
Overview
Background
Dr Gratten completed his undergraduate studies and PhD at The University of Queensland, before undertaking postdoctoral training in evolutionary and quantitative genetics at the University of Sheffield. He then returned to Australia and shifted research focus to psychiatric and neurological genetics, taking up a position as research fellow at the Queensland Brain Institute. In 2013, he was recruited to UQ's Centre for Neurogenetics and Statistical Genomics, and in 2017 was awarded an NHMRC Career Development Fellowship (Level 2). He established the Cognitive Health Genomics group at Mater Research Institute in 2018, with the goal to improve understanding of the etiology of psychiatric and neurological disorders through analysis and integration of whole genome datasets. He has received >$5M in research funding from the NHMRC, Autism Cooperative Research Centre and both Australian (BICARE) and international (Brain & Behavior Research Foundation) philanthropic funders.
Availability
- Honorary Professor Jake Gratten is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Bachelor (Honours) of Science, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Jake Gratten’s works on UQ eSpace
2013
Journal Article
Simplified Definitions of Elevated Pediatric Blood Pressure and High Adult Arterial Stiffness
Aatola, Heikki, Magnussen, Costan G., Koivistoinen, Teemu, Hutri-Kahonen, Nina, Juonala, Markus, Viikari, Jorma S. A., Lehtimaki, Terho, Raitakari, Olli T. and Kahonen, Mika (2013). Simplified Definitions of Elevated Pediatric Blood Pressure and High Adult Arterial Stiffness. Pediatrics, 132 (1), E70-E76. doi: 10.1542/peds.2012-3426
2013
Journal Article
Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake
Tanaka, Toshiko, Ngwa, Julius S., van Rooij, Frank J. A., Zillikens, M. Carola, Wojczynski, Mary K., Frazier-Wood, Alexis C., Houston, Denise K., Kanoni, Stavroula, Lemaitre, Rozenn N., Luan, Jian'an, Mikkila, Vera, Renstrom, Frida, Sonestedt, Emily, Zhao, Jing Hua, Chu, Audrey Y., Qi, Lu, Chasman, Daniel I., Otto, Marcia C. de Oliveira, Dhurandhar, Emily J., Feitosa, Mary F., Johansson, Ingegerd, Khaw, Kay-Tee, Lohman, Kurt K., Manichaikul, Ani, McKeown, Nicola M., Mozaffarian, Dariush, Singleton, Andrew, Stirrups, Kathleen, Viikari, Jorma ... Nettleton, Jennifer A. (2013). Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake. American Journal of Clinical Nutrition, 97 (6), 1395-1402. doi: 10.3945/ajcn.112.052183
2013
Journal Article
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Berndt, Sonja I., Gustafsson, Stefan, Maegi, Reedik, Ganna, Andrea, Wheeler, Eleanor, Feitosa, Mary F., Justice, Anne E., Monda, Keri L., Croteau-Chonka, Damien C., Day, Felix R., Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gentilini, Davide, Jackson, Anne U., Luan, Jian'an, Randall, Joshua C., Vedantam, Sailaja, Willer, Cristen J., Winkler, Thomas W., Wood, Andrew R., Workalemahu, Tsegaselassie, Hu, Yi-Juan, Lee, Sang Hong, Liang, Liming, Lin, Dan-Yu, Min, Josine L., Neale, Benjamin M., Thorleifsson, Gudmar ... Ingelsson, Erik (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics, 45 (5), 501-U69. doi: 10.1038/ng.2606
2013
Journal Article
Higher Maternal Body Mass Index Is Associated with an Increased Risk for Later Type 2 Diabetes in Offspring
Juonala, Markus, Jaaskelainen, Paula, Sabin, Matthew A., Viikari, Jorma S. A., Kahonen, Mika, Lehtimaki, Terho, Seppala, Ilkka, Hutri-Kahonen, Nina, Taittonen, Leena, Jokinen, Eero, Laitinen, Tomi, Magnussen, Costan G. and Raitakari, Olli T. (2013). Higher Maternal Body Mass Index Is Associated with an Increased Risk for Later Type 2 Diabetes in Offspring. Journal of Pediatrics, 162 (5), 918-U63. doi: 10.1016/j.jpeds.2012.10.062
