|
2020 Journal Article Novel drivers and modifiers of MPL-dependent oncogenic transformation identified by deep mutational scanningBridgford, Jessica L., Lee, Su Min, Lee, Christine M. M., Guglielmelli, Paola, Rumi, Elisa, Pietra, Daniela, Wilcox, Stephen, Chhabra, Yash, Rubin, Alan F., Cazzola, Mario, Vannucchi, Alessandro M., Brooks, Andrew J., Call, Matthew Edwin and Call, Melissa Joy (2020). Novel drivers and modifiers of MPL-dependent oncogenic transformation identified by deep mutational scanning. Blood, 135 (4), 287-292. doi: 10.1182/blood.2019002561 |
|
2019 Journal Article Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7Rα cause receptor hypersensitivityCampos, Livia Weijenborg, Zenatti, Priscila Pini, Pissinato, Leonardo Granato, Rodrigues, Gisele Olinto Libanio, Artico, Leonardo Luís, Guimarães, Thais Rafael, Archangelo, Leticia Fröhlich, Martínez, Leandro, Brooks, Andrew J. and Yunes, Jose Andres (2019). Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7Rα cause receptor hypersensitivity. Blood, 133 (11), 1259-1263. doi: 10.1182/blood-2018-09-872945 |
|
2018 Journal Article A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradationChhabra, Y., Wong, H. Y., Nikolajsen, L. F., Steinocher, H., Papadopulos, A., Tunny, K. A., Meunier, F. A., Smith, A. G., Kragelund, B. B., Brooks, A. J. and Waters, M. J. (2018). A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation. Oncogene, 37 (4), 489-501. doi: 10.1038/onc.2017.352 |
|
2018 Book Chapter Cytokine receptorsBrooks, Andrew J., Dehkhoda, Farhad and Kragelund, Birthe (2018). Cytokine receptors. Endocrinology: principles of endocrinology and hormone action. (pp. 157-185) edited by Antonino Belfiore and Derek LeRoith. Amsterdam, The Netherlands: Springer. doi: 10.1007/978-3-319-44675-2_8 |
|
2014 Journal Article Mechanism of activation of protein kinase JAK2 by the growth hormone receptorBrooks, Andrew J., Dai, Wei, O’Mara, Megan L., Abankwa, Daniel, Chhabra, Yash, Pelekanos, Rebecca A., Gardon, Olivier, Tunny, Kathryn A., Blucher, Kristopher M., Morton, Craig J., Parker, Michael W., Sierecki, Emma, Gambin, Yann, Gomez, Guillermo A., Alexandrov, Kirill, Wilson, Ian A., Doxastakis, Manolis, Mark, Alan E. and Waters, Michael J. (2014). Mechanism of activation of protein kinase JAK2 by the growth hormone receptor. Science, 344 (6185) 1249783, 1249783.1-1249783.12. doi: 10.1126/science.1249783 |
|
2010 Journal Article The growth hormone receptor: mechanism of activation and clinical implicationsBrooks, Andrew J. and Waters, Michael J. (2010). The growth hormone receptor: mechanism of activation and clinical implications. Nature Reviews Endocrinology, 6 (9), 515-525. doi: 10.1038/nrendo.2010.123 |
|
2008 Journal Article An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathwayRowlinson, Scott W., Yoshizato, Hideo, Barclay, Johanna L., Brooks, Andrew J., Behncken, Stuart N., Kerr, Linda M., Millard, Kirstin, Palethorpe, Kathryn, Nielsen, Katherine, Clyde-Smith, Jodie, Hancock, John F. and Waters, Michael J. (2008). An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway. Nature Cell Biology, 10 (6), 740-747. doi: 10.1038/ncb1737 |
|
2024 Journal Article Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survivalDang, Thi Viet Trinh, Gillinder, Kevin R., Nguyen, Quan, Mulay, Onkar, Vo, Tuan, Mehdi, Ahmed M., Zhou, Chenhao, Brooks, Andrew J., Leggatt, Graham R., Hume, David A., Frazer, Ian H. and Chandra, Janin (2024). Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survival. Clinical and Translational Immunology, 13 (12) e70018, 1-18. doi: 10.1002/cti2.70018 |
|
2024 Journal Article The roles of Growth Hormone dependent JAK-STAT5 and Lyn kinase signalling in determining lifespan and cancer incidenceChhabra, Yash, Bielefeldt-Ohmann, Helle, Brooks, Tania Louise, Brooks, Andrew James and Waters, Michael J (2024). The roles of Growth Hormone dependent JAK-STAT5 and Lyn kinase signalling in determining lifespan and cancer incidence. Endocrinology, 165 (11) ARTN bqae136. doi: 10.1210/endocr/bqae136 |
|
2024 Conference Publication Epithelial cancers demonstrate IL34-associated dysfunction of Langerhans cellsDang, Thi Viet Trinh, Gillinder, Kevin R., Nguyen, Quan, Mulay, Onkar, Vo, Tuan, Mehdi, Ahmed M., Zhou, Chenhao, Brooks, Andrew J., Asplett, Kiran, Leggatt, Graham R., Hume, David A., Frazer, Ian H. and Chandra, Janin (2024). Epithelial cancers demonstrate IL34-associated dysfunction of Langerhans cells. AACR Special Conference in Cancer Research: Tumor Immunology and Immunotherapy, Boston, MA, United States, 18-21 October 2024. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/2326-6074.tumimm24-a001 |
|
