Overview
Background
Jianying Han (PhD) is an Early Career Research Fellow and Natural Product Chemist at the Institute for Molecular Bioscience, specialising in the discovery of structurally novel and biologically active small molecules from unique microbial resources. His research focuses on unlocking the chemical diversity of underexplored microorganisms, particularly rare Actinobacteria and other environmentally derived microbes. Dr Han integrates microbial cultivation strategies, genome-guided discovery, and advanced chemical analysis to activate silent biosynthetic pathways and reveal new classes of natural products. His work employs innovative approaches including high-throughput cultivation matrices, co-cultivation, precursor-directed biosynthesis, and microbial biotransformation to expand the chemical space accessible from microbial metabolites. Through these strategies, He aims to identify new bioactive compounds with potential applications in agriculture, biotechnology, and pharmaceutical discovery, while contributing to the development of Australia’s microbial resources and bioeconomy.
Availability
- Dr Jianying Han is:
- Available for supervision
Qualifications
- Doctor of Philosophy, Griffith University
Works
Search Professor Jianying Han’s works on UQ eSpace
2021
Journal Article
Peculiarities of meroterpenoids and their bioproduction
Han, Jianying, Jiang, Lan, Zhang, Lixin, Quinn, Ronald J., Liu, Xueting and Feng, Yunjiang (2021). Peculiarities of meroterpenoids and their bioproduction. Applied Microbiology and Biotechnology, 105 (10), 3987-4003. doi: 10.1007/s00253-021-11312-z
2021
Journal Article
Antimicrobial benzyltetrahydroisoquinoline-derived alkaloids from the leaves of Doryphora aromatica
Liu, Miaomiao, Han, Jianying, Feng, Yunjiang, Guymer, Gordon, Forster, Paul and Quinn, Ronald J. (2021). Antimicrobial benzyltetrahydroisoquinoline-derived alkaloids from the leaves of Doryphora aromatica. Journal of Natural Products, 84 (3), 676-682. doi: 10.1021/acs.jnatprod.0c01093
2020
Journal Article
Chemical constituents from Macleaya cordata (Willd) R. Br. and their phenotypic functions against a Parkinson's disease patient-derived cell line
Nguyen, Duy Thanh, Iqbal, Jamila, Han, Jianying, Pierens, Gregory K., Wood, Stephen A., Mellick, George D. and Feng, Yunjiang (2020). Chemical constituents from Macleaya cordata (Willd) R. Br. and their phenotypic functions against a Parkinson's disease patient-derived cell line. Bioorganic and Medicinal Chemistry, 28 (21) 115732, 1-9. doi: 10.1016/j.bmc.2020.115732
2020
Journal Article
Discovery of a natural product that binds to the mycobacterium tuberculosis protein Rv1466 using native mass spectrometry
Elnaas, Ali R., Grice, Darren, Han, Jianying, Feng, Yunjiang, Capua, Angela Di, Mak, Tin, Laureanti, Joseph A., Buchko, Garry W., Myler, Peter J., Cook, Gregory, Quinn, Ronald J. and Liu, Miaomiao (2020). Discovery of a natural product that binds to the mycobacterium tuberculosis protein Rv1466 using native mass spectrometry. Molecules, 25 (10) 2384, 2384. doi: 10.3390/molecules25102384
2020
Journal Article
Genome-based mining of new antimicrobial meroterpenoids from the phytopathogenic fungus Bipolaris sorokiniana strain 11134
Han, Jianying, Zhang, Jingyu, Song, Zhijun, Zhu, Guoliang, Liu, Miaomiao, Dai, Huanqin, Hsiang, Tom, Liu, Xueting, Zhang, Lixin, Quinn, Ronald J and Feng, Yunjiang (2020). Genome-based mining of new antimicrobial meroterpenoids from the phytopathogenic fungus Bipolaris sorokiniana strain 11134. Applied Microbiology and Biotechnology, 104 (9), 3835-3846. doi: 10.1007/s00253-020-10522-1
2020
Conference Publication
Exploring the potential of endophytes and fungi as sources of antimicrobial compounds.
