Dr Robert Reid
Dr

Robert Reid

Email: 

Background

I am an Organic Chemist and research the design and preparation of new medicines for diseases including arthritis and cancer

Dr. Robert C. Reid was awarded B.Sc. Hons 1 (1986) and Ph.D. (1990) degrees from the University of Sydney, Department of Organic Chemistry. He studied the stereospecific total synthesis of complex natural products with Professor Max J. Crossley and then undertook postdoctoral studies with Professor Sir Jack E. Baldwin FRS at the Dyson Perrins Laboratory, Oxford University UK (1990-93) studying the biosynthesis of penicillins. He is a Senior Research Fellow at the Institute for Molecular Bioscience (formerly known as the Centre for Drug Design and Development) at the University of Queensland with Professor David Fairlie. Research interests include Organic Synthesis, medicinal chemistry, drug design and development, nonpeptidic GPCR antagonists, natural products, protease inhibitors, other enzyme inhibitors, and peptidomimetics.

Availability

Dr Robert Reid is:
Available for supervision
Media expert

Fields of research

Biomedical and Clinical Sciences Chemical Sciences Medicinal and biomolecular chemistry Organic chemistry Pharmacology and pharmaceutical sciences

Qualifications

  • Bachelor (Honours) of Science (Advanced), University of Sydney
  • Doctor of Philosophy of Organic Chemistry, University of Sydney

Search Professor Robert Reid’s works on UQ eSpace

103 works between 1994 and 2025
All (103) Journal Article (85) Other Outputs (5) Conference Publication (11) Book Chapter (2)

21 - 40 of 103 works

2019

Journal Article

Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro

Algate, Kent, Haynes, David, Fitzsimmons, Tracy, Romeo, Ornella, Wagner, Florence, Holson, Edward, Reid, Robert, Fairlie, David, Bartold, Peter and Cantley, Melissa (2019). Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro. Journal of Cellular Biochemistry, 121 (1) jcb.29137, 244-258. doi: 10.1002/jcb.29137

Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro

2018

Conference Publication

Chemical synthesis and applications of a novel fluorescent probe for human complement C3a receptor

Wu, Chongyang, de Araujo, Aline, Wu, Kai-Chen, Reid, Robert, Durek, Thomas, Lim, Junxian and Fairlie, David (2018). Chemical synthesis and applications of a novel fluorescent probe for human complement C3a receptor. 256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond, Boston Ma, Aug 19-23, 2018. WASHINGTON: AMER CHEMICAL SOC.

Chemical synthesis and applications of a novel fluorescent probe for human complement C3a receptor

2018

Journal Article

Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis

Kim, Soo-Hyun, Redvers, Richard P., Chi, Lap Hing, Ling, Xiawei, Lucke, Andrew J., Reid, Robert C., Fairlie, David P., Baptista Moreno Martin, Ana Carolina, Anderson, Robin L., Denoyer, Delphine and Pouliot, Normand (2018). Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis. Disease Models and Mechanisms, 11 (7) Y, DMM034850. doi: 10.1242/dmm.034850

Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis

2018

Other Outputs

Modulators of protease activated receptors

Fairlie, David, Liu, Ligong, Yau, Mei-Kwan, Suen, Jacky Yung, Reid, Robert, Lohman, Rink-Jan, Iyer, Abishek Venkatasubramanian, Lim, Junxian and Brown, Lindsay Charles (2018). Modulators of protease activated receptors. US09868763B2.

Modulators of protease activated receptors

2018

Journal Article

Chemical approaches to modulating complement-mediated diseases

Iyer, Abishek, Xu, Weijun, Reid, Robert C and Fairlie, David P (2018). Chemical approaches to modulating complement-mediated diseases. Journal of Medicinal Chemistry, 61 (8), 3253-3276. doi: 10.1021/acs.jmedchem.7b00882

Chemical approaches to modulating complement-mediated diseases

2017

Journal Article

Europium-labeled synthetic C3a protein as a novel fluorescent probe for human complement C3a receptor

Dantas de Araujo, Aline, Wu, Chongyang, Wu, Kai-Chen, Reid, Robert C., Durek, Thomas, Lim, Junxian and Fairlie, David P. (2017). Europium-labeled synthetic C3a protein as a novel fluorescent probe for human complement C3a receptor. Bioconjugate Chemistry, 28 (6), 1669-1676. doi: 10.1021/acs.bioconjchem.7b00132

Europium-labeled synthetic C3a protein as a novel fluorescent probe for human complement C3a receptor

2017

Journal Article

Insecticidal activities of histone deacetylase inhibitors against a dipteran parasite of sheep, Lucilia cuprina

