Honorary Professor Jake Gratten
Honorary Professor

Jake Gratten

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Background

Dr Gratten completed his undergraduate studies and PhD at The University of Queensland, before undertaking postdoctoral training in evolutionary and quantitative genetics at the University of Sheffield. He then returned to Australia and shifted research focus to psychiatric and neurological genetics, taking up a position as research fellow at the Queensland Brain Institute. In 2013, he was recruited to UQ's Centre for Neurogenetics and Statistical Genomics, and in 2017 was awarded an NHMRC Career Development Fellowship (Level 2). He established the Cognitive Health Genomics group at Mater Research Institute in 2018, with the goal to improve understanding of the etiology of psychiatric and neurological disorders through analysis and integration of whole genome datasets. He has received >$5M in research funding from the NHMRC, Autism Cooperative Research Centre and both Australian (BICARE) and international (Brain & Behavior Research Foundation) philanthropic funders.

Availability

Honorary Professor Jake Gratten is:
Available for supervision

Fields of research

Biological Sciences Biomedical and Clinical Sciences Genetics Zoology

Qualifications

  • Bachelor of Science, The University of Queensland
  • Bachelor (Honours) of Science, The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Search Professor Jake Gratten’s works on UQ eSpace

204 works between 2001 and 2024
All (204) Journal Article (191) Conference Publication (11) Other Outputs (2)

181 - 200 of 204 works

2010

Journal Article

Genome mapping in intensively studied wild vertebrate populations

Slate, Jon, Santure, Anna W., Feulner, Philine G. D., Brown, Emily A., Ball, Alex D., Johnston, Susan E. and Gratten, Jake (2010). Genome mapping in intensively studied wild vertebrate populations. Trends in Genetics, 26 (6), 275-284. doi: 10.1016/j.tig.2010.03.005

Genome mapping in intensively studied wild vertebrate populations

2010

Journal Article

Distinct Variants at <i>LIN28B</i> Influence Growth in Height from Birth to Adulthood

Widen, Elisabeth, Ripatti, Samuli, Cousminer, Diana L., Surakka, Ida, Lappalainen, Tuuli, Jaervelin, Marjo-Riitta, Eriksson, Johan G., Raitakari, Olli, Salomaa, Veikko, Sovio, Ulla, Hartikainen, Anna-Liisa, Pouta, Anneli, McCarthy, Mark I., Osmond, Clive, Kajantie, Eero, Lehtimaki, Terho, Viikari, Jorma, Kahonen, Mika, Tyler-Smith, Chris, Freimer, Nelson, Hirschhorn, Joel N., Peltonen, Leena and Palotie, Aarno (2010). Distinct Variants at LIN28B Influence Growth in Height from Birth to Adulthood. American Journal of Human Genetics, 86 (5), 773-782. doi: 10.1016/j.ajhg.2010.03.010

Distinct Variants at <i>LIN28B</i> Influence Growth in Height from Birth to Adulthood

2010

Journal Article

Erratum to: Gene mapping in the wild with SNPs: Guidelines and future directions (Genetica, (2009), 136, (97-107), 10.1007/s10709-008-9317-z)

Slate, Jon, Gratten, Jake, Beraldi, Dario, Stapley, Jessica, Hale, Matt and Pemberton, Josephine M. (2010). Erratum to: Gene mapping in the wild with SNPs: Guidelines and future directions (Genetica, (2009), 136, (97-107), 10.1007/s10709-008-9317-z). Genetica, 138 (4), 467-467. doi: 10.1007/s10709-010-9445-0

Erratum to: Gene mapping in the wild with SNPs: Guidelines and future directions (Genetica, (2009), 136, (97-107), 10.1007/s10709-008-9317-z)

2010

Journal Article

The genetic basis of recessive self colour pattern in a wild sheep population

Gratten, J., Pilkington, J. G., Brown, E. A., Beraldi, D., Pemberton, J. M. and Slate, J. (2010). The genetic basis of recessive self colour pattern in a wild sheep population. Heredity, 104 (2), 206-214. doi: 10.1038/hdy.2009.105

The genetic basis of recessive self colour pattern in a wild sheep population

2010

Journal Article

Horn type and horn length genes map to the same chromosomal region in Soay sheep

Johnston, S. E., Beraldi, D., McRae, A. F., Pemberton, J. M. and Slate, J. (2010). Horn type and horn length genes map to the same chromosomal region in Soay sheep. Heredity, 104 (2), 196-205. doi: 10.1038/hdy.2009.109

