Professor David Hume
Professor

David Hume

Email: 
Phone: 
+61 7 3443 7315

Background

The research interests of the Hume Laboratory centre on the biology of macrophages and osteoclasts. These are cells of haematopoietic origin that are closely related to each other but have distinctly different activities.

David Hume was a group leader at the Institute for Molecular Bioscience (1988-2007) and subsequently Director of the Roslin Institute at the University of Edinburgh in Scotland from 2007-2017. He is currently a Professorial Research Fellow at the Mater Research Institute-UQ, located at the Translational Research Institute

Availability

Professor David Hume is:
Available for supervision

Fields of research

Biological Sciences Genetics Immunology

Qualifications

  • Bachelor (Honours) of Science (Advanced), Australian National University
  • Doctor of Philosophy, Australian National University

Research interests

  • Macrophages Biology

    Professor David Hume is a Professorial Research Fellow at the Mater Research Institute-UQ located at the Translational Research Institute. He was previously Director of The Roslin Institute at the University of Edinburgh (2007-2017). From 1988-2007, he was at the Institute for Molecular Bioscience at the University of Queensland, serving as Deputy Director of the CRC for Chronic Inflammatory Diseases, and Director of the ARC Special Centre for Functional and Applied Genomics. At Mater, David co-leads the Macrophage Biology Research Group with Dr Kate Irvine. He has authored over 450 scientific publications and has supervised more than 55 PhD graduates. He is an international authority in genome sciences, with a particular focus on the function of macrophages—specialised cells of the immune system involved in innate immunity against infections, inflammatory disease and cancer. David’s research focusses on macrophages in normal growth, development and physiology, infectious disease resistance and progression and complications of inflammation. His lab investigates mechanisms that regulate the biological functions of macrophages and explores avenues to boost their normal function and/or limit the damage they cause in inflammatory and infectious diseases. He is also interested in the genetic variations in macrophage function between individuals that contribute to susceptibility to inflammatory and infectious diseases. David has been elected to Fellowships in the Royal Society of Edinburgh, the UK Academy of Medical Sciences and the Royal Society of Biology. Since 2000, he has been a leading member of the FANTOM Consortium, which has made extensive contributions to mammalian genome and transcriptome annotation. David has a 35 year track record of attracting major strategic funding (CRC for Chronic Inflammatory Disease, ARC Special Research Centre in Australia; BBSRC Institute Strategic Programmes, Wellcome Trust Centres, UK Agritech Centre and Bill and Melinda Gates Centre Foundation in the UK) as well as continuous research project funding from NHMRC, ARC, BBSRC, MRC and the Wellcome Trust. "I trained as a metabolic biochemist at the Australian National University, and was very fortunate to have a great mentor in Dr Maurie Weidemann. Throughout my career, I have tried to mentor others with the same level of enthusiasm and support given to me. Being a biological scientist in the early 21st century is very much like being a physical scientist in the early 20th century. Each day brings new technologies and completely unexpected discoveries. I believe that the most novel breakthroughs and advances in human medicine and biotechnology come from basic discovery science, and fundamental understanding of macrophage biology has been my research focus for the whole of my career. That said, the applications of that understanding to human disease are clear, especially in the areas of tissue repair and regenerative medicine, and I am committed to pursuing those applications to benefit patients."

Search Professor David Hume’s works on UQ eSpace

627 works between 1976 and 2025
All (627) Journal Article (508) Book Chapter (14) Conference Publication (101) Book (1) Other Outputs (3)

541 - 560 of 627 works

1994

Journal Article

Comparison of the expression and function of the transcription factor PU.1 (Spi-1 proto-oncogene) between murine macrophages and B lymphocytes

Ross, I. L., Dunn, T. L., Yue, X., Roy, S., Barnett, C. J. and Hume, DA (1994). Comparison of the expression and function of the transcription factor PU.1 (Spi-1 proto-oncogene) between murine macrophages and B lymphocytes. Oncogene, 9 (1), 121-132.

