Professor David Hume
Professor

David Hume

Email: 
Phone: 
+61 7 3443 7315

Background

The research interests of the Hume Laboratory centre on the biology of macrophages and osteoclasts. These are cells of haematopoietic origin that are closely related to each other but have distinctly different activities.

David Hume was a group leader at the Institute for Molecular Bioscience (1988-2007) and subsequently Director of the Roslin Institute at the University of Edinburgh in Scotland from 2007-2017. He is currently a Professorial Research Fellow at the Mater Research Institute-UQ, located at the Translational Research Institute

Availability

Professor David Hume is:
Available for supervision

Fields of research

Biological Sciences Genetics Immunology

Qualifications

  • Bachelor (Honours) of Science (Advanced), Australian National University
  • Doctor of Philosophy, Australian National University

Research interests

  • Macrophages Biology

    Professor David Hume is a Professorial Research Fellow at the Mater Research Institute-UQ located at the Translational Research Institute. He was previously Director of The Roslin Institute at the University of Edinburgh (2007-2017). From 1988-2007, he was at the Institute for Molecular Bioscience at the University of Queensland, serving as Deputy Director of the CRC for Chronic Inflammatory Diseases, and Director of the ARC Special Centre for Functional and Applied Genomics. At Mater, David co-leads the Macrophage Biology Research Group with Dr Kate Irvine. He has authored over 450 scientific publications and has supervised more than 55 PhD graduates. He is an international authority in genome sciences, with a particular focus on the function of macrophages—specialised cells of the immune system involved in innate immunity against infections, inflammatory disease and cancer. David’s research focusses on macrophages in normal growth, development and physiology, infectious disease resistance and progression and complications of inflammation. His lab investigates mechanisms that regulate the biological functions of macrophages and explores avenues to boost their normal function and/or limit the damage they cause in inflammatory and infectious diseases. He is also interested in the genetic variations in macrophage function between individuals that contribute to susceptibility to inflammatory and infectious diseases. David has been elected to Fellowships in the Royal Society of Edinburgh, the UK Academy of Medical Sciences and the Royal Society of Biology. Since 2000, he has been a leading member of the FANTOM Consortium, which has made extensive contributions to mammalian genome and transcriptome annotation. David has a 35 year track record of attracting major strategic funding (CRC for Chronic Inflammatory Disease, ARC Special Research Centre in Australia; BBSRC Institute Strategic Programmes, Wellcome Trust Centres, UK Agritech Centre and Bill and Melinda Gates Centre Foundation in the UK) as well as continuous research project funding from NHMRC, ARC, BBSRC, MRC and the Wellcome Trust. "I trained as a metabolic biochemist at the Australian National University, and was very fortunate to have a great mentor in Dr Maurie Weidemann. Throughout my career, I have tried to mentor others with the same level of enthusiasm and support given to me. Being a biological scientist in the early 21st century is very much like being a physical scientist in the early 20th century. Each day brings new technologies and completely unexpected discoveries. I believe that the most novel breakthroughs and advances in human medicine and biotechnology come from basic discovery science, and fundamental understanding of macrophage biology has been my research focus for the whole of my career. That said, the applications of that understanding to human disease are clear, especially in the areas of tissue repair and regenerative medicine, and I am committed to pursuing those applications to benefit patients."

Search Professor David Hume’s works on UQ eSpace

627 works between 1976 and 2025
All (627) Journal Article (508) Book Chapter (14) Conference Publication (101) Book (1) Other Outputs (3)

581 - 600 of 627 works

1987

Journal Article

Selective resistance of bone marrow-derived hemopoietic progenitor cells to gliotoxin

Müllbacher, A., Hume, D., Braithwaite, A. W., Waring, P. and Eichner, R. D. (1987). Selective resistance of bone marrow-derived hemopoietic progenitor cells to gliotoxin. Proceedings of the National Academy of Sciences of the United States of America, 84 (11), 3822-3825. doi: 10.1073/pnas.84.11.3822

Selective resistance of bone marrow-derived hemopoietic progenitor cells to gliotoxin

1987

Journal Article

Regulation of proliferation of bone marrow-derived macrophages

Hume, D. A, Allan, W., Fabrus, B., Weidemann, M. J., Hapel, A. J. and Bartelmez, S. (1987). Regulation of proliferation of bone marrow-derived macrophages. Lymphokine Research, 6 (2), 127-139.