Bagnall, Neil H., Hines, Barney M., Lucke, Andrew J., Gupta, Praveer K., Reid, Robert C., Fairlie, David P. and Kotze, Andrew C. (2017). Insecticidal activities of histone deacetylase inhibitors against a dipteran parasite of sheep, Lucilia cuprina. International Journal for Parasitology: Drugs and Drug Resistance, 7 (1), 51-60. doi: 10.1016/j.ijpddr.2017.01.001

Insecticidal activities of histone deacetylase inhibitors against a dipteran parasite of sheep, Lucilia cuprina

2017

Journal Article

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells

Mak, Jeffrey Y. W., Xu, Weijun, Reid, Robert C., Corbett, Alexandra J., Meehan, Bronwyn S., Wang, Huimeng, Chen, Zhenjun, Rossjohn, Jamie, McCluskey, James, Liu, Ligong and Fairlie, David P. (2017). Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells. Nature Communications, 8 (1) 14599, 14599. doi: 10.1038/ncomms14599

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells

2017

Journal Article

An HDAC6 inhibitor confers protection and selectively inhibits B-cell infiltration in DSS-induced colitis in mice

Do, Anh, Reid, Robert C., Lohman, Rink-Jan, Sweet, Matthew J., Fairlie, David P. and Iyer, Abishek (2017). An HDAC6 inhibitor confers protection and selectively inhibits B-cell infiltration in DSS-induced colitis in mice. The Journal of Pharmacology and Experimental Therapeutics, 360 (1), 140-151. doi: 10.1124/jpet.116.236711

An HDAC6 inhibitor confers protection and selectively inhibits B-cell infiltration in DSS-induced colitis in mice

2017

Conference Publication

Vitamin B2 related molecules that activate T cells

Mak, Jeffrey, Xu, Weijun, Reid, Robert, Corbett, Alexandra, Meehan, Bronwyn, Wang, Huimeng, Chen, Zhenjun, Rossjohn, Jamie, McCluskey, James, Liu, Ligong and Fairlie, David (2017). Vitamin B2 related molecules that activate T cells. 254th National Meeting and Exposition of the American-Chemical-Society (ACS) on Chemistry's Impact on the Global Economy, Washington DC, USA, 20-24 August 2017. Washington DC, USA: American Chemical Society.

Vitamin B2 related molecules that activate T cells

2017

Conference Publication

Activity of the histone deacetylase (HDAC) inhibitor AR-42 in a murine malaria model

Chua, Ming Jang, Do, Darren, Bachu, Prabhakar, Reid, Robert, Fairlie, David, Skinner-Adams, Tina and Andrews, Kathy (2017). Activity of the histone deacetylase (HDAC) inhibitor AR-42 in a murine malaria model. 66th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH), Baltimore, MD United States, 5-09 November 2017. Deerfield, IL United States: American Society of Tropical Medicine and Hygiene.

Activity of the histone deacetylase (HDAC) inhibitor AR-42 in a murine malaria model

2016

Journal Article

Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists

Seow, Vernon, Lim, Junxian, Cotterell, Adam J., Yau, Mei-Kwan, Xu, Weijun, Lohman, Rink-Jan, Kok, W. Mei, Stoermer, Martin J., Sweet, Matthew J., Reid, Robert C., Suen, Jacky Y. and Farilie, David P. (2016). Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists. Scientific Reports, 6 (1) 24575, 24575.1-24575.12. doi: 10.1038/srep24575

Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists

2016

Journal Article

Histone deacetylase inhibitors promote mitochondrial reactive oxygen species production and bacterial clearance by human macrophages

Ariffin, Juliana K., das Gupta, Kaustav, Kapetanovic, Ronan, Iyer, Abishek, Reid, Robert C., Fairlie, David P. and Sweet, Matthew J. (2016). Histone deacetylase inhibitors promote mitochondrial reactive oxygen species production and bacterial clearance by human macrophages. Antimicrobial Agents and Chemotherapy, 60 (3), 1521-1529. doi: 10.1128/AAC.01876-15

Histone deacetylase inhibitors promote mitochondrial reactive oxygen species production and bacterial clearance by human macrophages

2016

Journal Article

Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity

Yau, Mei-Kwan, Liu, Ligong, Lim, Junxian, Lohman, Rink-Jan, Cotterell, Adam J., Suen, Jacky Y., Vesey, David A., Reid, Robert C. and Fairlie, David P. (2016). Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity. Bioorganic and Medicinal Chemistry Letters, 26 (3), 986-991. doi: 10.1016/j.bmcl.2015.12.048

Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity

2016

Journal Article

Differential anti-inflammatory activity of HDAC inhibitors in human macrophages and rat arthritis