2013
Journal Article
The Molecular Genetic Architecture of Self-Employment
van der Loos, Matthijs J. H. M., Rietveld, Cornelius A., Eklund, Niina, Koellinger, Philipp D., Rivadeneira, Fernando, Abecasis, Goncalo R., Ankra-Badu, Georgina A., Baumeister, Sebastian E., Benjamin, Daniel J., Biffar, Reiner, Blankenberg, Stefan, Boomsma, Dorret I., Cesarini, David, Cucca, Francesco, de Geus, Eco J. C., Dedoussis, George, Deloukas, Panos, Dimitriou, Maria, Eiriksdottir, Guony, Eriksson, Johan, Gieger, Christian, Gudnason, Vilmundur, Hoehne, Birgit, Holle, Rolf, Hottenga, Jouke-Jan, Isaacs, Aaron, Jarvelin, Marjo-Riitta, Johannesson, Magnus, Kaakinen, Marika ... Thurik, A. Roy (2013). The Molecular Genetic Architecture of Self-Employment. Plos One, 8 (4) e60542. doi: 10.1371/journal.pone.0060542
2013
Journal Article
Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies
Hruby, Adela, Ngwa, Julius S., Renstrom, Frida, Wojczynski, Mary K., Ganna, Andrea, Hallmans, Goran, Houston, Denise K., Jacques, Paul F., Kanoni, Stavroula, Lehtimaki, Terho, Lemaitre, Rozenn N., Manichaikul, Ani, North, Kari E., Ntalla, Ioanna, Sonestedt, Emily, Tanaka, Toshiko, van Rooij, Frank J. A., Bandinelli, Stefania, Djousse, Luc, Grigoriou, Efi., Johansson, Ingegerd, Lohman, Kurt K., Pankow, James S., Raitakari, Olli T., Riserus, Ulf, Yannakoulia, Mary, Zillikens, M. Carola, Hassanali, Neelam, Liu, Yongmei ... Nettleton, Jennifer A. (2013). Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies. Journal of Nutrition, 143 (3), 345-353. doi: 10.3945/jn.112.172049
2013
Journal Article
Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure
Paternoster, Lavinia, Lorentzon, Mattias, Lehtimaki, Terho, Eriksson, Joel, Kahonen, Mika, Raitakari, Olli, Laaksonen, Marika, Sievanen, Harri, Viikari, Jorma V, Lyytikainen, Leo-Pekka, Mellstrom, Dan, Karlsson, Magnus, Ljunggren, Osten, Grundberg, Elin, Kemp, John P., Sayers, Adrian, Nethander, Maria, Evans, David M., Vandenput, Liesbeth, Tobias, Jon H. and Ohlsson, Claes (2013). Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure. PLoS Genetics, 9 (2) e1003247, 1-15. doi: 10.1371/journal.pgen.1003247
2013
Journal Article
Fetal growth, omega-3 (n-3) fatty acids, and progression of subclinical atherosclerosis: preventing fetal origins of disease? The Cardiovascular Risk in Young Finns Study
Skilton, Michael R., Mikkila, Vera, Wurtz, Peter, Ala-Korpela, Mika, Sim, Kyra A., Soininen, Pasi, Kangas, Antti J., Viikari, Jorma S. A., Juonala, Markus, Laitinen, Tomi, Lehtimaki, Terho, Taittonen, Leena, Kahonen, Mika, Celermajer, David S. and Raitakari, Olli T. (2013). Fetal growth, omega-3 (n-3) fatty acids, and progression of subclinical atherosclerosis: preventing fetal origins of disease? The Cardiovascular Risk in Young Finns Study. American Journal of Clinical Nutrition, 97 (1), 58-65. doi: 10.3945/ajcn.112.044198
2012
Journal Article
A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern
Sinner, Moritz F., Porthan, Kimmo, Noseworthy, Peter A., Havulinna, Aki S., Tikkanen, Jani T., Mueller-Nurasyid, Martina, Peloso, Gina, Ulivi, Sheila, Beckmann, Britt Maria, Brockhaus, A. Catharina, Cooper, Rebecca R., Gasparini, Paolo, Hengstenberg, Christian, Hwang, Shih-Jen, Iorio, Annamaria, Junttila, M. Juhani, Klopp, Norman, Kahonen, Mika, Laaksonen, Maarit A., Lehtimaki, Terho, Lichtner, Peter, Lyytikainen, Leo-Pekka, Martens, Eimo, Meisinger, Christa, Meitinger, Thomas, Merchant, Faisal M., Nieminen, Markku S., Peters, Annette, Pietila, Arto ... Salomaa, Veikko (2012). A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern. Heart Rhythm, 9 (10), 1627-1634. doi: 10.1016/j.hrthm.2012.06.008
