Jake Gratten

Understanding mechanisms underlying multiple sclerosis using large-scale multi-omics

We are seeking a highly motivated PhD candidate with a background and interest in human genomics, statistics and neurodegenerative disease to join the Cognitive Health Genomics group at the Mater Research Institute, UQ. The successful candidate would work on an NHMRC-funded study to improve understanding of the pathophysiology of multiple sclerosis by integrating large-scale multi-omics data using cutting-edge statistical methods.

Requirements

• Bachelor’s degree with first class honours, or Masters, in statistics, mathematics, bioinformatics, human genetics, animal breeding, or an equivalent field.
• Prior research experience in human genomics or animal breeding, including a familiarity with high-throughput genomic data and working in a high-performance computing environment.
• Skills in the R statistical computing language and/or python, C++ or an equivalent computing language.
• High degree of motivation and organisation, and an ability to work both independently and as part of a team.
• Excellent written and oral communications skills in English.

For further information please contact Prof Jake Gratten, jacob.gratten@mater.uq.edu.au.

Understanding co-occurring conditions in autism using large-scale multi-omics

This PhD project aims to improve understanding of causal factors, biological mechanisms and predictors of co-occuring conditions (including gastrointestinal complaints, sleep problems and immune conditions) in autism spectrum disorder (ASD) using large-scale integrative multi-omics.

Improved understanding of Parkinson's disease using large-scale multi-omics

This PhD project aims to improve understanding of the pathophysiology of Parkinson’s disease (PD) onset and progression by integrating single cell and spatial transcriptomics data in post-mortem brain samples from donors with and without a diagnosis of PD.