
Overview
Availability
- Professor Glenn King is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Science, University of Sydney
- Doctor of Philosophy, University of Sydney
Research interests
-
Bugs and drugs
Our research harnesses the chemistry of venoms from arthropod predators, such as spiders, scorpions and centipedes, to develop novel pharmaceuticals to treat chronic pain, epilepsy and stroke. Stroke is the second-leading cause of death worldwide. In addition, it causes an extremely high incidence of disability in surviving victims due to the brain damage suffered during stroke. Likewise, chronic pain is a huge medical problem that affects one in five adults. There are few drugs available for treating chronic pain, and many of these have limited efficacy and dose-limiting side effects. Animal venoms are a rich source of stable natural peptides that potently modulate the activity of a wide range of neuronal ion channels and receptors. We have the largest collection of arthropod venoms in the world, a high-throughput pipeline for venoms-based drug discovery, protocols for rapid protein expression and structure determination, and links to key laboratories for testing the efficacy of lead molecules in rodent models of pain, epilepsy and stroke. We are using these world-class resources to move us closer to achieving our aim of developing novel analgesics for pain relief, novel drugs for treating severe paediatric epilepsies, and novel neuroprotective agents for treating stroke victims. An equally important focus of our research is on helping to safeguard Australia’s agricultural crops and reduce the spread of disease from insect pests by discovering new environmentally friendly insecticides. Currently, arthropod pests destroy approximately 15 per cent of the world’s food supply and spread pernicious diseases such as dengue and malaria. Our work is finding better, safer ways to control disease-spreading pests and protect crops.
Works
Search Professor Glenn King’s works on UQ eSpace
2004
Journal Article
Australian funnel-web spiders: master insecticide chemists
Tedford, H. W., Sollod, B. L., Maggio, F. and King, G. F. (2004). Australian funnel-web spiders: master insecticide chemists. Toxicon, 43 (5), 601-618. doi: 10.1016/j.toxicon.2004.02.010
2004
Journal Article
Structure and mechanism of action of Sda, an inhibitor of the histidine kinases that regulate initiation of sporulation in Bacillus subtilis
Rowland, S. L., Burkholder, W. F., Cunningham, K. A., Maciejewski, M. W., Grossman, A. D. and King, G. F. (2004). Structure and mechanism of action of Sda, an inhibitor of the histidine kinases that regulate initiation of sporulation in Bacillus subtilis. Molecular Cell, 13 (5), 689-701. doi: 10.1016/S1097-2765(04)00084-X
2004
Journal Article
Positioning of the MinE binding site on the MinD surface suggests a plausible mechanism for activation of the Escherichia coli MinD ATPase during division site selection
Ma, L. Y., King, G. F. and Rothfield, L. (2004). Positioning of the MinE binding site on the MinD surface suggests a plausible mechanism for activation of the Escherichia coli MinD ATPase during division site selection. Molecular Microbiology, 54 (1), 99-108. doi: 10.1111/j.1365-2958.2004.04265.x
2004
Journal Article
Differential hydrolysis of erythrocyte and mitochondrial membrane phospholipids by two phospholipase A(2) isoenzymes (NK-PLA(2)-I and NK-PLA(2)-II) from the venom of the Indian monocled cobra Naja kaouthia
Doley, R., King, G. F. and Mukherjee, A. K. (2004). Differential hydrolysis of erythrocyte and mitochondrial membrane phospholipids by two phospholipase A(2) isoenzymes (NK-PLA(2)-I and NK-PLA(2)-II) from the venom of the Indian monocled cobra Naja kaouthia. Archives of Biochemistry And Biophysics, 425 (1), 1-13. doi: 10.1016/j.abb.2004.02.007
2004
Journal Article
The wonderful world of spiders: preface to the special Toxicon issue on spider venoms
King, Glenn F. (2004). The wonderful world of spiders: preface to the special Toxicon issue on spider venoms. Toxicon, 43 (5), 471-475. doi: 10.1016/j.toxicon.2004.02.001
2003
Journal Article
The MinD membrane targeting sequence is a transplantable lipid-binding helix
Szeto, T. H., Rowland, S. L., Habrukowich, C. L. and King, G. F. (2003). The MinD membrane targeting sequence is a transplantable lipid-binding helix. Journal of Biological Chemistry, 278 (41), 40050-40056. doi: 10.1074/jbc.M306876200
2003
Book Chapter
Macromolecular structure determination: comparison of crystallography and NMR
Guss, J. M. and King, G. F. (2003). Macromolecular structure determination: comparison of crystallography and NMR. Encyclopedia of the Human Genome. (pp. xx-xx) edited by David N. Cooper. Hoboken, N. J .: Wiley.
