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2018 Journal Article Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in miceGordon, Richard, Albornoz, Eduardo A., Christie, Daniel C., Langley, Monica R., Kumar, Vinod, Mantovani, Susanna, Robertson, Avril A. B., Butler, Mark S., Rowe, Dominic B., O'Neill, Luke A., Kanthasamy, Anumantha G., Schroder, Kate, Cooper, Matthew A. and Woodruff, Trent M. (2018). Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Science Translational Medicine, 10 (465) aah4066, eaah4066. doi: 10.1126/scitranslmed.aah4066 |
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2017 Journal Article Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammationChen, Weiqiang, Foo, Suan-Sin, Zaid, Ali, Teng, Terk-Shin, Herrero, Lara J., Wolf, Stefan, Tharmarajah, Kothila, Vu, Luan D., van Vreden, Caryn, Taylor, Adam, Freitas, Joseph R., Li, Rachel W., Woodruff, Trent M., Gordon, Richard, Ojcius, David M., Nakaya, Helder I., Kanneganti, Thirumala-Devi, O’Neill, Luke A. J., Robertson, Avril A. B., King, Nicholas J., Suhrbier, Andreas, Cooper, Matthew A., Ng, Lisa F. P. and Mahalingam, Suresh (2017). Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation. Nature Microbiology, 2 (10), 1-11. doi: 10.1038/s41564-017-0015-4 |
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2016 Journal Article Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degenerationGordon, Richard, Neal, Matthew L., Luo, Jie, Langley, Monica R., Harischandra, Dilshan S., Panicker, Nikhil, Charli, Adhithiya, Jin, Huajun, Anantharam, Vellareddy, Woodruff, Trent M., Zhou, Qun-Yong, Kanthasamy, Anumantha G. and Kanthasamy, Arthi (2016). Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration. Nature Communications, 7 (1) 12932, 12932.1-12932.18. doi: 10.1038/ncomms12932 |
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2016 Journal Article Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's diseaseGordon, Richard, Singh, Neeraj, Lawana, Vivek, Ghosh, Anamitra, Harischandra, Dilshan S., Jin, Huajun, Hogan, Colleen, Sarkar, Souvarish, Rokad, Dharmin, Panicker, Nikhil, Anantharam, Vellareddy, Kanthasamy, Anumantha G. and Kanthasamy, Arthi (2016). Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease. Neurobiology of Disease, 93, 96-114. doi: 10.1016/j.nbd.2016.04.008 |
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2016 Journal Article Motor deficits associated with Huntington's disease occur in the absence of striatal degeneration in BACHD transgenic miceMantovani, Susanna, Gordon, Richard, Li, Rui, Christie, Daniel C., Kumar, Vinod and Woodruff, Trent M. (2016). Motor deficits associated with Huntington's disease occur in the absence of striatal degeneration in BACHD transgenic mice. Human Molecular Genetics, 25 (9) ddw050, 1780-1791. doi: 10.1093/hmg/ddw050 |
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2015 Journal Article The complement receptor C5aR controls acute inflammation and astrogliosis following spinal cord injuryBrennan, Faith H., Gordon, Richard, Lao, Hong W., Biggins, Patrick J., Taylor, Stephen M., Franklin, Robin J. M., Woodruff, Trent M. and Ruitenberg, Marc J. (2015). The complement receptor C5aR controls acute inflammation and astrogliosis following spinal cord injury. Journal of Neuroscience, 35 (16), 6517-6531. doi: 10.1523/JNEUROSCI.5218-14.2015 |
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2023 Journal Article Pharmacological inhibition of PTEN rescues dopaminergic neurons by attenuating apoptotic and neuroinflammatory signaling eventsJohnson, Aishwarya Mary, Jose, Sara, Palakkott, Abdul Rasheed, Khan, Farheen Badrealam, Jayabalan, Nanthini, Kizhakkayil, Jaleel, AlNaqbi, Shamma Abdulla Ali, Scott, Mark GH, Ayoub, Mohammed Akli, Gordon, Richard and Saminathan, Hariharan (2023). Pharmacological inhibition of PTEN rescues dopaminergic neurons by attenuating apoptotic and neuroinflammatory signaling events. Journal of Neuroimmune Pharmacology, 18 (3), 462-475. doi: 10.1007/s11481-023-10077-8 |
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2023 Journal Article Response to comment on “Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice”Albornoz, Eduardo A., Gordon, Richard, Kumar, Vinod, Robertson, Avril A. B., Schroder, Kate and Woodruff, Trent M. (2023). Response to comment on “Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice”. Science Translational Medicine, 15 (696) adh0604, 1-4. doi: 10.1126/scitranslmed.adh0604 |
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2023 Journal Article A review of RRx-001: a late-stage multi-indication inhibitor of NLRP3 activation and chronic inflammationJayabalan, Nanthini, Oronsky, Bryan, Cabrales, Pedro, Reid, Tony, Caroen, Scott, Johnson, Aishwarya M., Birch, Natalia A., O’Sullivan, John D. and Gordon, Richard (2023). A review of RRx-001: a late-stage multi-indication inhibitor of NLRP3 activation and chronic inflammation. Drugs, 83 (5), 389-402. doi: 10.1007/s40265-023-01838-z |
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2023 Journal Article RRx-001: a chimeric triple action NLRP3 inhibitor, Nrf2 inducer, and nitric oxide superagonistOronsky, Bryan, Takahashi, Lori, Gordon, Richard, Cabrales, Pedro, Caroen, Scott and Reid, Tony (2023). RRx-001: a chimeric triple action NLRP3 inhibitor, Nrf2 inducer, and nitric oxide superagonist. Frontiers in Oncology, 13 1204143, 1-8. doi: 10.3389/fonc.2023.1204143 |