2012
Journal Article
Maintenance of genetic variation in human personality: testing evolutionary models by estimating heritability due to common causal variants and investigating the effect of distant inbreeding
Verweij, Karin J. H., Yang, Jian, Lahti, Jari, Veijola, Juha, Hintsanen, Mirka, Pulkki-Raback, Laura, Heinonen, Kati, Pouta, Anneli, Pesonen, Anu-Katriina, Widen, Elisabeth, Taanila, Anja, Isohanni, Matti, Miettunen, Jouko, Palotie, Aarno, Penke, Lars, Service, Susan K., Heath, Andrew C., Montgomery, Grant W., Raitakari, Olli, Kahonen, Mika, Viikari, Jorma, Raikkonen, Katri, Eriksson, Johan G., Keltikangas-Jarvinen, Liisa, Lehtimaki, Terho, Martin, Nicholas G., Jarvelin, Marjo-Riitta, Visscher, Peter M., Keller, Matthew C. and Zietsch, Brendan P. (2012). Maintenance of genetic variation in human personality: testing evolutionary models by estimating heritability due to common causal variants and investigating the effect of distant inbreeding. Evolution, 66 (10), 3238-3251. doi: 10.1111/j.1558-5646.2012.01679.x
2012
Journal Article
Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium
Verhoeven, Virginie J. M., Hysi, Pirro G., Saw, Seang-Mei, Vitart, Veronique, Mirshahi, Alireza, Guggenheim, Jeremy A., Cotch, Mary Frances, Yamashiro, Kenji, Baird, Paul N., Mackey, David A., Wojciechowski, Robert, Ikram, M. Kamran, Hewitt, Alex W., Duggal, Priya, Janmahasatian, Sarayut, Khor, Chiea-Chuen, Fan, Qiao, Zhou, Xin, Young, Terri L., Tai, E-Shyong, Goh, Liang-Kee, Li, Yi-Ju, Aung, Tin, Vithana, Eranga, Teo, Yik-Ying, Tay, Wanting, Sim, Xueling, Rudan, Igor, Hayward, Caroline ... Klaver, Caroline C. W. (2012). Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium. Human Genetics, 131 (9), 1467-1480. doi: 10.1007/s00439-012-1176-0
2012
Journal Article
Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA
Ramasamy, Adaikalavan, Kuokkanen, Mikko, Vedantam, Sailaja, Gajdos, Zofia K., Alves, Alexessander Couto, Lyon, Helen N., Ferreira, Manuel A. R., Strachan, David P., Zhao, Jing Hua, Abramson, Michael J., Brown, Matthew A., Coin, Lachlan, Dharmage, Shyamali C., Duffy, David L., Haahtela, Tari, Heath, Andrew C., Janson, Christer, Kahonen, Mika, Khaw, Kay-Tee, Laitinen, Jaana, Le Souef, Peter, Lehtimaki, Terho, Madden, Pamela A. F., Marks, Guy B., Martin, Nicholas G., Matheson, Melanie C., Palmer, Cameron D., Palotie, Aarno, Pouta, Anneli ... Hirschhorn, Joel N. (2012). Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA. PLoS One, 7 (9 Article No. e44008) e44008, e44008-1-e44008-10. doi: 10.1371/journal.pone.0044008
2012
Journal Article
Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis
Inouye, Michael, Ripatti, Samuli, Kettunen, Johannes, Lyytikainen, Leo-Pekka, Oksala, Niku, Laurila, Pirkka-Pekka, Kangas, Antti J., Soininen, Pasi, Savolainen, Markku J., Viikari, Jorma, Kahonen, Mika, Perola, Markus, Salomaa, Veikko, Raitakari, Olli, Lehtimaki, Terho, Taskinen, Marja-Riitta, Jaervelin, Marjo-Riitta, Ala-Korpela, Mika, Palotie, Aarno and de Bakker, Paul I. W. (2012). Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis. Plos Genetics, 8 (8) e1002907. doi: 10.1371/journal.pgen.1002907
2012
Journal Article
Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers
Hartz, Sarah M., Short, Susan E., Saccone, Nancy L., Culverhouse, Robert, Chen, LiShiun, Schwantes-An, Tae-Hwi, Coon, Hilary, Han, Younghun, Stephens, Sarah H., Sun, Juzhong, Chen, Xiangning, Ducci, Francesca, Dueker, Nicole, Franceschini, Nora, Frank, Josef, Geller, Frank, Guobjartsson, Daniel, Hansel, Nadia N., Jiang, Chenhui, Keskitalo-Vuokko, Kaisu, Liu, Zhen, Lyytikainen, Leo-Pekka, Michel, Martha, Rawal, Rajesh, Hum, Sc, Rosenberger, Albert, Scheet, Paul, Shaffer, John R., Teumer, Alexander ... Bierut, Laura J. (2012). Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. Archives of General Psychiatry, 69 (8), 854-861. doi: 10.1001/archgenpsychiatry.2012.124