2003
Journal Article
Mapping the MinE site involved in interaction with the MinD division site selection protein of Escherichia coli
Ma, L. Y., King, G. and Rothfield, L. (2003). Mapping the MinE site involved in interaction with the MinD division site selection protein of Escherichia coli. Journal of Bacteriology, 185 (16), 4948-4955. doi: 10.1128/JB.185.16.4948-4955.2003
2002
Journal Article
Polar explorers: Membrane proteins that determine division site placement (vol 106, pg 13, 2001)
Rothfield, LI, Shih, YL and King, G (2002). Polar explorers: Membrane proteins that determine division site placement (vol 106, pg 13, 2001). Cell, 110 (4), 533-533. doi: 10.1016/S0092-8674(02)00903-0
2002
Journal Article
Scanning mutagenesis of a Janus-faced atracotoxin reveals a bipartite surface patch that is essential for neurotoxic function
Maggio, F. and King, G. F. (2002). Scanning mutagenesis of a Janus-faced atracotoxin reveals a bipartite surface patch that is essential for neurotoxic function. Journal of Biological Chemistry, 277 (25), 22806-22813. doi: 10.1074/jbc.M202297200
2002
Journal Article
Membrane localization of MinD is mediated by a C-terminal motif that is conserved across eubacteria, archaea, and chloroplasts
Szeto, T. H., Rowland, S. L., Rothfield, L. I. and King, G. F. (2002). Membrane localization of MinD is mediated by a C-terminal motif that is conserved across eubacteria, archaea, and chloroplasts. Proceedings of The National Academy of Sciences of The United States of America, 99 (24), 15693-15698. doi: 10.1073/pnas.232590599
2002
Journal Article
Letter to the Editor: Backbone and side-chain 1H, 15N, and 13C assignments for chick cofilin
Bains, N. P. S., Gorbatyuk, V. Y., Nosworthy, N. J., Robson, S. A., Maciejewski, M. W., dos Remedios, C. G. and King, G. F. (2002). Letter to the Editor: Backbone and side-chain 1H, 15N, and 13C assignments for chick cofilin. Journal of Biomolecular Nmr, 22 (2), 193-194. doi: 10.1023/A:1014227808686
2002
Journal Article
Role of interfacial hydrophobic residues in the stabilization of the leucine zipper structures of the transcription factors c-Fos and c-Jun
Boysen, R. I., Jong, A. J. O., Wilce, J. A., King, G. F. and Hearn, M. T. W. (2002). Role of interfacial hydrophobic residues in the stabilization of the leucine zipper structures of the transcription factors c-Fos and c-Jun. Journal of Biological Chemistry, 277 (1), 23-31. doi: 10.1074/jbc.M104556200
2002
Journal Article
Division site placement in E.coli: mutations that prevent formation of the MinE ring lead to loss of the normal midcell arrest of growth of polar MinD membrane domains
Shih, Y. L., Fu, X. L., King, G. F., Le, T. and Rothfield, L. (2002). Division site placement in E.coli: mutations that prevent formation of the MinE ring lead to loss of the normal midcell arrest of growth of polar MinD membrane domains. Embo Journal, 21 (13), 3347-3357. doi: 10.1093/emboj/cdf323
2002
Journal Article
Structure and function of insecticidal neurotoxins from Australian funnel-web spiders
King, G. F., Tedford, H. W. and Maggio, F. (2002). Structure and function of insecticidal neurotoxins from Australian funnel-web spiders. Journal of Toxicology: Toxin Reviews, 21 (4), 359-389. doi: 10.1081/TXR-120014409
2002
Journal Article
The Bacillus subtilis cell division proteins FtsL and DivIC are intrinsically unstable and do not interact with one another in the absence of other septasomal components