Lohman, Rink-Jan, Iyer, Abishek, Fairlie, Thomas J., Cotterell, Adam, Gupta, Praveer, Reid, Robert C., Vesey, David A., Sweet, Matthew J. and Fairlie, David P. (2016). Differential anti-inflammatory activity of HDAC inhibitors in human macrophages and rat arthritis. Journal of Pharmacology and Experimental Therapeutics, 356 (2), 387-396. doi: 10.1124/jpet.115.229328

Differential anti-inflammatory activity of HDAC inhibitors in human macrophages and rat arthritis

2016

Journal Article

Potent small agonists of protease activated receptor 2

Yau, Mei-Kwan, Suen, Jacky Y., Xu, Weijun, Lim, Junxian, Liu, Ligong, Adams, Mark N., He, Yaowu, Hooper, John D., Reid, Robert C. and Fairlie, David P. (2016). Potent small agonists of protease activated receptor 2. ACS Medicinal Chemistry Letters, 7 (1), 105-110. doi: 10.1021/acsmedchemlett.5b00429

Potent small agonists of protease activated receptor 2

2016

Journal Article

PAR2 modulators derived from GB88

Yau, Mei-Kwan, Liu, Ligong, Suen, Jacky Y., Lim, Junxian, Lohman, Rink-Jan, Jiang, Yuhong, Cotterell, Adam J., Barry, Grant D., Mak, Jeffrey Y. W., Vesey, David A., Reid, Robert C. and Fairlie, David P. (2016). PAR2 modulators derived from GB88. ACS Medicinal Chemistry Letters, 7 (12), 1179-1184. doi: 10.1021/acsmedchemlett.6b00306

PAR2 modulators derived from GB88

2015

Journal Article

Histone deacetylase enzymes as drug targets for the control of the sheep blowfly, Lucilia cuprina

Kotze, Andrew C., Hines, Barney M., Bagnall, Neil H., Anstead, Clare A., Gupta, Praveer, Reid, Robert C., Ruffell, Angela P. and Fairlie, David P. (2015). Histone deacetylase enzymes as drug targets for the control of the sheep blowfly, Lucilia cuprina. International Journal for Parasitology: Drugs and Drug Resistance, 5 (3), 201-208. doi: 10.1016/j.ijpddr.2015.09.003

Histone deacetylase enzymes as drug targets for the control of the sheep blowfly, Lucilia cuprina

2015

Journal Article

Potent complement C3a receptor agonists derived from oxazole amino acids: structure-activity relationships

Singh, Ranee, Reed, Anthony N., Chu, Peifei, Scully, Conor C. G., Yau, Mei-Kwan, Suen, Jacky Y., Durek, Thomas, Reid, Robert C. and Fairlie, David P. (2015). Potent complement C3a receptor agonists derived from oxazole amino acids: structure-activity relationships. Bioorganic and Medicinal Chemistry Letters, 25 (23), 5604-5608. doi: 10.1016/j.bmcl.2015.10.038

Potent complement C3a receptor agonists derived from oxazole amino acids: structure-activity relationships

2015

Conference Publication

Potent small agonists of protease activated receptor 2

Yau, Mei Kwan, Suen, Jacky, Xu, Weijun, Lim, Junxian, Liu, Ligong, Adams, Mark, He, Yaowu, Hooper, John, Reid, Robert and Fairlie, David (2015). Potent small agonists of protease activated receptor 2. ACS Fall 2015, Boston, MA, United States, 16 - 20 August 2015. Washington, DC, United States: American Chemical Society.

Potent small agonists of protease activated receptor 2

Past funding

  • 2014
    Continuous-Flow Hydrogenation Reactor (H-Cube Pro)
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Peptide Drug Synthesis and Purification Unit
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    Combinatorial chemistry (high throughput synthesizer and purification system)
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2012
    Inhibitors of Secretory Phospholipases in Diet Induced Obese Rats
    NHMRC Project Grant
    Open grant
  • 2009 - 2012
    Protease Activated Receptor 2 : A New Drug Target For Inflammatory Diseases and Cancer
    NHMRC Project Grant
    Open grant
  • 2008 - 2010
    Molecular attributes and physiological significance of beta1L-adrenoceptors
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    DsbA inhibitors as potential antimicrobials
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    Targeting A Complement Receptor That Regulates Inflammatory Disease
    NHMRC Project Grant
    Open grant
  • 2000
    Development of inhibit
    UQ External Support Enabling Grant
    Open grant

Availability

Dr Robert Reid is:
Available for supervision

Looking for a supervisor? Read our advice on how to choose a supervisor.

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Dr Robert Reid directly for media enquiries about:

  • Chemical Analysis
  • HPLC
  • LCMS
  • Medicinal Chemistry
  • NMR
  • Organic Chemistry
  • Organic Synthesis
  • Spectroscopy

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au