Comparison of the expression and function of the transcription factor PU.1 (Spi-1 proto-oncogene) between murine macrophages and B lymphocytes

1994

Journal Article

The HIV-1 regulatory protein Nef has a specific function in a murine macrophage cell line

Murphy, K. M., Sweet, M. J. and Hume, D. A. (1994). The HIV-1 regulatory protein Nef has a specific function in a murine macrophage cell line. Journal of Leukocyte Biology, 56 (3), 294-303. doi: 10.1002/jlb.56.3.294

The HIV-1 regulatory protein Nef has a specific function in a murine macrophage cell line

1993

Journal Article

Effects of the tat and nef gene products of human immunodeficiency virus type 1 (HIV-1) on transcription controlled by the HIV-1 long terminal repeat and on cell growth in macrophages

Murphy, Kathleen M., Sweet, Matthew J., Ross, Ian L. and Hume, David A. (1993). Effects of the tat and nef gene products of human immunodeficiency virus type 1 (HIV-1) on transcription controlled by the HIV-1 long terminal repeat and on cell growth in macrophages. Journal of Virology, 67 (12), 6956-6964. doi: 10.1128/jvi.67.12.6956-6964.1993

Effects of the tat and nef gene products of human immunodeficiency virus type 1 (HIV-1) on transcription controlled by the HIV-1 long terminal repeat and on cell growth in macrophages

1993

Journal Article

Isolation and characterization of the genes encoding mouse and human type-5 acid phosphatase

Cassady, A. Ian, King, Andrew G., Cross, Nicholas C. P. and Hume, David A. (1993). Isolation and characterization of the genes encoding mouse and human type-5 acid phosphatase. Gene, 130 (2), 201-207. doi: 10.1016/0378-1119(93)90420-8

Isolation and characterization of the genes encoding mouse and human type-5 acid phosphatase

1993

Journal Article

Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation

Yue, Xie, Favot, Paula, Dunn, Timothy L., Cassady, A. Ian and Hume, David A. (1993). Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation. Molecular and Cellular Biology, 13 (6), 3191-3201. doi: 10.1128/MCB.13.6.3191

Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation

1993

Journal Article

Electroporation and DNA-dependent cell-death in murine macrophages

Stacey, Katryn J., Ross, Ian L. and Hume, David A. (1993). Electroporation and DNA-dependent cell-death in murine macrophages. Immunology and Cell Biology, 71 (2), 75-85. doi: 10.1038/icb.1993.8

Electroporation and DNA-dependent cell-death in murine macrophages

1993

Conference Publication

Regulation of the Urokinase-Type Plasminogen-Activator Gene by Csf-1 and Phorbol Ester

Stacey, K. J., Fowles, L. F., Coleman, M. S., Ostrowski, M. and Hume, D. A. (1993). Regulation of the Urokinase-Type Plasminogen-Activator Gene by Csf-1 and Phorbol Ester. -, -, -. United Kingdom: John Wiley & Sons.

Regulation of the Urokinase-Type Plasminogen-Activator Gene by Csf-1 and Phorbol Ester

1993

Journal Article

Dendritic Cells, the Major Antigen-Presenting Cells of the Human Colonic Lamina Propria

Pavli, P, Hume, DA, Vandepol, E and Doe, WF (1993). Dendritic Cells, the Major Antigen-Presenting Cells of the Human Colonic Lamina Propria. Immunology, 78 (1), 132-141.

Dendritic Cells, the Major Antigen-Presenting Cells of the Human Colonic Lamina Propria

1993

Conference Publication

Roles of Macrophage-Colony-Stimulating Factor (Csf-1) and its Receptor (C-Fms) in Tumor Progression

Favot, P, Fidler, IJ and Hume, DA (1993). Roles of Macrophage-Colony-Stimulating Factor (Csf-1) and its Receptor (C-Fms) in Tumor Progression. FEDERATION AMER SOC EXP BIOL.

