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2017

Journal Article

Performance of risk prediction for inflammatory bowel disease based on genotyping platform and genomic risk score method

Chen, Guo-Bo, Lee, Sang Hong, Montgomery, Grant W., Wray, Naomi R., Visscher, Peter M., Gearry, Richard B., Lawrance, Ian C., Andrews, Jane M., Bampton, Peter, Mahy, Gillian, Bell, Sally, Walsh, Alissa, Connor, Susan, Sparrow, Miles, Bowdler, Lisa M., Simms, Lisa A., Krishnaprasad, Krupa, Radford-Smith, Graham L. and Moser, Gerhard (2017). Performance of risk prediction for inflammatory bowel disease based on genotyping platform and genomic risk score method. BMC Medical Genetics, 18 (1) 94, 94. doi: 10.1186/s12881-017-0451-2

Performance of risk prediction for inflammatory bowel disease based on genotyping platform and genomic risk score method

2017

Journal Article

Detection and quantification of inbreeding depression for complex traits from SNP data

Yengo, Loic, Zhu, Zhihong, Wray, Naomi R., Weir, Bruce S., Yang, Jian, Robinson, Matthew R. and Visscher, Peter M. (2017). Detection and quantification of inbreeding depression for complex traits from SNP data. PNAS: Proceedings of the National Academy of Sciences of the United States of America, 114 (32), 8602-8607. doi: 10.1073/pnas.1621096114

Detection and quantification of inbreeding depression for complex traits from SNP data

2017

Journal Article

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

Willems, Sara M., Wright, Daniel J., Day, Felix R., Trajanoska, Katerina, Joshi, Peter K., Morris, John A., Matteini, Amy M., Garton, Fleur C., Grarup, Niels, Oskolkov, Nikolay, Thalamuthu, Anbupalam, Mangino, Massimo, Liu, Jun, Demirkan, Ayse, Lek, Monkol, Xu, Liwen, Wang, Guan, Oldmeadow, Christopher, Gaulton, Kyle J., Lotta, Luca A., Miyamoto-Mikami, Eri, Rivas, Manuel A., White, Tom, Loh, Po-Ru, Aadahl, Mette, Amin, Najaf, Attia, John R., Austin, Krista, Benyamin, Beben ... Ohlsson, Claes (2017). Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness. Nature Communications, 8 (1) 16015, 16015. doi: 10.1038/ncomms16015

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

2017

Journal Article

A direct test of the diathesis–stress model for depression

Colodro-Conde, L., Couvy-Duchesne, B., Zhu, G., Coventry, W. L., Byrne, E. M., Gordon, S., Wright, M. J., Montgomery, G. W., Madden, P. A. F., Ripke, S., Eaves, L. J., Heath, A. C., Wray, N. R., Medland, S. E. and Martin, N. G. (2017). A direct test of the diathesis–stress model for depression. Molecular Psychiatry, 23 (7), 1590-1596. doi: 10.1038/mp.2017.130

A direct test of the diathesis–stress model for depression

2017

Journal Article

10 years of GWAS discovery: biology, function, and translation

Visscher, Peter M., Wray, Naomi R., Zhang, Qian, Sklar, Pamela, McCarthy, Mark I., Brown, Matthew A. and Yang, Jian (2017). 10 years of GWAS discovery: biology, function, and translation. American Journal of Human Genetics, 101 (1), 5-22. doi: 10.1016/j.ajhg.2017.06.005

10 years of GWAS discovery: biology, function, and translation

2017

Journal Article

Whole exome sequencing and DNA methylation analysis in a clinical amyotrophic lateral sclerosis cohort

Garton, Fleur C., Benyamin, Beben, Zhao, Qiongyi, Liu, Zhijun, Gratten, Jacob, Henders, Anjali K., Zhang, Zong-Hong, Edson, Janette, Furlong, Sarah, Morgan, Sarah, Heggie, Susan, Thorpe, Kathryn, Pfluger, Casey, Mather, Karen A., Sachdev, Perminder S., McRae, Allan F., Robinson, Matthew R., Shah, Sonia, Visscher, Peter M., Mangelsdorf, Marie, Henderson, Robert D., Wray, Naomi R. and McCombe, Pamela A. (2017). Whole exome sequencing and DNA methylation analysis in a clinical amyotrophic lateral sclerosis cohort. Molecular Genetics and Genomic Medicine, 5 (4), 418-428. doi: 10.1002/mgg3.302

Whole exome sequencing and DNA methylation analysis in a clinical amyotrophic lateral sclerosis cohort

2017

Journal Article

Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia.

