
Overview
Background
Dr Gratten completed his undergraduate studies and PhD at The University of Queensland, before undertaking postdoctoral training in evolutionary and quantitative genetics at the University of Sheffield. He then returned to Australia and shifted research focus to psychiatric and neurological genetics, taking up a position as research fellow at the Queensland Brain Institute. In 2013, he was recruited to UQ's Centre for Neurogenetics and Statistical Genomics, and in 2017 was awarded an NHMRC Career Development Fellowship (Level 2). He established the Cognitive Health Genomics group at Mater Research Institute in 2018, with the goal to improve understanding of the etiology of psychiatric and neurological disorders through analysis and integration of whole genome datasets. He has received >$5M in research funding from the NHMRC, Autism Cooperative Research Centre and both Australian (BICARE) and international (Brain & Behavior Research Foundation) philanthropic funders.
Availability
- Honorary Professor Jake Gratten is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Bachelor (Honours) of Science, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Jake Gratten’s works on UQ eSpace
2017
Journal Article
Whole exome sequencing and DNA methylation analysis in a clinical amyotrophic lateral sclerosis cohort
Garton, Fleur C., Benyamin, Beben, Zhao, Qiongyi, Liu, Zhijun, Gratten, Jacob, Henders, Anjali K., Zhang, Zong-Hong, Edson, Janette, Furlong, Sarah, Morgan, Sarah, Heggie, Susan, Thorpe, Kathryn, Pfluger, Casey, Mather, Karen A., Sachdev, Perminder S., McRae, Allan F., Robinson, Matthew R., Shah, Sonia, Visscher, Peter M., Mangelsdorf, Marie, Henderson, Robert D., Wray, Naomi R. and McCombe, Pamela A. (2017). Whole exome sequencing and DNA methylation analysis in a clinical amyotrophic lateral sclerosis cohort. Molecular Genetics and Genomic Medicine, 5 (4), 418-428. doi: 10.1002/mgg3.302
2017
Journal Article
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease
Ji, Sun-Gou, Juran, Brian D., Mucha, Soeren, Folseraas, Trine, Jostins, Luke, Melum, Espen, Kumasaka, Natsuhiko, Atkinson, Elizabeth J., Schlicht, Erik M., Liu, Jimmy Z., Shah, Tejas, Gutierrez-Achury, Javier, Boberg, Kirsten M., Bergquist, Annika, Vermeire, Severine, Eksteen, Bertus, Durie, Peter R., Farkkila, Martti, Mueller, Tobias, Schramm, Christoph, Sterneck, Martina, Weismueller, Tobias J., Gotthardt, Daniel N., Ellinghaus, David, Braun, Felix, Teufel, Andreas, Laudes, Mattias, Lieb, Wolfgang, Jacobs, Gunnar ... Anderson, Carl A. (2017). Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. Nature Genetics, 49 (2), 269-273. doi: 10.1038/ng.3745
2017
Conference Publication
Evidence for genetic overlap between schizophrenia and maternal age at first birth
Mehta, Divya, Tropf, Felix, Gratten, Jacob, Bacanu, Silviu, Bakshi, Andrew, Mowry, Bryan, Kendler, Kenneth, Yang, Jian, Visscher, Peter, McGrath, John, Mills, Melinda, Wray, Naomi and Lee, Sang Hong (2017). Evidence for genetic overlap between schizophrenia and maternal age at first birth. 23rd Annual World Congress of Psychiatric Genetics (WCPG), Toronto, ON, Canada, 16-20 October 2015. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2015.09.010
2017
Conference Publication
Genome-wide association study of schizophrenia in the Iban of Sarawak reveals genetic overlap with Han Chinese and, to a lesser extent, Europeans
Periyasamy, Sathish, Barrett, Robert, Yue, Weihua, Gratten, Jacob, Nertney, Deborah, McLean, Duncan, Smith, Heather, Filippich, Cheryl, Loa, Peter, Zhang, Dai, Yolken, Robert and Mowry, Bryan (2017). Genome-wide association study of schizophrenia in the Iban of Sarawak reveals genetic overlap with Han Chinese and, to a lesser extent, Europeans. 23rd Annual World Congress of Psychiatric Genetics (WCPG), Toronto Canada, 16-20 October 2015. Amsterdam, Netherlands: Elsevier .