Roles of Macrophage-Colony-Stimulating Factor (Csf-1) and its Receptor (C-Fms) in Tumor Progression

1993

Journal Article

The resistance of macrophage-like tumour cell lines to growth inhibition by lipopolysaccharide and pertussis toxin

Xie, Yue, von Gavel, Stephanie, Cassady, A. Ian, Stacey, Katryn J., Dunn, Timothy L. and Hume, David A. (1993). The resistance of macrophage-like tumour cell lines to growth inhibition by lipopolysaccharide and pertussis toxin. British Journal of Haematology, 84 (3), 392-401. doi: 10.1111/j.1365-2141.1993.tb03092.x

The resistance of macrophage-like tumour cell lines to growth inhibition by lipopolysaccharide and pertussis toxin

1993

Conference Publication

Molecular-Biology of Macrophage Differentiation

Hume, DA (1993). Molecular-Biology of Macrophage Differentiation. FEDERATION AMER SOC EXP BIOL.

Molecular-Biology of Macrophage Differentiation

1992

Journal Article

Involvement of γ‐aminobutyric acid and N‐methyl‐D‐aspartate receptors in the inhibitory effect of ethanol on pentylenetetrazole‐induced c‐fos expression in rat brain

Le, Fei, Wilce, Peter A., Hume, David A. and Shanley, Brian C. (1992). Involvement of γ‐aminobutyric acid and N‐methyl‐D‐aspartate receptors in the inhibitory effect of ethanol on pentylenetetrazole‐induced c‐fos expression in rat brain. Journal of Neurochemistry, 59 (4), 1309-1315. doi: 10.1111/j.1471-4159.1992.tb08442.x

Involvement of γ‐aminobutyric acid and N‐methyl‐D‐aspartate receptors in the inhibitory effect of ethanol on pentylenetetrazole‐induced c‐fos expression in rat brain

1992

Journal Article

Induction of class II major histocompatibility antigens on thyroid, adult pancreatic-islet, and fetal proislet allografts

Warren, Hilary S., Hodder, Michelle J., Allan, William, Hume, David A. and Simeonovic, Charmaine J. (1992). Induction of class II major histocompatibility antigens on thyroid, adult pancreatic-islet, and fetal proislet allografts. Transplantation, 53 (4), 834-840. doi: 10.1097/00007890-199204000-00025

Induction of class II major histocompatibility antigens on thyroid, adult pancreatic-islet, and fetal proislet allografts

1992

Journal Article

Effect of recombinant human macrophage colony-stimulating factor 1 on immunopathology of experimental brucellosis in mice

Doyle, Anthony G., Halliday, William J., Barnett, Christopher J., Dunn, Timothy L. and Hume, David A. (1992). Effect of recombinant human macrophage colony-stimulating factor 1 on immunopathology of experimental brucellosis in mice. Infection and Immunity, 60 (4), 1465-1472. doi: 10.1128/IAI.60.4.1465-1472.1992

Effect of recombinant human macrophage colony-stimulating factor 1 on immunopathology of experimental brucellosis in mice

1992

Book Chapter

The regulation of urokinase plasminogen activator gene expression in macrophages

Stacey, K. J., Cassady, A. I., Nimmo, K. A., Murphy, K. M., von der Ahe, D., Pearson, D., Botteri, F., Nagamine, Y. and Hume, D. A. (1992). The regulation of urokinase plasminogen activator gene expression in macrophages. Mononuclear Phagocytes: Biology of Monocytes and Macrophages. (pp. 233-240) edited by van Furth, R.. Dordrecht , Netherlands: Kluwer Academic Publishers. doi: 10.1007/978-94-015-8070-0

The regulation of urokinase plasminogen activator gene expression in macrophages

1992

Journal Article

Letter to the editor

Hume, D., McGarry, M. P. and Stewart, C. (1992). Letter to the editor. Journal of Leukocyte Biology, 51 (5), 517-518. doi: 10.1002/jlb.51.5.517

