Honorary Professor Jake Gratten
Honorary Professor

Jake Gratten

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Background

Dr Gratten completed his undergraduate studies and PhD at The University of Queensland, before undertaking postdoctoral training in evolutionary and quantitative genetics at the University of Sheffield. He then returned to Australia and shifted research focus to psychiatric and neurological genetics, taking up a position as research fellow at the Queensland Brain Institute. In 2013, he was recruited to UQ's Centre for Neurogenetics and Statistical Genomics, and in 2017 was awarded an NHMRC Career Development Fellowship (Level 2). He established the Cognitive Health Genomics group at Mater Research Institute in 2018, with the goal to improve understanding of the etiology of psychiatric and neurological disorders through analysis and integration of whole genome datasets. He has received >$5M in research funding from the NHMRC, Autism Cooperative Research Centre and both Australian (BICARE) and international (Brain & Behavior Research Foundation) philanthropic funders.

Availability

Honorary Professor Jake Gratten is:
Available for supervision

Fields of research

Biological Sciences Biomedical and Clinical Sciences Genetics Zoology

Qualifications

  • Bachelor of Science, The University of Queensland
  • Bachelor (Honours) of Science, The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Search Professor Jake Gratten’s works on UQ eSpace

204 works between 2001 and 2024
All (204) Journal Article (191) Conference Publication (11) Other Outputs (2)

121 - 140 of 204 works

2014

Journal Article

A metabolic view on menopause and ageing

Auro, Kirsi, Joensuu, Anni, Fischer, Krista, Kettunen, Johannes, Salo, Perttu, Mattsson, Hannele, Niironen, Marjo, Kaprio, Jaakko, Eriksson, Johan G., Lehtimaki, Terho, Raitakari, Olli, Jula, Antti, Tiitinen, Aila, Jauhiainen, Matti, Soininen, Pasi, Kangas, Antti J., Kahonen, Mika, Havulinna, Aki S., Ala-Korpela, Mika, Salomaa, Veikko, Metspalu, Andres and Perola, Markus (2014). A metabolic view on menopause and ageing. Nature Communications, 5 4708. doi: 10.1038/ncomms5708

A metabolic view on menopause and ageing

2014

Journal Article

Mitochondrial DNA Variants in Obesity

Knoll, Nadja, Jarick, Ivonne, Volckmar, Anna-Lena, Klingenspor, Martin, Illig, Thomas, Grallert, Harald, Gieger, Christian, Wichmann, Heinz-Erich, Peters, Annette, Wiegand, Susanna, Biebermann, Heike, Fischer-Posovszky, Pamela, Wabitsch, Martin, Voelzke, Henry, Nauck, Matthias, Teumer, Alexander, Rosskopf, Dieter, Rimmbach, Christian, Schreiber, Stefan, Jacobs, Gunnar, Lieb, Wolfgang, Franke, Andre, Hebebrand, Johannes and Hinney, Anke (2014). Mitochondrial DNA Variants in Obesity. Plos One, 9 (5) e94882. doi: 10.1371/journal.pone.0094882

Mitochondrial DNA Variants in Obesity

2014

Journal Article

High Birth Weight Is Associated With Obesity and Increased Carotid Wall Thickness in Young Adults The Cardiovascular Risk in Young Finns Study

Skilton, Michael R., Siitonen, Niina, Wuertz, Peter, Viikari, Jorma S. A., Juonala, Markus, Seppaelae, Ilkka, Laitinen, Tomi, Lehtimaeki, Terho, Taittonen, Leena, Kaehoenen, Mika, Celermajer, David S. and Raitakari, Olli T. (2014). High Birth Weight Is Associated With Obesity and Increased Carotid Wall Thickness in Young Adults The Cardiovascular Risk in Young Finns Study. Arteriosclerosis Thrombosis and Vascular Biology, 34 (5), 1064-1068. doi: 10.1161/ATVBAHA.113.302934

High Birth Weight Is Associated With Obesity and Increased Carotid Wall Thickness in Young Adults The Cardiovascular Risk in Young Finns Study

2014

Journal Article

Association of the novel single-nucleotide polymorphism which increases oxidized low-density lipoprotein levels with cerebrovascular disease events

