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2020 Journal Article Potent thiophene antagonists of human complement C3a receptor with anti-inflammatory activityRowley, Jessica A., Reid, Robert C., Poon, Eunice K. Y., Wu, Kai-Chen, Lim, Junxian, Lohman, Rink-Jan, Hamidon, Johan K., Yau, Mei-Kwan, Halili, Maria A., Durek, Thomas, Iyer, Abishek and Fairlie, David P. (2020). Potent thiophene antagonists of human complement C3a receptor with anti-inflammatory activity. Journal of Medicinal Chemistry, 63 (2) acs.jmedchem.9b00927, 529-541. doi: 10.1021/acs.jmedchem.9b00927 |
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2017 Journal Article Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3aLohman, Rink-Jan, Hamidon, Johan K., Reid, Robert C., Rowley, Jessica A., Yau, Mei-Kwan, Halili, Maria A., Nielsen, Daniel S., Lim, Junxian, Wu, Kai-Chen, Loh, Zhixuan, Do, Anh, Suen, Jacky Y., Iyer, Abishek and Fairlie, David P. (2017). Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a. Nature Communications, 8 (1) 351, 351. doi: 10.1038/s41467-017-00414-w |
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2014 Journal Article Stereoelectronic effects dictate molecular conformation and biological function of heterocyclic amidesReid, Robert C., Yau, Mei-Kwan, Singh, Ranee, Lim, Junxian and Fairlie, David P. (2014). Stereoelectronic effects dictate molecular conformation and biological function of heterocyclic amides. Journal of the American Chemical Society, 136 (34), 11914-11917. doi: 10.1021/ja506518t |
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2013 Journal Article Downsizing a human inflammatory protein to a small molecule with equal potency and functionalityReid, Robert C., Yau, Mei-Kwan, Singh, Ranee, Hamidon, Johan K., Reed, Anthony N., Chu, Peifei, Suen, Jacky Y., Stoermer, Martin J., Blakeney, Jade S., Lim, Junxian, Faber, Jonathan M. and David P. Fairlie, (2013). Downsizing a human inflammatory protein to a small molecule with equal potency and functionality. Nature Communications, 4 (2802) 2802, 1-9. doi: 10.1038/ncomms3802 |
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2025 Journal Article Histone deacetylase 7 mediates lipopolysaccharide-inducible mitochondrial fission in macrophagesAbrol, Rishika, Afroz, Syeda Farhana, Curson, James E. B., Raven, Karoline D., Das Gupta, Kaustav, Gunther, Kimberley S., Jones, Alun, Reid, Robert C., Xiong, Zherui, Gunter, Jennifer H., Engel, Jessica A., Engwerda, Christian R., Blumenthal, Antje, Fairlie, David P., Parton, Robert G., Zuryn, Steven, Kapetanovic, Ronan, Ramnath, Divya and Sweet, Matthew J. (2025). Histone deacetylase 7 mediates lipopolysaccharide-inducible mitochondrial fission in macrophages. Journal of Cell Science, 138 (19) jcs.264376, 1-14. doi: 10.1242/jcs.264376 |
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2024 Journal Article Histone deacetylase 7 activates 6-phosphogluconate dehydrogenase via an enzyme-independent mechanism that involves the N-terminal protein-protein interaction domainWang, Yizhuo, Curson, James E.B., Ramnath, Divya, Das Gupta, Kaustav, Reid, Robert C., Karunakaran, Denuja, Fairlie, David P. and Sweet, Matthew J. (2024). Histone deacetylase 7 activates 6-phosphogluconate dehydrogenase via an enzyme-independent mechanism that involves the N-terminal protein-protein interaction domain. Biochemical Journal, 481 (21), 1569-1584. doi: 10.1042/bcj20240380 |
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2023 Journal Article HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophagesDas Gupta, Kaustav, Ramnath, Divya, von Pein, Jessica B., Curson, James E. B., Wang, Yizhuo, Abrol, Rishika, Kakkanat, Asha, Moradi, Shayli Varasteh, Gunther, Kimberley S., Murthy, Ambika M. V., Stocks, Claudia J., Kapetanovic, Ronan, Reid, Robert C., Iyer, Abishek, Ilka, Zoe C., Nauseef, William M., Plan, Manuel, Luo, Lin, Stow, Jennifer L., Schroder, Kate, Karunakaran, Denuja, Alexandrov, Kirill, Shakespear, Melanie R., Schembri, Mark A., Fairlie, David P. and Sweet, Matthew J. (2023). HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages. Proceedings of the National Academy of Sciences, 120 (4) e2212813120, 1-12. doi: 10.1073/pnas.2212813120 |
