Dr Robert Reid
Dr

Robert Reid

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Background

I am an Organic Chemist and research the design and preparation of new medicines for diseases including arthritis and cancer

Dr. Robert C. Reid was awarded B.Sc. Hons 1 (1986) and Ph.D. (1990) degrees from the University of Sydney, Department of Organic Chemistry. He studied the stereospecific total synthesis of complex natural products with Professor Max J. Crossley and then undertook postdoctoral studies with Professor Sir Jack E. Baldwin FRS at the Dyson Perrins Laboratory, Oxford University UK (1990-93) studying the biosynthesis of penicillins. He is a Senior Research Fellow at the Institute for Molecular Bioscience (formerly known as the Centre for Drug Design and Development) at the University of Queensland with Professor David Fairlie. Research interests include Organic Synthesis, medicinal chemistry, drug design and development, nonpeptidic GPCR antagonists, natural products, protease inhibitors, other enzyme inhibitors, and peptidomimetics.

Availability

Dr Robert Reid is:
Available for supervision
Media expert

Fields of research

Biomedical and Clinical Sciences Chemical Sciences Medicinal and biomolecular chemistry Organic chemistry Pharmacology and pharmaceutical sciences

Qualifications

  • Bachelor (Honours) of Science (Advanced), University of Sydney
  • Doctor of Philosophy of Organic Chemistry, University of Sydney

Search Professor Robert Reid’s works on UQ eSpace

103 works between 1994 and 2025
All (103) Journal Article (85) Other Outputs (5) Conference Publication (11) Book Chapter (2)

81 - 100 of 103 works

2004

Journal Article

Protective effects of a potent C5a receptor antagonist on experimental acute limb ishemia-reperfusion in rats

Woodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2004). Protective effects of a potent C5a receptor antagonist on experimental acute limb ishemia-reperfusion in rats. Journal of Surgical Research, 116 (1), 81-90. doi: 10.1016/j.jss.2003.04.001

Protective effects of a potent C5a receptor antagonist on experimental acute limb ishemia-reperfusion in rats

2004

Journal Article

Countering cooperative effects in protease inhibitors using constrained b-strand-mimicking templates in focused combinatorial libraries

Reid, Robert C., Pattenden, Lenard K., Tyndall, Joel D. A., Martin, Jennifer L., Walsh, Terry and Fairlie, David P. (2004). Countering cooperative effects in protease inhibitors using constrained b-strand-mimicking templates in focused combinatorial libraries. Journal of Medicinal Chemistry, 47 (7), 1641-1651. doi: 10.1021/jm030337m

Countering cooperative effects in protease inhibitors using constrained b-strand-mimicking templates in focused combinatorial libraries

2003

Journal Article

A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease

Woodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2003). A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease. Journal of Immunology, 171 (10), 5514-5520. doi: 10.4049/jimmunol.171.10.5514

A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease

2003

Journal Article

Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist

Arumugam, Thiruma V., Arnold, Naomi, Proctor, Lavinia M., Newman, Michelle, Reid, Robert C., Hansford, Karl A., Fairlie, David P., Shiels, Ian A. and Taylor, Stephen M. (2003). Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist. British Journal of Pharmacology, 140 (1), 71-80. doi: 10.1038/sj.bjp.0705402

Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist

2003

Journal Article

A convergent solution-phase synthesis of the macrocycle Ac-Phe-[Orn-Pro-D-Cha-Trp-Arg], a potent new antiinflammatory drug

Reid, Robert C., Abbenante, Giovanni, Taylor, Stephen M. and Fairlie, David P. (2003). A convergent solution-phase synthesis of the macrocycle Ac-Phe-[Orn-Pro-D-Cha-Trp-Arg], a potent new antiinflammatory drug. Journal of Organic Chemistry, 68 (11), 4464-4471. doi: 10.1021/jo034228r

A convergent solution-phase synthesis of the macrocycle Ac-Phe-[Orn-Pro-D-Cha-Trp-Arg], a potent new antiinflammatory drug

2003

Journal Article

D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A(2) (IIa) with antiinflammatory activity