Makela, Kari-Matti, Traylor, Matthew, Oksala, Niku, Kleber, Marcus E., Seppala, Ilkka, Lyytikainen, Leo-Pekka, Hernesniemi, Jussi A., Kahonen, Mika, Bevan, Steve, Rothwell, Peter M., Sudlow, Cathie, Dichgans, Martin, Delgado, Graciela, Grammer, Tanja B., Scharnagl, Hubert, Markus, Hugh S., Maerz, Winfried and Lehtimaki, Terho (2014). Association of the novel single-nucleotide polymorphism which increases oxidized low-density lipoprotein levels with cerebrovascular disease events. Atherosclerosis, 234 (1), 214-217. doi: 10.1016/j.atherosclerosis.2014.03.002

Association of the novel single-nucleotide polymorphism which increases oxidized low-density lipoprotein levels with cerebrovascular disease events

2014

Journal Article

Association of Physical Activity in Childhood and Early Adulthood With Carotid Artery Elasticity 21 Years Later: The Cardiovascular Risk in Young Finns Study

Palve, Kristiina S., Pahkala, Katja, Magnussen, Costan G., Koivistoinen, Teemu, Juonala, Markus, Kahonen, Mika, Lehtimaki, Terho, Ronnemaa, Tapani, Viikari, Jorma S. A. and Raitakari, Olli T. (2014). Association of Physical Activity in Childhood and Early Adulthood With Carotid Artery Elasticity 21 Years Later: The Cardiovascular Risk in Young Finns Study. Journal of the American Heart Association, 3 (2) e000594. doi: 10.1161/JAHA.113.000594

Association of Physical Activity in Childhood and Early Adulthood With Carotid Artery Elasticity 21 Years Later: The Cardiovascular Risk in Young Finns Study

2014

Journal Article

Does bone resorption stimulate periosteal expansion? A cross-sectional analysis of beta-C-telopeptides of type I collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT

Kemp, John P., Sayers, Adrian, Paternoster, Lavinia, Evans, David M., Deere, Kevin, St Pourcain, Beate, Timpson, Nicholas J., Ring, Susan M., Lorentzon, Mattias, Lehtimäki, Terho, Eriksson, Joel, Kähönen, Mika, Raitakari, Olli, Laaksonen, Marika, Sievänen, Harri, Viikari, Jorma, Lyytikäinen, Leo‐Pekka, Smith, George Davey, Fraser, William D., Vandenput, Liesbeth, Ohlsson, Claes and Tobias, Jon H. (2014). Does bone resorption stimulate periosteal expansion? A cross-sectional analysis of beta-C-telopeptides of type I collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT. Journal of Bone and Mineral Research, 29 (4), 1015-1024. doi: 10.1002/jbmr.2093

Does bone resorption stimulate periosteal expansion? A cross-sectional analysis of beta-C-telopeptides of type I collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT

2014

Journal Article

Sympathetic activity-associated periodic repolarization dynamics predict mortality following myocardial infarction

Rizas, Konstantinos D., Nieminen, Tuomo, Barthel, Petra, Zuern, Christine S., Kahonen, Mika, Viik, Jani, Lehtimaki, Terho, Nikus, Kjell, Eick, Christian, Greiner, Tim O., Wendel, Hans R., Seizer, Peter, Schreieck, Juergen, Gawaz, Meinrad, Schmidt, Georg and Bauer, Axel (2014). Sympathetic activity-associated periodic repolarization dynamics predict mortality following myocardial infarction. Journal of Clinical Investigation, 124 (4), 1770-1780. doi: 10.1172/JCI70085

Sympathetic activity-associated periodic repolarization dynamics predict mortality following myocardial infarction

2014

Journal Article

Genome-wide association study on dimethylarginines reveals novel <i>AGXT2</i> variants associated with heart rate variability but not with overall mortality

Seppala, Ilkka, Kleber, Marcus E., Lyytikainen, Leo-Pekka, Hernesniemi, Jussi A., Makela, Kari-Matti, Oksala, Niku, Laaksonen, Reijo, Pilz, Stefan, Tomaschitz, Andreas, Silbernagel, Gunther, Boehm, Bernhard O., Grammer, Tanja B., Koskinen, Tuomas, Juonala, Markus, Hutri-Kahonen, Nina, Alfthan, Georg, Viikari, Jorma S. A., Kahonen, Mika, Raitakari, Olli T., Marz, Winfried, Meinitzer, Andreas and Lehtimaki, Terho (2014). Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality. European Heart Journal, 35 (8), 524-531. doi: 10.1093/eurheartj/eht447