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2023 Journal Article Ras related protein Rab5a regulates complement C5a receptor trafficking, chemotaxis and chemokine secretion in human macrophagesWu, Kai-Chen, Condon, Nicholas D., Hill, Timothy A., Reid, Robert C., Fairlie, David and Lim, Junxian (2023). Ras related protein Rab5a regulates complement C5a receptor trafficking, chemotaxis and chemokine secretion in human macrophages. Journal of Innate Immunity, 15 (1), 468-484. doi: 10.1159/000530012 |
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2022 Journal Article Temporal perturbation of histone deacetylase activity reveals a requirement for HDAC1–3 in mesendoderm cell differentiationSinniah, Enakshi, Wu, Zhixuan, Shen, Sophie, Naval-Sanchez, Marina, Chen, Xiaoli, Lim, Junxian, Helfer, Abbigail, Iyer, Abishek, Tng, Jiahui, Lucke, Andrew J., Reid, Robert C., Redd, Meredith A., Nefzger, Christian M., Fairlie, David P. and Palpant, Nathan J. (2022). Temporal perturbation of histone deacetylase activity reveals a requirement for HDAC1–3 in mesendoderm cell differentiation. Cell Reports, 39 (7) 110818, 1-21. doi: 10.1016/j.celrep.2022.110818 |
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2022 Journal Article The histone deacetylase Hdac7 supports LPS‐inducible glycolysis and Il‐1β production in murine macrophages via distinct mechanismsRamnath, Divya, Das Gupta, Kaustav, Wang, Yizhuo, Abrol, Rishika, Curson, James E. B., Lim, Junxian, Reid, Robert C., Mansell, Ashley, Blumenthal, Antje, Karunakaran, Denuja, Fairlie, David P. and Sweet, Matthew J. (2022). The histone deacetylase Hdac7 supports LPS‐inducible glycolysis and Il‐1β production in murine macrophages via distinct mechanisms. Journal of Leukocyte Biology, 111 (2), 327-336. doi: 10.1002/jlb.2mr1021-260r |
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2022 Journal Article QSAR classification models for prediction of hydroxamate histone deacetylase inhibitor activity against malaria parasitesHesping, Eva, Chua, Ming Jang, Pflieger, Marc, Qian, Yunan, Dong, Lilong, Bachu, Prabhakar, Liu, Ligong, Kurz, Thomas, Fisher, Gillian M., Skinner-Adams, Tina S., Reid, Robert C., Fairlie, David P., Andrews, Katherine T. and Gorse, Alain-Dominique J.P. (2022). QSAR classification models for prediction of hydroxamate histone deacetylase inhibitor activity against malaria parasites. ACS Infectious Diseases, 8 (1), 106-117. doi: 10.1021/acsinfecdis.1c00355 |
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2021 Journal Article De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complexChen, Kai-En, Guo, Qian, Hill, Timothy A., Cui, Yi, Kendall, Amy K., Yang, Zhe, Hall, Ryan J., Healy, Michael D., Sacharz, Joanna, Norwood, Suzanne J., Fonseka, Sachini, Xie, Boyang, Reid, Robert C., Leneva, Natalya, Parton, Robert G., Ghai, Rajesh, Stroud, David A., Fairlie, David P, Suga, Hiroaki, Jackson, Lauren P., Teasdale, Rohan D., Passioura, Toby and Collins, Brett M. (2021). De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex. Science Advances, 7 (49) eabg4007, eabg4007. doi: 10.1126/sciadv.abg4007 |
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2021 Journal Article Histone deacetylase inhibitor AR-42 and achiral analogues kill malaria parasites in vitro and in miceChua, Ming Jang, Tng, Jiahui, Hesping, Eva, Fisher, Gillian M., Goodman, Christopher D., Skinner-Adams, Tina, Do, Darren, Lucke, Andrew J., Reid, Robert C., Fairlie, David P. and Andrews, Katherine T. (2021). Histone deacetylase inhibitor AR-42 and achiral analogues kill malaria parasites in vitro and in mice. International Journal for Parasitology: Drugs and Drug Resistance, 17, 118-127. doi: 10.1016/j.ijpddr.2021.08.006 |
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2021 Journal Article HDAC7 inhibition by phenacetyl and phenylbenzoyl hydroxamatesMak, Jeffrey Y. W., Wu, Kai-Chen, Gupta, Praveer K., Barbero, Sheila, McLaughlin, Maddison G., Lucke, Andrew J., Tng, Jiahui, Lim, Junxian, Loh, Zhixuan, Sweet, Matthew J, Reid, Robert C., Liu, Ligong and Fairlie, David P. (2021). HDAC7 inhibition by phenacetyl and phenylbenzoyl hydroxamates. Journal of Medicinal Chemistry, 64 (4), 2186-2204. doi: 10.1021/acs.jmedchem.0c01967 |
