Dr Robert Reid
Dr

Robert Reid

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Background

I am an Organic Chemist and research the design and preparation of new medicines for diseases including arthritis and cancer

Dr. Robert C. Reid was awarded B.Sc. Hons 1 (1986) and Ph.D. (1990) degrees from the University of Sydney, Department of Organic Chemistry. He studied the stereospecific total synthesis of complex natural products with Professor Max J. Crossley and then undertook postdoctoral studies with Professor Sir Jack E. Baldwin FRS at the Dyson Perrins Laboratory, Oxford University UK (1990-93) studying the biosynthesis of penicillins. He is a Senior Research Fellow at the Institute for Molecular Bioscience (formerly known as the Centre for Drug Design and Development) at the University of Queensland with Professor David Fairlie. Research interests include Organic Synthesis, medicinal chemistry, drug design and development, nonpeptidic GPCR antagonists, natural products, protease inhibitors, other enzyme inhibitors, and peptidomimetics.

Availability

Dr Robert Reid is:
Available for supervision
Media expert

Fields of research

Biomedical and Clinical Sciences Chemical Sciences Medicinal and biomolecular chemistry Organic chemistry Pharmacology and pharmaceutical sciences

Qualifications

  • Bachelor (Honours) of Science (Advanced), University of Sydney
  • Doctor of Philosophy of Organic Chemistry, University of Sydney

Search Professor Robert Reid’s works on UQ eSpace

103 works between 1994 and 2025
All (103) Journal Article (85) Other Outputs (5) Conference Publication (11) Book Chapter (2)

41 - 60 of 103 works

2015

Journal Article

Peptide inhibitors of the Escherichia coli DsbA oxidative machinery essential for bacterial virulence

Duprez, Wilko, Premkumar, Lakshmanane, Halili, Maria A., Lindahl, Fredrik, Reid, Robert C., Fairlie, David P. and Martin, Jennifer L. (2015). Peptide inhibitors of the Escherichia coli DsbA oxidative machinery essential for bacterial virulence. Journal of Medicinal Chemistry, 58 (2), 577-587. doi: 10.1021/jm500955s

Peptide inhibitors of the Escherichia coli DsbA oxidative machinery essential for bacterial virulence

2015

Journal Article

Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system

Halili, Maria A., Bachu, Prabhakar, Lindahl, Fredrik, Bechara, Cherine, Mohanty, Biswaranjan, Reid, Robert C., Scanlon, Martin, Robinson, Carol V., Fairlie, David P. and Martin, Jennifer L. (2015). Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system. ACS Chemical Biology, 10 (4), 957-964. doi: 10.1021/cb500988r

Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system

2015

Conference Publication

Downsizing Proteins Without Losing Potency or Function

Fairlie, David P. , Yau, Mei-Kwan , Hamidon, Johan K. , Singh, Ranee , Lim, Junxian , Suen, Jacky Y. , Rowley, Jessica A. , Lohman, Rink-Jan , Stoermer, Martin J. , Iyer, Abishek and Reid, Robert C. (2015). Downsizing Proteins Without Losing Potency or Function. American Peptide Symposium 2015, Orlando , Florida, United States, 20-25 June 2015. American Peptide Society. doi: 10.17952/24APS.2015.016

Downsizing Proteins Without Losing Potency or Function

2014

Journal Article

Potent heterocyclic ligands for human complement C3a receptor

Reid, Robert C., Yau, Mei-Kwan, Singh, Ranee, Hamidon, Johan K., Lim, Junxian, Stoermer, Martin J. and Fairlie, David P. (2014). Potent heterocyclic ligands for human complement C3a receptor. Journal of Medicinal Chemistry, 57 (20), 8459-8470. doi: 10.1021/jm500956p

Potent heterocyclic ligands for human complement C3a receptor

2013

Journal Article

Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages

Shakespear, Melanie R., Hohenhaus, Daniel M., Kelly, Greg M., Kamal, Nabilah A., Gupta, Praveer, Labzin, Larisa I., Schroder, Kate, Garceau, Valerie, Barbero, Sheila, Iyer, Abishek, Hume, David A., Reid, Robert C., Irvine, Katharine M., Fairlie, David P. and Sweet, Matthew J. (2013). Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages. Journal of Biological Chemistry, 288 (35), 25362-25374. doi: 10.1074/jbc.M113.496281

Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages

2013

Journal Article

C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling

Liu, Junxian, Iyer, Abishek, Suen, Jacky Y., Seow, Vernon, Reid, Robert C., Brown, Lindsay and Fairlie, David P. (2013). C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling. The FASEB Journal, 27 (2), 822-831. doi: 10.1096/fj.12-220582

C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling

2013

Conference Publication

Toward more orally bioavailable inhibitors of phospholipase A(2) GIIA (pla2g2a) to treat chronic inflammation

Barbero, Sheila, Reid, Robert C., Stoermer, Martin J., Lohman, Rink J. and Fairlie, David P. (2013). Toward more orally bioavailable inhibitors of phospholipase A(2) GIIA (pla2g2a) to treat chronic inflammation. 246th National Meeting of the American-Chemical-Society (ACS), Indianapolis, IN, United States, 8-12 September 2013. Washington, DC, United States: American Chemical Society.

