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Professor Peter Visscher
Professor

Peter Visscher

Email: 
Phone: 
+61 7 344 37045

Overview

Background

Visscher joined the University of Queensland in 2011, where he is Professor of Quantitative Genetics. He is a Laureate Fellow of the Australian Research Council. Visscher was elected a Fellow of the Australian Academy of Science in 2010, a Fellow of the Royal Society (London) in 2018 and a Foreign Member of the Royal Netherlands Academy of Arts and Sciences in 2018.

Visscher’s research is about genetic variation for complex traits (including quantitative traits and disease) in populations, with the broad aim to understand and quantify the causes and consequences of human trait variation.

Prof Peter Visscher, Prof Naomi Wray and Prof Jian Yang together comprise the Executive Team of the Program in Complex Trait Genomics (PCTG). PCTG comprises a critical mass of more than 30 post-doctoral researchers plus research assistants and students, all supported by external grant funding. Their skills lie in the ability to develop and apply statistical methods within the framework of quantitative, population and statistical genetics and to use theory to understand and predict results from data analyses. They play leading roles in the international research consortia. The focus of current research activities is in the detection and fine-mapping of loci underlying complex traits (including common disease), based upon theoretical studies and applications of methods to large datasets, in population genetics studies using theoretical approaches and high-density genetic marker data, and in systems genomics studies.

Availability

Professor Peter Visscher is:
Not available for supervision

Fields of research

Qualifications

  • Masters (Coursework) of Science, University of Edinburgh
  • Doctor of Philosophy, University of Edinburgh

Research impacts

Visscher's research focuses on understanding individual differences betweeen people in traits that are important for health outcomes and ageing. A better understanding of the genes that underlie variation in risk to diseases may lead to better treatments.

Works

Search Professor Peter Visscher’s works on UQ eSpace

803 works between 1987 and 2025

221 - 240 of 803 works

2018

Journal Article

Multi-trait analysis of genome-wide association summary statistics using MTAG

Turley, Patrick, Walters, Raymond K., Maghzian, Omeed, Okbay, Aysu, Lee, James J., Fontana, Mark Alan, Nguyen-Viet, Tuan Anh, Wedow, Robbee, Zacher, Meghan, Furlotte, Nicholas A., Magnusson, Patrik, Oskarsson, Sven, Johannesson, Magnus, Visscher, Peter M., Laibson, David, Cesarini, David, Neale, Benjamin M., Benjamin, Daniel J., 23andMe Research Team and Social Science Genetic Association Consortium (2018). Multi-trait analysis of genome-wide association summary statistics using MTAG. Nature Genetics, 50 (229+), 229-237. doi: 10.1038/s41588-017-0009-4

Multi-trait analysis of genome-wide association summary statistics using MTAG

2018

Journal Article

Accuracy of inferred APOE genotypes for a range of genotyping arrays and imputation reference panels

Lupton, Michelle K., Medland, Sarah E., Gordon, Scott D., Goncalves, Tabatha, MacGregor, Stuart, Mackey, David A., Young, Terri L., Duffy, David L., Visscher, Peter M., Wray, Naomi R., Nyholt, Dale R., Bain, Lisa, Ferreira, Manuel A., Henders, Anjali K., Wallace, Leanne, Montgomery, Grant W., Wright, Margaret J. and Martin, Nicholas G. (2018). Accuracy of inferred APOE genotypes for a range of genotyping arrays and imputation reference panels. Journal of Alzheimer's Disease, 64 (1), 49-54. doi: 10.3233/JAD-171104

Accuracy of inferred APOE genotypes for a range of genotyping arrays and imputation reference panels

2018

Conference Publication

Evolutionary history and adaptation from high-coverage whole-genome sequences of the pygmy population of Flores, Indonesia

Tucci, Serena, McCoy, Rajiv, Vernot, Benjamin, Vohr, Sam, Robinson, Matthew R., Barbieri, Chiara, Fu, Wenqing, Sudoyo, Herawati, Visscher, Peter M., Barbujani, Guido, Akey, Joshua M. and Green, Richard E. (2018). Evolutionary history and adaptation from high-coverage whole-genome sequences of the pygmy population of Flores, Indonesia. 87th Annual Meeting of the American-Association-of-Physical-Anthropologists (AAPA), Austin, TX, United States, 11-14 April 2018. Hoboken, NJ, United States: John Wiley & Sons.