Witt, S. H., Streit, F., Jungkunz, M., Frank, J., Awasthi, S., Reinbold, C. S., Treutlein, J., Degenhardt, F., Forstner, A. J., Heilmann-Heimbach, S., Dietl, L., Schwarze, C. E., Schendel, D., Strohmaier, J., Abdellaoui, A., Adolfsson, R., Air, T. M., Akil, H., Alda, M., Alliey-Rodriguez, N., Andreassen, O. A., Babadjanova, G., Bass, N. J., Bauer, M., Baune, B. T., Bellivier, F., Bergen, S., Bethell, A., Biernacka, J. M. ... Rietschel, M. (2017). Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia.. Translational psychiatry, 7 (6), e1155-e1155. doi: 10.1038/tp.2017.115

Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia.

2017

Journal Article

Extra-motor abnormalities in amyotrophic lateral sclerosis: another layer of heterogeneity

McCombe, P. A., Wray, N. R. and Henderson, R. D. (2017). Extra-motor abnormalities in amyotrophic lateral sclerosis: another layer of heterogeneity. Expert Review of Neurotherapeutics, 17 (6), 561-577. doi: 10.1080/14737175.2017.1273772

Extra-motor abnormalities in amyotrophic lateral sclerosis: another layer of heterogeneity

2017

Journal Article

Maternal depression and family adversity: linked pathways to offspring depression?

Najman, Jake M., Plotnikova, M., Williams, G. M., Alati, R., Mamun, A. A., Scott, J., Clavarino, A. M. and Wray, N. (2017). Maternal depression and family adversity: linked pathways to offspring depression?. Journal of Psychiatric Research, 88, 97-104. doi: 10.1016/j.jpsychires.2017.01.006

Maternal depression and family adversity: linked pathways to offspring depression?

2017

Journal Article

Genetic signatures of high-altitude adaptation in Tibetans

Yang, Jian, Jin, Zi-Bing, Chen, Jie, Huang, Xiu-Feng, Li, Xiao-Man, Liang, Yuan-Bo, Mao, Jian-Yang, Chen, Xin, Zheng, Zhili, Bakshi, Andrew, Zheng, Dong-Dong, Zheng, Mei-Qin, Wray, Naomi R., Visscher, Peter M., Lu, Fan and Qu, Jia (2017). Genetic signatures of high-altitude adaptation in Tibetans. Proceedings of the National Academy of Sciences, 114 (16), 4189-4194. doi: 10.1073/pnas.1617042114

Genetic signatures of high-altitude adaptation in Tibetans

2017

Journal Article

Genetic effects influencing risk for major depressive disorder in China and Europe

Bigdeli, T. B., Ripke, S., Peterson, R. E., Trzaskowski, M., Bacanu, S-A, Abdellaoui, A., Andlauer, T. F. M., Beekman, A. T. F., Berger, K., Blackwood, D. H. R., Boomsma, D. I., Breen, G., Buttenschon, H. N., Byrne, E. M., Cichon, S., Clarke, T-K, Couvy-Duchesne, B., Craddock, N., de Geus, E. J. C., Degenhardt, F., Dunn, E. C., Edwards, A. C., Fanous, A. H., Forstner, A. J., Frank, J., Gill, M., Gordon, S. D., Grabe, H. J., Hamilton, S. P. ... Kendler, K. S. (2017). Genetic effects influencing risk for major depressive disorder in China and Europe. Translational Psychiatry, 7 (3) e1074, e1074-e1074. doi: 10.1038/tp.2016.292

Genetic effects influencing risk for major depressive disorder in China and Europe

2017

Journal Article

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

McLaughlin, Russell L., Schijven, Dick, Van Rheenen, Wouter, Van Eijk, Kriste R., O'Brien, Margaret, Kahn, Rene S., Ophoff, Roel A., Goris, An, Bradley, Daniel G., Al-Chalabi, Ammar, Van Den Berg, Leonard H., Luykx, Jurjen J., Hardiman, Orla, Veldink, Jan H., Project MinE GWAS Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Catts, Stanley V., Gratten, Jacob, Lee, S. Hong, Wray, Naomi R., Visscher, Peter M. and Mowry, Bryan J. (2017). Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. Nature Communications, 8 (1) 14774, 14774. doi: 10.1038/ncomms14774

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

2017

Journal Article

Using information of relatives in genomic prediction to apply effective stratified medicine

Lee, S. Hong, Weerasinghe, W. M. Shalanee P., Wray, Naomi R., Goddard, Michael E. and Van Der Werf, Julius H. J. (2017). Using information of relatives in genomic prediction to apply effective stratified medicine. Scientific Reports, 7 (1) 42091, 42091. doi: 10.1038/srep42091

Using information of relatives in genomic prediction to apply effective stratified medicine

