Professor Rob Capon
Professor

Rob Capon

Email: 
Phone: 
+61 7 334 62372
Phone: 
+61 7 334 62979

Background

My research group specializes in the detection, isolation, identification and evaluation of biologically active small molecules from Nature (natural products). We acquire valuable knowledge on how and why natural products are made, and apply this knowledge to better understand living systems, and solve important scientific and societal challenges.

To achieve these goals we have established specialist capabilities that extend across;

Microbiology – the isolation, characterization and cultivation of bacterial and fungal strains.

Chemistry – the extraction and fractionation of natural extracts, the purification, chemical and spectroscopic characterization, and structure elucidation of natural products, and the use of synthetic and medicinal chemistry to explore bioactive scaffolds.

Biology – to evaluate extracts and natural products against an array of bioassays, leading to new human pharmaceuticals that target such indications as infectious and neurodegenerative diseases, cancer, pain and epilepsy, as well as new animal health products and new crop protection agents.

Availability

Professor Rob Capon is:
Not available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Bachelor (Honours) of Science (Advanced), University of Western Australia
  • Doctor of Philosophy, University of Western Australia

Research interests

  • Natural Products Chemistry and Biodiscovery

    I lead an internationally recognised and multidisciplinary research group specialising in the detection, isolation, identification and evaluation of biologically active natural products, with an emphasis on those from marine and microbial sources. The aim of this research is to acquire knowledge of the chemical and biological properties of new classes of natural product, to inspire innovative solutions to important scientific and societal challenges. These include new methods and molecular tools to probe and better understand living systems; new and improved treatments for infectious, inflammatory, and neurodegenerative diseases, cancer and pain; new agrochemicals to safeguard animal health; and new approaches to protect crops and the environment.

Research impacts

With over 35 years experience in biodiscovery science, my research has lead to the study of several thousand natural products, many rare or new to science, and many with valuable chemical and biological properties. Over the last decade my research group has made numerous discoveries across basic and applied natural products science, leading to multiple high impact publications and several patents. I am recognised internationally as an expert in organic, natural products, analytical, synthetic and medicinal chemistry, and chemical ecology, and have a reputation for entering into and delivering on strategic collaborations.

My research activities are currently organised around five thematic programs;

Marine Biodiscovery: Documenting, evaluating and exploiting the chemical and biological properties of natural products from Australian marine invertebrates and algae.

Microbial Biodiscovery: Documenting, evaluating and exploiting the chemical and biological properties of natural products from Australian marine and terrestrial, bacteria and fungi.

Chemical Ecology: Documenting, evaluating and exploiting natural chemical interactions between members of either the same, or different species – extending across and between microbes, plants and animals.

Pharmaceutical Biodiscovery: Applying knowledge of natural products to inspire the development of new pharmaceuticals, to treat indications such infectious and neurodegenerative diseases, cancer and pain.

Agrochemical Biodiscovery: Applying knowledge of natural products to inspire the development of agrochemicals, to enhance the health and productivity of livestock and crops.

Search Professor Rob Capon’s works on UQ eSpace

403 works between 1979 and 2025
All (403) Journal Article (370) Other Outputs (3) Conference Publication (23) Book Chapter (7)

121 - 140 of 403 works

2018

Journal Article

Cacolides: sesterterpene butenolides from a Southern Australian marine sponge, Cacospongia sp.

Khushi, Shamsunnahar, Nahar, Laizuman, Salim, Angela and Capon, Robert (2018). Cacolides: sesterterpene butenolides from a Southern Australian marine sponge, Cacospongia sp.. Marine Drugs, 16 (11) 456, 456. doi: 10.3390/md16110456

Cacolides: sesterterpene butenolides from a Southern Australian marine sponge, Cacospongia sp.