Toward more orally bioavailable inhibitors of phospholipase A(2) GIIA (pla2g2a) to treat chronic inflammation

2013

Journal Article

Efficient chemical synthesis of human complement protein C3a

Ghassemian, Artin, Wang, Ching-I Anderson, Yau, Mei-Kwan, Reid, Robert C., Lewis, Richard J., Fairlie, David P., Alewood, Paul F. and Durek, Thomas (2013). Efficient chemical synthesis of human complement protein C3a. Chemical Communications, 49 (23), 2356-2358. doi: 10.1039/c3cc40537k

Efficient chemical synthesis of human complement protein C3a

2012

Journal Article

An inhibitor of phospholipase A2 group IIA modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats

Iyer, Abishek, Lim, Junxian, Poudyal, Hemant, Reid, Robert C., Suen, Jacky Y., Webster, Julie, Prins, Johannes B., Whitehead, Jonathan P., Fairlie, David P. and Brown, Lindsay (2012). An inhibitor of phospholipase A2 group IIA modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats. Diabetes, 61 (9), 2320-2329. doi: 10.2337/db11-1179

An inhibitor of phospholipase A2 group IIA modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats

2012

Journal Article

Towards isozyme-selective HDA inhibitors for interrogating disease

Gupta, Praveer, Reid, Robert C., Iyer, Abishek, Sweet, Matthew J. and Fairlie, David (2012). Towards isozyme-selective HDA inhibitors for interrogating disease. Current Topics in Medicinal Chemistry, 12 (14), 1479-1499. doi: 10.2174/156802612802652420

Towards isozyme-selective HDA inhibitors for interrogating disease

2011

Journal Article

Inhibition of inflammation and fibrosis by a complement C5a receptor antagonist in DOCA-salt hypertensive rats

Iyer, Abishek, Woodruff, Trent M., Wu, Mike C. L., Stylianou, Con, Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and Brown, Lindsay (2011). Inhibition of inflammation and fibrosis by a complement C5a receptor antagonist in DOCA-salt hypertensive rats. Journal of Cardiovascular Pharmacology, 58 (5), 479-486. doi: 10.1097/FJC.0b013e31822a7a09

Inhibition of inflammation and fibrosis by a complement C5a receptor antagonist in DOCA-salt hypertensive rats

2011

Conference Publication

Novel agonists and antagonists for protease activated receptor 2

Yau, Annika M., Liu, Ligong, Reid, Robert C., Barry, Grant D., Suen, Jacky Y., Lohman, Rink-Jan, Le, Giang T., Cotterell, Adam and Fairlie, David P. (2011). Novel agonists and antagonists for protease activated receptor 2. National Meeting of the American Chemical Society (242nd, ACS, 2011), Denver, CO, U.S.A., 28 August-1 September 2011. WASHINGTON: AMER CHEMICAL SOC.

Novel agonists and antagonists for protease activated receptor 2

2010

Journal Article

Inhibitors selective for HDAC6 in enzymes and cells

Gupta, Praveer K., Reid, Robert C., Liu, Ligong, Lucke, Andrew J., Broomfield, Steve A., Andrews, Melanie R., Sweet, Matthew J. and Fairlie, David P. (2010). Inhibitors selective for HDAC6 in enzymes and cells. Bioorganic & Medicinal Chemistry Letters, 20 (23), 7067-7070. doi: 10.1016/j.bmcl.2010.09.100

Inhibitors selective for HDAC6 in enzymes and cells

2010

Journal Article

Antimalarial histone deacetylase inhibitors containing cinnamate or NSAID components

Wheatley, Nicole C., Andrews, Katherine T., Tran, Truc L., Lucke, Andrew J., Reid, Robert C. and Fairlie, David P. (2010). Antimalarial histone deacetylase inhibitors containing cinnamate or NSAID components. Bioorganic & Medicinal Chemistry Letters, 20 (23), 7080-7084. doi: 10.1016/j.bmcl.2010.09.096