Robson, S. A., Michie, K. A., Mackay, J. P., Harry, E. and King, G. F. (2002). The Bacillus subtilis cell division proteins FtsL and DivIC are intrinsically unstable and do not interact with one another in the absence of other septasomal components. Molecular Microbiology, 44 (3), 663-674. doi: 10.1046/j.1365-2958.2002.02920.x
2002
Journal Article
Role of the structurally disordered N- and C-terminal residues in the Janus-faced atracotoxins
Maggio, F. and King, G. F. (2002). Role of the structurally disordered N- and C-terminal residues in the Janus-faced atracotoxins. Toxicon, 40 (9), 1355-1361. doi: 10.1016/S0041-0101(02)00154-X
2001
Journal Article
The dimerization function of MinC resides in a structurally autonomous C-terminal domain
Szeto, T. H., Rowland, S. L. and King, G. F. (2001). The dimerization function of MinC resides in a structurally autonomous C-terminal domain. Journal of Bacteriology, 183 (22), 6684-6687. doi: 10.1128/JB.183.22.6684-6687.2001
2001
Journal Article
Functional significance of the beta-hairpin in the insecticidal neurotoxin omega-atracotoxin-Hv1a
Tedford, H. W., Fletcher, J. I. and King, G. F. (2001). Functional significance of the beta-hairpin in the insecticidal neurotoxin omega-atracotoxin-Hv1a. Journal of Biological Chemistry, 276 (28), 26568-26576. doi: 10.1074/jbc.M102199200
2001
Book Chapter
Termination of replication in bacteria
Wilce, Jackie A., Wake, R. Gerry and King, Glenn F. (2001). Termination of replication in bacteria. Encyclopedia of life sciences. (pp. 1-7) Hoboken, NJ, United States: John Wiley and Sons. doi: 10.1038/npg.els.0001056
Funding
Current funding
Past funding
Supervision
Availability
- Professor Glenn King is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Identifying the structure, function, and mechanism of action of cardiotoxic components in the venoms of box (Chironex fleckeri) and Irukandji (Carukia barnesi) jellyfish
Principal Advisor
Other advisors: Professor Nathan Palpant, Dr Andrew Walker
-
Doctor Philosophy
Understanding the production, composition, and function of venom produced by the box jellyfish Chironex fleckeri and the Irukandji jellyfish Carukia barnesi
Principal Advisor
Other advisors: Professor Nathan Palpant, Dr Andrew Walker
-
Doctor Philosophy
Understanding the production, composition, and function of venom produced by the box jellyfish Chironex fleckeri and the Irukandji jellyfish Carukia barnesi
Principal Advisor
Other advisors: Professor Nathan Palpant, Dr Andrew Walker
-
Doctor Philosophy
Venom-derived drugs for targeting ion channels involved in genetic epilepsies
Principal Advisor
Other advisors: Associate Professor Lata Vadlamudi
-
Doctor Philosophy
Development of a first-in-class biologic drug for stroke
Principal Advisor
Other advisors: Dr Natalie Saez
-
Doctor Philosophy
Evolution and function of nettle caterpillar venom toxins
Associate Advisor
Other advisors: Dr Andrew Walker
-
Doctor Philosophy
Characterising the Structure and Function of Caterpillar Venom Toxins
Associate Advisor
Other advisors: Dr Andrew Walker
-
Master Philosophy
Pharmacological screening of Columbian scorpion venoms
Associate Advisor
Other advisors: Dr Andrew Walker
-
Doctor Philosophy
Using genetics to predict drug efficacy and on-target side effects of pharmacological agents
Associate Advisor
Other advisors: Associate Professor Sonia Shah, Professor David Evans
-
Doctor Philosophy
Evaluation of Phylogenetic Patterns of Scorpion Pathophysiological Effects and Effectiveness of Next-Generation Antivenoms
Associate Advisor
Other advisors: Dr Sam Robinson, Professor Bryan Fry
-