2018

Journal Article

Talaropeptides A-D: Structure and Biosynthesis of Extensively N-methylated Linear Peptides From an Australian Marine Tunicate-Derived Talaromyces sp

Dewapriya, Pradeep, Khalil, Zeinab G., Prasad, Pritesh, Salim, Angela A., Cruz-Morales, Pablo, Marcellin, Esteban and Capon, Robert J. (2018). Talaropeptides A-D: Structure and Biosynthesis of Extensively N-methylated Linear Peptides From an Australian Marine Tunicate-Derived Talaromyces sp. Frontiers in Chemistry, 6 394, 394. doi: 10.3389/fchem.2018.00394

Talaropeptides A-D: Structure and Biosynthesis of Extensively N-methylated Linear Peptides From an Australian Marine Tunicate-Derived Talaromyces sp

2018

Journal Article

Inter-Kingdom beach warfare: Microbial chemical communication activates natural chemical defences

Khalil, Zeinab G., Cruz-Morales, Pablo, Licona-Cassani, Cuauhtemoc, Marcellin, Esteban and Capon, Robert J. (2018). Inter-Kingdom beach warfare: Microbial chemical communication activates natural chemical defences. The ISME journal, 13 (1), 147-158. doi: 10.1038/s41396-018-0265-z

Inter-Kingdom beach warfare: Microbial chemical communication activates natural chemical defences

2018

Journal Article

The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research

McAlpine, James B., Chen, Shao-Nong, Kutateladze, Andrei, MacMillan, John B., Appendino, Giovanni, Barison, Andersson, Beniddir, Mehdi A., Biavatti, Maique W., Bluml, Stefan, Boufridi, Asmaa, Butler, Mark S., Capon, Robert J., Choi, Young H., Coppage, David, Crews, Phillip, Crimmins, Michael T., Csete, Marie, Dewapriya, Pradeep, Egan, Joseph M., Garson, Mary J., Genta-Jouve, Grégory, Gerwick, William H., Gross, Harald, Harper, Mary Kay, Hermanto, Precilia, Hook, James M., Hunter, Luke, Jeannerat, Damien, Ji, Nai-Yun ... Pauli, Guido F. (2018). The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports, 36 (1), 35-107. doi: 10.1039/c7np00064b

The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research

2018

Journal Article

An oxanthroquinone derivative that disrupts RAS plasma membrane localization inhibits cancer cell growth

Tan, Lingxiao, Cho, Kwang-Jin, Neupane, Pratik, Capon, Robert J. and Hancock, John F. (2018). An oxanthroquinone derivative that disrupts RAS plasma membrane localization inhibits cancer cell growth. Journal of Biological Chemistry, 293 (35), jbc.RA118.003907-13706. doi: 10.1074/jbc.RA118.003907

An oxanthroquinone derivative that disrupts RAS plasma membrane localization inhibits cancer cell growth

2018

Journal Article

Pursuing sesterterpene lactams in Australian Irciniidae sponges

Prasad, Pritesh, Zhang, Ailian, Salim, Angela A and Capon, Robert J (2018). Pursuing sesterterpene lactams in Australian Irciniidae sponges. Fitoterapia, 126, 83-89. doi: 10.1016/j.fitote.2017.09.003

Pursuing sesterterpene lactams in Australian Irciniidae sponges

2018

Journal Article

Trichodermides A-E: New peptaibols isolated from the Australian termite nest-derived fungus trichoderma virens CMB-TN16

Jiao, Wei-Hua, Khalil, Zeinab, Dewapriya, Pradeep, Salim, Angela A, Lin, Hou-Wen and Capon, Robert J (2018). Trichodermides A-E: New peptaibols isolated from the Australian termite nest-derived fungus trichoderma virens CMB-TN16. Journal of Natural Products, 81 (4), 976-984. doi: 10.1021/acs.jnatprod.7b01072

Trichodermides A-E: New peptaibols isolated from the Australian termite nest-derived fungus trichoderma virens CMB-TN16

2018

Journal Article

Prolinimines: N-Amino-l-Pro-methyl Ester (Hydrazine) Schiff Bases from a Fish Gastrointestinal Tract-Derived Fungus, Trichoderma sp. CMB-F563