Regulation of proliferation of bone marrow-derived macrophages

1987

Journal Article

Induced Expression of Class-Ii Major Histocompatibility Complex Antigens On Thyroid But Not Pancreatic-Islet Allografts Following Transfer of Sensitized Lyt2+ T-Cells

Warren, HS, Simeonovic, CJ, Allan, W and Hume, DA (1987). Induced Expression of Class-Ii Major Histocompatibility Complex Antigens On Thyroid But Not Pancreatic-Islet Allografts Following Transfer of Sensitized Lyt2+ T-Cells. Transplantation Proceedings, 19 (1), 213-213.

Induced Expression of Class-Ii Major Histocompatibility Complex Antigens On Thyroid But Not Pancreatic-Islet Allografts Following Transfer of Sensitized Lyt2+ T-Cells

1987

Conference Publication

Inhibition of Mouse Intestinal Lamina Propria and Peyers Patch Antigen-Presenting Cell-Activity by Lamina Propria Macrophages

Pavli, P, Doe, WF and Hume, DA (1987). Inhibition of Mouse Intestinal Lamina Propria and Peyers Patch Antigen-Presenting Cell-Activity by Lamina Propria Macrophages. W B SAUNDERS CO.

Inhibition of Mouse Intestinal Lamina Propria and Peyers Patch Antigen-Presenting Cell-Activity by Lamina Propria Macrophages

1986

Journal Article

Immunohistochemical analysis of the involvement of F4/80 and Ia-positive macrophages in mouse-liver infected with lymphocytic choriomeningitis virus

Dixon, J. E., Allan, J. E., Doherty, P. C. and Hume, D. A. (1986). Immunohistochemical analysis of the involvement of F4/80 and Ia-positive macrophages in mouse-liver infected with lymphocytic choriomeningitis virus. Journal of Leukocyte Biology, 40 (5), 617-628. doi: 10.1002/jlb.40.5.617

Immunohistochemical analysis of the involvement of F4/80 and Ia-positive macrophages in mouse-liver infected with lymphocytic choriomeningitis virus

1986

Conference Publication

Characterization of the Inflammatory Response in the Central-Nervous-System During Viral-Infection

Dixon, JE, Allan, JE, Ceredig, R, Hume, DA and Doherty, PC (1986). Characterization of the Inflammatory Response in the Central-Nervous-System During Viral-Infection. ADIS PRESS AUSTRALASIA P/L.

Characterization of the Inflammatory Response in the Central-Nervous-System During Viral-Infection

1986

Journal Article

Localization and function of tissue macrophages

Gordon, Siamon, Crocker, Paul R., Morris, Lynn, Lee, Szu Hee, Perry, V. Hugh and Hume, David A. (1986). Localization and function of tissue macrophages. Ciba Foundation Symposia, 118, 54-67. doi: 10.1002/9780470720998.ch5

Localization and function of tissue macrophages

1986

Conference Publication

Immunohistochemical Characterization of Macrophages in the Intestinal-Mucosa Using the Mature Macrophage Antigen 25F9

Hume, DA, Allan, W, Hogan, PG and Doe, WF (1986). Immunohistochemical Characterization of Macrophages in the Intestinal-Mucosa Using the Mature Macrophage Antigen 25F9. W B SAUNDERS CO.

Immunohistochemical Characterization of Macrophages in the Intestinal-Mucosa Using the Mature Macrophage Antigen 25F9

1985

Journal Article

Immunohistochemical analysis of murine mononuclear phagocytes that express class II major histocompatibility antigens

Hume, D. A. (1985). Immunohistochemical analysis of murine mononuclear phagocytes that express class II major histocompatibility antigens. Immunobiology, 170 (5), 381-389. doi: 10.1016/S0171-2985(85)80062-0

Immunohistochemical analysis of murine mononuclear phagocytes that express class II major histocompatibility antigens

1985

Journal Article

The biology of macrophages

Hume, D. A. (1985). The biology of macrophages. Science progress, 69 (276), 485-494.

The biology of macrophages

1985

Journal Article

Preparation and characterization of human-bone marrow-derived macrophages

Hume, D. A., Allan, W., Golder, J., Stephens, R. W., Doe, W. F. and Warren, H. S. (1985). Preparation and characterization of human-bone marrow-derived macrophages. Journal of Leukocyte Biology, 38 (4), 541-552. doi: 10.1002/jlb.38.4.541

Preparation and characterization of human-bone marrow-derived macrophages

1985

Journal Article

Regulation of the production of granulocyte-macrophage colony-stimulating factor by macrophage-like tumour cell lines

Hume, David A., Summers, Kim M., Cohen, Donna R. and Allan, William (1985). Regulation of the production of granulocyte-macrophage colony-stimulating factor by macrophage-like tumour cell lines. FEBS Letters, 180 (2), 271-274. doi: 10.1016/0014-5793(85)81084-X

Regulation of the production of granulocyte-macrophage colony-stimulating factor by macrophage-like tumour cell lines

1985

Journal Article

Expression of Glandular Kallikrein Genes in Lymphoid and Hematopoietic Tissues and Cell-Lines

Summers, KM and Hume, DA (1985). Expression of Glandular Kallikrein Genes in Lymphoid and Hematopoietic Tissues and Cell-Lines. Lymphokine Research, 4 (3), 229-235.