Letter to the editor

1992

Journal Article

Rezensionen

Lüthe, Rudolf and Hume, David (1992). Rezensionen. Deutsche Zeitschrift fur Philosophie, 40 (12), 1471-1488. doi: 10.1524/dzph.1992.40.12.1471

Rezensionen

1992

Journal Article

Synergistic activation of the replication of HIV-1 in primary lymphoblasts by DEAE-dextran and IL-2: control of HIV replication

Todd, B., Pope, J. H., Ross, I. L. and Hume, D. A. (1992). Synergistic activation of the replication of HIV-1 in primary lymphoblasts by DEAE-dextran and IL-2: control of HIV replication. Journal of Virological Diseases, 1, 24-33.

Synergistic activation of the replication of HIV-1 in primary lymphoblasts by DEAE-dextran and IL-2: control of HIV replication

1992

Journal Article

The deleterious effect of macrophage colony-stimulating factor (CSF-1) on the pathology of experimental candidiasis in mice

Hume, D. A. and Denkins, Y. (1992). The deleterious effect of macrophage colony-stimulating factor (CSF-1) on the pathology of experimental candidiasis in mice. Lymphokine and Cytokine Research, 11 (2), 95-98.

The deleterious effect of macrophage colony-stimulating factor (CSF-1) on the pathology of experimental candidiasis in mice

1991

Journal Article

Constitutive expression of the urokinase plasminogen activator gene in murine RAW264 macrophages involves distal and 5' non-coding sequences that are conserved between mouse and pig

Cassady, A. Ian, Stacey, Katryn J., Nimmo, Karen A., Murphy, Kathleen M., von der Ahe, Dietmar, Pearson, David, Botteri, Florence M., Nagamine, Yoshikuni and Hume, David A. (1991). Constitutive expression of the urokinase plasminogen activator gene in murine RAW264 macrophages involves distal and 5' non-coding sequences that are conserved between mouse and pig. Nucleic Acids Research, 19 (24), 6839-6847. doi: 10.1093/nar/19.24.6839

Constitutive expression of the urokinase plasminogen activator gene in murine RAW264 macrophages involves distal and 5' non-coding sequences that are conserved between mouse and pig

Current funding

  • 2024 - 2027
    A macrophage-centric holistic view of postnatal development
    ARC Discovery Projects
    Open grant
  • 2022 - 2026
    Macrophage Biology in Health and Disease
    NHMRC Investigator Grants
    Open grant