Evolutionary history and adaptation from high-coverage whole-genome sequences of the pygmy population of Flores, Indonesia

2018

Conference Publication

Signatures of negative selection in the genetic architecture of human complex traits

Zeng, Jian, de Vlaming, Ronald, Wu, Yang, Robinson, Matthew R., Lloyd-Jones, Luke R., Yengo, Loic, Yap, Chloe X., Xue, Angli, Sidorenko, Julia, Mcrae, Allan F., Powell, Joseph E., Montgomery, Grant W., Metspalu, Andres, Esko, Tonu, Gibson, Greg, Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2018). Signatures of negative selection in the genetic architecture of human complex traits. 48th Annual Meeting of the Behavior-Genetics-Association (BGA), Boston MA, United States, 20-23 June 2018. New York, NY United States: Springer New York.

Signatures of negative selection in the genetic architecture of human complex traits

2018

Conference Publication

Fine-mapping reveals complex genetic architecture underlying DNA methylation

Chundru, V. Kartik, Marioni, Riccardo E., Deary, Ian J., Wray, Naomi R., Visscher, Peter M. and McRae, Allan F. (2018). Fine-mapping reveals complex genetic architecture underlying DNA methylation. Human Genome Meeting, Yokohama, Japan, 12-15 March 2018. London, United Kingdom: Henry Stewart Publications. doi: 10.1186/s40246-018-0138-6

Fine-mapping reveals complex genetic architecture underlying DNA methylation

2018

Journal Article

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

Wang, Yunzhang, Karlsson, Robert, Lampa, Erik, Zhang, Qian, Hedman, Åsa K., Almgren, Malin, Almqvist, Catarina, McRae, Allan F., Marioni, Riccardo E., Ingelsson, Erik, Visscher, Peter M., Deary, Ian J., Lind, Lars, Morris, Tiffany, Beck, Stephan, Pedersen, Nancy L. and Hägg, Sara (2018). Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins. Epigenetics, 13 (9), 1-13. doi: 10.1080/15592294.2018.1526028

Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins

2018

Journal Article

Association of whole-genome and NETRIN1 signaling pathway–derived polygenic risk scores for major depressive disorder and white matter microstructure in the UK Biobank

Barbu, Miruna C., Zeng, Yanni, Shen, Xueyi, Cox, Simon R., Clarke, Toni-Kim, Gibson, Jude, Adams, Mark J., Johnstone, Mandy, Haley, Chris S., Lawrie, Stephen M., Deary, Ian J., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F.M., Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T.F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H.R., Bryois, Julien ... Whalley, Heather C. (2018). Association of whole-genome and NETRIN1 signaling pathway–derived polygenic risk scores for major depressive disorder and white matter microstructure in the UK Biobank. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 4 (1), 91-100. doi: 10.1016/j.bpsc.2018.07.006

Association of whole-genome and NETRIN1 signaling pathway–derived polygenic risk scores for major depressive disorder and white matter microstructure in the UK Biobank

2018

Conference Publication

Invited abstract: Leveraging big GWAS data to address question about selection, pleiotropy, assortative mating and epidemiology

Visscher, Peter M., Wray, Naomi R. and Yang, Jian (2018). Invited abstract: Leveraging big GWAS data to address question about selection, pleiotropy, assortative mating and epidemiology. 27th Annual Meeting of the International Genetic Epidemiology Society (IGES), San Diego, CA, United States, 14-16 October 2018. Hoboken, NJ, United States: John Wiley & Sons.

Invited abstract: Leveraging big GWAS data to address question about selection, pleiotropy, assortative mating and epidemiology

2017

Journal Article

Challenges in understanding common disease

Visscher, Peter M (2017). Challenges in understanding common disease. Genome medicine, 9 (1) 112, 1-4. doi: 10.1186/s13073-017-0506-1

Challenges in understanding common disease

2017

Journal Article

Gene networks associated with non-syndromic intellectual disability

Lee, Soohyun, Rudd, Stephen, Gratten, Jacob, Visscher, Peter M., Prins, Johannes B. and Dawson, Paul A. (2017). Gene networks associated with non-syndromic intellectual disability. Journal of Neurogenetics, 32 (1), 6-14. doi: 10.1080/01677063.2017.1404058