Horn type and horn length genes map to the same chromosomal region in Soay sheep

2010

Journal Article

Association genetics, population genomics, and conservation: Revealing the genes underlying adaptation in natural populations of plants and animals

Nichols, Krista M., Neale, David B., Gratten, Jake, Wilson, Alastair J., McRae, Allan F., Beraldi, Dario, Visscher, Peter M., Pemberton, Josephine M. and Slate, Jon (2010). Association genetics, population genomics, and conservation: Revealing the genes underlying adaptation in natural populations of plants and animals. Molecular Approaches in Natural Resource Conservation and Management, 123-168.

Association genetics, population genomics, and conservation: Revealing the genes underlying adaptation in natural populations of plants and animals

2009

Journal Article

Ageing and cardiovascular responses to head-up tilt in healthy subjects

Tahvanainen, Anna, Leskinen, Miia, Koskela, Jenni, Ilveskoski, Erkki, Nordhausen, Klaus, Oja, Hannu, Kahonen, Mika, Koobi, Tiit, Mustonen, Jukka and Porsti, Ilkka (2009). Ageing and cardiovascular responses to head-up tilt in healthy subjects. Atherosclerosis, 207 (2), 445-451. doi: 10.1016/j.atherosclerosis.2009.06.001

Ageing and cardiovascular responses to head-up tilt in healthy subjects

2009

Journal Article

Gene mapping in the wild with SNPs: Guidelines and future directions

Slate, Jon, Gratten, Jake, Beraldi, Dario, Stapley, Jessica, Hale, Matt and Pemberton, Josephine M. (2009). Gene mapping in the wild with SNPs: Guidelines and future directions. Genetica, 136 (1), 97-107. doi: 10.1007/s10709-008-9317-z

Gene mapping in the wild with SNPs: Guidelines and future directions

2009

Journal Article

Post-Exercise Assessment of Cardiac Repolarization Alternans in Patients With Coronary Artery Disease Using the Modified Moving Average Method

Slawnych, Michael P., Nieminen, Tuomo, Kahonen, Mika, Kavanagh, Katherine M., Lehtimaki, Terho, Ramadan, Darlene, Viik, Jari, Aggarwal, Sandeep G., Lehtinen, Rami, Ellis, Linda, Nikus, Kjell and Exner, Derek V. (2009). Post-Exercise Assessment of Cardiac Repolarization Alternans in Patients With Coronary Artery Disease Using the Modified Moving Average Method. Journal of the American College of Cardiology, 53 (13), 1130-1137. doi: 10.1016/j.jacc.2008.12.026

Post-Exercise Assessment of Cardiac Repolarization Alternans in Patients With Coronary Artery Disease Using the Modified Moving Average Method

2008

Journal Article

Multiplex SNP-SCALE: A cost-effective medium-throughput SNP genotyping method

Kenta, T., Gratten, J., Haigh, N. S., Hinten, G. N., Slate, J., Butlin, R. K. and Burke, T. (2008). Multiplex SNP-SCALE: A cost-effective medium-throughput SNP genotyping method. Molecular Ecology Resources, 8 (6), 1230-1238. doi: 10.1111/j.1755-0998.2008.02190.x

Multiplex SNP-SCALE: A cost-effective medium-throughput SNP genotyping method

2008

Journal Article

Lifetime body mass index and later atherosclerosis risk in young adults: examining causal links using Mendelian randomization in the Cardiovascular Risk in Young Finns study

Kivimaki, Mika, Smith, George Davey, Timpson, Nic J., Lawlor, Debbie A., Batty, G. David, Kahonen, Mika, Juonala, Markus, Ronnemaa, Tapani, Viikari, Jorma S. A., Lehtimaki, Terho and Raitakari, Olli T. (2008). Lifetime body mass index and later atherosclerosis risk in young adults: examining causal links using Mendelian randomization in the Cardiovascular Risk in Young Finns study. European Heart Journal, 29 (20), 2552-2560. doi: 10.1093/eurheartj/ehn252

Lifetime body mass index and later atherosclerosis risk in young adults: examining causal links using Mendelian randomization in the Cardiovascular Risk in Young Finns study