Antimalarial histone deacetylase inhibitors containing cinnamate or NSAID components

2010

Journal Article

Selective Hexapeptide Agonists and Antagonists for Human Complement C3a Receptor (Journal of Medicinal Chemistry (2010) 53 (4938)

Scully, Conor C. G., Blakeney, Jade S., Singh, Ranee, Hoang, Huy N., Abbenante, Giovanni, Reid, Robert C. and Fairlie, David P. (2010). Selective Hexapeptide Agonists and Antagonists for Human Complement C3a Receptor (Journal of Medicinal Chemistry (2010) 53 (4938). Journal of Medicinal Chemistry, 53 (22), 8208-8208. doi: 10.1021/jm1013314

Selective Hexapeptide Agonists and Antagonists for Human Complement C3a Receptor (Journal of Medicinal Chemistry (2010) 53 (4938)

2010

Journal Article

Novel agonists and antagonists for human protease activated receptor 2

Barry, Grant D., Suen, Jacky Y., Le, Giang T., Cotterell, Adam, Reid, Robert C. and Fairlie, David P. (2010). Novel agonists and antagonists for human protease activated receptor 2. Journal of Medicinal Chemistry, 53 (20), 7428-7440. doi: 10.1021/jm100984y

Novel agonists and antagonists for human protease activated receptor 2

2010

Journal Article

Benzhydrylamine linker grafting: A strategy for the improved synthesis of C-terminal peptide amides

Alewood, Dianne, Hopping, Gene, Brust, Andreas, Reid, Robert C. and Alewood, Paul F. (2010). Benzhydrylamine linker grafting: A strategy for the improved synthesis of C-terminal peptide amides. Journal of Peptide Science, 16 (10), 551-557. doi: 10.1002/psc.1248

Benzhydrylamine linker grafting: A strategy for the improved synthesis of C-terminal peptide amides

2010

Journal Article

Selective hexapeptide agonists and antagonists for human complement C3a receptor

Scully, Conor C. G., Blakeney, Jade S., Singh, Ranee, Hoang, Huy N., Abbenante, Giovanni, Reid, Robert C. and Fairlie, David P. (2010). Selective hexapeptide agonists and antagonists for human complement C3a receptor. Journal of Medicinal Chemistry, 53 (13), 4938-4948. doi: 10.1021/jm1003705

Selective hexapeptide agonists and antagonists for human complement C3a receptor

2010

Journal Article

Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS

Halili, Maria A., Andrews, Melanie R., Labzin, Larisa I., Schroder, Kate, Matthias, Gabriele, Cao, Chun, Lovelace, Erica, Reid, Robert C., Le, Giang T., Hume, David A., Irvine, Katharine M., Matthias, Patrick, Fairlie, David P. and Sweet, Matthew J. (2010). Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. Journal of Leukocyte Biology, 87 (6), 1103-1114. doi: 10.1189/jlb.0509363

Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS

2010

Journal Article

Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats

Iyer, Abishek, Fenning, Andrew, Lim, Junxian, Le, Giang T, Reid, Robert C, Halili, Maria A, Fairlie, David P and Brown, Lindsay (2010). Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats. British Journal of Pharmacology, 159 (7), 1408-1417. doi: 10.1111/j.1476-5381.2010.00637.x

Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats

Past funding

  • 2014
    Continuous-Flow Hydrogenation Reactor (H-Cube Pro)
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Peptide Drug Synthesis and Purification Unit
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    Combinatorial chemistry (high throughput synthesizer and purification system)
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2012
    Inhibitors of Secretory Phospholipases in Diet Induced Obese Rats
    NHMRC Project Grant
    Open grant
  • 2009 - 2012
    Protease Activated Receptor 2 : A New Drug Target For Inflammatory Diseases and Cancer
    NHMRC Project Grant
    Open grant
  • 2008 - 2010
    Molecular attributes and physiological significance of beta1L-adrenoceptors
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    DsbA inhibitors as potential antimicrobials
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    Targeting A Complement Receptor That Regulates Inflammatory Disease
    NHMRC Project Grant
    Open grant
  • 2000
    Development of inhibit
    UQ External Support Enabling Grant
    Open grant

Availability

Dr Robert Reid is:
Available for supervision

Looking for a supervisor? Read our advice on how to choose a supervisor.

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Dr Robert Reid directly for media enquiries about:

  • Chemical Analysis
  • HPLC
  • LCMS
  • Medicinal Chemistry
  • NMR
  • Organic Chemistry
  • Organic Synthesis
  • Spectroscopy

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