Genome-wide association study on dimethylarginines reveals novel <i>AGXT2</i> variants associated with heart rate variability but not with overall mortality

2014

Journal Article

Large-scale genomics unveils the genetic architecture of psychiatric disorders

Gratten, Jacob, Wray, Naomi R., Keller, Matthew C. and Visscher, Peter M. (2014). Large-scale genomics unveils the genetic architecture of psychiatric disorders. Nature Neuroscience, 17 (6), 782-790. doi: 10.1038/nn.3708

Large-scale genomics unveils the genetic architecture of psychiatric disorders

2014

Journal Article

Biological insights from 108 schizophrenia-associated genetic loci

Schizophrenia Working Group of the Psychiatric Genomics Consortium, Catts, Stanley V., Gratten, Jacob, Lee, S. Hong, Wray, Naomi R., Visscher, Peter M., Mowry, Bryan J., Nertney, Deborah A., Psychosis Endophenotypes International Consortium and Wellcome Trust Case-Control Consortium 2 (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature, 511 (7510), 421-427. doi: 10.1038/nature13595

Biological insights from 108 schizophrenia-associated genetic loci

2014

Journal Article

Lifestyle factors and health-related quality of life in colorectal cancer survivors

Schlesinger, Sabrina, Walter, Jessica, Hampe, Jochen, von Schoenfels, Witigo, Hinz, Sebastian, Kuechler, Thomas, Jacobs, Gunnar, Schafmayer, Clemens and Noethlings, Ute (2014). Lifestyle factors and health-related quality of life in colorectal cancer survivors. Cancer Causes & Control, 25 (1), 99-110. doi: 10.1007/s10552-013-0313-y

Lifestyle factors and health-related quality of life in colorectal cancer survivors

2013

Journal Article

Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking

Stephens, Sarah H., Hartz, Sarah M., Hoft, Nicole R., Saccone, Nancy L., Corley, Robin C., Hewitt, John K., Hopfer, Christian J., Breslau, Naomi, Coon, Hilary, Chen, Xiangning, Ducci, Francesca, Dueker, Nicole, Franceschini, Nora, Frank, Josef, Han, Younghun, Hansel, Nadia N., Jiang, Chenhui, Korhonen, Tellervo, Lind, Penelope A., Liu, Jason, Lyytikaeinen, Leo-Pekka, Michel, Martha, Shaffer, John R., Short, Susan E., Sun, Juzhong, Teumer, Alexander, Thompson, John R., Vogelzangs, Nicole, Vink, Jacqueline M. ... Ehringer, Marissa A. (2013). Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking. Genetic Epidemiology, 37 (8), 846-859. doi: 10.1002/gepi.21760

Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking

2013

Journal Article

Common variants associated with plasma triglycerides and risk for coronary artery disease

Do, Ron, Willer, Cristen J., Schmidt, Ellen M., Sengupta, Sebanti, Gao, Chi, Peloso, Gina M., Gustafsson, Stefan, Kanoni, Stavroula, Ganna, Andrea, Chen, Jin, Buchkovich, Martin L., Mora, Samia, Beckmann, Jacques S., Bragg-Gresham, Jennifer L., Chang, Hsing-Yi, Demirkan, Ayse, Den Hertog, Heleen M., Donnelly, Louise A., Ehret, Georg B., Esko, Tonu, Feitosa, Mary F., Ferreira, Teresa, Fischer, Krista, Fontanillas, Pierre, Fraser, Ross M., Freitag, Daniel F., Gurdasani, Deepti, Heikkila, Kauko, Hyppoenen, Elina ... Kathiresan, Sekar (2013). Common variants associated with plasma triglycerides and risk for coronary artery disease. Nature Genetics, 45 (11), 1345-1352. doi: 10.1038/ng.2795

Common variants associated with plasma triglycerides and risk for coronary artery disease

2013

Journal Article

Life history trade-offs at a single locus maintain sexually selected genetic variation

Johnston, Susan E., Gratten, Jacob, Berenos, Camillo, Pilkington, Jill G., Clutton-Brock, Tim H., Pemberton, Josephine M. and Slate, Jon (2013). Life history trade-offs at a single locus maintain sexually selected genetic variation. Nature, 502 (7469), 93-95. doi: 10.1038/nature12489