Gene networks associated with non-syndromic intellectual disability

2017

Journal Article

Testing two evolutionary theories of human aging with DNA methylation data

Robins, Chloe, McRae, Allan F., Powell, Joseph E., Wiener, Howard W., Aslibekyan, Stella, Kennedy, Elizabeth M., Absher, Devin M., Arnett, Donna K., Montgomery, Grant W., Visscher, Peter M., Cutler, David J. and Conneely, Karen N. (2017). Testing two evolutionary theories of human aging with DNA methylation data. Genetics, 207 (4), 1547-1560. doi: 10.1534/genetics.117.300217

Testing two evolutionary theories of human aging with DNA methylation data

2017

Journal Article

A genome-wide association study suggests that <i>MAPK14</i> is associated with diabetic foot ulcers

Meng, W., Veluchamy, A., Hebert, H. L., Campbell, A., Colhoun, H. M. and Palmer, C. N. A. (2017). A genome-wide association study suggests that MAPK14 is associated with diabetic foot ulcers. British Journal of Dermatology, 177 (6), 1664-1670. doi: 10.1111/bjd.15787

A genome-wide association study suggests that <i>MAPK14</i> is associated with diabetic foot ulcers

2017

Journal Article

Rare variant analysis of human and rodent obesity genes in individuals with severe childhood obesity

Hendricks, Audrey E., Bochukova, Elena G., Marenne, Gaelle, Keogh, Julia M., Atanassova, Neli, Bounds, Rebecca, Wheeler, Eleanor, Mistry, Vanisha, Henning, Elana, Koerner, Antje, Muddyman, Dawn, McCarthy, Shane, Hinney, Anke, Hebebrand, Johannes, Scott, Robert A., Langenberg, Claudia, Wareham, Nick J., Surendran, Praveen, Howson, Joanna M., Butterworth, Adam S., Danesh, John, Nordestgaard, Borge G., Nielsen, Sune F., Afzal, Shoaib, Papadia, Sofia, Ashford, Sofie, Garg, Sumedha, Millhauser, Glenn L., Palomino, Rafael I. ... Yang, Jian (2017). Rare variant analysis of human and rodent obesity genes in individuals with severe childhood obesity. Scientific Reports, 7 (1) 4394, 4394.1-4394.14. doi: 10.1038/s41598-017-03054-8

Rare variant analysis of human and rodent obesity genes in individuals with severe childhood obesity

2017

Journal Article

Whole-exome sequencing in amyotrophic lateral sclerosis suggests NEK1 is a risk gene in Chinese

Gratten, Jacob, Zhao, Qiongyi, Benyamin, Beben, Garton, Fleur, He, Ji, Leo, Paul J., Mangelsdorf, Marie, Anderson, Lisa, Zhang, Zong-Hong, Chen, Lu, Chen, Xiang-Ding, Cremin, Katie, Deng, Hong-Weng, Edson, Janette, Han, Ying-Ying, Harris, Jessica, Henders, Anjali K., Jin, Zi-Bing, Li, Zhongshan, Lin, Yong, Liu, Xiaolu, Marshall, Mhairi, Mowry, Bryan J., Ran, Shu, Reutens, David C., Song, Sharon, Tan, Li-Jun, Tang, Lu, Wallace, Robyn H. ... Fan, Dongsheng (2017). Whole-exome sequencing in amyotrophic lateral sclerosis suggests NEK1 is a risk gene in Chinese. Genome Medicine, 9 (97) 97, 97. doi: 10.1186/s13073-017-0487-0

Whole-exome sequencing in amyotrophic lateral sclerosis suggests NEK1 is a risk gene in Chinese

2017

Journal Article

Prokaryotic diversity and biogeochemical characteristics of benthic microbial ecosystems at La Brava, a hypersaline lake at Salar de Atacama, Chile

Eugenia Farias, Maria, Cecilia Rasuk, Maria, Gallagher, Kimberley L., Contreras, Manuel, Kurth, Daniel, Beatriz Fernandez, Ana, Poire, Daniel, Novoa, Fernando and Visscher, Pieter T. (2017). Prokaryotic diversity and biogeochemical characteristics of benthic microbial ecosystems at La Brava, a hypersaline lake at Salar de Atacama, Chile. Plos One, 12 (11) e0186867, e0186867. doi: 10.1371/journal.pone.0186867

Prokaryotic diversity and biogeochemical characteristics of benthic microbial ecosystems at La Brava, a hypersaline lake at Salar de Atacama, Chile