Expression of Glandular Kallikrein Genes in Lymphoid and Hematopoietic Tissues and Cell-Lines

1985

Conference Publication

The Distribution of the 25F9 Macrophage-Specific Antigen in Human Gastrointestinal-Tract

Hume, DA, Allan, W, Hogan, PG and Doe, WF (1985). The Distribution of the 25F9 Macrophage-Specific Antigen in Human Gastrointestinal-Tract. ADIS PRESS AUSTRALASIA P/L.

The Distribution of the 25F9 Macrophage-Specific Antigen in Human Gastrointestinal-Tract

1985

Journal Article

Expression of 20-alpha-hydroxysteroid dehydrogenase in mouse macrophages, hematopoietic-cells, and cell-lines and its induction by colony-stimulating factors

Hapel, A. J., Osborne, J. M., Fung, M. C., Young, I. G., Allan, W. and Hume, D. A. (1985). Expression of 20-alpha-hydroxysteroid dehydrogenase in mouse macrophages, hematopoietic-cells, and cell-lines and its induction by colony-stimulating factors. Journal of Immunology, 134 (4), 2492-2497.

Expression of 20-alpha-hydroxysteroid dehydrogenase in mouse macrophages, hematopoietic-cells, and cell-lines and its induction by colony-stimulating factors

1985

Journal Article

Minactivin Expression in Human Monocyte and Macrophage Populations

Stephens, RW, Golder, JP, Fayle, Drh, Hume, DA, Hapel, AJ, Allan, W, Fordham, CJ and Doe, WF (1985). Minactivin Expression in Human Monocyte and Macrophage Populations. Blood, 66 (2), 333-337.

Minactivin Expression in Human Monocyte and Macrophage Populations

1985

Journal Article

Studies of peritoneal macrophage function in murine systemic lupus erythematosus. 2. Nature of elevated resident peritoneal cells in NZB and (NZB x NZW)F1 mice

Russell, P. J., Cahill, J., Cameron, F. and Hume, D. (1985). Studies of peritoneal macrophage function in murine systemic lupus erythematosus. 2. Nature of elevated resident peritoneal cells in NZB and (NZB x NZW)F1 mice. Journal of Leukocyte Biology, 38 (2), 241-254. doi: 10.1002/jlb.38.2.241

Studies of peritoneal macrophage function in murine systemic lupus erythematosus. 2. Nature of elevated resident peritoneal cells in NZB and (NZB x NZW)F1 mice

1985

Journal Article

Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain

Perry, V. H., Hume, D. A. and Gordon, S. (1985). Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain. Neuroscience, 15 (2), 313-326. doi: 10.1016/0306-4522(85)90215-5

Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain

1984

Journal Article

The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80: macrophages associated with epithelia

Hume, David A., Perry, V. Hugh and Gordon, Siamon (1984). The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80: macrophages associated with epithelia. Anatomical Record, 210 (3), 503-512. doi: 10.1002/ar.1092100311

The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80: macrophages associated with epithelia

1984

Journal Article

The correlation between plasminogen activator activity and thymidine incorporation in mouse bone marrow-derived macrophages: opposing actions of colony-stimulating factor, phorbol myristate acetate, dexamethasone and prostaglandin E

Hume, David A. and Gordon, Siamon (1984). The correlation between plasminogen activator activity and thymidine incorporation in mouse bone marrow-derived macrophages: opposing actions of colony-stimulating factor, phorbol myristate acetate, dexamethasone and prostaglandin E. Experimental Cell Research, 150 (2), 347-355. doi: 10.1016/0014-4827(84)90578-0

The correlation between plasminogen activator activity and thymidine incorporation in mouse bone marrow-derived macrophages: opposing actions of colony-stimulating factor, phorbol myristate acetate, dexamethasone and prostaglandin E

Current funding

  • 2024 - 2027
    A macrophage-centric holistic view of postnatal development
    ARC Discovery Projects
    Open grant
  • 2022 - 2026
    Macrophage Biology in Health and Disease
    NHMRC Investigator Grants
    Open grant

