
Overview
Background
The research interests of the Hume Laboratory centre on the biology of macrophages and osteoclasts. These are cells of haematopoietic origin that are closely related to each other but have distinctly different activities.
David Hume was a group leader at the Institute for Molecular Bioscience (1988-2007) and subsequently Director of the Roslin Institute at the University of Edinburgh in Scotland from 2007-2017. He is currently a Professorial Research Fellow at the Mater Research Institute-UQ, located at the Translational Research Institute
Availability
- Professor David Hume is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), Australian National University
- Doctor of Philosophy, Australian National University
Research interests
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Macrophages Biology
Professor David Hume is a Professorial Research Fellow at the Mater Research Institute-UQ located at the Translational Research Institute. He was previously Director of The Roslin Institute at the University of Edinburgh (2007-2017). From 1988-2007, he was at the Institute for Molecular Bioscience at the University of Queensland, serving as Deputy Director of the CRC for Chronic Inflammatory Diseases, and Director of the ARC Special Centre for Functional and Applied Genomics. At Mater, David co-leads the Macrophage Biology Research Group with Dr Kate Irvine. He has authored over 450 scientific publications and has supervised more than 55 PhD graduates. He is an international authority in genome sciences, with a particular focus on the function of macrophages—specialised cells of the immune system involved in innate immunity against infections, inflammatory disease and cancer. David’s research focusses on macrophages in normal growth, development and physiology, infectious disease resistance and progression and complications of inflammation. His lab investigates mechanisms that regulate the biological functions of macrophages and explores avenues to boost their normal function and/or limit the damage they cause in inflammatory and infectious diseases. He is also interested in the genetic variations in macrophage function between individuals that contribute to susceptibility to inflammatory and infectious diseases. David has been elected to Fellowships in the Royal Society of Edinburgh, the UK Academy of Medical Sciences and the Royal Society of Biology. Since 2000, he has been a leading member of the FANTOM Consortium, which has made extensive contributions to mammalian genome and transcriptome annotation. David has a 35 year track record of attracting major strategic funding (CRC for Chronic Inflammatory Disease, ARC Special Research Centre in Australia; BBSRC Institute Strategic Programmes, Wellcome Trust Centres, UK Agritech Centre and Bill and Melinda Gates Centre Foundation in the UK) as well as continuous research project funding from NHMRC, ARC, BBSRC, MRC and the Wellcome Trust. "I trained as a metabolic biochemist at the Australian National University, and was very fortunate to have a great mentor in Dr Maurie Weidemann. Throughout my career, I have tried to mentor others with the same level of enthusiasm and support given to me. Being a biological scientist in the early 21st century is very much like being a physical scientist in the early 20th century. Each day brings new technologies and completely unexpected discoveries. I believe that the most novel breakthroughs and advances in human medicine and biotechnology come from basic discovery science, and fundamental understanding of macrophage biology has been my research focus for the whole of my career. That said, the applications of that understanding to human disease are clear, especially in the areas of tissue repair and regenerative medicine, and I am committed to pursuing those applications to benefit patients."
Works
Search Professor David Hume’s works on UQ eSpace
2000
Journal Article
Co-operative induction of pro-inflammatory signaling by Toll-like receptors
Ozinsky, A., Smith, K. D., Hume, D. and Underhill, D. M. (2000). Co-operative induction of pro-inflammatory signaling by Toll-like receptors. Journal of Endotoxin Research, 6 (5), 393-396. doi: 10.1177/09680519000060051101
2000
Journal Article
Transgenic mice that overexpress the tartrate-resistant acid phosphatase gene exhibit in an increased rate of bone turnover
Angel, N., Cahill, M. M., King, A., Ostrowski, M., Cassady, A. I. and Hume, D. A. (2000). Transgenic mice that overexpress the tartrate-resistant acid phosphatase gene exhibit in an increased rate of bone turnover. Journal of Bone and Mineral Research, 15 (1), 103-110. doi: 10.1359/jbmr.2000.15.1.103
2000
Journal Article
Heat shock enhances transcriptional activation of the murine inducible nitric oxide synthase gene
Goldring, C. E., Reveneau, S., Chantome, A., Pance, A., Fleury, C., Hume, D. A. and Sester, D. (2000). Heat shock enhances transcriptional activation of the murine inducible nitric oxide synthase gene. The FASEB Journal, 15 (15), 2393-2395.