Mohamed, Osama G, Khalil, Zeinab G and Capon, Robert J (2018). Prolinimines: N-Amino-l-Pro-methyl Ester (Hydrazine) Schiff Bases from a Fish Gastrointestinal Tract-Derived Fungus, Trichoderma sp. CMB-F563. Organic letters, 20 (2), 377-380. doi: 10.1021/acs.orglett.7b03666

Prolinimines: N-Amino-l-Pro-methyl Ester (Hydrazine) Schiff Bases from a Fish Gastrointestinal Tract-Derived Fungus, Trichoderma sp. CMB-F563

2018

Conference Publication

Talaropeptides A–D: Structure and biosynthesis of extensively N-methylated linear peptides from an Australian marine tunicate-derived Talaromyces sp.

Dewapriya, Pradeep, Khalil, Zeinab G., Prasad, Pritesh, Salim, Angela A., Morales, Pablo C., Marcellin, Esteban and Capon, Robert J. (2018). Talaropeptides A–D: Structure and biosynthesis of extensively N-methylated linear peptides from an Australian marine tunicate-derived Talaromyces sp.. American Society of Pharmacognosy Annual Meeting ASP 2018, Lexington, KY United States, 21-25 July 2018.

Talaropeptides A–D: Structure and biosynthesis of extensively N-methylated linear peptides from an Australian marine tunicate-derived Talaromyces sp.

2018

Journal Article

Polyglutamic acid-trimethyl chitosan-based intranasal peptide nano-vaccine induces potent immune responses against group A streptococcus

Nevagi, Reshma J., Khalil, Zeinab G., Hussein, Waleed M., Powell, Jessica, Batzloff, Michael R., Capon, Robert J., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2018). Polyglutamic acid-trimethyl chitosan-based intranasal peptide nano-vaccine induces potent immune responses against group A streptococcus. Acta Biomaterialia, 80, 278-287. doi: 10.1016/j.actbio.2018.09.037

Polyglutamic acid-trimethyl chitosan-based intranasal peptide nano-vaccine induces potent immune responses against group A streptococcus

2018

Conference Publication

Predicting blood-brain barrier permeability of marine-derived kinase inhibitors

Plisson, Fabien, Piggott, Andrew, Hamilton, Nicholas and Capon, Robert (2018). Predicting blood-brain barrier permeability of marine-derived kinase inhibitors. 256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond, Boston, MA, United States, 19-23 August 2018. Washington, DC, United States: American Chemical Society (ASC).

Predicting blood-brain barrier permeability of marine-derived kinase inhibitors

2017

Other Outputs

Inhibitors of SOX 18 protein activity for treating angiogenesis- and/or lymphangiogenesis

Francois, Mathias, Zuegg, Johannes, Overman, Jeroen, Mamidyala, Sreeman Kumar, Salim, Angela Aguslyarti, Fontaine, Frank Roger, Cooper, Matthew Allister, Capon, Robert John and Robertson, Avril Alexis Barbara (2017). Inhibitors of SOX 18 protein activity for treating angiogenesis- and/or lymphangiogenesis. WO2018112545.

Inhibitors of SOX 18 protein activity for treating angiogenesis- and/or lymphangiogenesis

2017

Journal Article

Chemical Diversity from a Chinese Marine Red Alga, Symphyocladia latiuscula

Xu, Xiuli, Yang, Haijin, Khalil, Zeinab G, Yin, Liyuan, Xiao, Xue, Neupane, Pratik, Bernhardt, Paul V, Salim, Angela A, Song, Fuhang and Capon, Robert J (2017). Chemical Diversity from a Chinese Marine Red Alga, Symphyocladia latiuscula. Marine drugs, 15 (12) 374, 1-10. doi: 10.3390/md15120374

Chemical Diversity from a Chinese Marine Red Alga, Symphyocladia latiuscula

2017

Journal Article

Diverse cone-snail species harbor closely related streptomyces species with conserved chemical and genetic profiles, including polycyclic tetramic acid macrolactams