Past funding

  • 2021 - 2024
    Macrophage control of mammalian growth and development
    ARC Discovery Projects
    Open grant
  • 2019 - 2021
    Macrophage biology, inflammatory pathophysiology, transcriptional regulation, genetic analytics and clinical genetics
    Mater Foundation
    Open grant
  • 2019 - 2022
    CSF1 Therapy for Chronic Liver Disease
    NHMRC Project Grant
    Open grant
  • 2019 - 2021
    CSF1R and the control of microglial function
    NHMRC Project Grant
    Open grant
  • 2018 - 2020
    Osteal macrophages as therapeutic targets for fracture repair
    NHMRC Project Grant
    Open grant
  • 2008 - 2009
    Profiling the pro- and anti-inflammatory functions of histone deacetylases in macrophages
    Cancer Council Queensland
    Open grant
  • 2007 - 2010
    Cellular Activation and Apoptosis in Response to Foreign Cytoplasmic DNA
    NHMRC Project Grant
    Open grant
  • 2007 - 2008
    Regulation of human fibrillin genes in cardiovascular disease
    National Heart Foundation of Australia
    Open grant
  • 2007 - 2009
    Role of bone-associated macrophages in bone remodelling and bone disease
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    The c-type lectin, Mincle, is a macrophage receptor for Candida albicans.
    NHMRC Project Grant
    Open grant
  • 2006 - 2008
    Molecular genetics of the host response defect in cystic fibrosis
    NHMRC Project Grant
    Open grant
  • 2006 - 2007
    The role of DEP-1 as a tumour suppressor in breast cancer
    Queensland Cancer Fund
    Open grant
  • 2005 - 2008
    Human macrophage transcriptional network
    Riken Genomic Sciences Center
    Open grant
  • 2005
    Developmental Imaging Facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2005 - 2007
    Transcription control of the c-fms gene
    NHMRC Project Grant
    Open grant
  • 2004 - 2011
    Dynamic Imaging Facility for Cancer Biology
    Australian Cancer Research Foundation
    Open grant
  • 2004 - 2007
    The development of tyrosine kinase inhibitors for the treatment of inflammation and malignant disease.
    ARC Linkage Projects
    Open grant
  • 2004
    ARC Research Network in Microarray Technology
    ARC Seed Funding for Research Networks
    Open grant
  • 2004 - 2006
    Regulation Of Macrophage Function And Gene Expression By The Th2-Promoting Stimulus, ES-62
    NHMRC Project Grant
    Open grant
  • 2004 - 2006
    TLR9 And The Response To Foreign DNA
    NHMRC Project Grant
    Open grant
  • 2003 - 2006
    Gene expression profiling and de novo transcriptome sequencing using geneballs
    ARC Linkage Projects
    Open grant
  • 2003
    Agilent Microarray Scanner
    NHMRC Equipment Grant
    Open grant
  • 2003
    Alternative Splicing in the Mouse Transcriptome
    ARC Discovery Projects
    Open grant
  • 2003 - 2004
    Migration And Differentiation Of Dendritic Cells And Monocytes In Inflammatory Arthritis
    NHMRC Project Grant
    Open grant
  • 2003 - 2005
    Molecular genetics of cystic fibrosis
    NHMRC Project Grant
    Open grant
  • 2003 - 2005
    Molecular Genetics Of Macrophage Activation
    NHMRC Project Grant
    Open grant
  • 2003 - 2005
    Molecular genetics of macrophage activation
    NHMRC Project Grant - Standard
    Open grant
  • 2003
    Molecular Regulators of Cytokine Secretion
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2003
    Targeted Structural Genomics of Macrophage Proteins
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002 - 2006
    Towards Renal Regeneration
    United States National Institutes of Health
    Open grant
  • 2002 - 2008
    Education and training program
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Office
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Research Program 1
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Research Program 2
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Research Program 3
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Research Program 4
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002 - 2008
    Research Program 5
    CRC for Chronic Inflammatory Diseases
    Open grant
  • 2002
    Defining the human and mammalian methylomes and implications for medical research
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002 - 2004
    Osteoclast-specific gene regulation
    NHMRC Project Grant
    Open grant
  • 2002 - 2004
    Transciptional regulation of the c-fms (CFS-1R) gene in macrophages
    NHMRC Project Grant
    Open grant
  • 2001 - 2002
    Transgenic animal studies of the function of artificial zinc finger transcription factors
    Sangamo Biosciences Inc.
    Open grant
  • 2001 - 2002