Hansford, Karl A., Reid, Robert C., Clark, Chris I., Tyndall, Joel D. A., Whitehouse, Michael W., Guthrie, Tom, McGeary, Ross P., Schafer, Karl, Martin, Jennifer L. and Fairlie, David P. (2003). D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A(2) (IIa) with antiinflammatory activity. Chembiochem, 4 (2-3), 181-185. doi: 10.1002/cbic.200390029

D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A(2) (IIa) with antiinflammatory activity

2002

Journal Article

Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat

Woodruff, Trent M., Strachan, Anna J., Dryburgh, Nathan, Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2002). Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat. Arthritis and Rheumatism, 46 (9), 2476-2485. doi: 10.1002/art.10449

Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat

2002

Journal Article

Protective effect of a new C5a receptor antagonist against Ischemia-reperfusion injury in the rat small intestine

Arumugam, Thiruma V., Shiels, Ian A., Woodruff, Trent M., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2002). Protective effect of a new C5a receptor antagonist against Ischemia-reperfusion injury in the rat small intestine. Journal of Surgical Research, 103 (2), 260-267. doi: 10.1006/jsre.2002.6369

Protective effect of a new C5a receptor antagonist against Ischemia-reperfusion injury in the rat small intestine

2002

Other Outputs

Compounds and inhibitors of phospholipases

Reid, Robert C., Clark, Christopher I., Hansford, Karl, Stoermer, Martin J., McGeary, Ross P. and Fairlie, David P. (2002). Compounds and inhibitors of phospholipases. WO0208189.

Compounds and inhibitors of phospholipases

2002

Journal Article

beta-strand mimicking macrocyclic amino acids: Templates for protease inhibitors with antiviral activity

Glenn, MP, Pattenden, LK, Reid, RC, Tyssen, DP, Tyndall, JDA, Birch, CJ and Fairlie, DP (2002). beta-strand mimicking macrocyclic amino acids: Templates for protease inhibitors with antiviral activity. Journal of Medicinal Chemistry, 45 (2), 371-381. doi: 10.1021/jm010414i

beta-strand mimicking macrocyclic amino acids: Templates for protease inhibitors with antiviral activity

2002

Journal Article

Conformationally constrained macrocycles that mimic tripeptide beta-strands in water and aprotic solvents

Reid, RC, Kelso, MJ, Scanlon, MJ and Fairlie, DP (2002). Conformationally constrained macrocycles that mimic tripeptide beta-strands in water and aprotic solvents. Journal of The American Chemical Society, 124 (20), 5673-5683. doi: 10.1021/ja0256461

Conformationally constrained macrocycles that mimic tripeptide beta-strands in water and aprotic solvents

2002

Journal Article

Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist (vol 134, pg 1778, 2001)

Strachan, Anna J., Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2002). Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist (vol 134, pg 1778, 2001). British Journal of Pharmacology, 135 (2), 579-580. doi: 10.1038/sj.bjp.0704531

Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist (vol 134, pg 1778, 2001)

2001

Journal Article

Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist

Strachan, Anna J., Shiels, Ian A., Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and R. A. North (2001). Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist. British Journal of Pharmacology, 134 (12), 1778-1786. doi: 10.1038/sj.bjp.0704417

Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist

2000

Journal Article

Conformational selection of inhibitors and substrates by proteolytic enzymes: Implications for drug design and polypeptide processing

Fairlie, D. P., Tyndall, J. D. A., Reid, R. C., Wong, A. K., Abbenante, G., Scanlon, M. J., March, D. R., Bergman, D. A., Chai, C. L. L. and Burkett, B. A. (2000). Conformational selection of inhibitors and substrates by proteolytic enzymes: Implications for drug design and polypeptide processing. Journal of Medicinal Chemistry, 43 (7), 1271-1281. doi: 10.1021/jm990315t

Conformational selection of inhibitors and substrates by proteolytic enzymes: Implications for drug design and polypeptide processing