Han, Jianying (2020). Exploring the potential of endophytes and fungi as sources of antimicrobial compounds.. 5th Queensland Annual Chemistry Symposium, Brisbane, QLD, Australia, 27 November 2020.
2019
Journal Article
Brocaeloid D, a novel compound isolated from a wheat pathogenic fungus, Microdochium majus 99049
Zhang, Jingyu, Wang, Zhenzhen, Song, Zhijun, Karthik, Loganathan, Hou, Chengjian, Zhu, Guoliang, Jiang, Lan, Han, Jianying, Ma, Rong, Li, Li, Zhang, Lixin, Liu, Xueting and Hsiang, Tom (2019). Brocaeloid D, a novel compound isolated from a wheat pathogenic fungus, Microdochium majus 99049. Synthetic and Systems Biotechnology, 4 (4), 173-179. doi: 10.1016/j.synbio.2019.09.001
2019
Journal Article
Genome- and MS-based mining of antibacterial chlorinated chromones and xanthones from the phytopathogenic fungus Bipolaris sorokiniana strain 11134
Han, Jianying, Zhang, Jingyu, Song, Zhijun, Liu, Miaomiao, Hu, Jiansen, Hou, Chengjian, Zhu, Guoliang, Jiang, Lan, Xia, Xuekui, Quinn, Ronald J., Feng, Yunjiang, Zhang, Lixin, Hsiang, Tom and Liu, Xueting (2019). Genome- and MS-based mining of antibacterial chlorinated chromones and xanthones from the phytopathogenic fungus Bipolaris sorokiniana strain 11134. Applied Microbiology and Biotechnology, 103 (13), 5167-5181. doi: 10.1007/s00253-019-09821-z
2019
Conference Publication
Exploring the potential of endophytes and fungi as sources of anti-mycobacterial compounds
Han, Jianying, Quinn, Ronald and Feng, Yunjiang (2019). Exploring the potential of endophytes and fungi as sources of anti-mycobacterial compounds. Brisbane Life Science ECR Symposium (BLiSS), Brisbane, QLD, Australia, 7 June 2019.
2019
Conference Publication
Exploring the potential of endophytes and fungi as sources of antibacterial compounds
Han, Jianying (2019). Exploring the potential of endophytes and fungi as sources of antibacterial compounds. 6th GRIDD SIMM Annual Symposium, Brisbane, QLD, Australia, 11 October 2019.
2019
Conference Publication
Exploring the potential of endophytes and fungi as sources of anti-mycobacterial compounds
Han, Jianying, Liu, Xueting, Zhang, Lixin, Quinn, Ronald and Feng, Yunjiang (2019). Exploring the potential of endophytes and fungi as sources of anti-mycobacterial compounds. Gordon Research Conference, Castelldefels, Spain, 6-12 July 2019.
2019
Conference Publication
Exploring the potential of endophytes and fungi as sources of antibacterial compounds.
Han, Jianying (2019). Exploring the potential of endophytes and fungi as sources of antibacterial compounds.. 4th Queensland Annual Chemistry Symposium, Brisbane, QLD, Australia, 29 November 2019.
2018
Conference Publication
Exploring the potential of endophytes and fungi as sources of anti-mycobacterial compounds
Han, Jianying (2018). Exploring the potential of endophytes and fungi as sources of anti-mycobacterial compounds. 5th SIMM GRIDD symposium, Suzhou, China, 30-31 August 2028.
2018
Conference Publication
Exploring the potential of endophytes and fungi as sources of anti-mycobacterial compounds
Han, Jianying (2018). Exploring the potential of endophytes and fungi as sources of anti-mycobacterial compounds. 3rd Queensland Annual Chemistry Symposium, Brisbane, QLD, Australia, 23 November 2018.