Life history trade-offs at a single locus maintain sexually selected genetic variation

2013

Journal Article

Genome-Wide Association Study Identifies 3 Genomic Loci Significantly Associated With Serum Levels of Homoarginine The AtheroRemo Consortium

Kleber, Marcus E., Seppala, Ilkka, Pilz, Stefan, Hoffmann, Michael M., Tomaschitz, Andreas, Oksala, Niku, Raitoharju, Emma, Lyytikainen, Leo-Pekka, Makela, Kari-Matti, Laaksonen, Reijo, Kahonen, Mika, Raitakari, Olli T., Huang, Jie, Kienreich, Katharina, Fahrleitner-Pammer, Astrid, Drechsler, Christiane, Krane, Vera, Boehm, Bernhard O., Koenig, Wolfgang, Wanner, Christoph, Lehtimaki, Terho, Maerz, Winfried and Meinitzer, Andreas (2013). Genome-Wide Association Study Identifies 3 Genomic Loci Significantly Associated With Serum Levels of Homoarginine The AtheroRemo Consortium. Circulation-Cardiovascular Genetics, 6 (5), 505-513. doi: 10.1161/CIRCGENETICS.113.000108

Genome-Wide Association Study Identifies 3 Genomic Loci Significantly Associated With Serum Levels of Homoarginine The AtheroRemo Consortium

2013

Journal Article

Lipoprotein receptor-related protein 1 variants and dietary fatty acids: meta-analysis of European origin and African American studies

Smith, C. E., Ngwa, J., Tanaka, T., Qi, Q., Wojczynski, M. K., Lemaitre, R. N., Anderson, J. S., Manichaikul, A., Mikkila, V., Van Rooij, F. J. A., Ye, Z., Bandinelli, S., Frazier-Wood, A. C., Houston, D. K., Hu, F., Langenberg, C., McKeown, N. M., Mozaffarian, D., North, K. E., Viikari, J., Zillikens, M. C., Djousse, L., Hofman, A., Kahonen, M., Kabagambe, E. K., Loos, R. J. F., Saylor, G. B., Forouhi, N. G., Liu, Y. ... Nettleton, J. A. (2013). Lipoprotein receptor-related protein 1 variants and dietary fatty acids: meta-analysis of European origin and African American studies. International Journal of Obesity, 37 (9), 1211-1220. doi: 10.1038/ijo.2012.215

Lipoprotein receptor-related protein 1 variants and dietary fatty acids: meta-analysis of European origin and African American studies

2013

Journal Article

Comparing schizophrenia symptoms in the Iban of Sarawak with other populations to elucidate clinical heterogeneity

McLean, Duncan, Barrett, Robert, Loa, Peter, Thara, Rangaswamy, John, Sujit, McGrath, John, Gratten, Jake and Mowry, Bryan (2013). Comparing schizophrenia symptoms in the Iban of Sarawak with other populations to elucidate clinical heterogeneity. Asia-Pacific Psychiatry, 7 (1), 36-44. doi: 10.1111/appy.12093

Comparing schizophrenia symptoms in the Iban of Sarawak with other populations to elucidate clinical heterogeneity

2013

Journal Article

Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error

Cheng C.-Y., Schache M., Ikram M.K., Young T.L., Guggenheim J.A., Vitart V., MacGregor S., Verhoeven V.J.M., Barathi V.A., Liao J., Hysi P.G., Bailey-Wilson J.E., St. Pourcain B., Kemp J.P., McMahon G., Timpson N.J., Evans D.M., Montgomery G.W., Mishra A., Wang Y.X., Wang J.J., Rochtchina E., Polasek O., Wright A.F., Amin N., Van Leeuwen E.M., Wilson J.F., Pennell C.E., Van Duijn C.M. ... Consortium for Refractive Error and Myopia (2013). Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. American Journal of Human Genetics, 93 (2), 264-277. doi: 10.1016/j.ajhg.2013.06.016

Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error

2013

Journal Article

Introgression and the fate of domesticated genes in a wild mammal population

Feulner, Philine G. D., Gratten, Jacob, Kijas, James W., Visscher, Peter M., Pemberton, Josephine M. and Slate, Jon (2013). Introgression and the fate of domesticated genes in a wild mammal population. Molecular Ecology, 22 (16), 4210-4221. doi: 10.1111/mec.12378

