
Overview
Background
How to build a brain—2.0
For 25 years I was sole chief investigator on 17 NHMRC-ARC project grants that provided funding to decipher the molecular & cellular bases of brain development and regeneration in fish, frogs and mice. This work culminated in the discovery of how to genetically construct an evolutionary novel axon tract in the embryonic brain. This is what I now call an easy problem.
Now my lab has turned its attention to the hardest problem in the natural sciences—how does the brain experience subjective feelings?
Together with my collaborator Professor Deborah Brown (Professor of Philosophy at UQ) we have approached this problem through the sensation of pain and model organisms. We advance the framework of the brain as an inference machine that generates models of its own internal processes (Key and Brown, 2018). When hierarchically arranged, the outputs of these models represent progressive levels of awareness that are antecedent to feelings (i.e. the brain’s experience of its own neural activity). We have proposed a parallel forwards model algorithm and to date have found that fish and molluscs lack the required neural architecture to execute this algorithm and therefore do not feel pain.
Key, B. and Brown, D. (2018) Designing brains for pain: Human to mollusc. Frontiers in physiology 9:1027.
Availability
- Professor Brian Key is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Education, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research interests
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brain development
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fish pain
Works
Search Professor Brian Key’s works on UQ eSpace
1998
Journal Article
Molecular development of the olfactory nerve pathway
Key, B (1998). Molecular development of the olfactory nerve pathway. Olfaction And Taste Xii, 855, 76-82. doi: 10.1111/j.1749-6632.1998.tb10548.x
1997
Journal Article
The central pathway of primary olfactory axons is abnormal in mice lacking the N-CAM-180 isoform
Treloar, H., Tomasiewicz, H., Magnuson, T. and Key, B. (1997). The central pathway of primary olfactory axons is abnormal in mice lacking the N-CAM-180 isoform. Developmental Neurobiology, 32 (7), 643-658. doi: 10.1002/(SICI)1097-4695(19970620)32:73.0.CO;2-4
1997
Journal Article
Role of galectin-1 in the olfactory nervous system
Key, B and Puche, AC (1997). Role of galectin-1 in the olfactory nervous system. Trends In Glycoscience And Glycotechnology, 9 (45), 41-45. doi: 10.4052/tigg.9.41
1997
Journal Article
Substrate-bound carbohydrates stimulate signal transduction and neurite outgrowth in an olfactory neuron cell line
Puche, AC, Bartlett, PF and Key, B (1997). Substrate-bound carbohydrates stimulate signal transduction and neurite outgrowth in an olfactory neuron cell line. Neuroreport, 8 (15), 3183-3188. doi: 10.1097/00001756-199710200-00001
1997
Journal Article
Presence of novel N-CAM glycoforms in the rat olfactory system
Dowsing, B, Puche, A, Hearn, C and Key, B (1997). Presence of novel N-CAM glycoforms in the rat olfactory system. Journal of Neurobiology, 32 (7), 659-670. doi: 10.1002/(SICI)1097-4695(19970620)32:73.0.CO;2-3
1996
Journal Article
Expression of a novel N-CAM glycoform (NOC-1) on axon tracts in embryonic Xenopus brain
Anderson, R. B. and Key, B. (1996). Expression of a novel N-CAM glycoform (NOC-1) on axon tracts in embryonic Xenopus brain. Developmental Dynamics, 207 (3), 263-269. doi: 10.1002/(SICI)1097-0177(199611)207:33.0.CO;2-F
1996
Journal Article
Role of galectin-1 in the developing mouse olfactory system
Puche, AC, Poirier, F, Hair, M, Bartlett, PF and Key, B (1996). Role of galectin-1 in the developing mouse olfactory system. Developmental Biology, 179 (1), 274-287. doi: 10.1006/dbio.1996.0257
1996
Journal Article
Expression of extracellular matrix molecules in the embryonic rat olfactory pathway
Treloar, H. B., Nurcombe, V. and Key, B. (1996). Expression of extracellular matrix molecules in the embryonic rat olfactory pathway. Journal of Neurobiology, 31 (1), 41-55. doi: 10.1002/(SICI)1097-4695(199609)31:13.0.CO;2-F
1996
Journal Article
Light-microscopic immunolocalization of fibroblast growth factor-1 and -2 in adult rat kidney
Cauchi, J, Alcorn, D, Cancilla, B, Key, B, Berka, JL, Nurcombe, , Ryan, GB and Bertram, JF (1996). Light-microscopic immunolocalization of fibroblast growth factor-1 and -2 in adult rat kidney. Cell and Tissue Research, 285 (2), 179-187. doi: 10.1007/s004410050635