2008

Journal Article

Gender and effects of a common genetic variant in the NOS1 regulator <i>NOS1AP</i> on cardiac repolarization in 3761 individuals from two independent populations

Tobin, Martin D., Kahonen, Mika, Braund, Peter, Nieminen, Tuomo, Hajat, Cother, Tomaszewski, Maciej, Viik, Jari, Lehtinen, Rami, Ng, G. Andre, Macfarlane, Peter W., Burton, Paul R., Lehtimaki, Terho and Samani, Nilesh J. (2008). Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations. International Journal of Epidemiology, 37 (5), 1132-1141. doi: 10.1093/ije/dyn091

Gender and effects of a common genetic variant in the NOS1 regulator <i>NOS1AP</i> on cardiac repolarization in 3761 individuals from two independent populations

2008

Journal Article

A localized negative genetic correlation constrains microevolution of coat color in wild sheep

Gratten, J., Wilson, A. J., McRae, A. F., Beraldi, D., Visscher, P. M., Pemberton, J. M. and Slate, J. (2008). A localized negative genetic correlation constrains microevolution of coat color in wild sheep. Science, 319 (5861), 318-320. doi: 10.1126/science.1151182

A localized negative genetic correlation constrains microevolution of coat color in wild sheep

2007

Journal Article

Molecular assessment of the genetic integrity, distinctiveness and phylogeographic context of the Saltwater crocodile (Crocodylus porosus) on Palau

Russello, M. A., Brazaitis, P., Gratten, J., Watkins-Colwell, G. J. and Caccone, A. (2007). Molecular assessment of the genetic integrity, distinctiveness and phylogeographic context of the Saltwater crocodile (Crocodylus porosus) on Palau. Conservation Genetics, 8 (4), 777-787. doi: 10.1007/s10592-006-9225-7

Molecular assessment of the genetic integrity, distinctiveness and phylogeographic context of the Saltwater crocodile (Crocodylus porosus) on Palau

2007

Journal Article

Mapping quantitative trait loci underlying fitness-related traits in a free-living sheep population

Beraldi, Dario, McRae, Allan F., Gratten, Jacob, Slate, Jon, Visscher, Peter M. and Pemberton, Josephine M. (2007). Mapping quantitative trait loci underlying fitness-related traits in a free-living sheep population. Evolution, 61 (6), 1403-1416. doi: 10.1111/j.1558-5646.2007.00106.x

Mapping quantitative trait loci underlying fitness-related traits in a free-living sheep population

2007

Journal Article

SNP-SCALE: SNP scoring by colour and length exclusion

Hinten, G. N., Hale, M. C., Gratten, J., Mossman, J. A., Lowder, B. V., Mann, M. K. and Slate, J. (2007). SNP-SCALE: SNP scoring by colour and length exclusion. Molecular Ecology Notes, 7 (3), 377-388. doi: 10.1111/j.1471-8286.2006.01648.x

SNP-SCALE: SNP scoring by colour and length exclusion

2007

Journal Article

Compelling evidence that a single nucleotide substitution in TYRP1 is responsible for coat-colour polymorphism in a free-living population of Soay sheep

Gratten, J., Beraldi, D., Lowder, B. V., McRae, A. F., Visscher, P. M., Pemberton, J. M. and Slate, J. (2007). Compelling evidence that a single nucleotide substitution in TYRP1 is responsible for coat-colour polymorphism in a free-living population of Soay sheep. Proceedings of the Royal Society of London: Biological Sciences, 274 (1610), 619-626. doi: 10.1098/rspb.2006.3762

Compelling evidence that a single nucleotide substitution in TYRP1 is responsible for coat-colour polymorphism in a free-living population of Soay sheep

2007

Journal Article

Quantitative trait loci (QTL) mapping of resistance to strongyles and coccidia in the free-living Soay sheep (Ovis aries)

Beraldi, Dario, McRae, Allan F., Gratten, Jacob, Slate, Jon, Visscher, Peter M., Pemberton, Josephine M. and Pilkington, Jill G. (2007). Quantitative trait loci (QTL) mapping of resistance to strongyles and coccidia in the free-living Soay sheep (Ovis aries). Journal of Parasitology, 37 (1), 121-129. doi: 10.1016/j.ijpara.2006.09.007