2000

Journal Article

Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease

Tyndall, J. D. A., Reid, R. C., Tyssen, D. P., Jardine, D. K., Todd, B., Passmore, M., March, D. R., Pattenden, L., Bergman, D. A., Alewood, D., Hu, S., Alewood, P.F., Birch, C. J., Martin, J. L. and Fairlie, D. (2000). Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease. Journal of Medicinal Chemistry, 43 (19), 3495-3504. doi: 10.1021/jm000013n

Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease

2000

Journal Article

Small peptides do not inhibit human non-pancreatic secretory phospholipase-A 2 (Type IIA)

Clark, C. I., Reid, R. C., McGeary, R. P., Schafer, K. and Fairlie, D. P. (2000). Small peptides do not inhibit human non-pancreatic secretory phospholipase-A 2 (Type IIA). Bioichemistry BIophysical Research Communications, 274 (3), 831-834. doi: 10.1006/bbrc.2000.3221

Small peptides do not inhibit human non-pancreatic secretory phospholipase-A 2 (Type IIA)

1999

Journal Article

Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease

Martin, J. L., Begun, J., Schindeler, A., Wickramasinghe, W. A., Alewood, D., Alewood, P. F., Bergman, D. A., Brinkworth, R. I., Abbenante, G., March, D. R., Reid, R. C., Fairlie, D. P. and Armstrong, Richard A. (1999). Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease. Biochemistry, 38 (25), 7978-7988. doi: 10.1021/bi990174x

Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease

1997

Journal Article

Conformationally constrained cyclic mimetics of protein and peptide surfaces.

Wong, A. K., Reid, R. C., Abbenante, J. and Fairlie, D. P. (1997). Conformationally constrained cyclic mimetics of protein and peptide surfaces.. Abstracts of Papers of The American Chemical Society, 214 (1), 388-ORGN.

Conformationally constrained cyclic mimetics of protein and peptide surfaces.

1997

Book Chapter

Mimicking extended conformations of protease substrates: Designing cyclic peptidomimetics to inhibit HIV-1 protease

Fairlie, D. P. and Reid, R. C. (1997). Mimicking extended conformations of protease substrates: Designing cyclic peptidomimetics to inhibit HIV-1 protease. Advances in amino acid mimetics and peptidomimetics. (pp. 77-107) London: JAI Press Inc.

Mimicking extended conformations of protease substrates: Designing cyclic peptidomimetics to inhibit HIV-1 protease

1997

Journal Article

A novel strategy for the design of potent peptidomimetic inhibitors of proteolytic enzymes: Application to HIV-1 protease.

Reid, R. C., Abbenante, G., March, D. R., Scanlon, M. and Fairlie, D. P. (1997). A novel strategy for the design of potent peptidomimetic inhibitors of proteolytic enzymes: Application to HIV-1 protease.. Abstracts of Papers of The American Chemical Society, 214, 177-MEDI.

A novel strategy for the design of potent peptidomimetic inhibitors of proteolytic enzymes: Application to HIV-1 protease.

Past funding

  • 2014
    Continuous-Flow Hydrogenation Reactor (H-Cube Pro)
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Peptide Drug Synthesis and Purification Unit
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    Combinatorial chemistry (high throughput synthesizer and purification system)
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2012
    Inhibitors of Secretory Phospholipases in Diet Induced Obese Rats
    NHMRC Project Grant
    Open grant
  • 2009 - 2012
    Protease Activated Receptor 2 : A New Drug Target For Inflammatory Diseases and Cancer
    NHMRC Project Grant
    Open grant
  • 2008 - 2010
    Molecular attributes and physiological significance of beta1L-adrenoceptors
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    DsbA inhibitors as potential antimicrobials
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    Targeting A Complement Receptor That Regulates Inflammatory Disease
    NHMRC Project Grant
    Open grant
  • 2000
    Development of inhibit
    UQ External Support Enabling Grant
    Open grant

Availability

Dr Robert Reid is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

Contact Dr Robert Reid directly for media enquiries about:

  • Chemical Analysis
  • HPLC
  • LCMS
  • Medicinal Chemistry
  • NMR
  • Organic Chemistry
  • Organic Synthesis
  • Spectroscopy

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