1996
Journal Article
Immunolocalization of fibroblast growth factor-1 and -2 in the embryonic rat kidney
Cancilla, B, Cauchi, J, Key, B, Nurcombe, , Alcorn, D and Bertram, J (1996). Immunolocalization of fibroblast growth factor-1 and -2 in the embryonic rat kidney. Nephrology, 2 (3), 167-174. doi: 10.1111/j.1440-1797.1996.tb00083.x
1996
Journal Article
Olfactory glomeruli are innervated by more than one distinct subset of primary sensory olfactory neurons in mice
Treloar, H, Walters, E, Margolis, F and Key, B (1996). Olfactory glomeruli are innervated by more than one distinct subset of primary sensory olfactory neurons in mice. Journal of Comparative Neurology, 367 (4), 550-562. doi: 10.1002/(SICI)1096-9861(19960415)367:43.0.CO;2-3
1996
Journal Article
Olfactory glomeruli are innervated by more than one distinct subset of primary sensory olfactory neurons in mice
Treloar, H, Walters, E, Margolis, F and Key, B (1996). Olfactory glomeruli are innervated by more than one distinct subset of primary sensory olfactory neurons in mice. The Journal of Comparative Neurology, 367 (4), 550-62. doi: 10.1002/%28SICI%291096-9861%2819960415%29367%3A43.0.CO%3B2-3
1996
Journal Article
Expression and localization of FGF-1 in the developing rat olfactory system
Key, B., Treloar, H. B., Wangerek, L., Ford, M. D. and Nurcombe, V. (1996). Expression and localization of FGF-1 in the developing rat olfactory system. Journal of Comparative Neurology, 366 (2), 197-206. doi: 10.1002/(SICI)1096-9861(19960304)366:23.0.CO;2-0
1996
Journal Article
N-acetyl-lactosamine in the rat olfactory system: Expression and potential role in neurite growth
Puche, A. C. and Key, B. (1996). N-acetyl-lactosamine in the rat olfactory system: Expression and potential role in neurite growth. Journal of Comparative Neurology, 364 (2), 267-278. doi: 10.1002/(SICI)1096-9861(19960108)364:23.0.CO;2-3
1996
Other Outputs
The binding, uptake and transport of exogenous molecules in nervous tissue
Key, Brian (1996). The binding, uptake and transport of exogenous molecules in nervous tissue. PhD Thesis, School of Biomedical Sciences, The University of Queensland. doi: 10.14264/512e057
1995
Journal Article
EXPRESSION OF THE AMYLOID PROTEIN-PRECURSOR OF ALZHEIMERS-DISEASE IN THE DEVELOPING RAT OLFACTORY SYSTEM
CLARRIS, HJ, KEY, B, BEYREUTHER, K, MASTERS, CL and SMALL, DH (1995). EXPRESSION OF THE AMYLOID PROTEIN-PRECURSOR OF ALZHEIMERS-DISEASE IN THE DEVELOPING RAT OLFACTORY SYSTEM. Developmental Brain Research, 88 (1), 87-95. doi: 10.1016/0165-3806(95)00083-P
1995
Journal Article
IDENTIFICATION OF CELLS EXPRESSING GALECTIN-1, A GALACTOSE-BINDING RECEPTOR, IN THE RAT OLFACTORY SYSTEM
PUCHE, AC and KEY, B (1995). IDENTIFICATION OF CELLS EXPRESSING GALECTIN-1, A GALACTOSE-BINDING RECEPTOR, IN THE RAT OLFACTORY SYSTEM. Journal of Comparative Neurology, 357 (4), 513-523. doi: 10.1002/cne.903570403
1995
Journal Article
Expression of transforming growth factor‐β type II receptor mRNA in embryonic and adult rat kidney
Clark, Amander T, Ford, Miriam D, Nurcombe, Victor, Alcorn, Daine, Key, Brian, Puche, Adam C and Bertram, John F (1995). Expression of transforming growth factor‐β type II receptor mRNA in embryonic and adult rat kidney. Nephrology, 1 (6), 547-553. doi: 10.1111/j.1440-1797.1995.tb00054.x
1993
Journal Article
DISTINCT SUBSETS OF SENSORY OLFACTORY NEURONS IN MOUSE - POSSIBLE ROLE IN THE FORMATION OF THE MOSAIC OLFACTORY PROJECTION
KEY, B and AKESON, RA (1993). DISTINCT SUBSETS OF SENSORY OLFACTORY NEURONS IN MOUSE - POSSIBLE ROLE IN THE FORMATION OF THE MOSAIC OLFACTORY PROJECTION. Journal of Comparative Neurology, 335 (3), 355-368. doi: 10.1002/cne.903350306
1992
Journal Article
LENS STRUCTURES EXIST TRANSIENTLY IN DEVELOPMENT OF TRANSGENIC MICE CARRYING AN ALPHA-CRYSTALLIN DIPHTHERIA-TOXIN HYBRID GENE
KEY, B, LIU, L, POTTER, SS, KAUR, S and AKESON, R (1992). LENS STRUCTURES EXIST TRANSIENTLY IN DEVELOPMENT OF TRANSGENIC MICE CARRYING AN ALPHA-CRYSTALLIN DIPHTHERIA-TOXIN HYBRID GENE. Experimental Eye Research, 55 (2), 357-367. doi: 10.1016/0014-4835(92)90200-C
Funding
Past funding
Supervision
Availability
- Professor Brian Key is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Towards closure of the fish pain debate
We are seeking an Arts-Biomedical Science graduate to partake in this ambitious project.
