Professor David Hume
Professor

David Hume

Email: 
Phone: 
+61 7 3443 7315

Background

The research interests of the Hume Laboratory centre on the biology of macrophages and osteoclasts. These are cells of haematopoietic origin that are closely related to each other but have distinctly different activities.

David Hume was a group leader at the Institute for Molecular Bioscience (1988-2007) and subsequently Director of the Roslin Institute at the University of Edinburgh in Scotland from 2007-2017. He is currently a Professorial Research Fellow at the Mater Research Institute-UQ, located at the Translational Research Institute

Availability

Professor David Hume is:
Available for supervision

Fields of research

Biological Sciences Genetics Immunology

Qualifications

  • Bachelor (Honours) of Science (Advanced), Australian National University
  • Doctor of Philosophy, Australian National University

Research interests

  • Macrophages Biology

    Professor David Hume is a Professorial Research Fellow at the Mater Research Institute-UQ located at the Translational Research Institute. He was previously Director of The Roslin Institute at the University of Edinburgh (2007-2017). From 1988-2007, he was at the Institute for Molecular Bioscience at the University of Queensland, serving as Deputy Director of the CRC for Chronic Inflammatory Diseases, and Director of the ARC Special Centre for Functional and Applied Genomics. At Mater, David co-leads the Macrophage Biology Research Group with Dr Kate Irvine. He has authored over 450 scientific publications and has supervised more than 55 PhD graduates. He is an international authority in genome sciences, with a particular focus on the function of macrophages—specialised cells of the immune system involved in innate immunity against infections, inflammatory disease and cancer. David’s research focusses on macrophages in normal growth, development and physiology, infectious disease resistance and progression and complications of inflammation. His lab investigates mechanisms that regulate the biological functions of macrophages and explores avenues to boost their normal function and/or limit the damage they cause in inflammatory and infectious diseases. He is also interested in the genetic variations in macrophage function between individuals that contribute to susceptibility to inflammatory and infectious diseases. David has been elected to Fellowships in the Royal Society of Edinburgh, the UK Academy of Medical Sciences and the Royal Society of Biology. Since 2000, he has been a leading member of the FANTOM Consortium, which has made extensive contributions to mammalian genome and transcriptome annotation. David has a 35 year track record of attracting major strategic funding (CRC for Chronic Inflammatory Disease, ARC Special Research Centre in Australia; BBSRC Institute Strategic Programmes, Wellcome Trust Centres, UK Agritech Centre and Bill and Melinda Gates Centre Foundation in the UK) as well as continuous research project funding from NHMRC, ARC, BBSRC, MRC and the Wellcome Trust. "I trained as a metabolic biochemist at the Australian National University, and was very fortunate to have a great mentor in Dr Maurie Weidemann. Throughout my career, I have tried to mentor others with the same level of enthusiasm and support given to me. Being a biological scientist in the early 21st century is very much like being a physical scientist in the early 20th century. Each day brings new technologies and completely unexpected discoveries. I believe that the most novel breakthroughs and advances in human medicine and biotechnology come from basic discovery science, and fundamental understanding of macrophage biology has been my research focus for the whole of my career. That said, the applications of that understanding to human disease are clear, especially in the areas of tissue repair and regenerative medicine, and I am committed to pursuing those applications to benefit patients."

Search Professor David Hume’s works on UQ eSpace

627 works between 1976 and 2025
All (627) Journal Article (508) Book Chapter (14) Conference Publication (101) Book (1) Other Outputs (3)

481 - 500 of 627 works

2000

Journal Article

Macrophage activation by immunostimulatory DNA

Stacey, K. J., Sester, D. P., Sweet, M. J. and Hume, D. A. (2000). Macrophage activation by immunostimulatory DNA. Current Topics in Microbiology and Immunology, 247, 41-58. doi: 10.1007/978-3-642-59672-8_3

Macrophage activation by immunostimulatory DNA

2000

Journal Article

Purple acid phosphatases from bacteria: Structural similarities to mammalian and plant enzymes

Schenk, G., Korsinczky, M. L. J., Hume, D. A., Hamilton, S. E. and De Jersey, J. (2000). Purple acid phosphatases from bacteria: Structural similarities to mammalian and plant enzymes. Gene, 255 (2), 419-424. doi: 10.1016/S0378-1119(00)00305-X

Purple acid phosphatases from bacteria: Structural similarities to mammalian and plant enzymes

2000

Conference Publication

Replication protein A binds preferentially to immunostimulatory oligonucleotides.