Past funding

  • 2021 - 2024
    Macrophage control of mammalian growth and development
    ARC Discovery Projects
    Open grant
  • 2019 - 2021
    Macrophage biology, inflammatory pathophysiology, transcriptional regulation, genetic analytics and clinical genetics
    Mater Foundation
    Open grant
  • 2019 - 2022
    CSF1 Therapy for Chronic Liver Disease
    NHMRC Project Grant
    Open grant
  • 2019 - 2021
    CSF1R and the control of microglial function
    NHMRC Project Grant
    Open grant
  • 2018 - 2020
    Osteal macrophages as therapeutic targets for fracture repair
    NHMRC Project Grant
    Open grant
  • 2008 - 2009
    Profiling the pro- and anti-inflammatory functions of histone deacetylases in macrophages
    Cancer Council Queensland
    Open grant
  • 2007 - 2010
    Cellular Activation and Apoptosis in Response to Foreign Cytoplasmic DNA
    NHMRC Project Grant
    Open grant
  • 2007 - 2008
    Regulation of human fibrillin genes in cardiovascular disease
    National Heart Foundation of Australia
    Open grant
  • 2007 - 2009
    Role of bone-associated macrophages in bone remodelling and bone disease
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    The c-type lectin, Mincle, is a macrophage receptor for Candida albicans.
    NHMRC Project Grant
    Open grant
  • 2006 - 2008
    Molecular genetics of the host response defect in cystic fibrosis
    NHMRC Project Grant
    Open grant
  • 2006 - 2007
    The role of DEP-1 as a tumour suppressor in breast cancer
    Queensland Cancer Fund
    Open grant
  • 2005 - 2008
    Human macrophage transcriptional network
    Riken Genomic Sciences Center
    Open grant
  • 2005
    Developmental Imaging Facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2005 - 2007
    Transcription control of the c-fms gene
    NHMRC Project Grant
    Open grant
  • 2004 - 2011
    Dynamic Imaging Facility for Cancer Biology
    Australian Cancer Research Foundation
    Open grant
  • 2004 - 2007
    The development of tyrosine kinase inhibitors for the treatment of inflammation and malignant disease.
    ARC Linkage Projects
    Open grant
  • 2004
    ARC Research Network in Microarray Technology
    ARC Seed Funding for Research Networks
    Open grant
  • 2004 - 2006
    Regulation Of Macrophage Function And Gene Expression By The Th2-Promoting Stimulus, ES-62
    NHMRC Project Grant
    Open grant
  • 2004 - 2006
    TLR9 And The Response To Foreign DNA
    NHMRC Project Grant
    Open grant
  • 2003 - 2006
    Gene expression profiling and de novo transcriptome sequencing using geneballs
    ARC Linkage Projects
    Open grant
  • 2003
    Agilent Microarray Scanner
    NHMRC Equipment Grant
    Open grant
  • 2003
    Alternative Splicing in the Mouse Transcriptome
    ARC Discovery Projects
    Open grant
  • 2003 - 2004
    Migration And Differentiation Of Dendritic Cells And Monocytes In Inflammatory Arthritis
    NHMRC Project Grant
    Open grant
  • 2003 - 2005
    Molecular genetics of cystic fibrosis
    NHMRC Project Grant
    Open grant
  • 2003 - 2005
    Molecular Genetics Of Macrophage Activation
    NHMRC Project Grant
    Open grant
  • 2003 - 2005
    Molecular genetics of macrophage activation
    NHMRC Project Grant - Standard
    Open grant
  • 2003
    Molecular Regulators of Cytokine Secretion
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2003
    Targeted Structural Genomics of Macrophage Proteins
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002 - 2006
    Towards Renal Regeneration
    United States National Institutes of Health
    Open grant
  • 2002 - 2008
    Education and training program
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Office
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Research Program 1
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Research Program 2
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Research Program 3
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Research Program 4
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Research Program 5
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002
    Defining the human and mammalian methylomes and implications for medical research
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002 - 2004
    Osteoclast-specific gene regulation
    NHMRC Project Grant
    Open grant
  • 2002 - 2004
    Transciptional regulation of the c-fms (CFS-1R) gene in macrophages
    NHMRC Project Grant
    Open grant
  • 2001 - 2002
    Transgenic animal studies of the function of artificial zinc finger transcription factors
    Sangamo Biosciences Inc.
    Open grant