Quezada, Michelle, Licona-Cassani, Cuauhtemoc, Cruz-Morales, Pablo, Salim, Angela A., Marcellin, Esteban, Capon, Robert J. and Barona-Gomez, Francisco (2017). Diverse cone-snail species harbor closely related streptomyces species with conserved chemical and genetic profiles, including polycyclic tetramic acid macrolactams. Frontiers in Microbiology, 8 (NOV) 2305, 2305. doi: 10.3389/fmicb.2017.02305

Diverse cone-snail species harbor closely related streptomyces species with conserved chemical and genetic profiles, including polycyclic tetramic acid macrolactams

2017

Journal Article

Amycolatopsins A-C: antimycobacterial glycosylated polyketide macrolides from the Australian soil Amycolatopsis sp. MST-108494

Khalil, Zeinab G., Salim, Angela A., Vuong, Daniel, Crombie, Andrew, Lacey, Ernest, Blumenthal, Antje and Capon, Robert J. (2017). Amycolatopsins A-C: antimycobacterial glycosylated polyketide macrolides from the Australian soil Amycolatopsis sp. MST-108494. The Journal of Antibiotics, 70 (12), 1097-1103. doi: 10.1038/ja.2017.119

Amycolatopsins A-C: antimycobacterial glycosylated polyketide macrolides from the Australian soil Amycolatopsis sp. MST-108494

2017

Journal Article

Cytochalasins from an Australian Marine Sediment-Derived Phomopsis sp. (CMB-M0042F): Acid-Mediated Intramolecular Cycloadditions Enhance Chemical Diversity

Shang, Zhuo, Raju, Ritesh, Salim, Angela A., Khalil, Zeinab G. and Capon, Robert J. (2017). Cytochalasins from an Australian Marine Sediment-Derived Phomopsis sp. (CMB-M0042F): Acid-Mediated Intramolecular Cycloadditions Enhance Chemical Diversity. Journal of Organic Chemistry, 82 (18), 9704-9709. doi: 10.1021/acs.joc.7b01793

Cytochalasins from an Australian Marine Sediment-Derived Phomopsis sp. (CMB-M0042F): Acid-Mediated Intramolecular Cycloadditions Enhance Chemical Diversity

2017

Journal Article

Does Osmotic Stress Affect Natural Product Expression in Fungi?

Overy, David, Correa, Hebelin, Roullier, Catherine, Chi, Wei-Chiung, Pang, Ka-Lai, Rateb, Mostafa, Ebel, Rainer, Shang, Zhuo, Capon, Rob, Bills, Gerald and Kerr, Russell (2017). Does Osmotic Stress Affect Natural Product Expression in Fungi?. Marine Drugs, 15 (8) 254, 254. doi: 10.3390/md15080254

Does Osmotic Stress Affect Natural Product Expression in Fungi?

2017

Journal Article

Microbiome-mediated biotransformation of cane toad bufagenins

Kamalakkannan, Venkatanambi, Salim, Angela A. and Capon, Robert J. (2017). Microbiome-mediated biotransformation of cane toad bufagenins. Journal of Natural Products, 80 (7), 2012-2017. doi: 10.1021/acs.jnatprod.7b00134

Microbiome-mediated biotransformation of cane toad bufagenins

2017

Journal Article

Cytotoxic spiroepoxide lactone and its putative biosynthetic precursor from Goniobranchus Splendidus

Forster, Louise C., Pierens, Gregory K., White, Andrew M., Cheney, Karen L., Dewapriya, Pradeep, Capon, Robert J. and Garson, Mary J. (2017). Cytotoxic spiroepoxide lactone and its putative biosynthetic precursor from Goniobranchus Splendidus. ACS Omega, 2 (6), 2672-2677. doi: 10.1021/acsomega.7b00641

Cytotoxic spiroepoxide lactone and its putative biosynthetic precursor from Goniobranchus Splendidus