Stacey, K. J., Sester, D. P., Murphy, K. M., Sweet, M. J. and Hume, D. A. (2000). Replication protein A binds preferentially to immunostimulatory oligonucleotides.. -, -, -. Bethesda, MD United States: Federation of American Societies for Experimental Biology.

Replication protein A binds preferentially to immunostimulatory oligonucleotides.

2000

Journal Article

Identification of mammalian-like purple acid phosphatases in a wide range of plants

Schenk, G., Ge, Y., Guddat, L., Carrington, L. E., Hume, D. A., Hamilton, S. E. and deJersey, J. (2000). Identification of mammalian-like purple acid phosphatases in a wide range of plants. Gene, 250 (1-2), 117-125. doi: 10.1016/S0378-1119(00)00186-4

Identification of mammalian-like purple acid phosphatases in a wide range of plants

2000

Conference Publication

Regulation of the TRAP promoter by MITF and PU.1 transcription factors during osteoclast differentiation.

Luchin, AI, Cassady, AI, Hume, DA and Ostrowski, MC (2000). Regulation of the TRAP promoter by MITF and PU.1 transcription factors during osteoclast differentiation.. AMER SOC CELL BIOLOGY.

Regulation of the TRAP promoter by MITF and PU.1 transcription factors during osteoclast differentiation.

2000

Journal Article

Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression

Hume, David A. (2000). Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression. Blood, 96 (7), 2323-2328. doi: 10.1182/blood.v96.7.2323.h8002323_2323_2328

Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression

1999

Journal Article

S100A8: Emerging functions and regulation

Passey, Robert J., Xu, Ken, Hume, David A. and Geczy, Carolyn L. (1999). S100A8: Emerging functions and regulation. Journal of Leukocyte Biology, 66 (4), 549-556. doi: 10.1002/jlb.66.4.549

S100A8: Emerging functions and regulation

1999

Journal Article

A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo

Passey, Robert J., Williams, Elizabeth, Lichanska, Agnieszka M., Wells, Christine, Hu, Shengping, Geczy, Carolyn L., Little, Melissa H. and Hume, David A. (1999). A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo. Journal of Immunology, 163 (4), 2209-2216.

A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo

1999

Journal Article

Differentiation of the mononuclear phagocyte system during mouse embryogenesis: The role of transcription factor PU.1

Lichanska, Agnieszka M., Browne, Catherine M., Henkel, Gregory W., Murphy, Kathleen M., Ostrowski, Michael C., McKercher, Scott R., Maki, Richard A. and Hume, David A. (1999). Differentiation of the mononuclear phagocyte system during mouse embryogenesis: The role of transcription factor PU.1. Blood, 94 (1), 127-138.

Differentiation of the mononuclear phagocyte system during mouse embryogenesis: The role of transcription factor PU.1

1999

Journal Article

Insulin-like Growth Factor-I (IGF-I) and IGF-I Receptor (IGF-IR) Immunoreactivity in Normal and Osteopetrotic (toothless, tl/tl) Rat Tibia

Joseph, Bobby K., Marks, Sandy C., Hume, David A., Waters, Michael J. and Symons, Anne L. (1999). Insulin-like Growth Factor-I (IGF-I) and IGF-I Receptor (IGF-IR) Immunoreactivity in Normal and Osteopetrotic (toothless, tl/tl) Rat Tibia. Growth Factors, 16 (4), 279-291. doi: 10.3109/08977199909069146

Insulin-like Growth Factor-I (IGF-I) and IGF-I Receptor (IGF-IR) Immunoreactivity in Normal and Osteopetrotic (toothless, tl/tl) Rat Tibia

1999

Journal Article

Young scientists in biomedical research

Hume, DA (1999). Young scientists in biomedical research. Science, 284 (5411), 49-49. doi: 10.1126/science.284.5411.49c

Young scientists in biomedical research

1999

Journal Article

Cloning and characterization of the murine genes for bHlH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members

Rehli, Michael, Den Elzen, Nicole, Cassady, A. Ian, Ostrowski, Michael C. and Hume, David A. (1999). Cloning and characterization of the murine genes for bHlH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members. Genomics, 56 (1), 111-120. doi: 10.1006/geno.1998.5588

Cloning and characterization of the murine genes for bHlH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members

1999

Journal Article

Mechanisms of regulation of the MacMarcks gene in macrophages by bacterial lipopolysaccharide