2016
Journal Article
Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence
Wang, Qin, Wurtz, Peter, Auro, Kirsi, Makinen, Ville-Petteri, Kangas, Antti J., Soininen, Pasi, Tiainen, Mika, Tynkkynen, Tuulia, Jokelainen, Jari, Santalahti, Kristiina, Salmi, Marko, Blankenberg, Stefan, Zeller, Tanja, Viikari, Jorma, Kahonen, Mika, Lehtimaki, Terho, Salomaa, Veikko, Perola, Markus, Jalkanen, Sirpa, Jarvelin, Marjo-Riitta, Raitakari, Olli T., Kettunen, Johannes, Lawlor, Debbie A. and Ala-Korpela, Mika (2016). Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence. Bmc Medicine, 14 205. doi: 10.1186/s12916-016-0733-0
2016
Journal Article
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses (vol 48, pg 624, 2016)
Okbay, Aysu, Baselmans, Bart M. L., De Neve, Jan-Emmanuel, Turley, Patrick, Nivard, Michel G., Fontana, Mark Alan, Meddens, S. Fleur W., Linner, Richard Karlsson, Rietveld, Cornelius A., Derringer, Jaime, Gratten, Jacob, Lee, James J., Liu, Jimmy Z., de Vlaming, Ronald, Ahluwalia, Tarunveer S., Buchwald, Jadwiga, Cavadino, Alana, Frazier-Wood, Alexis C., Furlotte, Nicholas A., Garfield, Victoria, Geisel, Marie Henrike, Gonzalez, Juan R., Haitjema, Saskia, Karlsson, Robert, van der Laan, Sander W., Ladwig, Karl-Heinz, Lahti, Jari, van der Lee, Sven J., Lind, Penelope A. ... Cesarini, David (2016). Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses (vol 48, pg 624, 2016). Nature Genetics, 48 (12), 1591-1591. doi: 10.1038/ng1216-1587b
2016
Journal Article
Genome-wide analysis identifies 12 loci influencing human reproductive behavior
Barban, Nicola, Jansen, Rick, de Vlaming, Ronald, Vaez, Ahmad, Mandemakers, Jornt J., Tropf, Felix C., Shen, Xia, Wilson, James F., Chasman, Daniel I., Nolte, Illa M., Tragante, Vinicius, van der Laan, Sander W., Perry, John R. B., Kong, Augustine, Ahluwalia, Tarunveer S., Albrecht, Eva, Yerges-Armstrong, Laura, Atzmon, Gil, Auro, Kirsi, Ayers, Kristin, Bakshi, Andrew, Ben-Avraham, Danny, Berger, Klaus, Bergman, Aviv, Bertram, Lars, Bielak, Lawrence F., Bjornsdottir, Gyda, Bonder, Marc Jan, Broer, Linda ... Mills, Melinda C. (2016). Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nature Genetics, 48 (12), 1462-1472. doi: 10.1038/ng.3698
2016
Journal Article
Genome-Wide Meta-Analysis of Sciatica in Finnish Population
Lemmela, Susanna, Solovieva, Svetlana, Shiri, Rahman, Benner, Christian, Heliovaara, Markku, Kettunen, Johannes, Anttila, Verneri, Ripatti, Samuli, Perola, Markus, Seppala, Ilkka, Juonala, Markus, Kahonen, Mika, Salomaa, Veikko, Viikari, Jorma, Raitakari, Olli T., Lehtimaki, Terho, Palotie, Aarno, Viikari-Juntura, Eira and Husgafvel-Pursiainen, Kirsti (2016). Genome-Wide Meta-Analysis of Sciatica in Finnish Population. Plos One, 11 (10) e0163877. doi: 10.1371/journal.pone.0163877
2016
Journal Article
Genome-wide associations for birth weight and correlations with adult disease
Horikoshi, Momoko, Beaumont, Robin N., Day, Felix R., Warrington, Nicole M., Kooijman, Marjolein N., Fernandez-Tajes, Juan, Feenstra, Bjarke, van Zuydam, Natalie R., Gaulton, Kyle J., Grarup, Niels, Bradfield, Jonathan P., Strachan, David P., Li-Gao, Ruifang, Ahluwalia, Tarunveer S., Kreiner, Eskil, Rueedi, Rico, Lyytikainen, Leo-Pekka, Cousminer, Diana L., Wu, Ying, Thiering, Elisabeth, Wang, Carol A., Have, Christian T., Hottenga, Jouke-Jan, Vilor-Tejedor, Natalia, Joshi, Peter K., Boh, Eileen Tai Hui, Ntalla, Ioanna, Pitkanen, Niina, Mahajan, Anubha ... Freathy, Rachel M. (2016). Genome-wide associations for birth weight and correlations with adult disease. Nature, 538 (7624), 248-252. doi: 10.1038/nature19806