2000
Journal Article
Ets-2 is a target for an Akt (protein kinase B)/Jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice
Smith, James L., Schaffner, Alicia E., Hofmeister, Joseph K., Hartman, Matthew Hartman, Wei, Guo, Forsthoefel, David, Hume, David A. and Ostrowski, Michael C. (2000). Ets-2 is a target for an Akt (protein kinase B)/Jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice. Molecular and Cellular Biology, 20 (21), 8026-8034. doi: 10.1128/MCB.20.21.8026-8034.2000
2000
Journal Article
Phosphorothioate backbone modification modulates macrophage activation by CpG DNA1
Sester, D. P., Naik, S., Beasley, S. J., Hume, D. A. and Stacey, K. J. (2000). Phosphorothioate backbone modification modulates macrophage activation by CpG DNA1. The Journal of Immunology, 165 (8), 4165-4173. doi: 10.4049/jimmunol.165.8.4165
2000
Conference Publication
Differential use of a non-canonical TATA box in the tartrate-resistant acid phosphatase (TRAP) gene promoter between macrophages and osteoclasts.
Cassady, AI, Merson, T, Suchting, S, Hong, TW and Hume, DA (2000). Differential use of a non-canonical TATA box in the tartrate-resistant acid phosphatase (TRAP) gene promoter between macrophages and osteoclasts.. AMER SOC BONE & MINERAL RES.
1999
Journal Article
S100A8: Emerging functions and regulation
Passey, Robert J., Xu, Ken, Hume, David A. and Geczy, Carolyn L. (1999). S100A8: Emerging functions and regulation. Journal of Leukocyte Biology, 66 (4), 549-556. doi: 10.1002/jlb.66.4.549
1999
Journal Article
A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo
Passey, Robert J., Williams, Elizabeth, Lichanska, Agnieszka M., Wells, Christine, Hu, Shengping, Geczy, Carolyn L., Little, Melissa H. and Hume, David A. (1999). A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo. Journal of Immunology, 163 (4), 2209-2216.
1999
Journal Article
Differentiation of the mononuclear phagocyte system during mouse embryogenesis: The role of transcription factor PU.1
Lichanska, Agnieszka M., Browne, Catherine M., Henkel, Gregory W., Murphy, Kathleen M., Ostrowski, Michael C., McKercher, Scott R., Maki, Richard A. and Hume, David A. (1999). Differentiation of the mononuclear phagocyte system during mouse embryogenesis: The role of transcription factor PU.1. Blood, 94 (1), 127-138.
1999
Journal Article
Insulin-like Growth Factor-I (IGF-I) and IGF-I Receptor (IGF-IR) Immunoreactivity in Normal and Osteopetrotic (toothless, tl/tl) Rat Tibia
Joseph, Bobby K., Marks, Sandy C., Hume, David A., Waters, Michael J. and Symons, Anne L. (1999). Insulin-like Growth Factor-I (IGF-I) and IGF-I Receptor (IGF-IR) Immunoreactivity in Normal and Osteopetrotic (toothless, tl/tl) Rat Tibia. Growth Factors, 16 (4), 279-291. doi: 10.3109/08977199909069146
1999
Journal Article
Young scientists in biomedical research
Hume, DA (1999). Young scientists in biomedical research. Science, 284 (5411), 49-49. doi: 10.1126/science.284.5411.49c
1999
Journal Article
Cloning and characterization of the murine genes for bHlH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members
Rehli, Michael, Den Elzen, Nicole, Cassady, A. Ian, Ostrowski, Michael C. and Hume, David A. (1999). Cloning and characterization of the murine genes for bHlH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members. Genomics, 56 (1), 111-120. doi: 10.1006/geno.1998.5588
1999
Conference Publication
Localisation of tartrate resistant acid phosphatase expression during early embryonic development in the mouse
Walsh, N., Angel, N., Williams, E. A., Cassady, A. I. and Hume, D. A. (1999). Localisation of tartrate resistant acid phosphatase expression during early embryonic development in the mouse. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Aust. Society for Biochemistry & Molecular Biology.