2017

Conference Publication

GWAS of educational attainment: phase 3-main results

Okbay, Aysu, Wedow, Robbee, Kong, Edward, Turley, Patrick, Lee, James, Zacher, Meghan, Thom, Kevin, Anh Tuan Nguyen, , Maghzian, Omeed, Linner, Richard Karlsson, Robinson, Matthew, Visscher, Peter, Benjamin, Daniel and Cesarini, David (2017). GWAS of educational attainment: phase 3-main results. 47th Annual Meeting of the Behavior-Genetics-Association (BGA), Oslo Norway, Jun 28-Jul 01, 2017. NEW YORK: SPRINGER.

GWAS of educational attainment: phase 3-main results

2017

Journal Article

Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis

Benyamin, Beben, He, Ji, Zhao, Qiongyi, Gratten, Jacob, Garton, Fleur, Leo, Paul J., Liu, Zhijun, Mangelsdorf, Marie, Al-Chalabi, Ammar, Anderson, Lisa, Butler, Timothy J., Chen, Lu, Chen, Xiang-Ding, Cremin, Katie, Deng, Hong-Weng, Devine, Matthew, Edson, Janette, Fifita, Jennifer A., Furlong, Sarah, Han, Ying-Ying, Harris, Jessica, Henders, Anjali K., Jeffree, Rosalind L., Jin, Zi-Bing, Li, Zhongshan, Li, Ting, Li, Mengmeng, Lin, Yong, Liu, Xiaolu ... Fan, Dongsheng (2017). Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis. Nature Communications, 8 (1) 611, 611. doi: 10.1038/s41467-017-00471-1

Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis

2017

Journal Article

Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood

Lukowski, Samuel W., Lloyd-Jones, Luke R., Holloway, Alexander, Kirsten, Holger, Hemani, Gibran, Yang, Jian, Small, Kerrin, Zhao, Jing, Metspalu, Andres, Dermitzakis, Emmanouil T., Gibson, Greg, Spector, Timothy D., Thiery, Joachim, Scholz, Markus, Montgomery, Grant W., Esko, Tonu, Visscher, Peter M. and Powell, Joseph E. (2017). Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood. Nature Communications, 8 (483) 483, 483. doi: 10.1038/s41467-017-00473-z

Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood

2017

Journal Article

Concepts, estimation and interpretation of SNP-based heritability

Yang, Jian, Zeng, Jian, Goddard, Michael E., Wray, Naomi R. and Visscher, Peter M. (2017). Concepts, estimation and interpretation of SNP-based heritability. Nature Genetics, 49 (9), 1304-1310. doi: 10.1038/ng.3941

Concepts, estimation and interpretation of SNP-based heritability

2017

Journal Article

Performance of risk prediction for inflammatory bowel disease based on genotyping platform and genomic risk score method

Chen, Guo-Bo, Lee, Sang Hong, Montgomery, Grant W., Wray, Naomi R., Visscher, Peter M., Gearry, Richard B., Lawrance, Ian C., Andrews, Jane M., Bampton, Peter, Mahy, Gillian, Bell, Sally, Walsh, Alissa, Connor, Susan, Sparrow, Miles, Bowdler, Lisa M., Simms, Lisa A., Krishnaprasad, Krupa, Radford-Smith, Graham L. and Moser, Gerhard (2017). Performance of risk prediction for inflammatory bowel disease based on genotyping platform and genomic risk score method. BMC Medical Genetics, 18 (1) 94, 94. doi: 10.1186/s12881-017-0451-2

Performance of risk prediction for inflammatory bowel disease based on genotyping platform and genomic risk score method

Funding

Current funding

  • 2019 - 2025
    Causes and consequence of human trait variation
    ARC Australian Laureate Fellowships
    Open grant