2017

Journal Article

Chaunopyran A: co-cultivation of marine mollusk-derived fungi activates a rare class of 2-alkenyl-tetrahydropyran

Shang, Zhuo, Salim, Angela A. and Capon, Robert J. (2017). Chaunopyran A: co-cultivation of marine mollusk-derived fungi activates a rare class of 2-alkenyl-tetrahydropyran. Journal of Natural Products, 80 (4), 1167-1172. doi: 10.1021/acs.jnatprod.7b00144

Chaunopyran A: co-cultivation of marine mollusk-derived fungi activates a rare class of 2-alkenyl-tetrahydropyran

Current funding

  • 2025 - 2028
    Novel antibacterials from nature targeting the bacterial cell envelope
    NHMRC IDEAS Grants
    Open grant
  • 2024 - 2029
    Professor Capon's Soils for Science Research
    Research Donation Generic
    Open grant
  • 2024 - 2026
    Gut Health anti-inflammatory potential of Yumbah abalone and mussels
    Marine Bioproducts Cooperative Research Centre
    Open grant
  • 2024 - 2027
    Harnessing microbial immunomodulatory function to improve treatment of inflammatory bowel diseases
    NHMRC IDEAS Grants
    Open grant
  • 2022 - 2026
    Australian marine microbes as a source of next generation antiparasitics
    Marine Bioproducts Cooperative Research Centre
    Open grant