2017

Journal Article

Trajectories of maternal depression: a 27-year population-based prospective study

Najman, J. M., Plotnikova, M., Williams, G. M., Alati, R., Mamun, A. A., Scott, J., Wray, N. and Clavarino, A. M. (2017). Trajectories of maternal depression: a 27-year population-based prospective study. Epidemiology and Psychiatric Sciences, 26 (1), 79-88. doi: 10.1017/S2045796015001109

Trajectories of maternal depression: a 27-year population-based prospective study

2017

Journal Article

Risk of psychiatric illness from advanced paternal age is not predominantly from de novo mutations

Gratten, Jacob, Wray, Naomi R., Peyrot, Wouter J., McGrath, John J., Visscher, Peter M. and Goddard, Michael E. (2017). Risk of psychiatric illness from advanced paternal age is not predominantly from de novo mutations. Obstetrical and Gynecological Survey, 72 (2), 96-96. doi: 10.1097/01.OGX.0000512485.13448.C7

Risk of psychiatric illness from advanced paternal age is not predominantly from de novo mutations

2017

Journal Article

Association of body mass index with DNA methylation and gene expression in blood cells and relations to cardiometabolic disease: a Mendelian randomization approach

Mendelson, Michael M., Marioni, Riccardo E., Joehanes, Roby, Liu, Chunyu, Hedman, Åsa K., Aslibekyan, Stella, Demerath, Ellen W., Guan, Weihua, Zhi, Degui, Yao, Chen, Huan, Tianxiao, Willinger, Christine, Chen, Brian, Courchesne, Paul, Multhaup, Michael, Irvin, Marguerite R., Cohain, Ariella, Schadt, Eric E., Grove, Megan L., Bressler, Jan, North, Kari, Sundstrom, Johan, Gustafsson, Stefan, Shah, Sonia, McRae, Allan F., Harris, Sarah E., Gibson, Jude, Redmond, Paul, Corley, Janie ... Deary, Ian J. (2017). Association of body mass index with DNA methylation and gene expression in blood cells and relations to cardiometabolic disease: a Mendelian randomization approach. PLoS Medicine, 14 (1) e1002215, e1002215. doi: 10.1371/journal.pmed.1002215

Association of body mass index with DNA methylation and gene expression in blood cells and relations to cardiometabolic disease: a Mendelian randomization approach

2017

Conference Publication

Multivariate polygenic risk scores increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder

Maier, Robert, Wray, Naomi, Robinson, Matt and Lee, Sang Hong (2017). Multivariate polygenic risk scores increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder. 23rd Annual World Congress of Psychiatric Genetics (WCPG), Toronto Canada, 16-20 October 2015. Amsterdam, Netherlands: Elsevier.

Multivariate polygenic risk scores increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder

2017

Conference Publication

Genetic architecture insights from joint investigations of rare CNVS and common SNPS

Bergen, Sarah, Kendler, Kenneth and Wray, Naomi (2017). Genetic architecture insights from joint investigations of rare CNVS and common SNPS. 23rd Annual World Congress of Psychiatric Genetics (WCPG), Toronto Canada, 16-20 October 2015. Amsterdam, Netherlands: Elsevier.

Genetic architecture insights from joint investigations of rare CNVS and common SNPS

2017

Journal Article

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

Marshall, Christian R., Howrigan, Daniel P., Merico, Daniele, Thiruvahindrapuram, Bhooma, Wu, Wenting, Greer, Douglas S., Antaki, Danny, Shetty, Aniket, Holmans, Peter A., Pinto, Dalila, Gujral, Madhusudan, Brandler, William M., Malhotra, Dheeraj, Wang, Zhouzhi, Fuentes Fajarado, Karin V., Maile, Michelle S., Ripke, Stephan, Agartz, Ingrid, Albus, Margot, Alexander, Madeline, Amin, Farooq, Atkins, Joshua, Bacanu, Silviu A., Belliveau, Richard A., Jr., Bergen, Sarah E., Bertalan, Marcelo, Bevilacqua, Elizabeth, Bigdeli, Tim B., Black, Donald W. ... Sebat, Jonathan (2017). Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nature Genetics, 49 (1), 27-35. doi: 10.1038/ng.3725

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

2017

Conference Publication

Multivariate genetic risk scores increase accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder

Maier, Robert, Wray, Naomi and Lee, Sang Hong (2017). Multivariate genetic risk scores increase accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder. 23rd Annual World Congress of Psychiatric Genetics (WCPG), Toronto Canada, 16-20 October 2015. Amsterdam, Netherlands: Elsevier.

Multivariate genetic risk scores increase accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder