Overview
Background
Jianying Han (PhD) is an Early Career Research Fellow and Natural Product Chemist at the Institute for Molecular Bioscience, specialising in the discovery of structurally novel and biologically active small molecules from unique microbial resources. His research focuses on unlocking the chemical diversity of underexplored microorganisms, particularly rare Actinobacteria and other environmentally derived microbes. Dr Han integrates microbial cultivation strategies, genome-guided discovery, and advanced chemical analysis to activate silent biosynthetic pathways and reveal new classes of natural products. His work employs innovative approaches including high-throughput cultivation matrices, co-cultivation, precursor-directed biosynthesis, and microbial biotransformation to expand the chemical space accessible from microbial metabolites. Through these strategies, He aims to identify new bioactive compounds with potential applications in agriculture, biotechnology, and pharmaceutical discovery, while contributing to the development of Australia’s microbial resources and bioeconomy.
Availability
- Dr Jianying Han is:
- Available for supervision
Qualifications
- Doctor of Philosophy, Griffith University
Works
Search Professor Jianying Han’s works on UQ eSpace
2026
Journal Article
Goondicones I–K and Cratermycins A–D: Cultivation Profiling Enabled the Search for New Anthelmintics from an Australian Pasture Soil-Derived Actinomadura sp
Han, Jianying, Bernhardt, Paul V., Bruhn, David F., Burkman, Erica, Roberts, Dana C., Moreno, Yovany, Salim, Angela A., Wu, Taizong and Capon, Robert J. (2026). Goondicones I–K and Cratermycins A–D: Cultivation Profiling Enabled the Search for New Anthelmintics from an Australian Pasture Soil-Derived Actinomadura sp. Journal of Agricultural and Food Chemistry, 74 (11), 9403-9413. doi: 10.1021/acs.jafc.5c17192
Featured
2026
Journal Article
Goondastatins and Goondazines: Triamide-Hydroxamate and Piperazine Anthelmintics from Australian Pasture Soil-Derived Actinomadura and Streptomyces spp
Han, Jianying, Bruhn, David F., Burkman, Erica, Roberts, Dana C., Gong, Kaikai, Moreno, Yovany, Salim, Angela A., Sritharan, Thulasi and Capon, Robert J. (2026). Goondastatins and Goondazines: Triamide-Hydroxamate and Piperazine Anthelmintics from Australian Pasture Soil-Derived Actinomadura and Streptomyces spp. Journal of Natural Products, 89 (3), 1071-1080. doi: 10.1021/acs.jnatprod.6c00120
2024
Journal Article
Goondicones A–H: Spiro-isoindolinone heartworm anthelmintics from an Australian pasture-soil-derived Streptomyces sp.
Han, Jianying, Bruhn, David F., Childs, Cynthia T., Moreno, Yovany, Salim, Angela A., Wu, Taizong and Capon, Robert J. (2024). Goondicones A–H: Spiro-isoindolinone heartworm anthelmintics from an Australian pasture-soil-derived Streptomyces sp.. Antibiotics, 13 (12) 1222, 1222. doi: 10.3390/antibiotics13121222
Featured
2024
Journal Article
Goondomycins A–H: Carbocyclic ansa-Polyketides from an Australian pasture Streptomyces with selective activity against Dirofilaria immitis
Han, Jianying, Bruhn, David F., Roberts, Dana C., Burkman, Erica, Moreno, Yovany, Salim, Angela A. and Capon, Robert J. (2024). Goondomycins A–H: Carbocyclic ansa-Polyketides from an Australian pasture Streptomyces with selective activity against Dirofilaria immitis. Journal of Natural Products, 87 (12), 2810-2821. doi: 10.1021/acs.jnatprod.4c00987
2024
Journal Article
Goondolinones A and B: Terpenyl-quinolin-4(1H)-ones from an Australian volcanic crater soil-derived Actinomadura sp., with selective activity against Dirofilaria immitis (Heartworm)
Han, Jianying, Bruhn, David F, Roberts, Dana C., Burkman, Erica J., Moreno, Yovany, Bernhardt, Paul V., Salim, Angela A. and Capon, Robert J. (2024). Goondolinones A and B: Terpenyl-quinolin-4(1H)-ones from an Australian volcanic crater soil-derived Actinomadura sp., with selective activity against Dirofilaria immitis (Heartworm). Journal of Natural Products, 87 (12), 2855-2862. doi: 10.1021/acs.jnatprod.4c01146
Featured
2024
Journal Article
Goondansamycins A–H: Benzenoid Ansamycins from an Australian volcanic crater soil-derived Actinomadura sp. S4S-00069B08
Han, Jianying, Bernhardt, Paul V. and Capon, Robert J. (2024). Goondansamycins A–H: Benzenoid Ansamycins from an Australian volcanic crater soil-derived Actinomadura sp. S4S-00069B08. Journal of Natural Products, 87 (5), 1471-1478. doi: 10.1021/acs.jnatprod.4c00336
Featured
2022
Journal Article
Anti-mycobacterial natural products and mechanisms of action
Han, Jianying, Liu, Xueting, Zhang, Lixin, Quinn, Ronald J. and Feng, Yunjiang (2022). Anti-mycobacterial natural products and mechanisms of action. Natural Product Reports, 39 (1), 77-89. doi: 10.1039/d1np00011j
Featured
2020
Journal Article
Genome-inspired chemical exploration of marine fungus aspergillus fumigatus MF071
Han, Jianying, Liu, Miaomiao, Jenkins, Ian D., Liu, Xueting, Zhang, Lixin, Quinn, Ronald J. and Feng, Yunjiang (2020). Genome-inspired chemical exploration of marine fungus aspergillus fumigatus MF071. Marine Drugs, 18 (7) md18070353, 352. doi: 10.3390/md18070352
2026
Journal Article
Goondoxazoles A–C: anthelmintic spiroketal polyketide alkaloids and other benzoxazoles from Australian pasture soil-derived Streptomyces spp.
Jin, Shengbin, Bruhn, David F., Burkman, Erica J., Childs, Cynthia T., Han, Jianying, Khalil, Zeinab G., Moreno, Yovany, Salim, Angela A., Samarasekera, Kaumadi, Tangerina, Marcelo M. P. and Capon, Robert J. (2026). Goondoxazoles A–C: anthelmintic spiroketal polyketide alkaloids and other benzoxazoles from Australian pasture soil-derived Streptomyces spp.. Antibiotics, 15 (3) 302, 302-3. doi: 10.3390/antibiotics15030302
2025
Journal Article
New sesquiterpenoids with anti-inflammatory effects from phytopathogenic fungus Bipolaris sorokiniana 11134
Yin, Qiang, Han, Jianying, Yang, Guixiang, Song, Zhijun, Zou, Keke, Lv, Kangjie, Lin, Zexu, Ma, Lei, Liu, Miaomiao, Feng, Yunjiang, Quinn, Ronald J., Hsiang, Tom, Zhang, Lixin, Liu, Xueting, Zhu, Guoliang and Zhang, Jingyu (2025). New sesquiterpenoids with anti-inflammatory effects from phytopathogenic fungus Bipolaris sorokiniana 11134. Natural Products and Bioprospecting, 15 (1) 29, 1-13. doi: 10.1007/s13659-025-00508-9
2025
Conference Publication
Goondomycins A–H: carbocyclic ansa-polyketides from an Australian pasture Streptomyces with selective activity against Dirofilaria immitis
Han, Jianying (2025). Goondomycins A–H: carbocyclic ansa-polyketides from an Australian pasture Streptomyces with selective activity against Dirofilaria immitis. 32nd International Symposium on the Chemistry of Natural Products and 12th International Congress on Biodiversity (ISCNP32 & ICOB12), Sydney, NSW, Australia, 24 - 28 August 2025.
2025
Journal Article
Discovery of lithospermate B as a potential ligand for the malarial E2 ubiquitin-conjugating enzyme via multiplexed native mass spectrometry
Han, Jianying, Van Voorhis, Wesley C., Quinn, Ronald J. and Liu, Miaomiao (2025). Discovery of lithospermate B as a potential ligand for the malarial E2 ubiquitin-conjugating enzyme via multiplexed native mass spectrometry. Chemosensors, 13 (5) 166, 1-13. doi: 10.3390/chemosensors13050166
2025
Journal Article
Nuclear magnetic resonance fingerprinting and principal component analysis strategies lead to anti-tuberculosis natural product discovery from actinomycetes
Han, Jianying, Liu, Xueting, Zhang, Lixin, Quinn, Ronald J. and Liu, Miaomiao (2025). Nuclear magnetic resonance fingerprinting and principal component analysis strategies lead to anti-tuberculosis natural product discovery from actinomycetes. Antibiotics, 14 (1) 108, 1-26. doi: 10.3390/antibiotics14010108
2024
Conference Publication
Goondomycins and goondolinones: carbocyclic ansa-polyketides and terpenyl-quinolin-4(1H)-ones with selective activity against Dirofilaria immitis (heartworm)
Han, Jianying (2024). Goondomycins and goondolinones: carbocyclic ansa-polyketides and terpenyl-quinolin-4(1H)-ones with selective activity against Dirofilaria immitis (heartworm). 3rd Aus-NZ Natural Products Chemistry & Biology Symposium / RACI NSW Natural Products Symposium, Sydney, NSW Australia, 11-12 November 2024.