1999
Journal Article
The actions of bacterial DNA on murine macrophages
Sester, D. P., Stacey, K. J., Sweet, M. J., Beasley, S. J., Cronau, S. L. and Hume, D. A. (1999). The actions of bacterial DNA on murine macrophages. Journal of Leukocyte Biology, 66 (4), 542-548. doi: 10.1002/jlb.66.4.542
1999
Conference Publication
The tartrate-resistant acid phosphatase (TRAP) promoter is regulated by the macrophage-osteoclast ets transcription factor, PU.1
Suchting, S. J., Merson, T. D., Angel, N., Cassady, A. I. and Hume, D. A. (1999). The tartrate-resistant acid phosphatase (TRAP) promoter is regulated by the macrophage-osteoclast ets transcription factor, PU.1. ComBio 99, Conrad Jupiters, Gold Coast, 27th - 30th September, 1999. Kent Town, SA: Aust. Society for Biochemistry & Molecular Biology.
1999
Journal Article
CAT2-mediated L-arginine transport and nitric oxide production in activated macrophages
Kakuda, D. K., Sweet, M. J., MacLeod, C. L., Hume, D. A. and Markovich, D. (1999). CAT2-mediated L-arginine transport and nitric oxide production in activated macrophages. Biochemical Journal, 340 (2), 549-553. doi: 10.1042/0264-6021:3400549
1999
Journal Article
Crystal structure of mammalian purple acid phosphatase
Guddat, L. W., McAlpine, A. S., Hume, D. A., Hamilton, S. E., De Jersey, J. and Martin, J. L. (1999). Crystal structure of mammalian purple acid phosphatase. Structure With Folding & Design, 7 (7), 757-767. doi: 10.1016/S0969-2126(99)80100-2
1999
Conference Publication
Crystallisation of a mammalian purple acid phosphatase
Hamilton, S. E., Guddat, L. W., McAlpine, A. S., Hume, D. A., De Jersey, J. and Martin, J. L. (1999). Crystallisation of a mammalian purple acid phosphatase. 24th Annual Lorne Conference on Protein Structure and Functin, Erskine House, Lorne, Vic., 7-11 February, 1999. Lorne: Lorne Aust..
1999
Conference Publication
CpG DNA effects macrophage CSF-1 receptor cell surface expression, proliferation and survival
Sester, D. P., Beasley, S. J., Sweet, M. J., Stacey, K. J. and Hume, D. A. (1999). CpG DNA effects macrophage CSF-1 receptor cell surface expression, proliferation and survival. 15th International Congress for Society for Leukocyte Biology, Churchill College, Cambridge UK, 22-26 September, 1999. Bethesda, Maryland: Society for Leukocyte Biology.
