J., Nemeroff, Charles B., Smith, Alicia K., Bradley, Bekh, Heim, Christine, Menke, Andreas, Lange, Jennifer F., Brückl, Tanja, Ising, Marcus, Wray, Naomi R., Erhardt, Angelika, Binder, Elisabeth B. and Mehta, Divya (2018). Correction to: lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling. Genome Biology, 19 (1) 61, 61-61. doi: 10.1186/s13059-018-1441-1

Correction to: lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling

2018

Journal Article

GWAS on family history of Alzheimer's disease

Marioni, Riccardo E., Harris, Sarah E., Zhang, Qian, McRae, Allan F., Hagenaars, Saskia P., Hill, W. David, Davies, Gail, Ritchie, Craig W., Gale, Catharine R., Starr, John M., Goate, Alison M., Porteous, David J., Yang, Jian, Evans, Kathryn L., Deary, Ian J., Wray, Naomi R. and Visscher, Peter M. (2018). GWAS on family history of Alzheimer's disease. Translational Psychiatry, 8 (1) 99, 99. doi: 10.1038/s41398-018-0150-6

GWAS on family history of Alzheimer's disease

2018

Journal Article

Comparison of genotypic and phenotypic correlations: Cheverud's conjecture in humans

Sodini, Sebastian M., Kemper, Kathryn E., Wray, Naomi R. and Trzaskowski, Maciej (2018). Comparison of genotypic and phenotypic correlations: Cheverud's conjecture in humans. Genetics, 209 (3), 941-948. doi: 10.1534/genetics.117.300630

Comparison of genotypic and phenotypic correlations: Cheverud's conjecture in humans

2018

Journal Article

Familiality of psychiatric disorders and risk of postpartum psychiatric episodes: a population-based cohort study

Bauer, Anna E., Maegbaek, Merete L., Liu, Xiaoqin, Wray, Naomi R., Sullivan, Patrick F., Miller, William C., Meltzer-Brody, Samantha and Munk-Olsen, Trine (2018). Familiality of psychiatric disorders and risk of postpartum psychiatric episodes: a population-based cohort study. The American Journal of Psychiatry, 175 (8), appiajp201817111184-791. doi: 10.1176/appi.ajp.2018.17111184

Familiality of psychiatric disorders and risk of postpartum psychiatric episodes: a population-based cohort study

2018

Journal Article

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till M. F., Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan F. T., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas R. H., Bryois, Julien, Buttenschon, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard, Clarke, Toni-Kim, Coleman, Jonathan I. R., Colodro-Conde, Lucia, Couvy-Duchesne, Baptiste, Craddock, Nick, Crawford, Gregory E., Crowley, Cheynna A. ... Sullivan, Patrick F. (2018). Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nature Genetics, 50 (5), 668-+. doi: 10.1038/s41588-018-0090-3

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

2018

Journal Article

Hypermetabolism in ALS is associated with greater functional decline and shorter survival

Steyn, Frederik J., Ioannides, Zara A., van Eijk, Ruben P. A., Heggie, Susan, Thorpe, Kathryn A., Ceslis, Amelia, Heshmat, Saman, Henders, Anjali K., Wray, Naomi R., van den Berg, Leonard H., Henderson, Robert D., McCombe, Pamela A. and Ngo, Shyuan T. (2018). Hypermetabolism in ALS is associated with greater functional decline and shorter survival. Journal of Neurology, Neurosurgery, and Psychiatry, 89 (10), jnnp-2017. doi: 10.1136/jnnp-2017-317887

Hypermetabolism in ALS is associated with greater functional decline and shorter survival

2018

Journal Article

Sizing up whole-genome sequencing studies of common diseases

Wray, Naomi R. and Gratten, Jacob (2018). Sizing up whole-genome sequencing studies of common diseases. Nature Genetics, 50 (5), 635-637. doi: 10.1038/s41588-018-0113-0

Sizing up whole-genome sequencing studies of common diseases

2018

Journal Article

Signatures of negative selection in the genetic architecture of human complex traits

Zeng, Jian, de Vlaming, Ronald, Wu, Yang, Robinson, Matthew R., Lloyd-Jones, Luke R., Yengo, Loic, Yap, Chloe X., Xue, Angli, Sidorenko, Julia, McRae, Allan F., Powell, Joseph E., Montgomery, Grant W., Metspalu, Andres, Esko, Tonu, Gibson, Greg, Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2018). Signatures of negative selection in the genetic architecture of human complex traits. Nature Genetics, 50 (5), 746-753. doi: 10.1038/s41588-018-0101-4

