
Overview
Background
Professor Ian Frazer is a clinician scientist, trained as a clinical immunologist in Scotland. As a professor at the University of Queensland, he leads a research group working at TRI in Brisbane, Australia on the immunobiology of epithelial cancers. He is recognised as co-inventor of the technology enabling the HPV vaccines, currently used worldwide to help prevent cervical cancer. He heads a biotechnology company, Jingang Medicine (Aus) Pty Ltd, working on new vaccine technologies, and is a board member of several companies and not for profit organisations. He was the inaugural president of the Australian Academy of Health and Medical Sciences, and a member of the Australian National Science and Technology Council. He chairs the Australian Medical Research Advisory Board of the Medical Research Future Fund.
He was recognised as Australian of the Year in 2006. He was recipient of the Prime Ministers Prize for Science, and of the Balzan Prize, in 2008, and was elected Fellow of the Royal Society of London in 2012. He was appointed Companion of the Order of Australia in the Queen’s Birthday Honours list in 2013.
Availability
- Professor Ian Frazer is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), University of Edinburgh
- Bachelor of Medicine Surgery, University of Edinburgh
- Doctoral Diploma of Medicine, University of Melbourne
- Royal College of Pathologists of Australasia, Royal College of Pathologists of Australasia
- Royal College of Physicians of Edinburgh, Royal College of Physicians of Edinburgh
Works
Search Professor Ian Frazer’s works on UQ eSpace
2001
Journal Article
Developmental genetics of red cell indices during puberty: A longitudinal twin study
Evans, D. M., Frazer, I. H., Boomsma, D. I. and Martin, N. G. (2001). Developmental genetics of red cell indices during puberty: A longitudinal twin study. International Journal of Human Genetics, 1 (1), 41-53. doi: 10.1080/09723757.2001.11885735
2001
Journal Article
Cervical carcinoma and human papillomavirus: on the road to preventing a major human cancer
Bosch, X. F., Munoz, N., de Sanjose, S., Franco, E. L. F., Lowy, D. R., Schiffman, M., Franceschi, S., Kruger Kjaer, S., Meijer, C. J. M. L., Frazer, I. H. and Cuzick, J. (2001). Cervical carcinoma and human papillomavirus: on the road to preventing a major human cancer. Journal of the National Cancer Institute, 93 (17), 1349-1350. doi: 10.1093/jnci/93.17.1349
2001
Conference Publication
Towards the development of edible vaccines for human papillomavirus in bananas
Miller, J, Becker, D, Dugdale, B, Harding, R, Aaskov, J, Frazer, I and Dale, J (2001). Towards the development of edible vaccines for human papillomavirus in bananas. OECD Workshop on Molecular Farming, Grande Motte France, Sep 03-06, 2000. PARIS: INST NATL RECHERCHE AGRONOMIQUE.
2001
Book Chapter
Wart and hepatitis vaccines
Frazer, I. H. (2001). Wart and hepatitis vaccines. Reproductive medicine in the twenty first century. (pp. 173-181) edited by D. L. Healy, R. McLachlan, G. T. Kovacs and O. Rodriguex-Armas. UK: The Parthenon Publishing Group Ltd.
2001
Journal Article
Efficiency of delivery of DNA to cells by bovine papillomavirus type-1 L1/L2 pseudovirions
Liu, Y., Frazer, I. H., Liu, W. J., Liu, X. S., McMillan, N. and Zhao, K. N. (2001). Efficiency of delivery of DNA to cells by bovine papillomavirus type-1 L1/L2 pseudovirions. Applied Microbiology And Biotechnology, 56 (1-2), 150-156. doi: 10.1007/s002530100655
2000
Journal Article
Differences in the post-translational modifications of human papillomavirus type 6b major capsid protein expressed from a baculovirus system compared with a vaccinia virus system
Fang, N., Frazer, I. H. and Fernando, G. J. (2000). Differences in the post-translational modifications of human papillomavirus type 6b major capsid protein expressed from a baculovirus system compared with a vaccinia virus system. Biotechnology And Applied Biochemistry, 32 (1), 27-33. doi: 10.1042/BA20000001
2000
Journal Article
Papillomavirus virus-like particles for the delivery of multiple cytotoxic T cell epitopes