1999
Journal Article
Regulation of the plasminogen activator inhibitor-2 (PAI-2) gene in murine macrophages. Demonstration of a novel pattern of responsiveness to bacterial endotoxin
Costelloe, E. O., Stacey, K. J., Antalis, T. M. and Hume, D. A. (1999). Regulation of the plasminogen activator inhibitor-2 (PAI-2) gene in murine macrophages. Demonstration of a novel pattern of responsiveness to bacterial endotoxin. Journal of Leukocyte Biology, 66 (1), 172-183. doi: 10.1002/jlb.66.1.172
Funding
Current funding
Past funding
Supervision
Availability
- Professor David Hume is:
- Available for supervision
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Available projects
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The role of macrophages in postnatal development
This project is associated with a successful ARC Discovery Grant and builds upon the discovery that mutation in the CSF1R gene, which controls the deveelopment of macrophages, has severe impacts on postnatal growth and organ development (See paper below). The phenotype can be reversed by transfer of wild-type bone marrow. The PhD project will focus on analysing the precose mechanisms that enable transplanted macrophages to restore normal development. It will develop a wide range of skills in the braod areas of cell and developmental biology, genomics and bioinformatics.
Enquiries to david.hume@uq.edu.au or Katharine.Irvine@uq.edu.au
Keshvari S, Caruso M, Teakle N, Batoon L, Sehgal A, Patkar OL, Ferrari-Cestari M, Snell CE, Chen C, Stevenson A, Davis FM, Bush SJ, Pridans C, Summers KM, Pettit AR, Irvine KM, Hume DA.
CSF1R-dependent macrophages control postnatal somatic growth and organ maturation. PLoS Genet. 2021 Jun 3;17(6):e1009605. doi: 10.1371/journal.pgen.1009605. Online ahead of print.PMID: 34081701
Supervision history
Current supervision
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Doctor Philosophy
Phenotypic impacts of hypomorphic mutations in the mouse Csf1r locus
Principal Advisor
Other advisors: Dr Katharine Irvine
-
Doctor Philosophy
Erythroid iron metabolism and its effect on systemic iron homeostasis
Principal Advisor
Other advisors: Dr Katharine Irvine
-
Doctor Philosophy
The redundant and non-redundant functions of CSF1R-dependent macrophages during postnatal development
Principal Advisor
Other advisors: Dr Katharine Irvine
-
Doctor Philosophy
Functions of CSF1R signalling in inflammation.
Associate Advisor
Other advisors: Professor Antje Blumenthal, Dr Katharine Irvine
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Doctor Philosophy
Regulation of Resident Tissue Macrophage Development and Function
Associate Advisor
Other advisors: Dr Sahar Keshvari, Dr Katharine Irvine
Completed supervision
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2024
Doctor Philosophy
Macrophage colony-stimulating factor in the treatment of non-alcoholic fatty liver disease
Principal Advisor
Other advisors: Dr Katharine Irvine, Dr Sahar Keshvari
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2023
Doctor Philosophy
Characterisation of a novel mouse model with a disease-causing Colony Stimulating Factor 1 Receptor mutation
Principal Advisor
Other advisors: Dr Katharine Irvine
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2023
Doctor Philosophy
The role of macrophages in the regulation of systemic metabolism
Principal Advisor
Other advisors: Dr Katharine Irvine, Dr Sahar Keshvari
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2009
Doctor Philosophy
Regulation and Function of Schlafen in Macrophage Biology
Principal Advisor
Other advisors: Professor Matt Sweet
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2007
Doctor Philosophy
THE STRUCTURAL BASIS FOR INTERACTION BETWEEN COLONY- STIMULATING FACTOR-1 AND ITS RECEPTOR, CSF-1R
Principal Advisor
Other advisors: Associate Professor Mark Smythe, Professor Bostjan Kobe, Dr Ian Ross
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2007
Doctor Philosophy
TRANSCRIPTIONAL REGULATION OF THE c-fms PROMOTER BY THE ETS FAMILY OF TRANSCRIPTION FACTORS
Principal Advisor