2016
Journal Article
No association of coronary artery disease with X-chromosomal variants in comprehensive international meta-analysis
Loley, Christina, Alver, Maris, Assimes, Themistocles L., Bjonnes, Andrew, Goel, Anuj, Gustafsson, Stefan, Hernesniemi, Jussi, Hopewell, Jemma C., Kanoni, Stavroula, Kleber, Marcus E., Lau, King Wai, Lu, Yingchang, Lyytikainen, Leo-Pekka, Nelson, Christopher P., Nikpay, Majid, Qu, Liming, Salfati, Elias, Scholz, Markus, Tukiainen, Taru, Willenborg, Christina, Won, Hong-Hee, Zeng, Lingyao, Zhang, Weihua, Anand, Sonia S., Beutner, Frank, Bottinger, Erwin P., Clarke, Robert, Dedoussis, George, Do, Ron ... Koenig, Inke R. (2016). No association of coronary artery disease with X-chromosomal variants in comprehensive international meta-analysis. Scientific Reports, 6 35278. doi: 10.1038/srep35278
2016
Journal Article
Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence
Wang, Qin, Wurtz, Peter, Auro, Kirsi, Morin-Papunen, Laure, Kangas, Antti J., Soininen, Pasi, Tiainen, Mika, Tynkkynen, Tuulia, Joensuu, Anni, Havulinna, Aki S., Aalto, Kristiina, Salmi, Marko, Blankenberg, Stefan, Zeller, Tanja, Viikari, Jorma, Kahonen, Mika, Lehtimaki, Terho, Salomaa, Veikko, Jalkanen, Sirpa, Jarvelin, Marjo-Riitta, Perola, Markus, Raitakari, Olli T., Lawlor, Debbie A., Kettunen, Johannes and Ala-Korpela, Mika (2016). Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence. International Journal of Epidemiology, 45 (5), 1445-1457. doi: 10.1093/ije/dyw147
2016
Journal Article
Metabolic signatures of birthweight in 18 288 adolescents and adults
Wurtz, Peter, Wang, Qin, Niironen, Marjo, Tynkkynen, Tuulia, Tiainen, Mika, Drenos, Fotios, Kangas, Antti J., Soininen, Pasi, Skilton, Michael R., Heikkila, Kauko, Pouta, Anneli, Kahonen, Mika, Lehtimaki, Terho, Rose, Richard J., Kajantie, Eero, Perola, Markus, Kaprio, Jaakko, Eriksson, Johan G., Raitakari, Olli T., Lawlor, Debbie A., Smith, George Davey, Jarvelin, Marjo-Riitta, Ala-Korpela, Mika and Auro, Kirsi (2016). Metabolic signatures of birthweight in 18 288 adolescents and adults. International Journal of Epidemiology, 45 (5), 1539-1550. doi: 10.1093/ije/dyw255
2016
Journal Article
Metabolic profiling of alcohol consumption in 9778 young adults
Wurtz, Peter, Cook, Sarah, Wang, Qin, Tiainen, Mika, Tynkkynen, Tuulia, Kangas, Antti J., Soininen, Pasi, Laitinen, Jaana, Viikari, Jorma, Kahonen, Mika, Lehtimaki, Terho, Perola, Markus, Blankenberg, Stefan, Zeller, Tanja, Mannisto, Satu, Salomaa, Veikko, Jarvelin, Marjo-Riitta, Raitakari, Olli T., Ala-Korpela, Mika and Leon, David A. (2016). Metabolic profiling of alcohol consumption in 9778 young adults. International Journal of Epidemiology, 45 (5), 1493-1506. doi: 10.1093/ije/dyw175
2016
Journal Article
Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative <i>GFI1B</i> Splice Variants in Human Hematopoiesis
Polfus, Linda M., Khajuria, Rajiv K., Schick, Ursula M., Pankratz, Nathan, Pazoki, Raha, Brody, Jennifer A., Chen, Ming-Huei, Auer, Paul L., Floyd, James S., Huang, Jie, Lange, Leslie, van Rooij, Frank J. A., Gibbs, Richard A., Metcalf, Ginger, Muzny, Donna, Veeraraghavan, Narayanan, Walter, Klaudia, Chen, Lu, Yanek, Lisa, Becker, Lewis C., Peloso, Gina M., Wakabayashi, Aoi, Kals, Mart, Metspalu, Andres, Esko, Tonu, Fox, Keolu, Wallace, Robert, Franceschini, Nora, Matijevic, Nena ... Sankaran, Vijay G. (2016). Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis. American Journal of Human Genetics, 99 (2), 481-488. doi: 10.1016/j.ajhg.2016.06.016