2024
Conference Publication
Goondomycins A–H: carbocyclic ansa-polyketides from an Australian pasture Streptomyces with selective activity against Dirofilaria immitis (heartworm)
Han, Jianying, Bruhn, David F., Roberts, Dana C., Burkman, Erica, Moreno, Yovany and Capon, Robert J. (2024). Goondomycins A–H: carbocyclic ansa-polyketides from an Australian pasture Streptomyces with selective activity against Dirofilaria immitis (heartworm). IMB Centre for Chemistry and Drug Discovery Symposium, St Lucia, QLD Australia, 7 November 2024.
2024
Journal Article
Rapid discovery of antimicrobial and antimalarial agents from natural product fragments
Han, Jianying, Liu, Xueting, Zhang, Lixin, Van Voorhis, Wesley C., Quinn, Ronald J. and Liu, Miaomiao (2024). Rapid discovery of antimicrobial and antimalarial agents from natural product fragments. Separations, 11 (7) 194, 194. doi: 10.3390/separations11070194
2024
Conference Publication
Genome- and MS-inspired microbial natural product discovery
Han, Jianying (2024). Genome- and MS-inspired microbial natural product discovery. Binzhou Medical University 2024 "Brain Pub" Graduate Academic Research Forum, Online, 23 March 2024.
2023
Conference Publication
The search for anthelmintics from Australian soil microbes based on integrated bioassay, MATRIX and GNPS molecular networking approach
Han, Jianying, Jin, Shengbin, Sritharan, Thulasi, Salim, Angela A., Khalil, Zeinab G. and Capon, Robert J. (2023). The search for anthelmintics from Australian soil microbes based on integrated bioassay, MATRIX and GNPS molecular networking approach. IMB Centre for Chemistry and Drug Discovery Symposium, Brisbane, QLD Australia, 2 November 2023.
2022
Conference Publication
Genome-inspired chemical investigation of phytopathogenic fungus Bipolaris sorokiniana strain 11134
Han, Jianying (2022). Genome-inspired chemical investigation of phytopathogenic fungus Bipolaris sorokiniana strain 11134. IMB Seminar Series: Chemistry and Structural Biology, Brisbane, QLD, Australia, 25 August 2022.
2021
Journal Article
Genome-guided investigation of anti-inflammatory sesterterpenoids with 5-15 trans-fused ring system from phytopathogenic fungi
Jiang, Lan, Zhu, Guoliang, Han, Jianying, Hou, Chengjian, Zhang, Xue, Wang, Zhixin, Yuan, Weize, Lv, Kangjie, Cong, Zhanren, Wang, Xinye, Chen, Xiangyin, Karthik, Loganathan, Yang, Huanting, Wang, Xuyuan, Tan, Gaoyi, Liu, Guang, Zhao, Liya, Xia, Xuekui, Liu, Xiangyang, Gao, Shushan, Ma, Lei, Liu, Mei, Ren, Biao, Dai, Huanqin, Quinn, Ronald J., Hsiang, Tom, Zhang, Jingyu, Zhang, Lixin and Liu, Xueting (2021). Genome-guided investigation of anti-inflammatory sesterterpenoids with 5-15 trans-fused ring system from phytopathogenic fungi. Applied Microbiology and Biotechnology, 105 (13), 5407-5417. doi: 10.1007/s00253-021-11192-3
Funding
Past funding
Supervision
Availability
- Dr Jianying Han is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
The discovery of new antibiotics to combat drug resistance
Associate Advisor
Other advisors: Dr Angela Salim, Professor Rob Capon
Media
Enquiries
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