Chang, S. S., Stacey, K. J., Costelloe, E. O., Aderem, A., Hume, D. A. and Chen, J. (1999). Mechanisms of regulation of the MacMarcks gene in macrophages by bacterial lipopolysaccharide. Journal of Leukocyte Biology, 66 (3), 528-534. doi: 10.1002/jlb.66.3.528

Mechanisms of regulation of the MacMarcks gene in macrophages by bacterial lipopolysaccharide

1999

Conference Publication

Post-Golgi trafficking of TNF-a in macrophages

Shurety, W., Brown, D. L., Merino-Trigo, A., Smit, D. J., Hume, D. A. and Stow, J. L. (1999). Post-Golgi trafficking of TNF-a in macrophages. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September 1999. Kent Town, SA: Aust. Society for Biochemistry and Molecular Biology In..

Post-Golgi trafficking of TNF-a in macrophages

1999

Conference Publication

Transgenic mice overexpressing tartrate-resistant acid phosphatase exhibit an increased rate of bone turnover

Cassady, A. I., Walsh, N., Angel, N., Cahill, M. M., Forwood, M. R., Ostrowski, M. and Hume, D. A. (1999). Transgenic mice overexpressing tartrate-resistant acid phosphatase exhibit an increased rate of bone turnover. 9th Annual Scientific Meeting ANZBMS, Cairns, 30 June - 2 July, 1999. Sydney: ANZBMS.

Transgenic mice overexpressing tartrate-resistant acid phosphatase exhibit an increased rate of bone turnover

1999

Journal Article

TFEC is a macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors

Rehli, M., Lichanska, A., Cassady, A. I., Ostrowski, M. and Hume, D. A. (1999). TFEC is a macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors. Journal of Immunology, 162 (3), 1559-1565.

TFEC is a macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors

1999

Conference Publication

Crystal structure of mammalian purple acid phosphatase: An enzyme with a binuclear metal centre

Guddat, L. W., McAlpine, A. S., Hume, D. A., Hamilton, S. E, De Jersey, J. and Martin, J. L. (1999). Crystal structure of mammalian purple acid phosphatase: An enzyme with a binuclear metal centre. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Aust. Society for Biochemistry & Molecular Biology.

Crystal structure of mammalian purple acid phosphatase: An enzyme with a binuclear metal centre

1999

Journal Article

Crystallization and preliminary X-ray diffraction studies of mammalian purple acid phosphatase

Guddat, L. W., McAlpine, A. S., Hume, D. A., De Jersey, J., Hamilton, S. E. and Martin, J. L. (1999). Crystallization and preliminary X-ray diffraction studies of mammalian purple acid phosphatase. Acta Crystallographica Section D: Biological Crystallography, 55 (8), 1462-1464. doi: 10.1107/S0907444999006241

Crystallization and preliminary X-ray diffraction studies of mammalian purple acid phosphatase

1999

Journal Article

Bacterial/CpG DNA down-modulates colony stimulating factor-1 receptor surface expression on murine bone marrow-derived macrophages with concomitant growth arrest and factor-independent survival

Sester, D. P., Beasley, S. J., Sweet, M. J., Fowles, L. F., Cronau, S., Stacey, K. J. and Hume, D. A. (1999). Bacterial/CpG DNA down-modulates colony stimulating factor-1 receptor surface expression on murine bone marrow-derived macrophages with concomitant growth arrest and factor-independent survival. Journal of Immunology, 163 (12), 6541-6550.

Bacterial/CpG DNA down-modulates colony stimulating factor-1 receptor surface expression on murine bone marrow-derived macrophages with concomitant growth arrest and factor-independent survival

1999

Conference Publication

An anti-sense intronic promoter in the C-fms gene regulates expression in activated macrophages

Himes, S. R., Goonetilleke, N. P. and Hume, D. A. (1999). An anti-sense intronic promoter in the C-fms gene regulates expression in activated macrophages. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Aust. Society for Biochemistry & Molecular Biology.