Introgression and the fate of domesticated genes in a wild mammal population

2013

Journal Article

Combined Effects of Child and Adult Elevated Blood Pressure on Subclinical Atherosclerosis: The International Childhood Cardiovascular Cohort Consortium

Juhola, Jonna, Magnussen, Costan G., Berenson, Gerald S., Venn, Alison, Burns, Trudy L., Sabin, Matthew A., Srinivasan, Sathanur R., Daniels, Stephen R., Davis, Patricia H., Chen, Wei, Kaehoenen, Mika, Taittonen, Leena, Urbina, Elaine, Viikari, Jorma S. A., Dwyer, Terence, Raitakari, Olli T. and Juonala, Markus (2013). Combined Effects of Child and Adult Elevated Blood Pressure on Subclinical Atherosclerosis: The International Childhood Cardiovascular Cohort Consortium. Circulation, 128 (3), 217-224. doi: 10.1161/CIRCULATIONAHA.113.001614

Combined Effects of Child and Adult Elevated Blood Pressure on Subclinical Atherosclerosis: The International Childhood Cardiovascular Cohort Consortium

Current funding

  • 2025 - 2029
    Centre of multiple sclerosis research translation (NHMRC CRE led by University of Tasmania)
    University of Tasmania
    Open grant
  • 2023 - 2027
    Unravelling the interplay between EBV genomics and host T cell immune regulation in multiple sclerosis (Ex-led UTas MRFF MS grant)
    University of Tasmania
    Open grant
  • 2023 - 2027
    Towards improved clinical outcomes for common brain disorders using large-scale statistical genomics
    NHMRC Investigator Grants
    Open grant

Past funding

  • 2022 - 2024
    Understanding the pathophysiology of Parkinson's disease using cellular genomics
    NHMRC IDEAS Grants
    Open grant
  • 2020 - 2021
    Vitamin D in autism; preventative mechanisms
    Child Development Grant
    Open grant
  • 2018 - 2020
    Investigating the molecular signature of ASD through integrative genomics (NHMRC Project Grant administered by UNSW)
    University of New South Wales
    Open grant
  • 2017 - 2020
    Understanding the etiology of psychiatric disorders through whole genome analyses
    NHMRC Career Development Fellowship
    Open grant
  • 2016 - 2018
    Genomic Analysis of Sex Differences in Prevalence of Psychiatric Disorders (2015 NARSAD Young Investigator Grant)
    Brain and Behavior Research Foundation
    Open grant
  • 2016 - 2019
    Genetic analysis of the relationship between parental age and risk of psychiatric disorders
    NHMRC Project Grant
    Open grant
  • 2015 - 2021
    Development and validation of systems genomics-based predictors for autism (Stage 1)
    CRC for Living with Autism Spectrum Disorders (Autism CRC Limited)
    Open grant
  • 2015 - 2020
    Multivariate whole genome estimation and prediction analysis of genomics data applied to psychiatric disorders
    NHMRC Project Grant
    Open grant
  • 2014 - 2018
    Genetic analysis of de novo and inherited exome variation in schizophrenia
    NHMRC Project Grant
    Open grant

Availability

Honorary Professor Jake Gratten is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Understanding mechanisms underlying multiple sclerosis using large-scale multi-omics

    We are seeking a highly motivated PhD candidate with a background and interest in human genomics, statistics and neurodegenerative disease to join the Cognitive Health Genomics group at the Mater Research Institute, UQ. The successful candidate would work on an NHMRC-funded study to improve understanding of the pathophysiology of multiple sclerosis by integrating large-scale multi-omics data using cutting-edge statistical methods.

    Requirements

    • Bachelor’s degree with first class honours, or Masters, in statistics, mathematics, bioinformatics, human genetics, animal breeding, or an equivalent field.
    • Prior research experience in human genomics or animal breeding, including a familiarity with high-throughput genomic data and working in a high-performance computing environment.
    • Skills in the R statistical computing language and/or python, C++ or an equivalent computing language.
    • High degree of motivation and organisation, and an ability to work both independently and as part of a team.
    • Excellent written and oral communications skills in English.

    For further information please contact Prof Jake Gratten, jacob.gratten@mater.uq.edu.au.

Supervision history

Current supervision

Completed supervision

Enquiries

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