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2020 Journal Article Achiral derivatives of hydroxamate AR-42 potently inhibit class I HDAC enzymes and cancer cell proliferationTng, Jiahui, Lim, Junxian, Wu, Kai-Chen, Lucke, Andrew J., Xu, Weijun, Reid, Robert C. and Fairlie, David P. (2020). Achiral derivatives of hydroxamate AR-42 potently inhibit class I HDAC enzymes and cancer cell proliferation. Journal of Medicinal Chemistry, 63 (11) acs.jmedchem.0c00230, 5956-5971. doi: 10.1021/acs.jmedchem.0c00230 |
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2020 Journal Article Class IIa histone deacetylases drive toll-like receptor-inducible glycolysis and macrophage inflammatory responses via pyruvate kinase M2Das Gupta, Kaustav, Shakespear, Melanie R., Curson, James E.B., Murthy, Ambika M.V., Iyer, Abishek, Hodson, Mark P., Ramnath, Divya, Tillu, Vikas A., von Pein, Jessica B., Reid, Robert C., Tunny, Kathryn, Hohenhaus, Daniel M., Moradi, Shayli Varasteh, Kelly, Gregory M., Kobayashi, Takumi, Gunter, Jennifer H., Stevenson, Alexander J., Xu, Weijun, Luo, Lin, Jones, Alun, Johnston, Wayne A., Blumenthal, Antje, Alexandrov, Kirill, Collins, Brett M., Stow, Jennifer L., Fairlie, David P. and Sweet, Matthew J. (2020). Class IIa histone deacetylases drive toll-like receptor-inducible glycolysis and macrophage inflammatory responses via pyruvate kinase M2. Cell Reports, 30 (8), 2712-2728.e8. doi: 10.1016/j.celrep.2020.02.007 |
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2019 Journal Article Inhibitors of class I histone deacetylases attenuate thioacetamide-induced liver fibrosis in mice by suppressing hepatic Type 2 inflammationLoh, Zhixuan, Fitzsimmons, Rebecca L., Reid, Robert C., Ramnath, Divya, Clouston, Andrew, Gupta, Praveer K., Irvine, Katharine M., Powell, Elizabeth E., Schroder, Kate, Stow, Jennifer L., Sweet, Matthew J., Fairlie, David P. and Iyer, Abishek (2019). Inhibitors of class I histone deacetylases attenuate thioacetamide-induced liver fibrosis in mice by suppressing hepatic Type 2 inflammation. British Journal of Pharmacology, 176 (19) bph.14768, 3775-3790. doi: 10.1111/bph.14768 |
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2019 Conference Publication Histone Deacetylase Inhibitors Attenuate Hepatic Fibrosis through Suppression of Group 2 Innate Lymphoid Cells and Type 2 InflammationIyer, Abishek, Loh, Zhixuan, Fitzsimmons, Rebecca L., Reid, Robert C., Ramnath, Divya, Clouston, Andrew, Irvine, Katharine M., Powell, Elizabeth E., Schroder, Kate, Stow, Jennifer L., Sweet, Matthew J. and Fairlie, David P. (2019). Histone Deacetylase Inhibitors Attenuate Hepatic Fibrosis through Suppression of Group 2 Innate Lymphoid Cells and Type 2 Inflammation. Experimental Biology Meeting (EB), Orlando Fl, Apr 06-09, 2019. HOBOKEN: WILEY. |
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2019 Journal Article Oxazole-benzenesulfonamide derivatives inhibit HIV-1 reverse transcriptase interaction with cellular eEF1A and reduce viral replicationRawle, Daniel J., Li, Dongsheng, Wu, Zhonglan, Wang, Lu, Choong, Marcus, Lor, Mary, Reid, Robert C., Fairlie, David P., Harris, Jonathan, Tachedjian, Gilda, Poulsen, Sally-Ann and Harrich, David (2019). Oxazole-benzenesulfonamide derivatives inhibit HIV-1 reverse transcriptase interaction with cellular eEF1A and reduce viral replication. Journal of Virology, 93 (12) e0023919. doi: 10.1128/jvi.00239-19 |
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2019 Journal Article Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitroAlgate, Kent, Haynes, David, Fitzsimmons, Tracy, Romeo, Ornella, Wagner, Florence, Holson, Edward, Reid, Robert, Fairlie, David, Bartold, Peter and Cantley, Melissa (2019). Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro. Journal of Cellular Biochemistry, 121 (1) jcb.29137, 244-258. doi: 10.1002/jcb.29137 |