An anti-sense intronic promoter in the C-fms gene regulates expression in activated macrophages

Current funding

  • 2024 - 2027
    A macrophage-centric holistic view of postnatal development
    ARC Discovery Projects
    Open grant
  • 2022 - 2026
    Macrophage Biology in Health and Disease
    NHMRC Investigator Grants
    Open grant

Past funding

  • 2021 - 2024
    Macrophage control of mammalian growth and development
    ARC Discovery Projects
    Open grant
  • 2019 - 2021
    Macrophage biology, inflammatory pathophysiology, transcriptional regulation, genetic analytics and clinical genetics
    Mater Foundation
    Open grant
  • 2019 - 2022
    CSF1 Therapy for Chronic Liver Disease
    NHMRC Project Grant
    Open grant
  • 2019 - 2021
    CSF1R and the control of microglial function
    NHMRC Project Grant
    Open grant
  • 2018 - 2020
    Osteal macrophages as therapeutic targets for fracture repair
    NHMRC Project Grant
    Open grant
  • 2008 - 2009
    Profiling the pro- and anti-inflammatory functions of histone deacetylases in macrophages
    Cancer Council Queensland
    Open grant
  • 2007 - 2010
    Cellular Activation and Apoptosis in Response to Foreign Cytoplasmic DNA
    NHMRC Project Grant
    Open grant
  • 2007 - 2008
    Regulation of human fibrillin genes in cardiovascular disease
    National Heart Foundation of Australia
    Open grant
  • 2007 - 2009
    Role of bone-associated macrophages in bone remodelling and bone disease
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    The c-type lectin, Mincle, is a macrophage receptor for Candida albicans.
    NHMRC Project Grant
    Open grant
  • 2006 - 2008
    Molecular genetics of the host response defect in cystic fibrosis
    NHMRC Project Grant
    Open grant
  • 2006 - 2007
    The role of DEP-1 as a tumour suppressor in breast cancer
    Queensland Cancer Fund
    Open grant
  • 2005 - 2008
    Human macrophage transcriptional network
    Riken Genomic Sciences Center
    Open grant
  • 2005
    Developmental Imaging Facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2005 - 2007
    Transcription control of the c-fms gene
    NHMRC Project Grant
    Open grant
  • 2004 - 2011
    Dynamic Imaging Facility for Cancer Biology
    Australian Cancer Research Foundation
    Open grant
  • 2004 - 2007
    The development of tyrosine kinase inhibitors for the treatment of inflammation and malignant disease.
    ARC Linkage Projects
    Open grant
  • 2004
    ARC Research Network in Microarray Technology
    ARC Seed Funding for Research Networks
    Open grant
  • 2004 - 2006
    Regulation Of Macrophage Function And Gene Expression By The Th2-Promoting Stimulus, ES-62
    NHMRC Project Grant
    Open grant
  • 2004 - 2006
    TLR9 And The Response To Foreign DNA
    NHMRC Project Grant
    Open grant
  • 2003 - 2006
    Gene expression profiling and de novo transcriptome sequencing using geneballs
    ARC Linkage Projects
    Open grant
  • 2003
    Agilent Microarray Scanner
    NHMRC Equipment Grant
    Open grant
  • 2003
    Alternative Splicing in the Mouse Transcriptome
    ARC Discovery Projects
    Open grant
  • 2003 - 2004
    Migration And Differentiation Of Dendritic Cells And Monocytes In Inflammatory Arthritis
    NHMRC Project Grant
    Open grant
  • 2003 - 2005
    Molecular genetics of cystic fibrosis
    NHMRC Project Grant
    Open grant
  • 2003 - 2005
    Molecular Genetics Of Macrophage Activation
    NHMRC Project Grant
    Open grant
  • 2003 - 2005
    Molecular genetics of macrophage activation
    NHMRC Project Grant - Standard
    Open grant
  • 2003
    Molecular Regulators of Cytokine Secretion
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2003
    Targeted Structural Genomics of Macrophage Proteins
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002 - 2006
    Towards Renal Regeneration
    United States National Institutes of Health
    Open grant
  • 2002 - 2008
    Education and training program
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Office
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Research Program 1
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Research Program 2
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Research Program 3
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Research Program 4
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Research Program 5
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002
    Defining the human and mammalian methylomes and implications for medical research
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002 - 2004
    Osteoclast-specific gene regulation
    NHMRC Project Grant
    Open grant
  • 2002 - 2004
    Transciptional regulation of the c-fms (CFS-1R) gene in macrophages
    NHMRC Project Grant
    Open grant
  • 2001 - 2002