Past funding

  • 2023 - 2024
    Decision tree for developing anti-inflammatory marine bioproducts
    Marine Bioproducts Cooperative Research Centre
    Open grant
  • 2023 - 2025
    Enhancing Australian biodiscovery molecule generation, storage and access (ARC LIEF administered by Griffith University)
    Griffith University
    Open grant
  • 2022 - 2025
    Australian Marine Bioproducts Program Leadership Services
    Marine Bioproducts Cooperative Research Centre
    Open grant
  • 2021 - 2023
    Advanced Nuclear Magnetic Resonance Technologies for Southeast Queensland
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2021 - 2025
    Drugs from Bugs: Developing New Inflammatory Bowel Disease Drugs from Gut Bacteria-Derived Bioactives
    United States Congressionally Directed Medical Research Programs - Peer Reviewed Medical Research Program
    Open grant
  • 2021 - 2025
    New antiparasitics to protect Australian livestock
    ARC Linkage Projects
    Open grant
  • 2020 - 2021
    Functionally characterizing IBD dysbiosis and harnessing gut bioactives to suppress IL-23 driven inflammation
    The Global Grants for Gut Health
    Open grant
  • 2020
    Behavioural evidence of pheromone use by an elasmobranch
    Sea World Research and Rescue Foundation Inc
    Open grant
  • 2019 - 2022
    Cane Toad Challenge
    Queensland Citizen Science Grants
    Open grant
  • 2019
    Chemical Purification Network
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2023
    Preclinical Validation of a Novel Drug Lead to Treat Tuberculosis
    United States Congressionally Directed Medical Research Programs - Peer Reviewed Medical Research Program
    Open grant
  • 2017 - 2018
    Cane Toad Challenge: Logan City
    Queensland National Parks & Wildlife Service
    Open grant
  • 2017 - 2018
    Cane Toad Challenge: Logan City
    Logan City Council
    Open grant
  • 2016 - 2021
    Nematode-induced microbial anthelmintics
    UniQuest Pty Ltd
    Open grant
  • 2016 - 2019
    Developing new antibiotics to treat tuberculosis
    Australian Tropical Medicine Commercialisation Programme
    Open grant
  • 2016
    4D Mass Spectrometer
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Integrative blood coagulation research core facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Patch-clamp electrophysiology platform for drug and insecticide discovery
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2016
    Chemical investigations aimed at identifying the queen bee attractant pheromone (RIRDC project administered by University of Sydney)
    University of Sydney
    Open grant
  • 2015
    Aquaculture: Anti-Infective Agents from the Sea
    UQ Collaboration and Industry Engagement Fund - Seed Research Grant
    Open grant
  • 2014 - 2017
    Antiparastic Agents to Safeguard Australian Livestock
    ARC Linkage Projects
    Open grant
  • 2014 - 2016
    A novel mechanism for therapeutically modulating neurotransmitter-activated ion channels
    NHMRC Project Grant
    Open grant
  • 2014
    Continuous-Flow Hydrogenation Reactor (H-Cube Pro)
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013 - 2018
    Discovery of the Systemic Regulator of Legume Nodulation
    ARC Discovery Projects
    Open grant
  • 2013
    High throughput electrophysiology platform
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2015
    Growing a Sustainable New Molecular Resource
    ARC Linkage Projects
    Open grant
  • 2012 - 2014
    Natural product modulators of the ubiquitin-pathway
    UQ Collaboration and Industry Engagement Fund
    Open grant
  • 2012 - 2014
    Chemi-biology computational platform for lead discovery in infectious disease
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2012 - 2014
    New Antibiotics: Engaging Microbial Chemical Diversity
    ARC Discovery Projects
    Open grant
  • 2011 - 2012
    K-Ras Inhibitors as a New Strategy to Combat Cancer
    University of Texas Health Science Center at Houston
    Open grant
  • 2011 - 2013
    Developing inhibitors of an essential histidine kinase in Staphylococcus aureus
    NHMRC Project Grant
    Open grant
  • 2011
    Freedom Evo 150 robotic worktable: Automated high throughput and long-time course spectrophotometric multiwell plate assay system
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2011
    Advanced molecular discovery and characterisation facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2010
    Automated liquid handling platform
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2013
    Developing novel selective glycine receptor potentiators as a means to control pain.
    NHMRC Project Grant
    Open grant
  • 2009 - 2012
    Towards Next Generation Anthelmintics
    ARC Linkage Projects
    Open grant
  • 2009
    Biotek Synergy 4 multimode microplate reader
    UQ Major Equipment and Infrastructure
    Open grant
  • 2008
    Biodiscovery@UQ-Chemical Analysis Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2007 - 2010
    Australian marine biodiversity as a source of new drugs to control neurodegenerative disease
    ARC Linkage Projects
    Open grant
  • 2006
    A new non-toxic approach to controlling bacterial infection
    Community Health and Tuberculosis Australia
    Open grant
  • 2006
    Biomolecular discovery and analysis facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2006 - 2008
    Novel Sodium Ion Channel Modulators From Australian Cephalopods
    ARC Discovery Projects
    Open grant
  • 2005 - 2006
    ESEG_Australian Microbial Biodiscovery: Exploration of Bioactive Chemical Space
    UQ External Support Enabling Grant
    Open grant
  • 2005
    NHMRC_Equipment Grant = Cellular imaging system for high throughput screening of ion channels
    NHMRC Equipment Grant
    Open grant
  • 2005
    NHMRC_Equipment Grant = High Throughput Screening
    NHMRC Equipment Grant
    Open grant
  • 2005
    Novel Marine-Derived Drug Leads for the Glycine and GABA a ion Channel Receptors
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2004 - 2007
    Anti cancer Agents from Australian Marine Biodiversity
    ARC Linkage Projects
    Open grant
  • 2004
    Australian Microbial Resources Research Network
    ARC Seed Funding for Research Networks
    Open grant
  • 2004
    Combating Head Lice With Marine Derived Anti-Parasitics
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2003
    New antibiotics from Australian microbes: Combating multiple drug resistance
    ARC Collaborative Grant (SPIRT)
    Open grant
  • 2003
    Marine metabolites as non toxic inhibitors of cell adhesion: Avoiding collateral damage in the war against disease
    ARC Australian Research Council (Large grants)
    Open grant

Availability

Professor Rob Capon is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Professor Rob Capon directly for media enquiries about:

  • Cane toad control
  • Chemical ecology
  • Drug discovery
  • Marine biodiscovery
  • Microbial biodiscovery
  • Natural products chemistry

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au