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2022 Journal Article Inflammasome activation in Parkinson's diseaseJewell, Shannon, Herath, Ashane M. and Gordon, Richard (2022). Inflammasome activation in Parkinson's disease. Journal of Parkinson's Disease, 12 (s1), S113-S128. doi: 10.3233/JPD-223338 |
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2022 Journal Article Mechanisms of NLRP3 activation and pathology during neurodegenerationJose, Sara, Groves, Natalie J., Roper, Kathrein E. and Gordon, Richard (2022). Mechanisms of NLRP3 activation and pathology during neurodegeneration. The International Journal of Biochemistry & Cell Biology, 151 106273, 106273. doi: 10.1016/j.biocel.2022.106273 |
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2022 Conference Publication A Novel Role for Glucocerebrosidase 1 (GBA1) in Parkinson's DiseaseJayabalan, Nanthini, Roper, Katherine Kerry, Woodhouse, Helen M., Adam, Robert J., O'Sullivan, John D. and Gordon, Richard (2022). A Novel Role for Glucocerebrosidase 1 (GBA1) in Parkinson's Disease. Experimental Biology Meeting 2022, Philadelphia, PA United States, 2-5 April 2022. Hoboken, NJ United States: John Wiley and Sons. doi: 10.1096/fasebj.2022.36.S1.R5391 |
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2022 Conference Publication LC-MS based urine metabolomic profiling indicate altered gut microbiome and host lipid metabolites in Parkinson's diseaseJewell, Shannon, Roper, Kerry, Woodhouse, Helen, Adam, Robert, O'Sullivan, John and Gordon, Richard (2022). LC-MS based urine metabolomic profiling indicate altered gut microbiome and host lipid metabolites in Parkinson's disease. Experimental Biology 2022 Meeting, Philadelphia, PA United States, 2-5 April 2022. Hoboken, NJ United States: John Wiley and Sons. doi: 10.1096/fasebj.2022.36.S1.R2928 |
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2022 Journal Article Environmental neurotoxicants and inflammasome activation in Parkinson’s disease – a focus on the gut-brain axisJohnson, Aishwarya M., Ou, Zhen-Yi Andy, Gordon, Richard and Saminathan, Hariharan (2022). Environmental neurotoxicants and inflammasome activation in Parkinson’s disease – a focus on the gut-brain axis. The International Journal of Biochemistry and Cell Biology, 142 106113, 106113. doi: 10.1016/j.biocel.2021.106113 |
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2020 Journal Article Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: Relevance to translational researchSaminathan, Hariharan, Charli, Adhithiya, Luo, Jie, Panicker, Nikhil, Gordon, Richard, Hostetter, Jesse M, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Anumantha G and Kanthasamy, Arthi (2020). Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: Relevance to translational research. European journal of pharmacology, 881 173259, 173259. doi: 10.1016/j.ejphar.2020.173259 |
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2020 Journal Article Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) enhances activation of STAT3/NLRC4 inflammasome signaling axis through PKCδ in astrocytes: implications for Parkinson's diseaseSamidurai, Manikandan, Tarale, Prashant, Janarthanam, Chelva, Estrada, Crystal Gomez, Gordon, Richard, Zenitsky, Gary, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Anumantha G. and Kanthasamy, Arthi (2020). Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) enhances activation of STAT3/NLRC4 inflammasome signaling axis through PKCδ in astrocytes: implications for Parkinson's disease. Cells, 9 (8) 1831, 1831-35. doi: 10.3390/cells9081831 |
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2020 Journal Article Interaction of the brain-selective sulfotransferase SULT4A1 with other cytosolic sulfotransferases: effects on protein expression and functionIdris, Misgana, Mitchell, Deanne J., Gordon, Richard, Sidharthan, Neelima P., Butcher, Neville J. and Minchin, Rodney F. (2020). Interaction of the brain-selective sulfotransferase SULT4A1 with other cytosolic sulfotransferases: effects on protein expression and function. Drug Metabolism and Disposition, 48 (5), 337-344. doi: 10.1124/dmd.119.089714 |
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2020 Journal Article The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteinsDeora, Vandana, Lee, John D., Albornoz, Eduardo A., McAlary, Luke, Jagaraj, Cyril J., Robertson, Avril A. B., Atkin, Julie D, Cooper, Matthew A., Schroder, Kate, Yerbury, Justin J., Gordon, Richard and Woodruff, Trent M. (2020). The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins. Glia, 68 (2) glia.23728, 407-421. doi: 10.1002/glia.23728 |
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2018 Journal Article Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytesNeal, Matthew, Luo, Jie, Harischandra, Dilshan S., Gordon, Richard, Sarkar, Souvarish, Jin, Huajun, Anantharam, Vellareddy, Désaubry, Laurent, Kanthasamy, Anumantha and Kanthasamy, Arthi (2018). Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes. Glia, 66 (10), 2137-2157. doi: 10.1002/glia.23467 |