    Transgenic animal studies of the function of artificial zinc finger transcription factors
    Sangamo Biosciences Inc.
    Open grant
  • 2001 - 2002
    Approaches to manipulating the expression of the c-fms gene
    Sangamo Biosciences Inc.
    Open grant
  • 2001
    MJ Research Tetrad - 4 x 96well block thermocycler
    Ramaciotti Foundation
    Open grant
  • 2000
    Control of osteociast differentiation
    Mayne Bequest Fund
    Open grant
  • 2000 - 2002
    Genes controlling the development of lung disease in cystic fibrosis mutant mice
    NHMRC Project Grant
    Open grant
  • 2000 - 2002
    Mechanisms of macrophage activation by immunostimulatory DNA
    NHMRC Project Grant
    Open grant
  • 2000
    Regulation of the Tartrate-Resistant Acid Phosphatase Gene.
    ARC Australian Research Council (Small grants)
    Open grant
  • 2000 - 2002
    The role of the microphthalmia transcription factor family in macrophage differentiation
    NHMRC Project Grant
    Open grant
  • 1999 - 2001
    Genetic interactions that regulate the response of macrophages to bacterial lipopolysaccharide
    Merck Genome Research Institute
    Open grant
  • 1999
    Function and regulation of the tartrate resistant acid phosphatase gene
    Mayne Bequest Fund
    Open grant
  • 1999 - 2001
    Human tartrate-resistant purple acid phosphatase: structure and function
    NHMRC Project Grant
    Open grant
  • 1999
    Mechanisms of action of CpG DNA as an activator of macrophage function
    Mayne Bequest Fund
    Open grant
  • 1999 - 2000
    Signal transduction from the macrophage colony-stimulating factor receptor
    Queensland Cancer Fund
    Open grant
  • 1999 - 2000
    Transcriptional regulation of the macrophage colony stimulating factor receptor (c-fms) gene
    NHMRC Project Grant
    Open grant
  • 1998 - 2000
    Transcriptional Regulation of the Macrophage Colony Stimulating Factor Receptor (c-fms) Gene
    NHMRC Project Grant
    Open grant
  • 1997 - 1998
    Crystallisation of tartrate resistant acid phosphatase
    Johnson & Johnson Research Pty Ltd
    Open grant
  • 1997
    Regulation of the HIV-1-LTR in macrophages
    NHMRC Extended Epidemiology Project Grant
    Open grant
  • 1997
    Development of candidate drugs for the treatment of osteoporosis
    Merck Sharp & Dohme Australia
    Open grant
  • 1997 - 1999
    Genes controlling the development of lung disease in normal and cystic fibrosis mice
    NHMRC Project Grant
    Open grant
  • 1997
    Microplate counting system
    NHMRC Equipment Grant
    Open grant
  • 1997
    Microplate counting system.
    Ramaciotti Foundation
    Open grant
  • 1996
    Macrophage DNA recepter project.
    CRC for Vaccine Technology
    Open grant
  • 1996 - 1998
    Function and regulation of the tartrate-resistant acid phosphatase gene
    NHMRC Project Grant
    Open grant
  • 1996 - 1998
    Protein tyrosine phosphatases in macrophages
    Queensland Cancer Fund
    Open grant
  • 1996 - 1998
    Regulation of the urokinase plasminogen activator gene by macrophaghe colony-stimulating factor
    NHMRC Project Grant
    Open grant
  • 1996
    Zeiss axiophot microscope
    NHMRC Equipment Grant
    Open grant
  • 1995 - 1997
    Regulation of HIV-1-LTR in macrophages
    NHMRC Project Grant - HIV/AIDS (CARG)
    Open grant
  • 1995 - 1997
    The role of c-fms and macrophage colony stimulating factor (CSF-1) in tumor progression
    Queensland Cancer Fund
    Open grant

Availability

Professor David Hume is:
Available for supervision

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Available projects

  • The role of macrophages in postnatal development

    This project is associated with a successful ARC Discovery Grant and builds upon the discovery that mutation in the CSF1R gene, which controls the deveelopment of macrophages, has severe impacts on postnatal growth and organ development (See paper below). The phenotype can be reversed by transfer of wild-type bone marrow. The PhD project will focus on analysing the precose mechanisms that enable transplanted macrophages to restore normal development. It will develop a wide range of skills in the braod areas of cell and developmental biology, genomics and bioinformatics.

    Enquiries to david.hume@uq.edu.au or Katharine.Irvine@uq.edu.au

    Keshvari S, Caruso M, Teakle N, Batoon L, Sehgal A, Patkar OL, Ferrari-Cestari M, Snell CE, Chen C, Stevenson A, Davis FM, Bush SJ, Pridans C, Summers KM, Pettit AR, Irvine KM, Hume DA.

    CSF1R-dependent macrophages control postnatal somatic growth and organ maturation. PLoS Genet. 2021 Jun 3;17(6):e1009605. doi: 10.1371/journal.pgen.1009605. Online ahead of print.PMID: 34081701

Supervision history

Current supervision

Completed supervision

Enquiries

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