2018
Conference Publication
Exploring the potential of endophytes and fungi as sources of anti-mycobacterial compounds
Han, Jianying, Quinn, Ronald and Feng, Yunjiang (2018). Exploring the potential of endophytes and fungi as sources of anti-mycobacterial compounds. Griffith Cross-Institute Infectious Diseases Symposium, Brisbane, QLD, Australia, 16 November 2028.
2017
Journal Article
A systems approach using OSMAC, Log P and NMR fingerprinting: an approach to novelty
Liu, Miaomiao, Grkovic, Tanja, Liu, Xueting, Han, Jianying, Zhang, Lixin and Quinn, Ronald J. (2017). A systems approach using OSMAC, Log P and NMR fingerprinting: an approach to novelty. Synthetic and Systems Biotechnology, 2 (4), 276-286. doi: 10.1016/j.synbio.2017.10.001
2016
Journal Article
Fungal biotransformation of tanshinone results in [4+2] cycloaddition with sorbicillinol: evidence for enzyme catalysis and increased antibacterial activity
He, Wenni, Liu, Miaomiao, Li, Xiaolin, Zhang, Xiaoping, Abdel-Mageed, Wael M., Li, Li, Wang, Wenzhao, Zhang, Jingyu, Han, Jianying, Dai, Huanqin, Quinn, Ronald J., Liu, Hung-wen, Luo, Houwei, Zhang, Lixin and Liu, Xueting (2016). Fungal biotransformation of tanshinone results in [4+2] cycloaddition with sorbicillinol: evidence for enzyme catalysis and increased antibacterial activity. Applied Microbiology and Biotechnology, 100 (19), 8349-8357. doi: 10.1007/s00253-016-7488-6
2016
Journal Article
Anti-MRSA and anti-TB metabolites from marine-derived Verrucosispora sp MS100047
Huang, Pei, Xie, Feng, Ren, Biao, Wang, Qian, Wang, Jian, Wang, Qi, Abdel-Mageed, Wael M., Liu, Miaomiao, Han, Jianying, Oyeleye, Ayokunmi, Shen, Jinzhao, Song, Fuhang, Dai, Huanqin, Liu, Xueting and Zhang, Lixin (2016). Anti-MRSA and anti-TB metabolites from marine-derived Verrucosispora sp MS100047. Applied Microbiology and Biotechnology, 100 (17), 7437-7447. doi: 10.1007/s00253-016-7406-y
2016
Journal Article
Discovery of tanshinone derivatives with anti-MRSA activity via targeted bio-transformation
He, Wenni, Liu, Miaomiao, Huang, Pei, Abdel-Mageed, Wael M., Han, Jianying, Watrous, Jeramie D., Nguyen, Don D., Wang, Wenzhao, Song, Fuhang, Dai, Huanqin, Zhang, Jingyu, Quinn, Ronald J., Grkovi, Tanja, Luo, Houwei, Zhang, Lixin and Liu, Xueting (2016). Discovery of tanshinone derivatives with anti-MRSA activity via targeted bio-transformation. Synthetic and Systems Biotechnology, 1 (3), 187-194. doi: 10.1016/j.synbio.2016.05.002
2015
Journal Article
NMR fingerprints, an integrated approach to uncover the unique components of the drug-like natural product metabolome of termite gut-associated Streptomyces species
Romero, C. A., Grkovic, T., Han, J., Zhang, L., French, J. R. J., Kurtboke, D. I. and Quinn, R. J. (2015). NMR fingerprints, an integrated approach to uncover the unique components of the drug-like natural product metabolome of termite gut-associated Streptomyces species. RSC Advances, 5 (126), 104524-104534. doi: 10.1039/c5ra17553d
Funding
Past funding
Supervision
Availability
- Dr Jianying Han is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
The discovery of new antibiotics to combat drug resistance
Associate Advisor
Other advisors: Dr Angela Salim, Professor Rob Capon
Media
Enquiries
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