Liu, WJ, Liu, XS, Zhao, KN, Leggatt, GR and Frazer, IH (2000). Papillomavirus virus-like particles for the delivery of multiple cytotoxic T cell epitopes. Virology, 273 (2), 374-382. doi: 10.1006/viro.2000.0435
2000
Journal Article
BPV1 E2 protein enhances packaging of full-length plasmid DNA in BPV1 pseudovirions
Zhao, Kong-Nan, Hengst, Kylie, Liu, Wen-Jun, Liu, Yue Hua, Liu, Xiao Song, Mcmillan, Nigel A. J. and Frazer, Ian H. (2000). BPV1 E2 protein enhances packaging of full-length plasmid DNA in BPV1 pseudovirions. Virology, 272 (2), 382-393. doi: 10.1006/viro.2000.0348
2000
Journal Article
E2F-1 induces proliferation-specific genes and suppresses squamous differentiation-specific genes in human epidermal keratinocytes
Dicker, Anthony J., Popa, Claudia, Dahler, Alison L., Serewko, Magdelena M., Hilditch-Maguire, Paige A., Frazer, Ian H. and Saunders, Nicholas A. (2000). E2F-1 induces proliferation-specific genes and suppresses squamous differentiation-specific genes in human epidermal keratinocytes. Oncogene, 19 (25), 2887-2894. doi: 10.1038/sj.onc.1203610
2000
Journal Article
Multiple conformational epitopes are recognized by natural and induced immunity to the E7 protein of human papilloma virus type 16 in man
Malcolm, Karen M., Meschede, Wolfgang, Pawlita, Michael, Koutsky, Laura A. and Frazer, Ian H. (2000). Multiple conformational epitopes are recognized by natural and induced immunity to the E7 protein of human papilloma virus type 16 in man. Intervirology, 43 (3), 165-173. doi: 10.1159/000025042
2000
Journal Article
Immune responses induced by BCG recombinant for human papillomavirus L1 and E7 proteins
Abdul Jabbar, I., Fernando, G. J., Saunders, N. A., Aldovini, A., Young, R., Malcolm, K. M. and Frazer, I. H. (2000). Immune responses induced by BCG recombinant for human papillomavirus L1 and E7 proteins. Vaccine, 18 (22), 2444-2453. doi: 10.1016/S0264-410X(99)00550-2
2000
Journal Article
Predictors of genital warts among women attending two family planning clinics
Frazer, I. H., Howard, J., Cox, C. and McFadyn, S. (2000). Predictors of genital warts among women attending two family planning clinics. Venereology, 13 (4), 157-162.
2000
Journal Article
HPV6b virus like particles are potent immunogens without adjuvant in man
Zhang, Li Fang, Zhou, Jian, Chen, Shao, Cai, Lian Lian, Bao, Qi Yu, Zheng, Fei Yun, Lu, Jie Qiang, Padmanabha, Jagadish, Hengst, Kylie, Malcolm, Karen and Frazer, Ian H. (2000). HPV6b virus like particles are potent immunogens without adjuvant in man. Vaccine, 18 (11-12), 1051-1058. doi: 10.1016/S0264-410X(99)00351-5
1999
Journal Article
Construction and production of fluorescent papillomavirus-like particles
Peng, S., Zhou, J. and Frazer, I. H. (1999). Construction and production of fluorescent papillomavirus-like particles. Journal of Tongji Medical University = Tung chi i ko ta hsueh hsueh pao, 19 (3), 170-174, 180.
1999
Journal Article
Capture ELISA and in vitro cell binding assay for the detection of antibodies to human papillomavirus type 6b virus-like particles in patients with anogenital warts
Peng, Shiwen, Qi, Yingmei, Christensen, Neil, Hengst, Kylie, Kennedy, Lynn, Frazer, Ian H. and Tindle, Robert W. (1999). Capture ELISA and in vitro cell binding assay for the detection of antibodies to human papillomavirus type 6b virus-like particles in patients with anogenital warts. Pathology, 31 (4), 418-422. doi: 10.1080/003130299104846
1999
Journal Article
Expression of the alpha 6 integrin confers papillomavirus binding upon receptor-negative B-cells
McMillan, Nigel A. J., Payne, Elizabeth, Frazer, Ian H. and Evander, Magnus (1999). Expression of the alpha 6 integrin confers papillomavirus binding upon receptor-negative B-cells. Virology, 261 (2), 271-279. doi: 10.1006/viro.1999.9825
1999
Journal Article
Genetic and environmental causes of variation in basal levels of blood cells
Evans, David M., Frazer, Ian H. and Martin, Nicholas G. (1999). Genetic and environmental causes of variation in basal levels of blood cells. Twin Research, 2 (4), 250-257. doi: 10.1375/twin.2.4.250
1999
Journal Article