Quantitative trait loci (QTL) mapping of resistance to strongyles and coccidia in the free-living Soay sheep (Ovis aries)

2006

Journal Article

Development of a linkage map and mapping of phenotypic polymorphisms in a free-living population of Soay sheep (Ovis aries)

Beraldi, Dario, McRae, Allan F., Gratten, Jacob, Slate, Jon, Visscher, Peter M. and Pemberton, Josephine M. (2006). Development of a linkage map and mapping of phenotypic polymorphisms in a free-living population of Soay sheep (Ovis aries). Genetics, 173 (3), 1521-1537. doi: 10.1534/genetics.106.057141

Development of a linkage map and mapping of phenotypic polymorphisms in a free-living population of Soay sheep (Ovis aries)

2003

Other Outputs

The molecular systematics, phylogeography and population genetics of Indo-Pacific Crocodylus

Gratten, Jacob (2003). The molecular systematics, phylogeography and population genetics of Indo-Pacific Crocodylus. PhD Thesis, School of Biological Sciences, The University of Queensland. doi: 10.14264/106777

The molecular systematics, phylogeography and population genetics of Indo-Pacific Crocodylus

Current funding

  • 2025 - 2029
    Centre of multiple sclerosis research translation (NHMRC CRE led by University of Tasmania)
    University of Tasmania
    Open grant
  • 2023 - 2027
    Unravelling the interplay between EBV genomics and host T cell immune regulation in multiple sclerosis (Ex-led UTas MRFF MS grant)
    University of Tasmania
    Open grant
  • 2023 - 2027
    Towards improved clinical outcomes for common brain disorders using large-scale statistical genomics
    NHMRC Investigator Grants
    Open grant

Past funding

  • 2022 - 2024
    Understanding the pathophysiology of Parkinson's disease using cellular genomics
    NHMRC IDEAS Grants
    Open grant
  • 2020 - 2021
    Vitamin D in autism; preventative mechanisms
    Child Development Grant
    Open grant
  • 2018 - 2020
    Investigating the molecular signature of ASD through integrative genomics (NHMRC Project Grant administered by UNSW)
    University of New South Wales
    Open grant
  • 2017 - 2020
    Understanding the etiology of psychiatric disorders through whole genome analyses
    NHMRC Career Development Fellowship
    Open grant
  • 2016 - 2018
    Genomic Analysis of Sex Differences in Prevalence of Psychiatric Disorders (2015 NARSAD Young Investigator Grant)
    Brain and Behavior Research Foundation
    Open grant
  • 2016 - 2019
    Genetic analysis of the relationship between parental age and risk of psychiatric disorders
    NHMRC Project Grant
    Open grant
  • 2015 - 2021
    Development and validation of systems genomics-based predictors for autism (Stage 1)
    CRC for Living with Autism Spectrum Disorders (Autism CRC Limited)
    Open grant
  • 2015 - 2020
    Multivariate whole genome estimation and prediction analysis of genomics data applied to psychiatric disorders
    NHMRC Project Grant
    Open grant
  • 2014 - 2018
    Genetic analysis of de novo and inherited exome variation in schizophrenia
    NHMRC Project Grant
    Open grant

Availability

Honorary Professor Jake Gratten is:
Available for supervision

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Available projects

  • Understanding mechanisms underlying multiple sclerosis using large-scale multi-omics

    We are seeking a highly motivated PhD candidate with a background and interest in human genomics, statistics and neurodegenerative disease to join the Cognitive Health Genomics group at the Mater Research Institute, UQ. The successful candidate would work on an NHMRC-funded study to improve understanding of the pathophysiology of multiple sclerosis by integrating large-scale multi-omics data using cutting-edge statistical methods.

    Requirements

    • Bachelor’s degree with first class honours, or Masters, in statistics, mathematics, bioinformatics, human genetics, animal breeding, or an equivalent field.
    • Prior research experience in human genomics or animal breeding, including a familiarity with high-throughput genomic data and working in a high-performance computing environment.
    • Skills in the R statistical computing language and/or python, C++ or an equivalent computing language.
    • High degree of motivation and organisation, and an ability to work both independently and as part of a team.
    • Excellent written and oral communications skills in English.

    For further information please contact Prof Jake Gratten, jacob.gratten@mater.uq.edu.au.

Supervision history

Current supervision

Completed supervision

Enquiries

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