Other advisors: Professor Kate Stacey
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2006
Doctor Philosophy
FUNCTIONAL CHARACTERISATION OF MACROPHAGE-SPECIFIC TRANSCRIPTS
Principal Advisor
-
2005
Doctor Philosophy
MECHANISMS OF INTERFERON-GAMMA PRIMING OF MACROPHAGE ACTIVATION BY CpG DNA
Principal Advisor
-
2004
Master Science
Study of gene expression profile of osteoclasts
Principal Advisor
-
2004
Doctor Philosophy
THE EXPRESSIONS AND FUNCTIONS OF G3BPs IN MACROPHAGES
Principal Advisor
-
2004
Doctor Philosophy
TRANSCRIPTIONAL ANALYSIS OF MACROPHAGE SIGNALLING IN RESPONSE TO LIPOPOLYSACCHARIDE
Principal Advisor
Other advisors: Professor Brandon Wainwright
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2003
Doctor Philosophy
THE FUNCTION AND REGULATION OF TARTRATE-RESISTANT ACID PHOSPHATASE (TRAP)
Principal Advisor
-
2003
Doctor Philosophy
Transcriptional regulation of c-fms gene expression
Principal Advisor
-
2003
Doctor Philosophy
MECHANISMS OF ACTION OF BACTERIAL DNA ON MACROPHAGE ACTIVATION
Principal Advisor
Other advisors: Professor Kate Stacey
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2025
Doctor Philosophy
The role of IL34 in HPV-mediated epithelial cancers
Associate Advisor
Other advisors: Associate Professor Graham Leggatt, Dr Janin Chandra, Professor Ian Frazer
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2024
Doctor Philosophy
Preclinical modelling of central nervous system complications and toxicities of cellular and immunotherapies for cancer treatment
Associate Advisor
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2021
Master Philosophy
Developing a Novel Immune Cell Therapy for Glioblastoma: A Novel Monocyte-based Cell-therapy for the Treatment of Glioblastoma
Associate Advisor
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2012
Doctor Philosophy
Characterisation of Myeloid Cells in the Peritoneal Foreign Body Response: Evidence for Phenotypic Plasticity
Associate Advisor
Other advisors: Associate Professor Barbara Rolfe
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2010
Doctor Philosophy
Osteal macrophages (osteomacs) are pivotal for intramembranous bone formation in vivo: Osteomacs facilitate osteoblast maintenance in vivo and enhance osteoblast-mediated bone deposition in a murine model of bone healing
Associate Advisor
Other advisors: Professor Allison Pettit, Dr Liza Raggatt
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2009
Doctor Philosophy
Short Sequence Tags Reveal Global Transcription Of Repetitive Elements In Mammalian Genomes
Associate Advisor
-
2009
Doctor Philosophy
Cellular activation and death in response to cytoplasmic DNA
Associate Advisor
Other advisors: Professor Kate Stacey
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2009
Doctor Philosophy
Role of macrophages, residing on the bone surface, in bone remodelling and repair
Associate Advisor
Other advisors: Professor Allison Pettit, Dr Liza Raggatt
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2007
Doctor Philosophy
FUNCTIONAL CHARACTERISATION OF THE ROLE OF PROTEIN TYROSINE PHOSPHATASE CD148 IN MACROPHAGES
Associate Advisor
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2006
Doctor Philosophy
THE ROLE OF MICROPHTHALMIA TRANSCRIPTION FACTOR (MITF) IN OSTEOCLAST GENE REGULATION
Associate Advisor
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2006
Doctor Philosophy
MOLECULAR AND FUNCTIONAL CHARACTERISATION OF POTENTIAL MURINE RENAL STEM CELLS
Associate Advisor
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2006
Doctor Philosophy
THE IMPORTANCE OF EPIGENETICS IN MAMMALS
Associate Advisor
-
2005
Doctor Philosophy
SHADES OF DOMAINS: BIOINFORMATIC IDENTIFICATION OF PROTEIN DOMAIN SUBTYPES AND CORRELATION WITH FUNCTIONAL SPECIFICITY
Associate Advisor
Other advisors: Associate Professor Rohan Teasdale
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2005
Doctor Philosophy
CELLULAR RESPONSES TO IMMUNOSTIMULATORY DNA
Associate Advisor
Other advisors: Professor Matt Sweet, Professor Kate Stacey
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