Nucleotides 1506-1625 of Bovine Papillomavirus Type 1 Genome can enhance DNA packaging by L1/L2 capsids
Zhao, Kong-Nan, Frazer, Ian H., Liu, Wen Jun, Williams, Mark and Zhou, Jian (1999). Nucleotides 1506-1625 of Bovine Papillomavirus Type 1 Genome can enhance DNA packaging by L1/L2 capsids. Virology, 259 (1), 211-218. doi: 10.1006/viro.1999.9714
1999
Journal Article
Papillomavirus capsid protein expression level depends on the match between codon usage and tRNA availability
Zhou, Jian, Liu, Wen Jun, Peng, Shi Wen, Sun, Xiao Yi and Frazer, Ian H. (1999). Papillomavirus capsid protein expression level depends on the match between codon usage and tRNA availability. Journal of Virology, 73 (6), 4972-4982. doi: 10.1128/JVI.73.6.4972-4982.1999
1999
Journal Article
Post translational modifications of recombinant human Papillomavirus type 6b major capsid protein
Fang, Ning-Xia, Frazer, Ian H., Zhou, Jian and Fernando, Germain J. P. (1999). Post translational modifications of recombinant human Papillomavirus type 6b major capsid protein. Virus Research, 60 (2), 113-121. doi: 10.1016/S0168-1702(98)00117-8
Funding
Current funding
Past funding
Supervision
Availability
- Professor Ian Frazer is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
The role of IL34 in HPV-mediated epithelial cancers
Principal Advisor
Other advisors: Associate Professor Graham Leggatt, Professor David Hume, Dr Janin Chandra
-
Doctor Philosophy
The role of IL34 in HPV-mediated epithelial cancers
Principal Advisor
Other advisors: Associate Professor Graham Leggatt, Professor David Hume, Dr Janin Chandra
-
Doctor Philosophy
The Role of Bacterially Induced Inflammation in Squamous Cell Carcinoma Development
Principal Advisor
Other advisors: Professor Phil Hugenholtz, Professor Mark Morrison, Dr Debottam Sinha, Dr Janin Chandra
-
Doctor Philosophy
The role of IL34 in HPV-mediated epithelial cancers
Principal Advisor
Other advisors: Associate Professor Graham Leggatt, Professor David Hume, Dr Janin Chandra
-
Doctor Philosophy
Spatial Multi-Omics Analysis of HPV-Positive Head and Neck Cancer: Tumour Oncogenesis and Discovery of Targeted Therapies
Associate Advisor
Other advisors: Dr Quan Nguyen, Associate Professor James Wells, Dr Jazmina Gonzalez Cruz
-
Doctor Philosophy
Spatial Multi-Omics Analysis of HPV-Positive Head and Neck Cancer: Tumour Oncogenesis and Discovery of Targeted Therapies
Associate Advisor
Other advisors: Dr Quan Nguyen, Associate Professor James Wells, Dr Jazmina Gonzalez Cruz
-
Doctor Philosophy
Assessment of predictors of response to checkpoint blockades in cancer patients.
Associate Advisor
Other advisors: Dr Ahmed Mehdi, Dr Janin Chandra, Dr Bree Tillett
Completed supervision
-
2024
Doctor Philosophy
The Role of Bacterially Induced Inflammation in Squamous Cell Carcinoma Development
Principal Advisor
Other advisors: Professor Phil Hugenholtz, Professor Mark Morrison, Dr Debottam Sinha, Dr Janin Chandra
-
2021
Doctor Philosophy
The role of the skin microbiota in cutaneous squamous cell carcinoma
Principal Advisor
Other advisors: Professor Mark Morrison
-
2020
Doctor Philosophy
Modulation of Immune Responses by HPV-Induced Epithelial Hyperplasia
Principal Advisor
Other advisors: Associate Professor Graham Leggatt, Dr Janin Chandra
-
2018
Doctor Philosophy
Association of Local Immune Suppression in Skin with HPV-Induced Epithelial Hyperplasia
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2017
Master Philosophy
Aetiology of Oral Cavity Squamous Cell Carcinoma - An Exploration utilising Next Generation Sequencing
Principal Advisor
-
2015
Doctor Philosophy
Mechanisms of 2,4-Dinitrochlorobenzene-induced acute inflammation in Human Papillomavirus type 16 E7 oncoprotein expressing skin
Principal Advisor
-
2014
Doctor Philosophy
Mechanisms of immunoregulation in human papillomavirus-associated epithelial hyperplasia: of mice and (wo)men
Principal Advisor
Other advisors: Professor Antje Blumenthal
-
2013
Doctor Philosophy
LANGERHANS CELLS IN SKIN EXPRESSING HUMAN PAPILLOMAVIRUS TYPE 16 E7
Principal Advisor
-
2010
Doctor Philosophy
CD4+ T cells provide help to CD8+ T cells in immune recall responses in skin
Principal Advisor