2024 Journal Article A scalable, spin‐free approach to generate enhanced induced pluripotent stem cell–derived natural killer cells for cancer immunotherapyRossi, Gustavo R., Sun, Jane, Lin, Cheng‐Yu, Wong, Joshua K.M., Alim, Louisa, Lam, Pui Yeng, Khosrotehrani, Kiarash, Wolvetang, Ernst, Cheetham, Seth W., Derrick, Emily B., Amoako, Akwasi, Lehner, Christoph, Brooks, Andrew J., Beavis, Paul A. and Souza‐Fonseca‐Guimaraes, Fernando (2024). A scalable, spin‐free approach to generate enhanced induced pluripotent stem cell–derived natural killer cells for cancer immunotherapy. Immunology & Cell Biology, 102 (10), 1-11. doi: 10.1111/imcb.12820 |
|
2024 Journal Article The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammationFernandez-Rojo, Manuel A., Pearen, Michael A., Burgess, Anita G., Ikonomopoulou, Maria P., Hoang-Le, Diem, Genz, Berit, Saggiomo, Silvia L., Nawaratna, Sujeevi S. K., Poli, Maura, Reissmann, Regina, Gobert, Geoffrey N., Deutsch, Urban, Engelhardt, Britta, Brooks, Andrew J., Jones, Alun, Arosio, Paolo and Ramm, Grant A. (2024). The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation. Science Signaling, 17 (830) eade4335, 1-16. doi: 10.1126/scisignal.ade4335 |
|
2024 Journal Article Seasonal differences in amounts of oviposition habitat and egg-laying by caddisflies in rivers with regulated versus unregulated flowsWahjudi, Handoko, Bovill, William D., Brooks, Andrew J. and Downes, Barbara J. (2024). Seasonal differences in amounts of oviposition habitat and egg-laying by caddisflies in rivers with regulated versus unregulated flows. Freshwater Biology, 69 (5), 645-659. doi: 10.1111/fwb.14236 |
|
2024 Journal Article Do magnesium and chloride ameliorate high sodium bicarbonate concentrations? A comparison between laboratory and mesocosm toxicity experimentsKefford, Ben J., Brooks, Andrew J., Shenton, Mark D., Hills, Kasey, Nichols, Susan J., Bray, Jonathan P. and Hyne, Ross V. (2024). Do magnesium and chloride ameliorate high sodium bicarbonate concentrations? A comparison between laboratory and mesocosm toxicity experiments. Science of the Total Environment, 912 169003, 1-13. doi: 10.1016/j.scitotenv.2023.169003 |
|
2024 Journal Article Location, location, location: Protein kinase nanoclustering for optimised signalling outputGormal, Rachel S., Martinez-Marmol, Ramon, Brooks, Andrew J. and Meunier, Frédéric A. (2024). Location, location, location: Protein kinase nanoclustering for optimised signalling output. eLife, 13 ARTN e93902, 1-21. doi: 10.7554/elife.93902 |
|
2023 Journal Article Author Correction: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligandsLinossi, Edmond M., Li, Kunlun, Veggiani, Gianluca, Tan, Cyrus, Dehkhoda, Farhad, Hockings, Colin, Calleja, Dale J., Keating, Narelle, Feltham, Rebecca, Brooks, Andrew J., Li, Shawn S., Sidhu, Sachdev S., Babon, Jeffrey J., Kershaw, Nadia J. and Nicholson, Sandra E. (2023). Author Correction: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. Nature Communications, 14 (1) 7951, 7951. doi: 10.1038/s41467-023-42706-4 |
|
2023 Journal Article Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradationChhabra, Yash, Seiffert, Pernille, Gormal, Rachel S., Vullings, Manon, Lee, Christine Mei Mei, Wallis, Tristan P., Dehkhoda, Farhad, Indrakumar, Sowmya, Jacobsen, Nina L., Lindorff-Larsen, Kresten, Durisic, Nela, Waters, Michael J., Meunier, Frederic A., Kragelund, Birthe B. and Brooks, Andrew J. (2023). Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation. Cell Reports, 42 (5) 112490, 112490. doi: 10.1016/j.celrep.2023.112490 |
|
2022 Conference Publication Gene-therapy based modulation of antigen-presenting cells within hyperproliferative epithelium to restore immunityDang, T. V. T., Gillinder, K. G., Brooks, A. J., Asplett, K., Tolley, L. K., Hume, D. A., Leggatt, G. R., Frazer, I. H. and Chandra, J. (2022). Gene-therapy based modulation of antigen-presenting cells within hyperproliferative epithelium to restore immunity. 29th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy (ESCGT), Edinburgh, United Kingdom, 11-14 October 2022. New Rochelle, NY United States: Mary Ann Liebert. |
|
2022 Journal Article Germline missense variants in SH2B3 underpin platelet count variation and inherited MPNButler, Liesl, Lee, Christine, Magor, Graham William, Morris, Rhiannon, Tallack, Michael, Lam, Charlene, Ivey, Adam, Lin, Jane, Deng, Zihao, Grigg, Andrew, Mason, Jane, Perchard, Malaika, Weston, Helen, Cummings, Nik, Brooks, Andrew, Babon, Jeffrey J, Murphy, Andrew J, Salmon, Jessica M and Perkins, Andrew Charles (2022). Germline missense variants in SH2B3 underpin platelet count variation and inherited MPN. Blood, 140 (S1), 1093-1094. doi: 10.1182/blood-2022-159416 |
|
2021 Journal Article Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligandsLinossi, Edmond M., Li, Kunlun, Veggiani, Gianluca, Tan, Cyrus, Dehkhoda, Farhad, Hockings, Colin, Calleja, Dale J., Keating, Narelle, Feltham, Rebecca, Brooks, Andrew J., Li, Shawn S., Sidhu, Sachdev S., Babon, Jeffrey J., Kershaw, Nadia J. and Nicholson, Sandra E. (2021). Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. Nature Communications, 12 (1) 7032, 7032. doi: 10.1038/s41467-021-26983-5 |