Past funding

  • 2022 - 2025
    Genetic architecture and evolution of complex traits across populations
    ARC Discovery Projects
    Open grant
  • 2018 - 2024
    Estimating the genetic and environmental architecture of psychiatric disorders (NIH Grant administered by the University of Colorado)
    University of Colorado
    Open grant
  • 2017 - 2023
    Complex trait genomics
    NHMRC Program Grant
    Open grant
  • 2016 - 2019
    Genetic analysis of the relationship between parental age and risk of psychiatric disorders
    NHMRC Project Grant
    Open grant
  • 2016 - 2019
    Phenotypic profiling from DNA using genetic and epigenetic information
    ARC Discovery Projects
    Open grant
  • 2016 - 2018
    The genetics of ageing in human populations
    ARC Discovery Projects
    Open grant
  • 2015 - 2019
    Sporadic ALS Australian Systems Genomics Consortium (SALSA-SGC)
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2015 - 2020
    Analysis of Genome-Wide Data in the Health and Retirement Study (NIH grant administered by the University of Southern California)
    University of Southern California
    Open grant
  • 2015 - 2019
    1/2 A Large-Scale Schizophrenia Association Study in Sweden (NIH grant administered by the University of North Carolina at Chapel Hill)
    University of North Carolina
    Open grant
  • 2015 - 2017
    Increasing the power of GxE detection by using multi-locus genome-wide predictors (NIH grant administered by Harvard Medical School)
    Harvard Medical School
    Open grant
  • 2015 - 2019
    NHMRC Research Fellowship: Neurogenetics and Statistical Genomics
    NHMRC Research Fellowship
    Open grant
  • 2014
    Deciphering the genetic code of diseases
    National Computational Merit Allocation Scheme
    Open grant
  • 2014
    Trans-ethnic and trans-omic statistical analyses to identify new ALS risk variants
    Motor Neurone Disease Research Institute of Australia Inc
    Open grant
  • 2013 - 2018
    Estimating the Frequencies and Population Specificities of Risk Alleles (NIH grant administered by the University of Colorado)
    University of Colorado
    Open grant
  • 2013 - 2016
    CAGE: Consortium for the Architecture of Gene Expression
    NHMRC Project Grant
    Open grant
  • 2013 - 2015
    Estimation and partitioning of the still-missing heritability for complex disease
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Estimation of non-additive genetic variance for complex traits using genome-wide SNP and sequence data
    ARC Discovery Projects
    Open grant
  • 2013 - 2016
    Exploiting SNP data in epidemiology and genetics through multivariate analysis of complex traits
    NHMRC Project Grant
    Open grant
  • 2013 - 2015
    The genetic architecture and evolution of quantitative traits (ARC Discovery Project administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2012 - 2018
    Statistical and Quantitative Genetics (NIH Grant administered by the University of Washington)
    University of Washington (Seattle)
    Open grant
  • 2012 - 2017
    Statistical genetic analyses of social and economic outcomes
    Stockholm School of Economics
    Open grant
  • 2012 - 2017
    Belgian Medical Genomics Initiative (BeMGI)
    University of Liege
    Open grant
  • 2012
    Explaining the Dark Matter of Genome-wide Association Studies for Complex Disease
    NHMRC Project Grant
    Open grant
  • 2011 - 2014
    Better Methods for Individual Risk Prediction of Complex Traits in Human Populations
    NHMRC Project Grant
    Open grant
  • 2011 - 2014
    NHMRC Research Fellowship (SPRF)
    NHMRC Research Fellowship
    Open grant
  • 2011 - 2017
    Theoretical Population Genetics (NIH Subcontract administered by the University of Washington)
    University of Washington (Seattle)
    Open grant
  • 2010 - 2013
    Identifying eQTLs and endophenotyping known CNVs in a large Australian schizophrenia sample
    NHMRC Project Grant
    Open grant
  • 2010 - 2012
    Why is most of the genetic variance for complex traits undetected by large powerful screens of common variants? (ARC Discovery Project administered by The University of Melbourne)
    University of Melbourne
    Open grant
  • 2007 - 2009
    Maximising knowledge from dense SNP data using multi-locus analysis
    ARC Discovery Projects
    Open grant

Supervision

Availability

Professor Peter Visscher is:
Not available for supervision

Supervision history

Current supervision

  • Doctor Philosophy

    Statistical methods and application to analyses genome and trait data from large biobanks

    Principal Advisor

    Other advisors: Dr Kathryn Kemper, Professor Loic Yengo

  • Doctor Philosophy

    Genetic architecture and evolution of complex traits across populations in humans

    Associate Advisor

    Other advisors: Professor Naomi Wray, Dr Fleur Garton, Dr Jian Zeng

  • Doctor Philosophy

    Integrating GWAS and molecular QTL data to dissect genetic architecture and improve polygenic prediction

    Associate Advisor

    Other advisors: Dr Jian Zeng

Completed supervision

Media

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