-
2010
Doctor Philosophy
Augmenting CD8+ T cell-mediated cutaneous immunotherapy in a murine model system
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2010
Doctor Philosophy
Role of dendritic epidermal T cells in skin graft rejection
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2009
Doctor Philosophy
Human Papillomavirus 16 E7 Inhibits the ability of IFN-γ in Enhancement of MHC Class I Antigen Presentation and CTL Lysis by Affecting IRF-1 Expression in Keratinocytes
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
-
2008
Doctor Philosophy
Studies on mechanisms of skin graft rejection
Principal Advisor
Other advisors: Honorary Professor Geoffrey Hill
-
2003
Doctor Philosophy
IMMUNE RESPONSE TO PAPILLOMAVIRUS INFECTION
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2002
Doctor Philosophy
DETERMINING CTL CHARACTERISTICS WHICH CORRELATE WITH TUMOUR REGRESSION IN VIVO
Principal Advisor
Other advisors: Associate Professor Graham Leggatt
-
2023
Doctor Philosophy
Local Delivery Of Immunotherapeutic Antibodies To Skin Cancers
Associate Advisor
Other advisors: Dr Jazmina Gonzalez Cruz, Associate Professor Graham Leggatt
-
2022
Doctor Philosophy
Understanding CD4+ T cell responses to HPV16 E7 antigen in a mouse model of precancerous skin
Associate Advisor
Other advisors: Dr Kelvin Tuong, Dr Janin Chandra
-
2021
Doctor Philosophy
The role of CD8+ T cells in the regression of squamous cell carcinoma
Associate Advisor
Other advisors: Dr Jazmina Gonzalez Cruz, Associate Professor James Wells
-
2017
Doctor Philosophy
Uncovering novel regulators of CD8+ T-cell function in the skin
Associate Advisor
Other advisors: Associate Professor James Wells
-
2016
Doctor Philosophy
Evaluating CD8+ T-cell function in skin and squamous cell carcinoma following systemic suppression with rapamycin and tacrolimus.
Associate Advisor
Other advisors: Professor Fiona Simpson, Associate Professor James Wells
-
2015
Doctor Philosophy
Characterisation of RP105's divergent functions in macrophage responses to mycobacteria and LPS
Associate Advisor
Other advisors: Professor Antje Blumenthal
-
2015
Doctor Philosophy
Contributions of Wnt signalling to immune responses during acute bacterial infection
Associate Advisor
Other advisors: Professor Antje Blumenthal
-
2011
Doctor Philosophy
The effects of the balance of Type I and Type II NKT cells on CD8 T cells and Tumour Therapy
Associate Advisor
Other advisors: Associate Professor Graham Leggatt
-
2008
Doctor Philosophy
Interactions among Control Beliefs, Illness Severity, Biological Factors and a Psychological Preparation for Heart Surgery: Predictors of Health Outcomes
Associate Advisor
Other advisors: Emeritus Professor Kenneth Pakenham
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2007
Doctor Philosophy
Treatment of Cervical Cancer using RNA-Interference Against Human Papillomavirus Oncogenes
Associate Advisor
-
2005
Doctor Philosophy
Regulation of squamous differentiation by the E2F family transcription factors
Associate Advisor
-
2003
Doctor Philosophy
DENDRITIC CELL IMMUNOTHERAPY BASED ON HUMAN PAPILLOMAVIRUS
Associate Advisor
Other advisors: Professor Ranjeny Thomas
-
2003
Doctor Philosophy
IDENTIFICATION AND CLONING OF GENES ASSOCIATED WITH SQUAMOUS CELL CARCINOMA IN HUMAN SKIN TUMOURS
Associate Advisor
-
2003
Doctor Philosophy
THE ROLE OF AP2 IN SQUAMOUS DIFFERENTIATION
Associate Advisor
-
Doctor Philosophy
Peripheral Mechanisms of CD8+ T Cell Tolerance in H-2b K14E7 Transgenic Mice
Associate Advisor
Other advisors: Associate Professor Graham Leggatt
Media
Enquiries
Contact Professor Ian Frazer directly for media enquiries about:
- Allergy
- Autoimmune disease
- Cancer - immunity
- Cancer - vaccines to prevent
- Cervical cancer vaccine
- Education - medical
- Genital wart virus disease
- Host-virus interactions
- Immunity
- Immunodeficiency
- Immunology
- Medical education
- Papillomavirus vaccines
- Pathology
- Transplantation immunology
- Tumour immunology
- Tumour vaccines
- Vaccines
- Viral infection
- Viral vaccines
- Viruses
- Warts - genital
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