Doctor Philosophy
Selective modulation voltage gated sodium channels to investigate pathophysiology and treatment for motor neuron disease
Associate Advisor
Other advisors: Dr Fernanda Cardoso
-
Doctor Philosophy
Evaluation of Phylogenetic Patterns of Scorpion Pathophysiological Effects and Effectiveness of Next-Generation Antivenoms
Associate Advisor
Other advisors: Dr Sam Robinson, Professor Bryan Fry
-
Doctor Philosophy
Utilising invertebrates to identify novel coagulotoxins
Associate Advisor
Other advisors: Professor Bryan Fry, Dr Andrew Walker
Completed supervision
-
2024
Doctor Philosophy
Enhancing the efficacy of venom-derived peptide therapeutics for the treatment of ion channel diseases
Principal Advisor
Other advisors: Dr Natalie Saez
-
2024
Doctor Philosophy
Cyclic peptides as therapeutics for ischemic heart disease and heart failure
Principal Advisor
Other advisors: Professor Nathan Palpant
-
2024
Doctor Philosophy
Venomous Mechanisms: Structural Studies of Venom Modalities
Principal Advisor
Other advisors: Associate Professor Michael Landsberg
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2023
Doctor Philosophy
Identification and Evaluation of Macrocyclic hASIC1a Inhibitors for Neuroprotective Applications
Principal Advisor
-
2023
Doctor Philosophy
Venom Components as Analgesics and Pharmacological Tools to Elucidate Mammalian Pain Signalling Pathways
Principal Advisor
Other advisors: Associate Professor Markus Muttenthaler, Dr Fernanda Cardoso
-
2022
Doctor Philosophy
Discovery and characterisation of two orally active insecticidal spider-venom peptides and elucidation of the molecular basis of their oral activity
Principal Advisor
-
2021
Doctor Philosophy
Is acid sensing ion channel 1a a viable therapeutic for spinal cord injury?
Principal Advisor
Other advisors: Professor Marc Ruitenberg
-
2021
Doctor Philosophy
Arthropod venoms in antiparasitic drug discovery: isolation and biological characterisation of venom-derived anthelmintic compounds
Principal Advisor
Other advisors: Adjunct Professor Andrew Kotze
-
2020
Doctor Philosophy
Discovery of novel cyclic peptide acid sensing ion channel-1a inhibitors to protect heart from ischemia-reperfusion injury
Principal Advisor
-
2020
Doctor Philosophy
Rational development of analgesics for the treatment of chronic pain: dissecting the molecular details of the interaction between gating modifier peptide modulators and human voltage-gated sodium channels
Principal Advisor
Other advisors: Professor Mehdi Mobli
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2019
Doctor Philosophy
Development of NaV1.1-selective agonists with potential for treatment of Dravet syndrome epilepsy
Principal Advisor
-
2019
Doctor Philosophy
Discovery and characterisation of novel spider venom peptides targeting the human NaV1.7 channel
Principal Advisor
-
2018
Doctor Philosophy
A combined proteomic and transcriptomic investigation of venom from Australian sea anemones
Principal Advisor
-
2017
Doctor Philosophy
Peptide modulators of ASIC1a: a putative drug target for the treatment of stroke
Principal Advisor
Other advisors: Dr Lachlan Rash
-
2017
Doctor Philosophy
Biotechnological applications of spider venom peptides
Principal Advisor
Other advisors: Dr Lachlan Rash
-
2016
Master Philosophy
Venoms-based discovery of novel modulators of human neuronal ¿7 and ¿3* nicotinic acetylcholine receptors
Principal Advisor
-
2015
Doctor Philosophy
Understanding the molecular basis of the interaction between spider toxins and the voltage sensor domain of voltage-gated ion channels