2016
Journal Article
Predicting gene targets from integrative analyses of summary data from GWAS and eQTL studies for 28 human complex traits
Pavlides, Jennifer M. Whitehead, Zhu, Zhihong, Gratten, Jacob, Mcrae, Allan F., Wray, Naomi R. and Yang, Jian (2016). Predicting gene targets from integrative analyses of summary data from GWAS and eQTL studies for 28 human complex traits. Genome Medicine, 8 (1) 84, 84. doi: 10.1186/s13073-016-0338-4
2016
Journal Article
Genetic pleiotropy in complex traits and diseases: implications for genomic medicine
Gratten, Jacob and Visscher, Peter M. (2016). Genetic pleiotropy in complex traits and diseases: implications for genomic medicine. Genome Medicine, 8 (78) 78, 1-3. doi: 10.1186/s13073-016-0332-x
2016
Journal Article
Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in <i>ANGPTL4</i> determining fasting TG levels
van Leeuwen, Elisabeth M., Sabo, Aniko, Bis, Joshua C., Huffman, Jennifer E., Manichaikul, Ani, Smith, Albert V., Feitosa, Mary F., Demissie, Serkalem, Joshi, Peter K., Duan, Qing, Marten, Jonathan, van Klinken, Jan B., Surakka, Ida, Nolte, Ilja M., Zhang, Weihua, Mbarek, Hamdi, Li-Gao, Ruifang, Trompet, Stella, Verweij, Niek, Evangelou, Evangelos, Lyytikainen, Leo-Pekka, Tayo, Bamidele O., Deelen, Joris, van der Most, Peter J., van der Laan, Sander W., Arking, Dan E., Morrison, Alanna, Dehghan, Abbas, Franco, Oscar H. ... van Duijn, Cornelia M. (2016). Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels. Journal of Medical Genetics, 53 (7), 441-449. doi: 10.1136/jmedgenet-2015-103439
2016
Journal Article
Childhood Infections, Socioeconomic Status, and Adult Cardiometabolic Risk
Liu, Richard S., Burgner, David P., Sabin, Matthew A., Magnussen, Costan G., Cheung, Michael, Hutri-Kahonen, Nina, Kahonen, Mika, Lehtimaki, Terho, Jokinen, Eero, Laitinen, Tomi, Taittonen, Leena, Dwyer, Terence, Viikari, Jorma S. A., Kivimaki, Mika, Raitakari, Olli T. and Juonala, Markus (2016). Childhood Infections, Socioeconomic Status, and Adult Cardiometabolic Risk. Pediatrics, 137 (6) e20160236. doi: 10.1542/peds.2016-0236
2016
Journal Article
International genome-wide association study consortium identifies novel loci associated with blood pressure in children and adolescents
Parmar, Priyakumari Ganesh, Taal, H. Rob, Timpson, Nicholas J., Thiering, Elisabeth, Lehtimaki, Terho, Marinelli, Marcella, Lind, Penelope A., Howe, Laura D., Verwoert, Germaine, Aalto, Ville, Uitterlinden, Andre G., Briollais, Laurent, Evans, Dave M., Wright, Margie J., Newnham, John P., Whitfield, John B., Lyytikainen, Leo-Pekka, Rivadeneira, Fernando, Boomsma, Dorrett I., Viikari, Jorma, Gillman, Matthew W., St Pourcain, Beate, Hottenga, Jouke-Jan, Montgomery, Grant W., Hofman, Albert, Kahonen, Mika, Martin, Nicholas G., Tobin, Martin D., Raitakari, Ollie ... Palmer, Lyle J. (2016). International genome-wide association study consortium identifies novel loci associated with blood pressure in children and adolescents. Circulation: Cardiovascular Genetics, 9 (3), 266-278. doi: 10.1161/CIRCGENETICS.115.001190
2016
Journal Article