Arguments to the effect that certain animals do or do not have feelings, such as pain, are presumptive arguments. Like legal arguments, presumptive arguments are defeasible arguments, the conclusions of which are thought to be rationally acceptable on the balance of considerations (Walton 1996, 2011). Also like legal arguments, they invite paradoxical worries about how an argument can be both defeasible yet rationally binding (Walton et al, 2008). In legal contexts, we do not have the luxury of leaving questions of guilt or innocence hanging. A decision must be made. So too in matters pertaining to animal welfare, it is necessary to evaluate whether we have sufficient reason to decide whether a particular species of animal does or does not feel pain if we are to ensure that our treatment of that species is ethically appropriate.
Each of the arguments in the animal consciousness debate can and has been evaluated on its own terms, but an interesting pattern emerges when viewed together as constituting a single dialogue involving multiple reasoners operating on divergent background assumptions and principles of reasoning. From this perspective, it can be seen where the blockages to consensus lie and what it would take to move the debate towards some form of closure so that decisions of importance to animal welfare could be undertaken with more confidence than they currently are. No meta-analysis of this debate as an instance of multi-agent reasoning has hitherto been undertaken. The overarching aim of this project is to conduct just such an analysis in an effort to identify principles that both sides of the debate might rationally agree upon and move the debate towards epistemic closure.
The principal aims are:
Aim 1. To reconstruct the debate about pain in non-human animals as an instance of multi-agent reasoning or dialogue to clarify precise points of agreement and disagreement,
Aim 2. To argue for shared principles of reasoning drawing on available neuroscientific evidence in order to create avenues towards closure, and
Aim 3. To address concerns about moral risk exceeding epistemic risk in judgements about non-human animal pain.
Supervision history
Current supervision
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Doctor Philosophy
Scepticism of other minds in the animal pain debate
Associate Advisor
Other advisors: Professor Deborah Brown
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Doctor Philosophy
Scepticism of other minds in the animal pain debate
Associate Advisor
Other advisors: Professor Deborah Brown
Completed supervision
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2019
Doctor Philosophy
The Non-Invasive Detection of Anatomical Injury Locations in Low Back Pain Patients Using Laser Displacement Mechanomyography
Principal Advisor
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2013
Doctor Philosophy
The Autism susceptibility gene nrxn1 interacts with an intellectual disability gene lrrtm2 in vivo to regulate locomotor behaviours and spinal cord cytoarchitecture
Principal Advisor
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2012
Doctor Philosophy
Functional Analysis of Repulsive Guidance Molecule A during Early Vertebrate Development
Principal Advisor
Other advisors: Professor Helen Cooper
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2010
Doctor Philosophy
The cellular and molecular mechanisms of olfactory ensheathing cell and axon migration
Principal Advisor
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2009
Doctor Philosophy
Cellular mechanisms of axon guidance and targeting in the olfactory system
Principal Advisor
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2007
Doctor Philosophy
CELLULAR MECHANISMS OF AXON TARGETING IN THE REGENERATING OLFACTORY SYSTEM
Principal Advisor
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2006
Doctor Philosophy
ROBO AND SLIT HAVE AN AXON GUIDANCE ROLE IN THE EMBRYONIC VERTEBRATE BRAIN
Principal Advisor
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2006
Doctor Philosophy
AXON GROWTH AND GUIDANCE IN THE EMBRYONIC VERTEBRATE FOREBRAIN
Principal Advisor
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2003
Doctor Philosophy
MECHANISMS OF AXON GROWTH AND GUIDANCE IN THE VERTEBRATE NERVOUS SYSTEM
Principal Advisor
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2014
Doctor Philosophy
Odorant and taste receptor systems in the heart: investigation of novel cardiac biology
Associate Advisor
Other advisors: Professor Wally Thomas, Professor Eugeni Roura
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2008
Doctor Philosophy
Characterisation and expression of zebrafish frizzled-3a (zfzd3a) during embryonic development
Associate Advisor
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2005
Master Philosophy
THE EFFECTS OF COCAINE EXPOSURE DURING EARLY LIFE ON RAT BRAIN DEVELOPMENT
Associate Advisor
Media
Enquiries
Contact Professor Brian Key directly for media enquiries about:
- brain development
- fish pain
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