  • 2001 - 2002
    Approaches to manipulating the expression of the c-fms gene
    Sangamo Biosciences Inc.
    Open grant
  • 2001
    MJ Research Tetrad - 4 x 96well block thermocycler
    Ramaciotti Foundation
    Open grant
  • 2000
    Control of osteociast differentiation
    Mayne Bequest Fund
    Open grant
  • 2000 - 2002
    Genes controlling the development of lung disease in cystic fibrosis mutant mice
    NHMRC Project Grant
    Open grant
  • 2000 - 2002
    Mechanisms of macrophage activation by immunostimulatory DNA
    NHMRC Project Grant
    Open grant
  • 2000
    Regulation of the Tartrate-Resistant Acid Phosphatase Gene.
    ARC Australian Research Council (Small grants)
    Open grant
  • 2000 - 2002
    The role of the microphthalmia transcription factor family in macrophage differentiation
    NHMRC Project Grant
    Open grant
  • 1999 - 2001
    Genetic interactions that regulate the response of macrophages to bacterial lipopolysaccharide
    Merck Genome Research Institute
    Open grant
  • 1999
    Function and regulation of the tartrate resistant acid phosphatase gene
    Mayne Bequest Fund
    Open grant
  • 1999 - 2001
    Human tartrate-resistant purple acid phosphatase: structure and function
    NHMRC Project Grant
    Open grant
  • 1999
    Mechanisms of action of CpG DNA as an activator of macrophage function
    Mayne Bequest Fund
    Open grant
  • 1999 - 2000
    Signal transduction from the macrophage colony-stimulating factor receptor
    Queensland Cancer Fund
    Open grant
  • 1999 - 2000
    Transcriptional regulation of the macrophage colony stimulating factor receptor (c-fms) gene
    NHMRC Project Grant
    Open grant
  • 1998 - 2000
    Transcriptional Regulation of the Macrophage Colony Stimulating Factor Receptor (c-fms) Gene
    NHMRC Project Grant
    Open grant
  • 1997 - 1998
    Crystallisation of tartrate resistant acid phosphatase
    Johnson & Johnson Research Pty Ltd
    Open grant
  • 1997
    Regulation of the HIV-1-LTR in macrophages
    NHMRC Extended Epidemiology Project Grant
    Open grant
  • 1997
    Development of candidate drugs for the treatment of osteoporosis
    Merck Sharp & Dohme Australia
    Open grant
  • 1997 - 1999
    Genes controlling the development of lung disease in normal and cystic fibrosis mice
    NHMRC Project Grant
    Open grant
  • 1997
    Microplate counting system
    NHMRC Equipment Grant
    Open grant
  • 1997
    Microplate counting system.
    Ramaciotti Foundation
    Open grant
  • 1996
    Macrophage DNA recepter project.
    CRC for Vaccine Technology
    Open grant
  • 1996 - 1998
    Function and regulation of the tartrate-resistant acid phosphatase gene
    NHMRC Project Grant
    Open grant
  • 1996 - 1998
    Protein tyrosine phosphatases in macrophages
    Queensland Cancer Fund
    Open grant
  • 1996 - 1998
    Regulation of the urokinase plasminogen activator gene by macrophaghe colony-stimulating factor
    NHMRC Project Grant
    Open grant
  • 1996
    Zeiss axiophot microscope
    NHMRC Equipment Grant
    Open grant
  • 1995 - 1997
    Regulation of HIV-1-LTR in macrophages
    NHMRC Project Grant - HIV/AIDS (CARG)
    Open grant
  • 1995 - 1997
    The role of c-fms and macrophage colony stimulating factor (CSF-1) in tumor progression
    Queensland Cancer Fund
    Open grant

Availability

Professor David Hume is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • The role of macrophages in postnatal development

    This project is associated with a successful ARC Discovery Grant and builds upon the discovery that mutation in the CSF1R gene, which controls the deveelopment of macrophages, has severe impacts on postnatal growth and organ development (See paper below). The phenotype can be reversed by transfer of wild-type bone marrow. The PhD project will focus on analysing the precose mechanisms that enable transplanted macrophages to restore normal development. It will develop a wide range of skills in the braod areas of cell and developmental biology, genomics and bioinformatics.

    Enquiries to david.hume@uq.edu.au or Katharine.Irvine@uq.edu.au

    Keshvari S, Caruso M, Teakle N, Batoon L, Sehgal A, Patkar OL, Ferrari-Cestari M, Snell CE, Chen C, Stevenson A, Davis FM, Bush SJ, Pridans C, Summers KM, Pettit AR, Irvine KM, Hume DA.

    CSF1R-dependent macrophages control postnatal somatic growth and organ maturation. PLoS Genet. 2021 Jun 3;17(6):e1009605. doi: 10.1371/journal.pgen.1009605. Online ahead of print.PMID: 34081701

Supervision history

Current supervision

Completed supervision

Enquiries

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