2012
Journal Article
Childhood Physical, Environmental, and Genetic Predictors of Adult Hypertension The Cardiovascular Risk in Young Finns Study
Juhola, Jonna, Oikonen, Mervi, Magnussen, Costan G., Mikkila, Vera, Siitonen, Niina, Jokinen, Eero, Laitinen, Tomi, Wurtz, Peter, Gidding, Samuel S., Taittonen, Leena, Seppala, Ilkka, Jula, Antti, Kahonen, Mika, Hutri-Kahonen, Nina, Lehtimaki, Terho, Viikari, Jorma S. A., Juonala, Markus and Raitakari, Olli T. (2012). Childhood Physical, Environmental, and Genetic Predictors of Adult Hypertension The Cardiovascular Risk in Young Finns Study. Circulation, 126 (4), 402-409. doi: 10.1161/CIRCULATIONAHA.111.085977
2012
Journal Article
A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone-Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation
Coviello, Andrea D., Haring, Robin, Wellons, Melissa, Vaidya, Dhananjay, Lehtimaki, Terho, Keildson, Sarah, Lunetta, Kathryn L., He, Chunyan, Fornage, Myriam, Lagou, Vasiliki, Mangino, Massimo, Onland-Moret, N. Charlotte, Chen, Brian, Eriksson, Joel, Garcia, Melissa, Mei, Yong, Koster, Annemarie, Lohman, Kurt, Lyytikainen, Leo-Pekka, Petersen, Ann-Kristin, Prescott, Jennifer, Stolk, Lisette, Vandenput, Liesbeth, Wood, Andrew R., Zhuang, Wei Vivian, Ruokonen, Aimo, Hartikainen, Anna-Liisa, Pouta, Anneli, Bandinelli, Stefania ... Perry, John R. B. (2012). A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone-Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation. Plos Genetics, 8 (7) e1002805. doi: 10.1371/journal.pgen.1002805
2012
Journal Article
WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk
Zheng, Hou-Feng, Tobias, Jon H., Duncan, Emma, Evans, David M., Eriksson, Joel, Paternoster, Lavinia, Yerges-Armstrong, Laura M., Lehtimaki, Terho, Bergstrom, Ulrica, Kahonen, Mika, Leo, Paul J., Raitakari, Olli, Laaksonen, Marika, Nicholson, Geoffrey C., Viikari, Jorma, Ladouceur, Martin, Lyytikainen, Leo-Pekka, Medina-Gomez, Carolina, Rivadeneira, Fernando, Prince, Richard L., Sievanen, Harri, Leslie, William D., Mellstrom, Dan, Eisman, John A., Moverare-Skrtic, Sofia, Goltzman, David, Hanley, David A., Jones, Graeme, Pourcain, Beate St. ... Lorentzon, Mattias (2012). WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. Plos Genetics, 8 (7) e1002745, e1002745.1-e1002745.13. doi: 10.1371/journal.pgen.1002745
2012
Journal Article
Evidence of inbreeding depression on human height
McQuillan, Ruth, Eklund, Niina, Pirastu, Nicola, Kuningas, Maris, McEvoy, Brian P., Esko, Tonu, Corre, Tanguy, Davies, Gail, Kaakinen, Marika, Lyytikainen, Leo-Pekka, Kristiansson, Kati, Havulinna, Aki S., Gogele, Martin, Vitart, Veronique, Tenesa, Albert, Aulchenko, Yurii, Hayward, Caroline, Johansson, Asa, Boban, Mladen, Ulivi, Sheila, Robino, Antonietta, Boraska, Vesna, Igl, Wilmar, Wild, Sarah H., Zgaga, Lina, Amin, Najaf, Theodoratou, Evropi, Polasek, Ozren, Girotto, Giorgia ... Wilson, James F. (2012). Evidence of inbreeding depression on human height. Plos Genetics, 8 (7) e1002655, e1002655. doi: 10.1371/journal.pgen.1002655
2012
Journal Article
Selection and microevolution of coat pattern are cryptic in a wild population of sheep
Gratten, J., Pilkington, J. G., Brown, E. A., Clutton-Brock, T. H., Pemberton, J. M. and Slate, J. (2012). Selection and microevolution of coat pattern are cryptic in a wild population of sheep. Molecular Ecology, 21 (12), 2977-2990. doi: 10.1111/j.1365-294X.2012.05536.x