Signatures of negative selection in the genetic architecture of human complex traits

2018

Journal Article

Improving genetic prediction by leveraging genetic correlations among human diseases and traits

Maier, Robert M, Zhu, Zhihong, Lee, Sang Hong, Trzaskowski, Maciej, Ruderfer, Douglas M, Stahl, Eli A, Ripke, Stephan, Wray, Naomi R, Yang, Jian, Visscher, Peter M and Robinson, Matthew R (2018). Improving genetic prediction by leveraging genetic correlations among human diseases and traits. Nature Communications, 9 (1) 989, 989. doi: 10.1038/s41467-017-02769-6

Improving genetic prediction by leveraging genetic correlations among human diseases and traits

2018

Journal Article

Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits

Wu, Yang, Zeng, Jian, Zhang, Futao, Zhu, Zhihong, Qi, Ting, Zheng, Zhili, Lloyd-Jones, Luke R., Marioni, Riccardo E., Martin, Nicholas G., Montgomery, Grant W., Deary, Ian J., Wray, Naomi R., Visscher, Peter M., McRae, Allan F. and Yang, Jian (2018). Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits. Nature Communications, 9 (918) 918, 918. doi: 10.1038/s41467-018-03371-0

Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits

2018

Journal Article

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

Pardiñas, Antonio F, Holmans, Peter, Pocklington, Andrew J, Escott-Price, Valentina, Ripke, Stephan, Carrera, Noa, Legge, Sophie E, Bishop, Sophie, Cameron, Darren, Hamshere, Marian L, Han, Jun, Hubbard, Leon, Lynham, Amy, Mantripragada, Kiran, Rees, Elliott, MacCabe, James H, McCarroll, Steven A, Baune, Bernhard T, Breen, Gerome, Byrne, Enda M., Dannlowski, Udo, Eley, Thalia C, Hayward, Caroline, Martin, Nicholas G., McIntosh, Andrew M, Plomin, Robert, Porteous, David J, Wray, Naomi R, Caballero, Armando ... CRESTAR Consortium (2018). Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics, 50 (3), 381-389. doi: 10.1038/s41588-018-0059-2

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

2018

Journal Article

Reply to Kardos et al.: estimation of inbreeding depression from SNP data

Yengo, Loic, Zhu, Zhihong, Wray, Naomi R., Weir, Bruce S., Yang, Jian, Robinson, Matthew R. and Visscher, Peter M. (2018). Reply to Kardos et al.: estimation of inbreeding depression from SNP data. Proceedings of the National Academy of Sciences, 115 (11), E2494-E2495. doi: 10.1073/pnas.1718598115

Reply to Kardos et al.: estimation of inbreeding depression from SNP data

2018

Journal Article

The value of polygenic analyses in psychiatry

Middeldorp, Christel M. and Wray, Naomi R. (2018). The value of polygenic analyses in psychiatry. World Psychiatry, 17 (1), 26-28. doi: 10.1002/wps.20480

The value of polygenic analyses in psychiatry

2018

Journal Article

GWAS of epigenetic aging rates in blood reveals a critical role for TERT

Lu, Ake T., Xue, Luting, Salfati, Elias L., Chen, Brian H., Ferrucci, Luigi, Levy, Daniel, Joehanes, Roby, Murabito, Joanne M., Kiel, Douglas P., Tsai, Pei-Chien, Yet, Idil, Bell, Jordana T., Mangino, Massimo, Tanaka, Toshiko, McRae, Allan F., Marioni, Riccardo E., Visscher, Peter M., Wray, Naomi R., Deary, Ian J., Levine, Morgan E., Quach, Austin, Assimes, Themistocles, Tsao, Philip S., Absher, Devin, Stewart, James D., Li, Yun, Reiner, Alex P., Hou, Lifang, Baccarelli, Andrea A. ... Horvath, Steve (2018). GWAS of epigenetic aging rates in blood reveals a critical role for TERT. Nature Communications, 9 (1) 387, 387. doi: 10.1038/s41467-017-02697-5