    Approaches to manipulating the expression of the c-fms gene
    Sangamo Biosciences Inc.
    Open grant
  • 2001
    MJ Research Tetrad - 4 x 96well block thermocycler
    Ramaciotti Foundation
    Open grant
  • 2000
    Control of osteociast differentiation
    Mayne Bequest Fund
    Open grant
  • 2000 - 2002
    Genes controlling the development of lung disease in cystic fibrosis mutant mice
    NHMRC Project Grant
    Open grant
  • 2000 - 2002
    Mechanisms of macrophage activation by immunostimulatory DNA
    NHMRC Project Grant
    Open grant
  • 2000
    Regulation of the Tartrate-Resistant Acid Phosphatase Gene.
    ARC Australian Research Council (Small grants)
    Open grant
  • 2000 - 2002
    The role of the microphthalmia transcription factor family in macrophage differentiation
    NHMRC Project Grant
    Open grant
  • 1999 - 2001
    Genetic interactions that regulate the response of macrophages to bacterial lipopolysaccharide
    Merck Genome Research Institute
    Open grant
  • 1999
    Function and regulation of the tartrate resistant acid phosphatase gene
    Mayne Bequest Fund
    Open grant
  • 1999 - 2001
    Human tartrate-resistant purple acid phosphatase: structure and function
    NHMRC Project Grant
    Open grant
  • 1999
    Mechanisms of action of CpG DNA as an activator of macrophage function
    Mayne Bequest Fund
    Open grant
  • 1999 - 2000
    Signal transduction from the macrophage colony-stimulating factor receptor
    Queensland Cancer Fund
    Open grant
  • 1999 - 2000
    Transcriptional regulation of the macrophage colony stimulating factor receptor (c-fms) gene
    NHMRC Project Grant
    Open grant
  • 1998 - 2000
    Transcriptional Regulation of the Macrophage Colony Stimulating Factor Receptor (c-fms) Gene
    NHMRC Project Grant
    Open grant
  • 1997 - 1998
    Crystallisation of tartrate resistant acid phosphatase
    Johnson & Johnson Research Pty Ltd
    Open grant
  • 1997
    Regulation of the HIV-1-LTR in macrophages
    NHMRC Extended Epidemiology Project Grant
    Open grant
  • 1997
    Development of candidate drugs for the treatment of osteoporosis
    Merck Sharp & Dohme Australia
    Open grant
  • 1997 - 1999
    Genes controlling the development of lung disease in normal and cystic fibrosis mice
    NHMRC Project Grant
    Open grant
  • 1997
    Microplate counting system
    NHMRC Equipment Grant
    Open grant
  • 1997
    Microplate counting system.
    Ramaciotti Foundation
    Open grant
  • 1996
    Macrophage DNA recepter project.
    CRC for Vaccine Technology
    Open grant
  • 1996 - 1998
    Function and regulation of the tartrate-resistant acid phosphatase gene
    NHMRC Project Grant
    Open grant
  • 1996 - 1998
    Protein tyrosine phosphatases in macrophages
    Queensland Cancer Fund
    Open grant
  • 1996 - 1998
    Regulation of the urokinase plasminogen activator gene by macrophaghe colony-stimulating factor
    NHMRC Project Grant
    Open grant
  • 1996
    Zeiss axiophot microscope
    NHMRC Equipment Grant
    Open grant
  • 1995 - 1997
    Regulation of HIV-1-LTR in macrophages
    NHMRC Project Grant - HIV/AIDS (CARG)
    Open grant
  • 1995 - 1997
    The role of c-fms and macrophage colony stimulating factor (CSF-1) in tumor progression
    Queensland Cancer Fund
    Open grant

Availability

Professor David Hume is:
Available for supervision

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Available projects

  • The role of macrophages in postnatal development

    This project is associated with a successful ARC Discovery Grant and builds upon the discovery that mutation in the CSF1R gene, which controls the deveelopment of macrophages, has severe impacts on postnatal growth and organ development (See paper below). The phenotype can be reversed by transfer of wild-type bone marrow. The PhD project will focus on analysing the precose mechanisms that enable transplanted macrophages to restore normal development. It will develop a wide range of skills in the braod areas of cell and developmental biology, genomics and bioinformatics.

    Enquiries to david.hume@uq.edu.au or Katharine.Irvine@uq.edu.au

    Keshvari S, Caruso M, Teakle N, Batoon L, Sehgal A, Patkar OL, Ferrari-Cestari M, Snell CE, Chen C, Stevenson A, Davis FM, Bush SJ, Pridans C, Summers KM, Pettit AR, Irvine KM, Hume DA.

    CSF1R-dependent macrophages control postnatal somatic growth and organ maturation. PLoS Genet. 2021 Jun 3;17(6):e1009605. doi: 10.1371/journal.pgen.1009605. Online ahead of print.PMID: 34081701

Supervision history

Current supervision

Completed supervision

Enquiries

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