Principal Advisor
Other advisors: Professor Mehdi Mobli
-
2015
Doctor Philosophy
Engineering Insect-Resistant Plants by Transgenic Expression of an Insecticidal Spider-Venom Peptide
Principal Advisor
-
2015
Doctor Philosophy
Bioinsecticides for the control of human disease vectors
Principal Advisor
Other advisors: Professor Mehdi Mobli
-
2015
Doctor Philosophy
Developing Novel Analgesics To Treat Chronic Pain: Inhibiting Voltage Gated Sodium Channel 1.7 With Spider-Venom Peptides
Principal Advisor
-
2014
Doctor Philosophy
Structural and mechanistic studies of a bacterial histidine kinase
Principal Advisor
-
2014
Doctor Philosophy
Centipede Venom Evolution: Casting light on a neglected group of venomous animals
Principal Advisor
Other advisors: Professor Bryan Fry
-
2013
Doctor Philosophy
Characterisation of spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads for the treatment of chronic pain
Principal Advisor
Other advisors: Professor Mehdi Mobli
-
2013
Doctor Philosophy
The Bio-logic of Venom Complexity: A Chemical and Evolutionary Investigation into the Role of Venom Complexity in Two Orders of Venomous Animals
Principal Advisor
-
2013
Doctor Philosophy
Characterising the molecular basis of the interaction between the putative drug target ASIC1a and pi-TRTX-Pc1a
Principal Advisor
Other advisors: Dr Lachlan Rash
-
2013
Doctor Philosophy
Dissecting the interaction between the sea anemone toxin APETx2 and its analgesic target, acid-sensing ion channel 3
Principal Advisor
Other advisors: Dr Lachlan Rash
-
2012
Doctor Philosophy
Probing the chemical diversity of venom from the Australian funnel-web spider Hadronyche infensa
Principal Advisor
-
2011
Doctor Philosophy
Isolation and characterization of orally active insecticidal peptides from spider venoms
Principal Advisor
-
2009
Doctor Philosophy
Unraveling the role of the bacterial cell division protein DivIB
Principal Advisor
-
2019
Doctor Philosophy
Discovery and modulation of acid-sensing ion channel modulating venom peptides
Associate Advisor
Other advisors: Dr Lachlan Rash
-
2019
Doctor Philosophy
Structural studies of the Yersinia entomophaga ABC toxin complex YenTc using cryo-EM
Associate Advisor
Other advisors: Associate Professor Michael Landsberg
-
2019
Doctor Philosophy
Tarantulas of Australia: phylogenetics and venomics
Associate Advisor
Other advisors: Associate Professor Lyn Cook, Professor Bryan Fry
-
2018
Doctor Philosophy
In vivo protein splicing of secreted cysteine-rich repeat proteins and their structural characterization by NMR spectroscopy
Associate Advisor
Other advisors: Professor Mehdi Mobli
-
2016
Doctor Philosophy
A philosophical and empirical investigation of the evolution of the toxicoferan reptile venom system
Associate Advisor
Other advisors: Professor Irina Vetter, Professor Bryan Fry
-
-
2013
Doctor Philosophy
The impact of parasitism on the host transcriptome and microRNA profile in Diadegma semiclausum - Plutella xylostella system
Associate Advisor
Other advisors: Professor Sassan Asgari
-
2012
Doctor Philosophy
Investigation of novel bioactive peptides from Australian venomous animals
Associate Advisor
Media
Enquiries
Contact Professor Glenn King directly for media enquiries about:
- Chronic pain
- Dravet syndrome
- drug discovery
- epilepsy
- Insecticides
- Ion channel drugs
- NMR spectroscopy
- pain drugs
- painkillers
- peptide drugs
- Protein structure
- Stroke
- Venomous animals
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