GWAS of epigenetic aging rates in blood reveals a critical role for TERT

2018

Journal Article

Causal associations between risk factors and common diseases inferred from GWAS summary data

Zhu, Zhihong, Zheng, Zhili, Zhang, Futao, Wu, Yang, Trzaskowski, Maciej, Maier, Robert, Robinson, Matthew R., McGrath, John J, Visscher, Peter M, Wray, Naomi R and Yang, Jian (2018). Causal associations between risk factors and common diseases inferred from GWAS summary data. Nature Communications, 9 (1) 224, 224. doi: 10.1038/s41467-017-02317-2

Causal associations between risk factors and common diseases inferred from GWAS summary data

2018

Journal Article

Genome-wide gene-environment interaction in depression: a systematic evaluation of candidate genes: the childhood trauma working-group of PGC-MDD

Van der Auwera, Sandra, Peyrot, Wouter J., Milaneschi, Yuri, Hertel, Johannes, Baune, Bernhard, Breen, Gerome, Byrne, Enda, Dunn, Erin C, Fisher, Helen, Homuth, Georg, Levinson, Douglas, Lewis, Cathryn, Mills, Natalie, Mullins, Niamh, Nauck, Matthias, Pistis, Giorgio, Preisig, Martin, Rietschel, Marcella, Ripke, Stephan, Sullivan, Patrick, Teumer, Alexander, Völzke, Henry, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Boomsma, Dorret I., Wray, Naomi R., Penninx, Brenda and Grabe, Hans (2018). Genome-wide gene-environment interaction in depression: a systematic evaluation of candidate genes: the childhood trauma working-group of PGC-MDD. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 177 (1), 40-49. doi: 10.1002/ajmg.b.32593

Genome-wide gene-environment interaction in depression: a systematic evaluation of candidate genes: the childhood trauma working-group of PGC-MDD

2018

Conference Publication

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depressive disorder

Trzaskowski, Maciej, Wray, Naomi and Sullivan, Patrick (2018). Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depressive disorder. Human Genome Meeting 2018, Yokohama, Japan, 12-15 March 2018. London, United Kingdom: BioMed Central . doi: 10.1186/s40246-018-0138-6

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depressive disorder

2018

Conference Publication

Invited abstract: Leveraging big GWAS data to address question about selection, pleiotropy, assortative mating and epidemiology

Visscher, Peter M., Wray, Naomi R. and Yang, Jian (2018). Invited abstract: Leveraging big GWAS data to address question about selection, pleiotropy, assortative mating and epidemiology. 27th Annual Meeting of the International Genetic Epidemiology Society (IGES), San Diego, CA, United States, 14-16 October 2018. Hoboken, NJ, United States: John Wiley & Sons.

Invited abstract: Leveraging big GWAS data to address question about selection, pleiotropy, assortative mating and epidemiology

2018

Conference Publication

Fine-mapping reveals complex genetic architecture underlying DNA methylation

Chundru, V. Kartik, Marioni, Riccardo E., Deary, Ian J., Wray, Naomi R., Visscher, Peter M. and McRae, Allan F. (2018). Fine-mapping reveals complex genetic architecture underlying DNA methylation. Human Genome Meeting, Yokohama, Japan, 12-15 March 2018. London, United Kingdom: Henry Stewart Publications. doi: 10.1186/s40246-018-0138-6

Fine-mapping reveals complex genetic architecture underlying DNA methylation

2018

Journal Article

Association of whole-genome and NETRIN1 signaling pathway–derived polygenic risk scores for major depressive disorder and white matter microstructure in the UK Biobank

Barbu, Miruna C., Zeng, Yanni, Shen, Xueyi, Cox, Simon R., Clarke, Toni-Kim, Gibson, Jude, Adams, Mark J., Johnstone, Mandy, Haley, Chris S., Lawrie, Stephen M., Deary, Ian J., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F.M., Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T.F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H.R., Bryois, Julien ... Whalley, Heather C. (2018). Association of whole-genome and NETRIN1 signaling pathway–derived polygenic risk scores for major depressive disorder and white matter microstructure in the UK Biobank. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 4 (1), 91-100. doi: 10.1016/j.bpsc.2018.07.006

Association of whole-genome and NETRIN1 signaling pathway–derived polygenic risk scores for major depressive disorder and white matter microstructure in the UK Biobank