2012
Journal Article
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
Estrada, Karol, Styrkarsdottir, Unnur, Evangelou, Evangelos, Hsu, Yi-Hsiang, Duncan, Emma L., Ntzani, Evangelia E., Oei, Ling, Albagha, Omar M. E., Amin, Najaf, Kemp, John P., Koller, Daniel L., Li, Guo, Liu, Ching-Ti, Minster, Ryan L., Moayyeri, Alireza, Vandenput, Liesbeth, Willner, Dana, Xiao, Su-Mei, Yerges-Armstrong, Laura M., Zheng, Hou-Feng, Alonso, Nerea, Eriksson, Joel, Kammerer, Candace M., Kaptoge, Stephen K., Leo, Paul J., Thorleifsson, Gudmar, Wilson, Scott G., Wilson, James F., Aalto, Ville ... Rivadeneira, Fernando (2012). Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nature Genetics, 44 (5), 491-501. doi: 10.1038/ng.2249
Funding
Current funding
Supervision
Availability
- Honorary Professor Jake Gratten is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
-
Understanding mechanisms underlying multiple sclerosis using large-scale multi-omics
We are seeking a highly motivated PhD candidate with a background and interest in human genomics, statistics and neurodegenerative disease to join the Cognitive Health Genomics group at the Mater Research Institute, UQ. The successful candidate would work on an NHMRC-funded study to improve understanding of the pathophysiology of multiple sclerosis by integrating large-scale multi-omics data using cutting-edge statistical methods.
Requirements
- Bachelor’s degree with first class honours, or Masters, in statistics, mathematics, bioinformatics, human genetics, animal breeding, or an equivalent field.
- Prior research experience in human genomics or animal breeding, including a familiarity with high-throughput genomic data and working in a high-performance computing environment.
- Skills in the R statistical computing language and/or python, C++ or an equivalent computing language.
- High degree of motivation and organisation, and an ability to work both independently and as part of a team.
- Excellent written and oral communications skills in English.
For further information please contact Prof Jake Gratten, jacob.gratten@mater.uq.edu.au.
Supervision history
Current supervision
-
Doctor Philosophy
Multiomics of common co-occurring conditions in autism spectrum disorder
Principal Advisor
Other advisors: Dr Allan McRae, Dr Yuanhao Yang
-
Doctor Philosophy
Cellular genomics of Parkinson's disease
Principal Advisor
Other advisors: Dr Quan Nguyen, Dr Allan McRae, Dr Yuanhao Yang
-
Doctor Philosophy
Using multi-omics approaches to characterise determinants of early growth trajectories and their consequences on later life health
Associate Advisor
Other advisors: Professor David Evans, Dr Nicole Warrington
Completed supervision
-
2022
Doctor Philosophy
Multi-omics data offer systemic insights into autism
Principal Advisor
Other advisors: Professor Naomi Wray, Professor Gerald Holtmann
-
2019
Doctor Philosophy
Systems Genomics of Parkinson's Disease
Principal Advisor
Other advisors: Professor Peter Visscher
-
2018
Master Philosophy
Integrating genome-wide association study data with gene expression to understand complex traits and common diseases
Principal Advisor
Other advisors: Dr Allan McRae, Professor Naomi Wray
-
2024
Doctor Philosophy
The Role of the Gut Microbiome in Psychiatric Illness: From Prenatal Risk Factors to Treatment Resistance
Associate Advisor
Other advisors: Professor Dan Siskind, Professor Darryl Eyles
-
2015
Doctor Philosophy
Analysis of non-coding RNA expression in schizophrenia brain
Associate Advisor
Other advisors: Professor Bryan Mowry
Media
Enquiries
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