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Okbay, Aysu, Baselmans, Bart M. L., De Neve, Jan-Emmanuel, Turley, Patrick, Nivard, Michel G., Fontana, Mark Alan, Meddens, S. Fleur W., Linner, Richard Karlsson, Rietveld, Cornelius A., Derringer, Jaime, Gratten, Jacob, Lee, James J., Liu, Jimmy Z., de Vlaming, Ronald, Ahluwalia, Tarunveer S., Buchwald, Jadwiga, Cavadino, Alana, Frazier-Wood, Alexis C., Furlotte, Nicholas A., Garfield, Victoria, Geisel, Marie Henrike, Gonzalez, Juan R., Haitjema, Saskia, Karlsson, Robert, van der Laan, Sander W., Ladwig, Karl-Heinz, Lahti, Jari, van der Lee, Sven J., Lind, Penelope A. ... Cesarini, David (2016). Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nature Genetics, 48 (6), 624-633. doi: 10.1038/ng.3552
Funding
Current funding
Supervision
Availability
- Honorary Professor Jake Gratten is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
-
Understanding mechanisms underlying multiple sclerosis using large-scale multi-omics
We are seeking a highly motivated PhD candidate with a background and interest in human genomics, statistics and neurodegenerative disease to join the Cognitive Health Genomics group at the Mater Research Institute, UQ. The successful candidate would work on an NHMRC-funded study to improve understanding of the pathophysiology of multiple sclerosis by integrating large-scale multi-omics data using cutting-edge statistical methods.
Requirements
- Bachelor’s degree with first class honours, or Masters, in statistics, mathematics, bioinformatics, human genetics, animal breeding, or an equivalent field.
- Prior research experience in human genomics or animal breeding, including a familiarity with high-throughput genomic data and working in a high-performance computing environment.
- Skills in the R statistical computing language and/or python, C++ or an equivalent computing language.
- High degree of motivation and organisation, and an ability to work both independently and as part of a team.
- Excellent written and oral communications skills in English.
For further information please contact Prof Jake Gratten, jacob.gratten@mater.uq.edu.au.
Supervision history
Current supervision
-
Doctor Philosophy
Cellular genomics of Parkinson's disease
Principal Advisor
Other advisors: Dr Quan Nguyen, Dr Allan McRae, Dr Yuanhao Yang
-
Doctor Philosophy
Multiomics of common co-occurring conditions in autism spectrum disorder
Principal Advisor
Other advisors: Dr Allan McRae, Dr Yuanhao Yang
-
Doctor Philosophy
Using multi-omics approaches to characterise determinants of early growth trajectories and their consequences on later life health
Associate Advisor
Other advisors: Professor David Evans, Dr Nicole Warrington
Completed supervision
-
2022
Doctor Philosophy
Multi-omics data offer systemic insights into autism
Principal Advisor
Other advisors: Professor Naomi Wray, Professor Gerald Holtmann
-
2019
Doctor Philosophy
Systems Genomics of Parkinson's Disease
Principal Advisor
Other advisors: Professor Peter Visscher
-
2018
Master Philosophy
Integrating genome-wide association study data with gene expression to understand complex traits and common diseases
Principal Advisor
Other advisors: Dr Allan McRae, Professor Naomi Wray
-
2024
Doctor Philosophy
The Role of the Gut Microbiome in Psychiatric Illness: From Prenatal Risk Factors to Treatment Resistance
Associate Advisor
Other advisors: Professor Dan Siskind, Professor Darryl Eyles
-
2015
Doctor Philosophy
Analysis of non-coding RNA expression in schizophrenia brain
Associate Advisor
Other advisors: Professor Bryan Mowry
Media
Enquiries
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